67,620 results match your criteria diastolic dysfunction


Telmisartan ameliorates cardiac fibrosis and diastolic function in cardiorenal heart failure with preserved ejection fraction.

Exp Biol Med (Maywood) 2021 Aug 3:15353702211035058. Epub 2021 Aug 3.

Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.

Chronic kidney disease (CKD) is a major contributor to the development of heart failure with preserved ejection fraction (HFpEF), whereas the underlying mechanism of cardiorenal HFpEF is still elusive. The aim of this study was to investigate the role of cardiac fibrosis in a rat model of cardiorenal HFpEF and explore whether treatment with Telmisartan, an inhibitor of renin-angiotensin-aldosterone system (RAAS), can ameliorate cardiac fibrosis and preserve diastolic function in cardiorenal HFpEF. Male rats were subjected to 5/6 subtotal nephrectomy (SNX) or sham operation (Sham), and rats were allowed four weeks to recover and form a stable condition of CKD. Read More

View Article and Full-Text PDF

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents.

J Vis Exp 2021 Jul 14(173). Epub 2021 Jul 14.

Unidade de Investigação Cardiovascular, Departamento de Cirurgia e Fisiologia, Faculdade de Medicina, Universidade do Porto;

To better understand the left ventricular (LV) reverse remodeling (RR), we describe a rodent model wherein, after aortic banding-induced LV remodeling, mice undergo RR upon removal of the aortic constriction. In this paper, we describe a step-by-step procedure to perform a minimally invasive surgical aortic debanding in mice. Echocardiography was subsequently used to assess the degree of cardiac hypertrophy and dysfunction during LV remodeling and RR and to determine the best timing for aortic debanding. Read More

View Article and Full-Text PDF

Phasic Flow Patterns of Right versus Left Coronary Arteries in Patients Undergoing Clinical Physiological Assessment.

EuroIntervention 2021 Aug 3. Epub 2021 Aug 3.

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Background: Coronary blood flow in humans is known to be predominantly diastolic. Small studies in animals and humans suggest this is less pronounced or even reversed in the right coronary artery.

Aims: This study aims to characterise the phasic patterns of coronary flow in the left versus right coronary arteries of patients undergoing invasive physiological assessment. Read More

View Article and Full-Text PDF

Prognostic Value of Diastolic Dysfunction Derived From D-SPECT in Coronary Artery Disease Patients With Normal Ejection Fraction.

Front Cardiovasc Med 2021 15;8:700027. Epub 2021 Jul 15.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Diastolic dysfunction (DD) with normal systolic function has been elucidated to be associated with heart failure and worse prognosis. The recently introduced single photon emission computed tomography (SPECT) with dedicated cardiac cadmium-zinc-telluride (CZT) cameras (D-SPECT) is a novel method to quantitate left ventricular functional parameters. We aimed to evaluate the prognostic value of DD derived from D-SPECT in coronary artery disease (CAD) patients with normal ejection fraction. Read More

View Article and Full-Text PDF

Impact of Dapagliflozin on the Left Ventricular Diastolic Function in Diabetic Patients with Heart Failure Complicating Cardiovascular Risk Factors.

Intern Med 2021 1;60(15):2367-2374. Epub 2021 Aug 1.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan.

Objective Our aim was to investigate the impact of the sodium glucose cotransporter type 2 (SGLT2) inhibitor on the left ventricular (LV) diastolic function in type 2 diabetes mellitus (T2DM) patients with chronic heart failure (HF) complicating cardiovascular risk factors. Methods We analyzed data from our previous prospective multicenter study, in which we investigated the effect of dapagliflozin on the LV diastolic function of T2DM patients with stable HF at five institutions in Japan. Patients who had been taking at least 1 antidiabetic drug other than SGLT2 inhibitors started treatment with dapagliflozin. Read More

View Article and Full-Text PDF

The SRSF4-GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy.

Circ Res 2021 Aug 2. Epub 2021 Aug 2.

Myocardial Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), SPAIN.

RNA-binding proteins (RBPs) play critical roles in human biology and disease. Aberrant RBP expression affects various steps in RNA processing, altering the function of the target RNAs. The RBP serine/arginine-rich splicing factor 4 (SRSF4) has been linked to neuropathies and cancer. Read More

View Article and Full-Text PDF

Left Ventricular Strain Rate for Intraoperative Evaluation of Cardiac Diastolic Function by Transesophageal Echocardiography: The Correlation Between Late Diastolic Peak Longitudinal Strain Rate and the Severity of Diastolic Dysfunction.

J Cardiothorac Vasc Anesth 2021 Jul 1. Epub 2021 Jul 1.

Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL; Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, IL.

Objectives: Speckle-tracking echocardiography is a promising tool for evaluating cardiac diastolic dysfunction. A correlation between left atrial strain rate during atrial contraction and the severity of diastolic dysfunction previously has been demonstrated. Because visualization of the left atrial walls is difficult with transesophageal echocardiography, the authors evaluated the use of left ventricular strain rate during atrial contraction as a substitute for left atrial strain rate to intraoperatively measure the extent of cardiac diastolic dysfunction. Read More

View Article and Full-Text PDF

Obstructive sleep apnea increases the risk of cardiovascular damage: a systematic review and meta-analysis of imaging studies.

Syst Rev 2021 Jul 30;10(1):212. Epub 2021 Jul 30.

Department of Otolaryngology Head & Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Road, Beijing, 100029, China.

Background: We aimed to perform a systematic review and meta-analysis of the association between obstructive sleep apnea (OSA) and cardiac as well as coronary impairment evaluated using imaging modalities. Finding of this study will provide more robust evidence regarding OSA-induced cardiovascular damage.

Methods: We systematically searched through PubMed, EMBASE, and Cochrane library databases for relevant literatures on the association between OSA and cardiovascular damage evaluated using imaging modalities, and manually searched the references of selected articles for additional relevant articles. Read More

View Article and Full-Text PDF

Hypertrophic Cardiomyopathy in Infants from the Perspective of Cardiomyocyte Maturation.

Korean Circ J 2021 Jun 18. Epub 2021 Jun 18.

Department of Pediatrics, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Hypertrophic cardiomyopathy (HCM) is characterized by ventricular wall hypertrophy with diastolic dysfunction. Pediatric HCM is distinguished from the adult in many aspects. Most children with HCM do not present clinically until the adolescent period, even when they are born with genetic mutations. Read More

View Article and Full-Text PDF

Cardiac structural and functional abnormalities in primary hyperparathyroidism.

J Endocrinol Invest 2021 Jul 29. Epub 2021 Jul 29.

Department of Medicine, Government Medical College Srinagar, Srinagar, Jammu and Kashmir, India.

Purpose: Studies on cardiac structural and functional abnormalities in primary hyperparathyroidism (PHPT) have yielded conflicting and inconsistent results. In this prospective case-control study, we sought to compare cardiac structure and function in symptomatic PHPT patients and controls.

Methods: One hundred consecutive symptomatic PHPT patients and 113 matched controls underwent echocardiographic evaluation by the same operator. Read More

View Article and Full-Text PDF

Is coronary artery tortuosity a precursor of atherosclerosis and/or left ventricular diastolic dysfunction?

Egypt Heart J 2021 Jul 28;73(1):68. Epub 2021 Jul 28.

Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.

View Article and Full-Text PDF

Association between diastolic stress test and H2FPEF score.

Arch Cardiol Mex 2021 Jul 28. Epub 2021 Jul 28.

Fellow of the American College of Cardiology (FACC) and the European Society of Cardiology (FESC); FEHFA, Department of Internal Medicine, Universidad de Antioquia, Medellín, Colombia.

Objective: Heart failure with preserved ejection fraction is a highly prevalent disease; some advances for improving the diagnosis are the development of the H2FPEF score and the diastolic stress test for the evaluation of diastolic function. The objective is to describe the clinical and echocardiographic characteristics of patients referred for stress tests, and the association between the H2FPEF score and the results of the diastolic test.

Methods: This is an analytical, observational, retrospective study. Read More

View Article and Full-Text PDF

Relationship between Innate Immune Response Toll-Like Receptor 4 (TLR-4) and the Pathophysiological Process of Obesity Cardiomyopathy.

Arq Bras Cardiol 2021 Jul;117(1):91-99

Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Faculdade de Medicina , Botucatu , SP - Brasil.

Background: Obesity is a chronic low-grade inflammation condition related to cardiac disorders. However, the mechanism responsible for obesity-related cardiac inflammation is unclear. The toll-like receptor 4 (TLR-4) belongs to a receptor of the transmembrane family responsible for the immune response whose activation stimulates the production of proinflammatory cytokines. Read More

View Article and Full-Text PDF

Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation.

J Gen Physiol 2021 Sep 28;153(9). Epub 2021 Jul 28.

Department of Biomedical Engineering, Yale University, New Haven, CT.

Hypertrophic cardiomyopathy (HCM) is an inherited disorder caused primarily by mutations to thick and thinfilament proteins. Although thin filament mutations are less prevalent than their oft-studied thick filament counterparts, they are frequently associated with severe patient phenotypes and can offer important insight into fundamental disease mechanisms. We have performed a detailed study of tropomyosin (TPM1) E192K, a variant of uncertain significance associated with HCM. Read More

View Article and Full-Text PDF
September 2021

Relatively Benign yet a Reversible Cause of Dilated Cardiomyopathy.

JACC Case Rep 2021 Jul 2;3(8):1081-1085. Epub 2021 Jun 2.

Department of Internal Medicine, Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Arrhythmia-induced cardiomyopathy secondary to frequent ventricular premature contractions is a well-studied phenomenon; however, there is a paucity of data showing a similar association with frequent atrial premature contractions (APCs). Early recognition and successful APC ablation can reverse left ventricular dysfunction in these patients. (). Read More

View Article and Full-Text PDF

Aging Induced Impairment of Vascular Function - Mitochondrial Redox Contributions and Physiological/Clinical Implications.

Antioxid Redox Signal 2021 Jul 27. Epub 2021 Jul 27.

University of Louisville, 5170, Physiology, Louisville, Kentucky, United States;

Significance: The vasculature responds to the respiratory needs of tissue by modulating luminal diameter through smooth muscle constriction or relaxation. Coronary perfusion, diastolic function, and coronary flow reserve are drastically reduced with aging. This loss of blood flow contributes to and exacerbates pathological processes such as angina pectoris, atherosclerosis, and coronary artery and microvascular disease. Read More

View Article and Full-Text PDF

Telomere length and metabolic syndrome traits: A Mendelian randomisation study.

Aging Cell 2021 Jul 27:e13445. Epub 2021 Jul 27.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Observational studies have revealed associations between short leucocyte telomere length (LTL), a TL marker in somatic tissues and multiple Metabolic Syndrome (MetS) traits. Animal studies have supported these findings by showing that increased telomere attrition leads to adipose tissue dysfunction and insulin resistance. We investigated the associations between genetically instrumented LTL and MetS traits using Mendelian Randomisation (MR). Read More

View Article and Full-Text PDF

Peripheral microcirculatory abnormalities are associated with cardiovascular risk in systemic sclerosis: a nailfold video capillaroscopy study.

Clin Rheumatol 2021 Jul 27. Epub 2021 Jul 27.

Fourth Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Konstantinoupoleos Str. 49, Thessaloniki, Greece.

Introduction: Microvascular dysfunction is the key element in the pathogenesis of systemic sclerosis (SSc), whereas the contribution of large and medium size vessel abnormalities is yet to be established. The aim of the present study is to assess the association between micro- and macrovascular function by utilizing a broad spectrum of assessments of vascular performance.

Methods: We included consecutive, consenting SSc patients who underwent nailfold video capillaroscopy (NVC) for microcirculation evaluation. Read More

View Article and Full-Text PDF

Subacute and chronic post-covid myoendocarditis: clinical presentation, role of coronavirus persistence and autoimmune mechanisms.

Kardiologiia 2021 Jul 1;61(6):11-27. Epub 2021 Jul 1.

The State Education Institution of Higher Professional Training the First I.M. Sechenov Moscow State Medical University (Sechenov University), Moscow, Russia.

Aim    To study clinical features of myoendocarditis and its possible mechanisms, including persistence of SARS-Cov-2 in the myocardium, in the long-term period following COVID-19.Material and methods    This cohort, prospective study included 15 patients aged 47.8±13. Read More

View Article and Full-Text PDF

Arsenic exposure and metabolism in relation to blood pressure changes in pregnant women.

Ecotoxicol Environ Saf 2021 Oct 24;222:112527. Epub 2021 Jul 24.

Key Laboratory of Environment and Health (Huazhong University of Science and Technology), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), school of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. Electronic address:

Arsenic is concerned with cardiovascular diseases including hypertension, atherosclerosis, and endothelial dysfunction. However, what effects the arsenic exposure and the arsenic metabolism have on hypertensive disorders of pregnancy (HDP) and blood pressure changes during pregnancy remain largely unknown. Our goal was to assess the associations of arsenic exposure and arsenic metabolism with HDP and blood pressure changes in pregnant women through a prospective birth cohort study. Read More

View Article and Full-Text PDF
October 2021

LEFT ATRIAL EXPANSION INDEX FOR NON-INVASIVE ESTIMATION OF PULMONARY CAPILLARY WEDGE PRESSURE: A CARDIAC CATHETERIZATION VALIDATION STUDY.

J Am Soc Echocardiogr 2021 Jul 23. Epub 2021 Jul 23.

Department of Medicine and Surgery, University Milano-Bicocca, Milano, Italy; Department of cardiac, neural and metabolic sciences, Istituto Auxologico Italiano, IRCCS, Milano, Italy.

Introduction: Pulmonary capillary wedge pressure (PCWP) plays a pivotal role in cardiac disease diagnosis and management. Right heart catheterization (RHC) invasively provides accurate PCWP measurement, but it is impractical for widespread use in all patients. The left atrial expansion index (LAEI), measured by transthoracic echocardiography (TTE), describes the relative LA volume increase during the LA reservoir phase. Read More

View Article and Full-Text PDF

Peripartum echocardiographic changes in women with hypertensive disorders of pregnancy.

Ultrasound Obstet Gynecol 2021 Jul 26. Epub 2021 Jul 26.

Molecular and Clinical Sciences Research Institute, St. George's University of London, London, UK.

Objectives: Women with hypertensive disorders of pregnancy (HDP) present with evidence of significant myocardial dysfunction on echocardiographic assessment at the time of diagnosis. Birth not only cures the syndrome of HDP, but is also associated with a reduction in cardiovascular (CV) volume and resistance load in the mother due to the delivery of the fetoplacental unit. The impact of this physiological change on maternal myocardial function in women with HDP has not been systematically evaluated. Read More

View Article and Full-Text PDF

Management of Acute Coronary Syndrome Following Blunt Chest Trauma: A Case Report.

Bull Emerg Trauma 2021 Jul;9(3):151-154

Consultant and Honorary Senior Lecturer in Intensive Care Medicine and Anaesthesia, St Mary's Hospital, Imperial College NHS Trust, London, United Kingdom.

Blunt chest trauma is a rare cause of acute coronary syndrome and can be masked by other injuries in polytrauma patients. It can have devastating consequences due to damage to the myocardial tissue if left un-recognized. Myocardial injury can result in life-threatening arrhythmias and complications such as systolic and diastolic dysfunction. Read More

View Article and Full-Text PDF

Cardiac, Macro-, and Micro-Circulatory Abnormalities in Association With Individual Metabolic Syndrome Component: The Northern Shanghai Study.

Front Cardiovasc Med 2021 9;8:690521. Epub 2021 Jul 9.

Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

This study investigated the association of metabolic syndrome (MS) and its components with cardiac, macro-, and micro-circulatory abnormalities in an elderly Chinese population. This cross-sectional study was conducted using data for 1,958 participants from the Northern Shanghai Study aged over 65 years without a history of cardiovascular disease. MS was defined according to the National Cholesterol Education Program Adult Treatment Panel III in 2005 (NCEPIII 2005). Read More

View Article and Full-Text PDF

Usefulness of Stress-Derived E/e' Ratio in Asymptomatic Hypertensive Patients.

Pulse (Basel) 2021 Jun 25;8(3-4):92-98. Epub 2020 Nov 25.

Department of Cardiology, Zagazig University Hospital, Zagazig, Egypt.

Purpose: We sought to investigate the usefulness of stress echocardiography-derived E/e' in predicting subclinical atherosclerosis in asymptomatic hypertensive patients.

Materials And Methods: 71 newly diagnosed untreated hypertensive patients (48 ± 13 years, 65% males) and 30 age- and sex-matched healthy controls were recruited. Resting and exercise echocardiography was performed to assess resting diastolic blood pressure and the diastolic stress parameters. Read More

View Article and Full-Text PDF

Electrical Features of the Diabetic Myocardium. Arrhythmic and Cardiovascular Safety Considerations in Diabetes.

Front Pharmacol 2021 8;12:687256. Epub 2021 Jul 8.

Department of Physiology, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.

Diabetes is a chronic metabolic disease characterized by hyperglycemia in the absence of treatment. Among the diabetes-associated complications, cardiovascular disease is the major cause of mortality and morbidity in diabetic patients. Diabetes causes a complex myocardial dysfunction, referred as diabetic cardiomyopathy, which even in the absence of other cardiac risk factors results in abnormal diastolic and systolic function. Read More

View Article and Full-Text PDF

Comparison of echocardiographic findings in women with late preeclampsia and healthy pregnant women: a case-control study.

J Matern Fetal Neonatal Med 2021 Jul 25:1-6. Epub 2021 Jul 25.

Department of Community Medicine, Alborz University of Medical Sciences, Karaj, Iran.

Background: Preeclampsia is one of the most common types of pregnancy disorders, and it is essential to know its cardiovascular complications. Therefore, we aimed to compare echocardiographic findings in women with late preeclampsia and healthy pregnant women.

Method: In this case-control study, 80 women with late preeclampsia and 80 healthy pregnant women were randomly selected and echocardiographic findings were determined and compared in the two groups. Read More

View Article and Full-Text PDF

Evaluation of fetal cardiac functions in the setting of maternal diabetes: Application of the global spherical index, global strain and fractional area change by the speckle tracking technique.

Eur J Obstet Gynecol Reprod Biol 2021 Jul 7;264:162-167. Epub 2021 Jul 7.

Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China. Electronic address:

Objective: To evaluate ventricular contractility and profile heart deformations in fetuses of hyperglycemic mothers using the Speckle tracking imaging (STI). The fractional area change (FAC), global longitudinal strain (GLS) and global sphericity index (GSI) of the 4-chamber view (4-CV) were computed.

Study Design: Dynamic 4-CV images of 60 fetuses exposed to maternal diabetes (MD) and 60 controls were retrospectively collected between 19 and 37 weeks of gestation. Read More

View Article and Full-Text PDF

Diabetes induces remodeling of the left atrial appendage independently of atrial fibrillation in a rodent model of type-2 diabetes.

Cardiovasc Diabetol 2021 Jul 23;20(1):149. Epub 2021 Jul 23.

Department of Cardiology, Barzilai University Medical Center, 2 Hahistadrut Street, 78278, Ashkelon, Israel.

Background: Diabetic patients have an increased predisposition to thromboembolic events, in most cases originating from thrombi in the left atrial appendage (LAA). Remodeling of the LAA, which predisposes to thrombi formation, has been previously described in diabetic patients with atrial fibrillation, but whether remodeling of the LAA occurs in diabetics also in the absence of atrial fibrillation is unknown. To investigate the contribution of diabetes, as opposed to atrial fibrillation, to remodeling of the LAA, we went from humans to the animal model. Read More

View Article and Full-Text PDF

State-of-the-Art Treatments for Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy.

J Clin Med 2021 Jul 7;10(14). Epub 2021 Jul 7.

Arrhythmia and Electrophysiology Research Center Gruppo Multimedica, Via Milanese 300, 20099 Sesto San Giovanni, Italy.

Atrial fibrillation (AF) and hypertrophic cardiomyopathy (HCM) are two very common clinical entities, which often occur simultaneously, giving a hard time to both patients and cardiologists. Myocyte hypertrophy, myocyte disarray and interstitial fibrosis in the left atrium (LA) predisposes to atrial arrhythmias due to modifications of the substrate that promote re-entry. AF is usually poorly tolerated due to the shortening of the diastolic time with rapid heart rates and the lack of the atrial contribution to the diastolic filling in patients who often have a previous diastolic dysfunction. Read More

View Article and Full-Text PDF