1,003 results match your criteria diagnostics categories


Validation of the Persian Translation of the Children's Test Anxiety Scale: A Multidimensional Rasch Model Analysis.

Eur J Investig Health Psychol Educ 2019 Aug 2;10(1):59-69. Epub 2019 Aug 2.

English Department, Islamic Azad University, Mashhad Branch, Mashhad 9187147578, Iran.

In this study, we examine the psychometric properties of the Persian translation of the Children's Test Anxiety Scale (CTAS) using the Rasch rating scale model. In the first step, rating scale diagnostics revealed that the thresholds were disordered. To remedy this problem, two categories were collapsed and a rating scale structure with three points turned out to have optimal properties. Read More

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Association of physical activity intensity and bout length with mortality: An observational study of 79,503 UK Biobank participants.

PLoS Med 2021 Sep 15;18(9):e1003757. Epub 2021 Sep 15.

MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, United Kingdom.

Background: Spending more time active (and less sedentary) is associated with health benefits such as improved cardiovascular health and lower risk of all-cause mortality. It is unclear whether these associations differ depending on whether time spent sedentary or in moderate-vigorous physical activity (MVPA) is accumulated in long or short bouts. In this study, we used a novel method that accounts for substitution (i. Read More

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September 2021

Recent Advances in Micro/Nanomaterial-Based Aptamer Selection Strategies.

Molecules 2021 Aug 26;26(17). Epub 2021 Aug 26.

School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea.

Aptamers are artificial nucleic acid ligands that have been employed in various fundamental studies and applications, such as biological analyses, disease diagnostics, targeted therapeutics, and environmental pollutant detection. This review focuses on the recent advances in aptamer discovery strategies that have been used to detect various chemicals and biomolecules. Recent examples of the strategies discussed here are based on the classification of these micro/nanomaterial-mediated systematic evolution of ligands by exponential enrichment (SELEX) platforms into three categories: bead-mediated, carbon-based nanomaterial-mediated, and other nanoparticle-mediated strategies. Read More

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Measuring Financial Burden in Families of Children Living With Life-Limiting Conditions: A Scoping Review of Cost Indicators and Outcome Measures.

Value Health 2021 Sep 7;24(9):1377-1389. Epub 2021 Aug 7.

Household Economics and Health Systems Research, Swiss Tropical and Public Health Institute, Basel, Switzerland.

Objectives: This study aimed to provide a comprehensive overview of cost indicators and outcome measures used to measure financial burden in families of children with life-limiting conditions.

Methods: A scoping review methodology was used to map the existing literature and provide an overview of available cost indicators and outcome measures. Key medical, economic, and scientific databases were systematically searched to identify relevant articles published in 2000 or later. Read More

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September 2021

Weighted Gene Co-Expression Network Analysis Combined with Machine Learning Validation to Identify Key Modules and Hub Genes Associated with SARS-CoV-2 Infection.

J Clin Med 2021 Aug 13;10(16). Epub 2021 Aug 13.

Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand 9717853577, Iran.

The coronavirus disease-2019 (COVID-19) pandemic has caused an enormous loss of lives. Various clinical trials of vaccines and drugs are being conducted worldwide; nevertheless, as of today, no effective drug exists for COVID-19. The identification of key genes and pathways in this disease may lead to finding potential drug targets and biomarkers. Read More

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A Genome-Wide Association Study on Liver Stiffness Changes during Hepatitis C Virus Infection Cure.

Diagnostics (Basel) 2021 Aug 20;11(8). Epub 2021 Aug 20.

Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital de Valme, 41014 Sevilla, Spain.

Liver stiffness (LS) at sustained virological response (SVR) after direct-acting antivirals (DAA)-based therapy is a predictor of liver events in hepatitis C virus (HCV)-infected patients. The study aim was to identify genetic factors associated with LS changes from the moment of starting anti-HCV therapy to SVR. This prospective study included HCV-infected patients from the GEHEP-011 cohort who achieved SVR with DAA-based therapy, with LS pre-treatment ≥ 9. Read More

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Can Ultrasound Elastography Discriminate between Rectal Adenoma and Cancer? A Systematic Review.

Cancers (Basel) 2021 Aug 18;13(16). Epub 2021 Aug 18.

Department of Radiology, Vejle Hospital, University Hospital of Southern Denmark, Beriderbakken 4, 7100 Vejle, Denmark.

Background: Rectal cancer is a common malignancy. Since the introduction of bowel-screening programs, the number of patients with advanced adenomas and early rectal cancer has increased. Despite improved diagnostics, the discrimination between rectal adenomas and early rectal cancer (i. Read More

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The Expressiveness of SNOMED CT for Wound Care: Mapping a Standardized Item Set for Leg Ulcers onto SNOMED CT.

JMIR Med Inform 2021 Aug 24. Epub 2021 Aug 24.

University of Applied Sciences Osnabrück, Albrechtstr. 30 49076 Osnabrück, Osnabrück, DE.

Background: Chronic health conditions are on the rise and are putting high economic pressure on health systems as they require well-coordinated prevention and treatment. Among chronic conditions, chronic wounds such as cardiovascular leg ulcers have a high prevalence. Their treatment is highly interdisciplinary and regularly spans multiple care settings and organizations, thus placing particularly high demands on interoperable information exchange that can be achieved using international semantic standards such as SNOMED CT. Read More

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Molecular Diagnosis of Rejection in Heart Transplantation.

Circ J 2021 Aug 21. Epub 2021 Aug 21.

Department of Cardiology, Cedars-Sinai Smidt Heart Institute.

Despite the overall success of heart transplantation as a definitive treatment for endstage heart failure, cardiac allograft rejection remains an important cause of morbidity and mortality. Endomyocardial biopsy has been the standard of care for rejection monitoring, but is associated with several diagnostic limitations and serious procedural complications. The use of molecular diagnostics has emerged over the past decade as a tool to potentially circumvent some of these limitations. Read More

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Caries Detection on Intraoral Images Using Artificial Intelligence.

J Dent Res 2021 Aug 20:220345211032524. Epub 2021 Aug 20.

Institute for Software Engineering, University of Duisburg-Essen, Essen, Germany.

Although visual examination (VE) is the preferred method for caries detection, the analysis of intraoral digital photographs in machine-readable form can be considered equivalent to VE. While photographic images are rarely used in clinical practice for diagnostic purposes, they are the fundamental requirement for automated image analysis when using artificial intelligence (AI) methods. Considering that AI has not been used for automatic caries detection on intraoral images so far, this diagnostic study aimed to develop a deep learning approach with convolutional neural networks (CNNs) for caries detection and categorization (test method) and to compare the diagnostic performance with respect to expert standards. Read More

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Deep learning based synthetic-CT generation in radiotherapy and PET: A review.

Med Phys 2021 Aug 18. Epub 2021 Aug 18.

Division of Biomedical Physics in Radiation Oncology, DKFZ German Cancer Research Center, Heidelberg, Germany.

Recently,deep learning (DL)-based methods for the generation of synthetic computed tomography (sCT) have received significant research attention as an alternative to classical ones. We present here a systematic review of these methods by grouping them into three categories, according to their clinical applications: (i) to replace computed tomography in magnetic resonance (MR) based treatment planning, (ii) facilitate cone-beam computed tomography based image-guided adaptive radiotherapy, and (iii) derive attenuation maps for the correction of positron emission tomography. Appropriate database searching was performed on journal articles published between January 2014 and December 2020. Read More

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Livestock herding and Fulani ethnicity are a combined risk factor for development of early adverse reactions to antivenom treatment: Findings from a cross-sectional study in Nigeria.

PLoS Negl Trop Dis 2021 Aug 12;15(8):e0009518. Epub 2021 Aug 12.

Centre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

Background: Adverse reactions to antivenom considerably complicate the clinical management of snakebite envenomed patients because it necessitates a temporary suspension of life-saving antivenom, increases costs and can compromise patient outcomes. This study sought to explore the association between cattle-herding occupation and ethnic group and the occurrence of early adverse reactions to antivenom.

Methods: This cross-sectional study was conducted between the 25th April and 11th July 2011 at the Kaltungo General Hospital in north east Nigeria. Read More

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Parents' experiences of the information provided at the antenatal clinic regarding foetal diagnostics - A qualitative interview study.

Sex Reprod Healthc 2021 Sep 5;29:100652. Epub 2021 Aug 5.

Centre of Perinatal Medicine and Health, Institute of Clinical Sciences, University of Gothenburg, 405 83 Gothenburg, Sweden; Department of Obstetrics and Gynecology, Region Västra Götaland, Sahlgrenska University Hospital, 416 85 Gothenburg, Sweden; Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, 413 46 Gothenburg, Sweden. Electronic address:

Objective: This study aimed to examine the pregnant women's and their partner's experience of the information given at the antenatal clinic regarding screening methods.

Methods: A qualitative interview study was conducted in the Gothenburg area in Sweden. Ten women and seven partners expecting their first child were interviewed adjacent to the second-trimester ultrasound examination. Read More

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September 2021

A multivariate statistical approach to predict COVID-19 count data with epidemiological interpretation and uncertainty quantification.

Stat Med 2021 Aug 10. Epub 2021 Aug 10.

Faculty of Economics, Università della Svizzera italiana (CH), Lugano, Italy.

For the analysis of COVID-19 pandemic data, we propose Bayesian multinomial and Dirichlet-multinomial autoregressive models for time-series of counts of patients in mutually exclusive and exhaustive observational categories, defined according to the severity of the patient status and the required treatment. Categories include hospitalized in regular wards (H) and in intensive care units (ICU), together with deceased (D) and recovered (R). These models explicitly formulate assumptions on the transition probabilities between these categories across time, thanks to a flexible formulation based on parameters that a priori follow normal distributions, possibly truncated to incorporate specific hypotheses having an epidemiological interpretation. Read More

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Validation and Classification of the 9-Item Voice Handicap Index (VHI-9i).

J Clin Med 2021 Jul 28;10(15). Epub 2021 Jul 28.

Department of Audiology and Phoniatrics, Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany.

The international nine-item Voice Handicap Index (VHI-9i) is a clinically established short-scale version of the original VHI, quantifying the patients' self-assessed vocal handicap. However, the current vocal impairment classification is based on percentiles. The main goals of this study were to establish test-retest reliability and a sound statistical basis for VHI-9i severity levels. Read More

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Recent Progress in Nanotechnology for COVID-19 Prevention, Diagnostics and Treatment.

Nanomaterials (Basel) 2021 Jul 9;11(7). Epub 2021 Jul 9.

Department of Mechanical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

The COVID-19 pandemic is currently an unprecedented public health threat. The rapid spread of infections has led to calls for alternative approaches to combat the virus. Nanotechnology is taking root against SARS-CoV-2 through prevention, diagnostics and treatment of infections. Read More

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Laboratory Diagnosis of SARS-CoV-2 Pneumonia.

Diagnostics (Basel) 2021 Jul 15;11(7). Epub 2021 Jul 15.

Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

The emergence and rapid proliferation of Coronavirus Disease-2019, throughout the past year, has put an unprecedented strain on the global schema of health infrastructure and health economy. The time-sensitive agenda of identifying the virus in humans and delivering a vaccine to the public constituted an effort to flatten the statistical curve of viral spread as it grew exponentially. At the forefront of this effort was an exigency of developing rapid and accurate diagnostic strategies. Read More

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Eimeria spp. in naturally infected beef cattle: Dynamics of oocysts excretion, prevalence, and comparison between parasitological diagnostics.

Prev Vet Med 2021 Sep 27;194:105447. Epub 2021 Jul 27.

Escola de Veterinária e Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil; Departamento de Biociências e Tecnologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. Electronic address:

Eimeria spp. infections cause mortality, reduced well-being, and substantial economic losses implications for cattle production worldwide. The present work followed up the excretion of Eimeria spp. Read More

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September 2021

Diabetes and Risk of Sudden Death in Coronary Artery Disease Patients Without Severe Systolic Dysfunction.

JACC Clin Electrophysiol 2021 Jul 21. Epub 2021 Jul 21.

Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address:

Objectives: This study sought to determine the absolute and relative associations of diabetes mellitus (DM) and hemoglobin A (HbA) with sudden and/or arrhythmic death (SAD) versus other modes of death in patients with coronary artery disease (CAD) who do not qualify for implantable cardioverter-defibrillators.

Background: Patients with CAD and DM are at elevated risk for SAD; however, it is unclear whether these patients would benefit from implantable cardioverter-defibrillators given competing causes of death and/or whether HbA might augment SAD risk stratification.

Methods: In the PRE-DETERMINE study of 5,764 patients with CAD with left ventricular ejection fraction (LVEF) of >30% to 35%, competing risk analyses were used to compare the absolute and relative risks of SAD versus non-SAD by DM status and HbA level and to identify risk factors for SAD among 1,782 patients with DM. Read More

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Using evidence, expert opinion and epidemiological model to understand pathways to survival and mortality: The Pathways to Survival (PATHS) Tool.

J Glob Health 2021 12;11:15001. Epub 2021 Jun 12.

Health Nutrition and Population, The World Bank, Washington, DC, USA.

Background: The reasons why episodes of illness can lead to fatal outcomes in affected persons in low resource settings are numerous and complex. A tool that allows policy makers to better understand those complexities could be useful to improve success of programmes that are implemented globally to reduce mortality.

Methods: We developed a "Pathways to Survival" (PATHS) tool: an epidemiological model using decision trees, available evidence and expert opinion. Read More

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A comprehensive review on avian chlamydiosis: a neglected zoonotic disease.

Trop Anim Health Prod 2021 Jul 27;53(4):414. Epub 2021 Jul 27.

Division of Public Health and Epidemiology, ICAR-Indian Veterinary Research Institute, Izatnagar, India.

Avian chlamydiosis is one of the important neglected diseases with critical zoonotic potential. Chlamydia psittaci, the causative agent, affects most categories of birds, livestock, companion animals, and humans. It has many obscured characters and epidemiological dimensions, which makes it unique among other bacterial agents. Read More

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Microbial-based cancer therapy-bugs as drugs: History & the essential role of medical imaging.

Cancer Treat Res Commun 2021 14;28:100436. Epub 2021 Jul 14.

Image-guided Bio-molecular Interventions Research & Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, Campus Box 358056, 815 Mercer Street, Room S470, Seattle, WA 98109, USA. Electronic address:

Microbial-based cancer therapy aims to use tumor-specific infectious microbes to fulfill the unmet medical needs for patients with difficult-to-treat malignancies. The NIH is calling to revisit the old concept from new perspectives, by incorporating advances in science and technology, to establish an alternative to the traditional categories of cancer managements. Medical imaging offers unique insight into the mechanisms of action, assessment of success/failure, and advantages/pitfalls of microbial-based cancer therapy, which in turn should facilitate the advances of this new initiative in modern medical oncology. Read More

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Phyllodes Tumors: A Scoping Review of the Literature.

Ann Surg Oncol 2021 Jul 22. Epub 2021 Jul 22.

Department of Surgery, University of Toronto, Toronto, ON, Canada.

Purpose: Phyllodes tumors are rare tumors of the breast, with most literature being retrospective with limited guidelines on the management of these patients. Scoping review was performed to highlight themes and gaps in the available literature.

Methods: A scoping review of the literature was performed as per PRISMA-ScR guidelines with titles, abstracts, and full texts reviewed in duplicate. Read More

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Moral motivation regarding dementia risk testing among affected persons in Germany and Israel.

J Med Ethics 2021 Jul 21. Epub 2021 Jul 21.

Department of Community Mental Health, University of Haifa, Haifa, Israel.

Recent advances in biomarkers may soon make it possible to identify persons at high risk for late-onset Alzheimer's disease at a presymptomatic (preclinical) stage. Popular demand for testing is increasing despite the lack of cure and effective prevention options and despite uncertainties regarding the predictive value of biomarker tests. This underscores the relevance of the ethical, cultural and social implications of predictive testing and the need to advance the bioethical debate beyond considerations of clinical consequences. Read More

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"The system has to be health literate, too" - perspectives among healthcare professionals on health literacy in transcultural treatment settings.

BMC Health Serv Res 2021 Jul 21;21(1):716. Epub 2021 Jul 21.

Cologne Center for Ethics, Rights, Economics, and Social Sciences of Health (CERES), University of Cologne and Research Unit Ethics, Faculty of Medicine and University Hospital Cologne, 50931, Cologne, Germany.

Background: Effective communication is a central aspect of organizational health literacy. Healthcare professionals are expected to ensure an effective and satisfactory flow of information and to support their patients in accessing, understanding, appraising, and applying health information. This qualitative study aimed to examine the health literacy-related challenges, needs, and applied solutions of healthcare professionals when engaging with persons with a migrant background. Read More

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"Omics" in traumatic brain injury: novel approaches to a complex disease.

Acta Neurochir (Wien) 2021 09 17;163(9):2581-2594. Epub 2021 Jul 17.

Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala, Sweden.

Background: To date, there is neither any pharmacological treatment with efficacy in traumatic brain injury (TBI) nor any method to halt the disease progress. This is due to an incomplete understanding of the vast complexity of the biological cascades and failure to appreciate the diversity of secondary injury mechanisms in TBI. In recent years, techniques for high-throughput characterization and quantification of biological molecules that include genomics, proteomics, and metabolomics have evolved and referred to as omics. Read More

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September 2021

Antibiotics and fecundability among female pregnancy planners: a prospective cohort study.

Hum Reprod 2021 Sep;36(10):2761-2768

Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Study Question: To what extent is female preconception antibiotic use associated with fecundability?

Summary Answer: Preconception antibiotic use overall was not appreciably associated with fecundability.

What Is Known Already: Antibiotics are commonly used by women and are generally thought to be safe for use during pregnancy. However, little is known about possible effects of antibiotic use on fecundability, the per-cycle probability of conception. Read More

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September 2021

Evolving therapeutic strategies for advanced hepatocellular carcinoma.

Expert Opin Pharmacother 2021 Jul 15:1-12. Epub 2021 Jul 15.

Department of Hematology-Oncology, Eisenhower Lucy Curci Cancer Center, Rancho Mirage, CA, USA.

While sorafenib dominated the therapeutic arena in advanced hepatocellular carcinoma (HCC) for almost a decade, newer agents and combinations have been changing the therapeutic landscape in the last years. The authors outline the etiopathogenesis and evaluate the diagnostics in HCC, followed by a comprehensive review of the currently approved and experimental treatment approaches, with a focus on various systemic agents and combinations of agents. The manuscript was subdivided into relevant categories, thus making it applicable for both clinical practice and research endeavors. Read More

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NT-proBNP for Risk Prediction in Heart Failure: Identification of Optimal Cutoffs Across Body Mass Index Categories.

JACC Heart Fail 2021 Sep 7;9(9):653-663. Epub 2021 Jul 7.

Singapore General Hospital, Singapore.

Objectives: The goal of this study was to assess the predictive power of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and the decision cutoffs in heart failure (HF) across body mass index (BMI) categories.

Background: Concentrations of NT-proBNP predict outcome in HF. Although the influence of BMI to reduce levels of NT-proBNP is known, the impact of obesity on prognostic value remains uncertain. Read More

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September 2021

Cervical Cancer Diagnostics Healthcare System Using Hybrid Object Detection Adversarial Networks.

IEEE J Biomed Health Inform 2021 Jul 2;PP. Epub 2021 Jul 2.

Cervical cancer is one of the common cancers among women and it causes significant mortality in many developing countries. Diagnosis of cervical lesions is done using pap smear test or visual inspection using acetic acid (staining). Digital colposcopy, an inexpensive methodology, provides painless and efficient screening results. Read More

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