743 results match your criteria dialysis prominent

Neutrophil Extracellular Traps in Systemic Lupus Erythematosus Stimulate IgG2 Production From B Lymphocytes.

Front Med (Lausanne) 2021 12;8:635436. Epub 2021 Apr 12.

Laboratory of Molecular Nephrology, Division of Nephrology and Transplantation, Scientific Institute for Research, Hospitalization and Health Care (IRCCS) Giannina Gaslini Institute, Genoa, Italy.

Circulating autoantibodies of IgG2 isotype predominate in Systemic Lupus Erythematosus (SLE) and concur to the development of the renal lesions characteristic of Lupus Nephritis (LN). Anti-dsDNA and anti-histones IgG2, together with anti-podocyte proteins (i.e. Read More

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Collapsing Glomerulopathy as a Complication of Type I Interferon-Mediated Glomerulopathy in a Patient With RNASEH2B-Related Aicardi-Goutières Syndrome.

Am J Kidney Dis 2021 Apr 16. Epub 2021 Apr 16.

Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Firenze, Firenze;; Nephrology and Dialysis Unit, Meyer Children's Hospital, Firenze, Italy. Electronic address:

Aicardi-Goutières syndrome (AGS) is a well-characterised monogenic type I interferonopathy presenting with prominent neurological manifestations. Among extra-neurological features, renal involvement has only been described in one IFIH1-mutated patient who developed membranous nephropathy. The pathogenic role of augmented interferon signalling in tissues other than the central nervous system remains to be elucidated. Read More

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CD28null and Regulatory T Cells Are Substantially Disrupted in Patients with End-Stage Renal Disease Due to Diabetes Mellitus.

Int J Mol Sci 2021 Mar 15;22(6). Epub 2021 Mar 15.

Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, 56442 Thessaloniki, Greece.

Background: End-stage renal disease (ESRD) is associated with alterations in T-cell immunity, including increased CD28null and reduced regulatory T cells (Tregs). However, whether immune disturbances are due to ESRD or primary disease is not yet clear. As diabetes mellitus is the leading cause of ESRD, we evaluated its impact on the immune profile of ESRD patients. Read More

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Renal Manifestations of Covid-19: Physiology and Pathophysiology.

J Clin Med 2021 Mar 15;10(6). Epub 2021 Mar 15.

The Bar-Ilan University Azrieli Faculty of Medicine, Safed 1311502, Israel.

Corona virus disease 2019 (COVID-19) imposes a serious public health pandemic affecting the whole world, as it is spreading exponentially. Besides its high infectivity, SARS-CoV-2 causes multiple serious derangements, where the most prominent is severe acute respiratory syndrome as well as multiple organ dysfunction including heart and kidney injury. While the deleterious impact of SARS-CoV-2 on pulmonary and cardiac systems have attracted remarkable attention, the adverse effects of this virus on the renal system is still underestimated. Read More

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Adipose-derived mesenchymal stem cells attenuate dialysis-induced peritoneal fibrosis by modulating macrophage polarization via interleukin-6.

Stem Cell Res Ther 2021 Mar 19;12(1):193. Epub 2021 Mar 19.

Institute of Clinical Medicine, School of Medicine, National Yang Ming Chiao Tung University, 2F, Shou-Ren Bldg., No.155, Sec.2, Li-Nong St., Beitou Dist, Taipei, 11221, Taiwan.

Background: Life-long peritoneal dialysis (PD) as a renal replacement therapy is limited by peritoneal fibrosis. Previous studies showed immunomodulatory and antifibrotic effects of adipose-derived mesenchymal stem cells (ADSCs) on peritoneal fibrosis. However, the role of the peritoneal macrophage in this process remains uninvestigated. Read More

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Analyzing the Long Time-Scale Dynamics of Uremic Toxins Bound to Sudlow Site II in Human Serum Albumin.

J Phys Chem B 2021 03 15;125(11):2910-2920. Epub 2021 Mar 15.

Department of Chemistry, University of Washington, Seattle, Washington 98195-1700, United States.

Protein bound uremic toxins (PBUTs), a series of chemicals that remain a challenge for removal strategies used on patients suffering with chronic kidney disease, could be strong candidates for MD study in order to better understand the interactions and time scales associated with binding mode transitions. Currently, traditional dialysis methods cannot satisfactorily remove PBUTs from the bloodstream. This is at least partly due to these toxin's high level of affinity for protein binding sites, particularly the prominent human serum albumin (HSA) and two of its drug binding sites (Sudlow site I and II). Read More

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Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries.

Sci Rep 2021 Mar 11;11(1):5784. Epub 2021 Mar 11.

Department of Pediatric Dentistry, Division of Oral Infection and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.

The mechanisms underlying immunoglobulin A nephropathy (IgAN), the most common chronic form of primary glomerulonephritis, remain poorly understood. Streptococcus mutans, a Gram-positive facultatively anaerobic oral bacterium, is a common cause of dental caries. In previous studies, S. Read More

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Preoperative Vision, Gender, and Operation Time Predict Visual Improvement After Epiretinal Membrane Vitrectomy: A Retrospective Study.

Clin Ophthalmol 2021 24;15:807-814. Epub 2021 Feb 24.

Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.

Background: To evaluate the efficacy of micro-incision vitrectomy surgery using a non-contact wide-angle viewing system for fovea-attached type epiretinal membrane, and to report the factors influencing the outcome.

Methods: A retrospective, comparative case series that included 50 patients with fovea-attached type epiretinal membrane who received micro-incision vitrectomy surgery using a non-contact wide-angle viewing system.

Results: All patients were followed-up for a minimum of 12 months. Read More

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February 2021

Telehealth's New Horizon: Providing Smart Hospital-Level Care in the Home.

Telemed J E Health 2021 Mar 3. Epub 2021 Mar 3.

William Perry Center for Hemispheric Defense Studies, National Defense University, Washington, District of Columbia, USA.

During the COVID-19 pandemic, medical providers have expanded telehealth into daily practice, with many medical and behavioral health care visits provided remotely over video or through phone. The telehealth market was already facilitating home health care with increasing levels of sophistication before COVID-19. Among the emerging telehealth practices, telephysical therapy; teleneurology; telemental health; chronic care management of congestive heart failure, chronic obstructive pulmonary disease, diabetes; home hospice; home mechanical ventilation; and home dialysis are some of the most prominent. Read More

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Ketoanalogue supplements reduce mortality in patients with pre-dialysis advanced diabetic kidney disease: A nationwide population-based study.

Clin Nutr 2021 Feb 6. Epub 2021 Feb 6.

Chang Gung University College of Medicine, Taoyuan, Taiwan; Division of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Community Medicine Research Center, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan. Electronic address:

Background & Aims: Metabolism dysregulation and protein energy wasting occur in patients with chronic kidney disease (CKD) and are associated with poor survival, especially in patients prior to starting dialysis. Accumulating evidence indicates that dietary supplementation with ketoanalogues (KAs, a mixture of branched-chain amino acids) exerts a variety of beneficial effects for patients with CKD. However, the role of KAs in diabetic kidney disease (DKD), one of the major causes of CKD, is still controversial. Read More

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February 2021

Serum Total Bilirubin and Progression of Chronic Kidney Disease and Mortality: A Systematic Review and Meta-Analysis.

Front Med (Lausanne) 2020 25;7:549. Epub 2021 Jan 25.

Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Previous studies have suggested that serum total bilirubin (STB) levels are associated with heightened chronic kidney disease (CKD) and mortality in both the general population and nephropathy patients. However, these results remain inconsistent. The aim of our study was to investigate whether STB was a predictor for progression of CKD and mortality by meta-analysis. Read More

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January 2021

NAD precursors, mitochondria targeting compounds and ADPribosylation inhibitors in treatment of inflammatory diseases and cancer.

Curr Med Chem 2021 Jan 18. Epub 2021 Jan 18.

Sol & Pharma s.r.l. Biotechnology Research, 66030 Mozzagrogna. Italy.

Mitochondrial dysfunction and oxidative stress are prominent features of a plethora of human disorders. Dysregulation of mitochondrial functions represents a common pathogenic mechanism of diseases such as neurodegenerative disorders and cancer. The maintenance of the Nicotinamide adenine dinucleotide (NAD+ ) pool, and a positive NAD+ /NADH ratio, are essential for mitochondrial and cell functions. Read More

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January 2021

Correlates of objective sleep quality in older peritoneal dialysis patients.

Ren Fail 2021 Dec;43(1):180-187

School of Nursing, Shanghai Jiao Tong University, Shanghai, China.

Background: Sleep disturbance is a prominent concern in dialysis patients and detrimentally impacts clinical and self-reported health outcomes. This study aimed to collect sleep data from in-home actigraphy and to explore possible predictors of sleep quality in older peritoneal dialysis patients.

Methods: This was a cross-sectional study. Read More

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December 2021

Host fibrinogen drives antimicrobial function in peritonitis through bacterial-mediated prothrombin activation.

Proc Natl Acad Sci U S A 2021 01 21;118(1). Epub 2020 Dec 21.

Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, and the UNC Blood Research Center, University of North Carolina, Chapel Hill, NC 27599;

The blood-clotting protein fibrinogen has been implicated in host defense following infection, but precise mechanisms of host protection and pathogen clearance remain undefined. Peritonitis caused by staphylococci species is a complication for patients with cirrhosis, indwelling catheters, or undergoing peritoneal dialysis. Here, we sought to characterize possible mechanisms of fibrin(ogen)-mediated antimicrobial responses. Read More

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January 2021

Impact of health-related quality of life on survival after dialysis initiation: a prospective cohort study in Korea.

Kidney Res Clin Pract 2020 Dec;39(4):426-440

Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea.

Background: The effect of each health-related quality of life (HRQOL) component on hemodialysis prognosis has not been well studied. We aimed to investigate the clinical factors associated with HRQOL and the effect of HRQOL after dialysis initiation on long-term survival in an Asian population.

Methods: A total of 568 hemodialysis patients were included from a nationwide prospective cohort study. Read More

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December 2020

Vitamin D receptor polymorphisms and bone health after kidney transplantation

Turk J Med Sci 2021 04 30;51(2):802-812. Epub 2021 Apr 30.

Department of Nephrology, Faculty of Medicine, Gazi University, Ankara, Turkey

Background/aim: Bone disease is one of the most prominent complications after kidney transplantation. Bone diseases include osteoporosis, persistent secondary hyperparathyroidism, and avascular necrosis (AVN). We investigated the relationship between the polymorphisms of the vitamin D receptor (VDR) gene and bone diseases occurring after kidney transplantation. Read More

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Regional distribution and severity of arterial calcification in patients with chronic kidney disease stages 1-5: a cross-sectional study of the Copenhagen chronic kidney disease cohort.

BMC Nephrol 2020 12 9;21(1):534. Epub 2020 Dec 9.

Department of Nephrology, Rigshospitalet University Hospital, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.

Background: Patients with chronic kidney disease (CKD) and arterial calcification are considered at increased risk of adverse cardiovascular outcomes. However, the optimal site for measurement of arterial calcification has not been determined. The primary aim of this study was to examine the pattern of arterial calcification in different stages of CKD. Read More

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December 2020

Examining barriers to timely waitlisting for kidney transplantation for Indigenous Australians in Central Australia.

Intern Med J 2020 Nov 30. Epub 2020 Nov 30.

Central Australian Renal Service, Alice Springs Hospital, Alice Springs, Northern Territory, Australia.

Background: Indigenous Australians are disproportionately affected by end stage kidney disease. Despite this, they face significant delays being assessed and waitlisted for kidney transplant.

Aims: To examine the kidney transplant waitlisting process in our region, to compare the workup process between Indigenous Australians and non-Indigenous patients, and identify major sources of delay. Read More

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November 2020

Lipohypertrophy in Elderly Insulin-Treated Patients With Type 2 Diabetes.

Diabetes Ther 2021 Jan 21;12(1):107-119. Epub 2020 Nov 21.

Diabetes, Endocrinology and Metabotic Disease, IRCCS San Raffaele Pisana, Rome, Italy.

Background: The number of older adults with insulin-treated diabetes mellitus (DM) is steadily increasing worldwide. Errors in the insulin injection technique can lead to skin lipohypertrophy (LH), which is the accumulation of fat cells and fibrin in the subcutaneous tissue. While lipohypertrophic lesions/nodules (LHs) due to incorrect insulin injection techniques are very common, they are often flat and hardly visible and thus require thorough deep palpation examination and ultrasonography (US) for detection. Read More

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January 2021

Analyses of hemodialysis arteriovenous fistula geometric configuration and its associations with maturation and reintervention.

J Vasc Surg 2021 May 20;73(5):1778-1786.e1. Epub 2020 Oct 20.

Division of Nephrology and Hypertension, University of Utah, Salt Lake City, Utah; Renal Section, Medical Service, Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah. Electronic address:

Objective: An arteriovenous fistula (AVF) is the preferred vascular access for chronic hemodialysis; however, the rates of AVF maturation failure and reintervention remain high. We investigated the AVF geometric parameters and their associations with AVF physiologic maturation and reintervention in a prospective multicenter study.

Methods: From 2011 to 2016, patients undergoing vein end-to-artery side upper extremity AVF creation surgery were recruited. Read More

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Prof. Dimitar Hrisoho, Md, Phd, Founder of Nephrology in the R. N. Macedonia.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2020 Sep;41(2):103-114

University Department of Nephrology,Medical Faculty, University of Ss. Cyril and Methodius, Skopje, North Macedonia.

Prof. Dr. Dimitar T. Read More

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September 2020

Electrospinning of PVA-carboxymethyl cellulose nanofibers for flufenamic acid drug delivery.

Int J Biol Macromol 2020 Nov 21;163:1780-1786. Epub 2020 Sep 21.

Department of Chemical Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.

A prominent medical application of nanotechnology is represented in drug delivery. In this work, carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) were used for producing CMC/PVA aqueous-based nanofibers loaded with flufenamic acid (FFA) as a drug containing amine groups. The CMC/PVA solutions with 90/10, 80/20, 70/30, 60/40 and 50/50 ratios were considered for electrospinning. Read More

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November 2020

COVID-19: Therapeutics and interventions currently under consideration.

R B McFee

Dis Mon 2020 Sep 28;66(9):101058. Epub 2020 Jul 28.

Medical Director, Ellis Medical Consulting, Massachusetts, USA. Electronic address:

With the emergence of COVID-19 extensive research began to identify medications, candidate compounds and other therapeutic approaches. The complex virology of COVID-19 may provide multiple potential target points for antiviral therapy, and vaccines; extensive global research is underway to exploit these potential opportunities. The complex pathophysiology, pulmonary and extrapulmonary disease, and immune mediated effects such as cytokine storm, make medical management more challenging than many viral illnesses. Read More

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September 2020

[Hygiene in nephrology].

M Girndt

Nephrologe 2020 Jul 16:1-10. Epub 2020 Jul 16.

Klinik für Innere Medizin II, Nephrologie, Rheumatologie, Endokrinologie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle/Saale, Deutschland.

Patients with chronic kidney diseases are particularly at risk of infections and must therefore be protected against the risks of infection in dialysis treatment. Viral hepatitis no longer plays a very prominent role in dialysis facilities because nosocomial transmission can be reliably avoided. Nowadays, patients colonized with multidrug-resistant bacteria, including methicillin-resistant (MRSA), multidrug-resistant gram-negative bacteria or vancomycin-resistant enterococci, are more common. Read More

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Risk Factors for Muscle Loss in Hemodialysis Patients with High Comorbidity.

Nutrients 2020 Aug 19;12(9). Epub 2020 Aug 19.

Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.

With expanding kidney transplantation programs, remaining hemodialysis patients are more likely to have a high comorbidity burden and may therefore be more prone to lose muscle mass. Our aim was to analyze risk factors for muscle loss in hemodialysis patients with high comorbidity. Fifty-four chronic hemodialysis patients (Charlson Comorbidity Index 9. Read More

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Non-Compaction Cardiomyopathy Presented with Atrial Fibrillation: A Case Report and Literature Review.

Am J Med Case Rep 2020 29;8(9):281-283. Epub 2020 May 29.

Department of Medicine, State University of New York Downstate Health Science University, Brooklyn, NY 11203 USA.

Background: Left ventricular non-compaction cardiomyopathy (LVNC) is a rare congenital cardiomyopathy characterized by increased trabeculation in one or more segments of the ventricle. LVNC presented with non-specific symptoms and highly variable clinical presentation ranging from asymptomatic to progressive heart failure and recurrent or life-threatening arrhythmias.

Case Presentation: 54-year-old Black man with a history of hypertension, diabetes and end-stage renal disease presented with one day palpitations and lightheadedness following a dialysis session. Read More

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Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients.

BMC Nephrol 2020 07 13;21(1):271. Epub 2020 Jul 13.

Department of Nephrology, Zhongshan Hospital, Fudan University, NO180, Feng'lin Road, Xuhui District, Shanghai, 200032, P.R. China.

Background: Patients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of immune system, which is recently concerned as a significant factor for increased risk of various morbidities. Nevertheless, there are few dates explicating the relevancy of T cell senescence to mortality. In this study, we prospectively studied the predictive value of T cell senescence for mortality in hemodialysis patients. Read More

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Sodium and manganese salt DNA thin films: An infrared spectroscopy study.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Nov 24;241:118646. Epub 2020 Jun 24.

Department of Physics and Biophysics, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia; Centre of Excellence in Reproductive and Regenerative Medicine, University of Zagreb School of Medicine, 10000 Zagreb, Croatia. Electronic address:

In this work we have investigated influence of divalent Mn ions on the structure of dsDNA utilizing Fourier transform infrared spectroscopy on DNA thin films obtained from sodium and manganese salt DNA (Na-DNA and Mn-DNA) in manganese chloride solutions and manganese salt DNA in pure water. In the range of low Mn content, 0.0067 ≤ r = [manganese]/[phosphate] ≤ 0. Read More

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November 2020

Genetic Deletion of Vasohibin-2 Exacerbates Ischemia-Reperfusion-Induced Acute Kidney Injury.

Int J Mol Sci 2020 Jun 26;21(12). Epub 2020 Jun 26.

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 7008558, Japan.

Acute kidney injury (AKI) has been increasingly recognized as a risk factor for transition to chronic kidney disease. Recent evidence suggests that endothelial damage in peritubular capillaries can accelerate the progression of renal injury. Vasohibin-2 (VASH2) is a novel proangiogenic factor that promotes tumor angiogenesis. Read More

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Pneumonia-induced endothelial amyloids reduce dendritic spine density in brain neurons.

Sci Rep 2020 06 9;10(1):9327. Epub 2020 Jun 9.

Departments of Physiology and Cell Biology, Mobile, Alabama, 36688, USA.

Pseudomonas aeruginosa pneumonia elicits endothelial cell release of cytotoxic amyloids that can be recovered from the bronchoalveolar lavage and cerebrospinal fluids of critically ill patients. Introduction of these cytotoxic amyloids into the lateral ventricle impairs learning and memory in mice. However, it is unclear whether the amyloids of lung origin (1) are neurotropic, and (2) cause structural remodeling of hippocampal dendrites. Read More

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