13,434 results match your criteria dichotomous variablesresults


Case-control study about magnitude of exposure to wood smoke and risk of developing lung cancer.

Eur J Cancer Prev 2021 Jun 10. Epub 2021 Jun 10.

Servicio Clínico de Neumología Oncológica, Instituto Nacional de Enfermedades Respiratorias División de Posgrado, Facultad de Medicina, Universidad Nacional Autónoma de México Thoracic Oncology Unit, Instituto Nacional de Cancerología, México City, México.

Introduction: Exposure to biomass combustion products, particularly firewood, has been considered as a potential carcinogen for developing lung cancer. In this regard, current evidence is widely heterogeneous; besides, in most studies, wood smoke exposure is not appropriately quantified, which further complicates the analysis of wood smoke as a potential carcinogen. The aim of the present study was to estimate the risk of developing lung cancer according to the degree of exposure to wood smoke in patients who use firewood for cooking. Read More

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Roxadustat for the treatment of anemia in patients with chronic kidney diseases: a meta-analysis.

Aging (Albany NY) 2021 Jun 11;13. Epub 2021 Jun 11.

Department of Thyroid Surgery, The First Hospital of Jilin University, Jilin Province, China.

Background: Anemia is a common complication of chronic kidney disease (CKD). Treating renal anemia with erythropoiesis-stimulating agents (ESAs) or erythropoietin analogs is effective but has side effects. Therefore, we performed a meta-analysis to assess the efficacy and safety of roxadustat in treating CKD-induced anemia. Read More

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Systematic review and meta-analyses of cholecystectomy as a treatment of biliary hyperkinesia.

Clin J Gastroenterol 2021 Jun 11. Epub 2021 Jun 11.

Consultant Upper GI Surgeon, North Cumbria University Hospitals NHS Trust, Carlisle, UK.

Biliary hyperkinesia is typically diagnosed in patients with biliary-like pain and no evidence of gall stones on imaging modalities but who have had biliary scintigraphy scan (HIDA) that shows ejection fraction ≥ 80%. This study aims to identify whether the removal of the gall bladder can alleviate the symptoms associated with biliary hyperkinesia. Systematic search following PRISMA guidelines was done from inception to January 2020 using PubMed/Medline, OVID, Embase, Cochrane database of systemic reviews, Cochrane central register of controlled trials, The Database of Abstracts of Reviews of Effects (DARE) and Cochrane library databases. Read More

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Acupuncture treatment for emotional problems in infertile women: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26306

Department of Korean Medicine Obstetrics and Gynecology, Pusan National University Korean Medicine Hospital.

Background: Infertility causes emotional and psychological problems, including anxiety, depression, low self-efficacy, and chronic mental stress in women. These emotional problems can negatively affect fertility treatment. Numerous studies have reported the clinical therapeutic effects of acupuncture on emotional problems; however, the efficacy and safety of acupuncture treatment for emotional problems in infertile women remain unclear. Read More

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Shaofu Zhuyu decoction for primary dysmenorrhea: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26226

College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.

Background: Primary dysmenorrhea (PD), one of the common gynecological diseases, is more common in adolescent women. According to epidemiological investigation, the incidence of PD accounts for about 60% of all patients with dysmenorrhea, and its symptoms seriously affect the normal working life of women, so it is important to find a more safe and effective treatment. In recent years, traditional Chinese medicine has made a lot of achievements in the treatment of female PD, among which a number of clinical studies have shown that Shaofu Zhuyu decoction (SFZY) can significantly improve the symptoms of dysmenorrhea and improve the therapeutic effect. Read More

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Effect of training programmes on nurses' ability to care for subjects with pressure injuries: A meta-analysis.

Int Wound J 2021 Jun 10. Epub 2021 Jun 10.

Department of General Ward, Shaoxing Central Hospital, Shaoxing, China.

We performed a meta-analysis to evaluate the education effects on nurses' ability to care for subjects with pressure injuries. A systematic literature search up to April 2021 was carried out, and 29 studies included 5704 nurses at the start of the study; 3800 of them were experiment or post-training and 3804 were control or per-training. They were reporting relationships between the education effects on nurses' ability to care for subjects with pressure injuries. Read More

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Systematic review and network meta-analysis: efficacy of licensed drugs for abdominal bloating in irritable bowel syndrome with constipation.

Aliment Pharmacol Ther 2021 Jun 11. Epub 2021 Jun 11.

Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.

Background: Although bloating is a highly prevalent and troublesome symptom in irritable bowel syndrome with constipation (IBS-C), treatment is empirical with no specific guidelines for its management.

Aim: To conduct a pairwise and network meta-analysis, using a frequentist approach, of Food and Drug Administration-licensed drugs for IBS-C comparing their efficacy for abdominal bloating as a specific endpoint.

Methods: We searched the medical literature through December 2020 to identify randomised controlled trials (RCTs) in IBS-C, with abdominal bloating reported as a dichotomous assessment. Read More

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Maternal plasma choline and betaine in late pregnancy and child growth up to age 8 years in the KOALA Birth Cohort Study.

Am J Clin Nutr 2021 Jun 10. Epub 2021 Jun 10.

Department of Epidemiology, Maastricht University Medical Centre+, Maastricht, Netherlands.

Background: Sufficient choline and betaine during pregnancy are needed for fetal growth and development.

Objectives: We aimed to investigate the associations between maternal plasma choline and betaine in the third trimester of pregnancy and child growth from birth up to 8 years of age.

Methods: Concentrations of choline and betaine were measured in plasma of 1331 pregnant women from the KOALA (Kind, Ouders en gezondheid: Aandacht voor Leefstijl en Aanleg) Birth Cohort Study in the Netherlands. Read More

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Quality of Life and Functioning of People With Mental Disorders Who Underwent Deinstitutionalization Using Assisted Living Facilities: A Cross-Sectional Study.

Front Psychol 2021 25;12:622973. Epub 2021 May 25.

Graduate Program in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, Brazil.

Context: People with mental disorders can acquire long-term disabilities, which could impair their functioning and quality of life (QoL), requiring permanent care and social support. Systematic data on QoL and functioning, which could support a better management of these people, were not available.

Objective: To analyze the QoL, level of functioning and their association with sociodemographic and clinical factors of people with mental disorders who underwent deinstitutionalization using assisted living facilities. Read More

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Meta-analysis comparing valve-in-valve TAVR and redo-SAVR in patients with degenerated bioprosthetic aortic valve.

Catheter Cardiovasc Interv 2021 Jun 10. Epub 2021 Jun 10.

Cardiovascular Medicine, Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania, USA.

Introduction: The comparative efficacy and safety of valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) and redo-surgical AVR (redo-SAVR) in patients with degenerated bioprosthetic aortic valves remain unknown.

Method: Digital databases were searched to identify relevant articles. Unadjusted odds ratios for dichotomous outcomes were calculated using a random effect model. Read More

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Rheumatologist perspective of the Brazilian consensus for detection of auto antibodies in HEp-2 CELLS.

Adv Rheumatol 2021 Jun 9;61(1):32. Epub 2021 Jun 9.

Pontifícia Universidade Católica de Goiás (PUC Goiás), Escola de Ciências Médicas, Farmacêuticas e Biomédicas, Avenida Universitária 1.440, Setor Universitário, Goiânia, GO, Brazil.

Objective: To evaluate the perception of rheumatologists regarding the recommendations of the Brazilian Consensus for detection of Autoantibodies (BCA) on HEp-2 Cells by Indirect Immunofluorescence assay (IFA) and how BCA recommendations help in clinical practice.

Methodology: A structured questionnaire regarding the BCA recommendations for detection and interpretations of autoantibodies in HEp-2 cells was applied to randomly selected rheumatologists. The results were tabulated using the Microsoft® Excel program, expressed as a simple percentage and the dichotomous data were analyzed using the Chi-square test and the Epi Info® program. Read More

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Awareness and outcomes of the fruits and veggies (FNV) campaign to promote fruit and vegetable consumption among targeted audiences in California and Virginia: a cross-sectional study.

BMC Public Health 2021 Jun 9;21(1):1100. Epub 2021 Jun 9.

Department of Human Nutrition, Foods, and Exercise, Virginia Tech, 257 Wallace Hall, 295 West Campus Drive, Blacksburg, Virginia, 24061, USA.

Background: In 2015, the Partnership for a Healthier America launched the branded Fruits & Veggies (FNV) Campaign to apply a unique industry-inspired marketing approach to promote fruit and vegetable sales and intake to moms and teens in two US pilot markets: Fresno, California and Hampton Roads, Virginia. The aims of this cross-sectional study were to: 1) assess brand awareness and fruit- and vegetable-related outcomes among FNV Campaign target audiences in the California and Virginia market locations; and 2) examine whether reported awareness of the FNV Campaign was associated with differences in fruit- and vegetable-related cognitive and behavioral outcomes.

Methods: Data for this cross-sectional study were collected using an online survey administered to a non-probability convenience sample (n = 1604; February-July 2017) of youth aged 14-20 years (n = 744) and moms aged 21-36 years (n = 860) in the two pilot markets. Read More

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The effect of the herbal medicine on severity of cyclic mastalgia: a systematic review and meta-analysis.

J Complement Integr Med 2021 May 20. Epub 2021 May 20.

Social Determinants of Health Research Center, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

Cyclic mastalgia is one of the most prevalent problems in women of reproductive age and sometimes it is so severe that it influences their activities and requires treatment. The available drug treatments for mastalgia are not satisfactory and most patients have inclined towards complementary and alternative medicine including herbal medicines. Therefore, in order to evaluate the effectiveness and side effects of herbal medicines conducting systematic review studies and meta-analysis seems essential, thus this systematic review was conducted with the aim of determining the effect of herbal medicines on cyclic mastalgia and its probable side effects. Read More

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Xuefu Zhuyu decoction for nonalcoholic fatty liver disease: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(19):e25358

Hainan Medical University, Haikou, Hainan, China.

Background: Nonalcoholic fatty liver disease (NAFLD) includes nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH), which ranks only second to viral hepatitis and poses an increasingly serious challenge to global public health and economy. NAFLD has attracted more and more attention, but there is no drugs with exact curative effects are available. The commonly used drugs for the treatment of NAFLD in clinical practice are statins, such drugs, inevitably increase the burden on the live. Read More

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Ultra-rapid-acting insulins for adults with diabetes mellitus: a systematic review and meta-analysis.

Diabetes Obes Metab 2021 Jun 9. Epub 2021 Jun 9.

Clinical Research and Evidence-Based Medicine Unit, Second Medical Department, Aristotle University of Thessaloniki, Thessaloniki, Greece.

We performed a systematic review and meta-analysis of randomized controlled trials to assess the efficacy and safety of the novel, ultra-rapid acting insulins aspart and lispro in adults with type 1 or type 2 diabetes. Our primary outcome was change in HbA1c from baseline. We additionally assessed eight efficacy and six safety endpoints. Read More

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Recent Sexual Assault Predicting Changes in Coping Motives for Alcohol Use in First-Year College Women.

Violence Vict 2021 Jun;36(3):424-435

Department of Psychology, George Mason University, Fairfax, Virginia, USA.

Sexual assault and heavy alcohol consumption are common among college students. There is strong evidence that the two are associated, but more remains to be understood about the nature of the relationship. Drinking motives have been found to mediate the relationship between sexual assault and drinking problems and between depression and alcohol risk (Kenney, Anderson, & Stein, 2018; Lindgren, Neighbors, Blayney, Mullins, & Kasen, 2012), however drinking motives have not been studied as an outcome. Read More

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Urologic oncology randomized controlled trials are frequently fragile - A review of the urology literature.

Urol Oncol 2021 Jun 5. Epub 2021 Jun 5.

Department of urology, Chaim Sheba Medical Center, IL. Electronic address:

Background: Randomized controlled trials (RCT) in urologic oncology are the basis of patient management. Considerable debate exists on the limitation of statistical reporting of randomized controlled trials. Fragility index (FI) is a measure of the number of events upon which the trials statistical results depend on. Read More

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[Consistency of peripheral whole blood and venous serum procalcitonin in children: a multicenter parallel controlled study].

Zhonghua Er Ke Za Zhi 2021 Jun;59(6):471-477

Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China.

To explore the consistency of peripheral whole blood and venous serum procalcitonin (PCT) levels, and the value of peripheral whole blood PCT in evaluating pediatric bacterial infection. This multicenter cross-sectional parallel control study was conducted in 11 children's hospital. All the 1 898 patients older than 28 days admitted to these hospitals from March 2018 to February 2019 had their peripheral whole blood and venous serum PCT detected simultaneously with unified equipment, reagent and method. Read More

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Factors associated with residual symptom burden in patients with peritoneal dialysis: a cohort study

Rev Med Inst Mex Seguro Soc 2020 ;58(2):174-180

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades Dr. Bernardo Sepúlveda Gutiérrez, Servicio de Medicina Interna, Ciudad de México. México.

Background: Patients on peritoneal dialysis have residual symptoms that reduce their quality of life.

Objective: To determine the associated factors of residual symptom burden in patients with continuous ambulatory peritoneal dialysis (CAPD).

Material And Mehotds: An observational, longitudinal, prospective and analytical study was carried out in patients with chronic kidney disease, who were candidates for peritoneal dialysis. Read More

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January 2020

Traumatic events and psychotic experiences: a nationally representative study in Thailand.

Epidemiol Psychiatr Sci 2021 Jun 8;30:e47. Epub 2021 Jun 8.

ESRC Centre for Society and Mental Health, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Aims: Most research exploring the link between traumatic events and psychotic experiences has focused on either Australia, Europe or North America. In this study, we expand the existing knowledge to Thailand and investigate the impact of the type and the number of traumatic events on psychotic experiences in Thailand.

Methods: We used data from the nationally representative 2013 Thai National Mental Health Survey (TNMHS), including questions on traumatic events and psychotic experiences. Read More

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Rapid versus standard antimicrobial susceptibility testing to guide treatment of bloodstream infection.

Cochrane Database Syst Rev 2021 05 4;5:CD013235. Epub 2021 May 4.

Medical Microbiology Department, SouthWest London Pathology, Jenner Wing St George's Hospital, London, UK.

Background: Rapid antimicrobial susceptibility tests are expected to reduce the time to clinically important results of a blood culture. This might enable clinicians to better target therapy to a person's needs, and thereby, improve health outcomes (mortality, length of hospital stay), and reduce unnecessary prescribing of broad-spectrum antibiotics; thereby reducing antimicrobial resistance rates.

Objectives: To assess the effects of rapid susceptibility testing versus standard susceptibility testing for bloodstream infections (BSIs). Read More

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The use of statins was associated with reduced COVID-19 mortality: a systematic review and meta-analysis.

Ann Med 2021 12;53(1):874-884

Research Center of Medical Informatics, Kaohsiung Veterans General Hospital, Kaohsiung City, ROC.

Background: Statins are widely used to treat people with metabolic and cardiovascular disorders. The effect of statins on coronavirus disease 2019 (COVID-19) is unclear. To investigate the association between statins and COVID-19 outcomes and, if possible, identify the subgroup population that benefits most from statin use. Read More

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December 2021

Adrenal venous sampling with adrenocorticotropic hormone stimulation: A meta-analysis.

Int J Clin Pract 2021 Jun 6:e14438. Epub 2021 Jun 6.

Department Of Urology, Yaan People's Hospital, Yaan, Sichuan, 625000, China.

Background: This meta-analysis was performed to compare the effect of adrenal venous sampling with adrenocorticotropic hormone to that without adrenocorticotropic hormone in subjects with primary aldosteronism.

Methods: A systematic literature search up to May 2020 was performed and 17 studies were detected with 1878 subjects who had adrenal venous sampling operations. They reported relationships between with and without adrenocorticotropic hormone stimulation during adrenal venous sampling in subjects with primary aldosteronism. Read More

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Risk Models for Advanced Melanoma Patients Under Anti-PD-1 Monotherapy- Analyses of Pooled Data From Two Clinical Trials.

Front Oncol 2021 20;11:639085. Epub 2021 May 20.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Melanoma, Peking University Cancer Hospital and Institute, Beijing, China.

The best response and survival outcomes between advanced melanoma patients treated with the anti-PD-1 monotherapy vary greatly, rendering a risk model in need to optimally stratify patients based on their likelihood to benefit from the said treatment. We performed an analysis of 89 advanced melanoma patients treated with the anti-PD-1 monotherapy from two prospective clinical trials at the Peking University Cancer Hospital from April 2016 to May 2018. Clinicodemographical characteristics, baseline and early-on-treatment (median 0. Read More

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Implicit Associations With Nature and Urban Environments: Effects of Lower-Level Processed Image Properties.

Front Psychol 2021 20;12:591403. Epub 2021 May 20.

Social, Environmental, and Economic Psychology, University of Koblenz-Landau, Landau, Germany.

Nature experiences usually lead to restorative effects, such as positive affective states and reduced stress. Even watching nature compared to urban images, which are known to differ in several image properties that are processed at early stages, can lead to such effects. One potential pathway explaining how the visual input alone evokes restoration is that image properties processed at early stages in the visual system evoke positive associations. Read More

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Thalamic but Not Subthalamic Neuromodulation Simplifies Word Use in Spontaneous Language.

Front Hum Neurosci 2021 20;15:656188. Epub 2021 May 20.

Department of Neurology, Motor and Cognition Group, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Several investigations have shown language impairments following electrode implantation surgery for Deep Brain Stimulation (DBS) in movement disorders. The impact of the actual stimulation, however, differs between DBS targets with further deterioration in formal language tests induced by thalamic DBS in contrast to subtle improvement observed in subthalamic DBS. Here, we studied speech samples from interviews with participants treated with DBS of the thalamic ventral intermediate nucleus (VIM) for essential tremor (ET), or the subthalamic nucleus (STN) for Parkinson's disease (PD), and healthy volunteers (each = 13). Read More

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Effects of March of Dimes Supportive Pregnancy Care on Social Support and Postpartum Depression.

Health Educ Behav 2021 Jun 6:10901981211019919. Epub 2021 Jun 6.

Vanderbilt University, Nashville, TN, USA.

Purpose: Group prenatal care, which integrates medical care with patient education and empowerment in a group setting, has the potential to build social support among pregnant women and reduce the risk of postpartum depression (PPD). Past research on group care's effects on social support or PPD has produced inconsistent findings. Studies have tended to (1) examine direct effects on social support or PPD and (2) treat group care participation as a dichotomous variable. Read More

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Sleep Bruxism and Temporomandibular Disorders: a scoping review of the literature.

J Dent 2021 Jun 3:103711. Epub 2021 Jun 3.

Professor and Chair, Department of Orofacial pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Objective: To provide a scoping review of the literature by assessing all the English-language papers that investigated the relationship between sleep bruxism (SB) and temporomandibular disorders (TMDs).

Study Data And Sources: A search was performed in the National Library of Medicine (PubMed) and Scopus databases, in order to identify all the articles published assessing the relationship between SB and TMDs, by several different approaches. The selected articles were then structurally read and summarized in PICO tables. Read More

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Is there a relationship between sagittal cervical spine mobility and generalised joint hypermobility? A cross-sectional study of 1000 healthy Australians.

Physiotherapy 2021 Jan 2;112:150-157. Epub 2021 Jan 2.

The University of Sydney, School of Medical Sciences, Faculty of Medicine and Health, Camperdown, NSW 2006, Australia. Electronic address:

Objectives: The primary aim was to determine the association between sagittal cervical mobility and the presence and extent of GJH across the lifespan. Secondary aims were to determine which features explain variability in cervical range of motion (CROM) and to establish the sagittal cervical hypermobile range in both genders across the lifespan.

Design: Cross-sectional observational study. Read More

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January 2021

Systematic Review and Meta-Analysis of the Effect of Perineural Catheters in Major Lower Limb Amputations.

Eur J Vasc Endovasc Surg 2021 Jun 1. Epub 2021 Jun 1.

Department of Vascular Surgery, Royal Gwent Hospital, Newport, United Kingdom. Electronic address:

Objective: Controlling pain after major lower limb amputation (MLLA) is of critical importance to patients and clinicians. The aim of this systematic review and meta-analysis was to assess the effect of perineural catheters (PNCs) on post-operative pain, post-operative morphine requirement, in-hospital mortality, long term phantom limb pain, and chronic stump pain.

Methods: A systematic review using PubMed, EMBASE via OVID and the Cochrane library from database inception (1946) to 20 October 2020 was performed according to PRISMA guidelines. Read More

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