3,079,055 results match your criteria diagnostic therapeutic


Tailored molecular imaging of pheochromocytoma and paraganglioma: which tracer and when.

Neuroendocrinology 2022 Jan 20. Epub 2022 Jan 20.

Pheochromocytoma and paraganglioma are rare neoplasms that fall within the category of neuroendocrine tumors. In the last decade, their diagnostic algorithm has been modified to include the evaluation of molecular pathways, genotype and biochemical phenotype, in order to correctly interpret anatomical and functional imaging results and tailor the best therapeutic choices to patients. More specifically, the identification of germline mutations has led to a three-way cluster classification: pseudo-hypoxic cluster, cluster of kinase receptor signaling and protein translation pathways, and cluster of Wnt-altered pathway. Read More

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January 2022

Involvement of N6-methyladenosine modifications of long noncoding RNAs in systemic lupus erythematosus.

Mol Immunol 2022 Jan 17;143:77-84. Epub 2022 Jan 17.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Laboratory of Inflammation and Immune Mediated Diseases, Anhui Medical University, Hefei, Anhui, 230032, China. Electronic address:

Background: LncRNAs are potential biomarkers for SLE, but the epigenetic regulatory mechanisms of N6-methyladenosine (m6A) modification in SLE remain largely unclear.

Methods: In this study, we established m6A modification profile and investigated the potential roles of m6A-related lncRNAs in SLE. The m6A modification profile of SLE was established using MeRIP-seq. Read More

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January 2022

CD200S-positive granulated lymphoid cells in endometrium appear to be CD56-positive uterine NK cells.

J Reprod Immunol 2022 Jan 14;150:103477. Epub 2022 Jan 14.

Department of Obstetrics and Gynecology, Faculty of Health Sciences, McMaster University, Canada.

The eutopic secretory phase endometrium in endometriosis overproduces and releases a soluble immunosuppressive CD200 molecule (CD200L) and is populated by stromal cells that contain a truncated CD200 (CD200S) that promotes a proinflammatory environment. The CD200S cell population persists when pregnancy occurs and are abundant in the early pregnancy decidua of women with missed abortion. In the present study, CD200S, CD56, and CD68 cells were enumerated in formalin-fixed paraffin-embedded tissue sections from women with endometriosis and non-endometriosis controls. Read More

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January 2022

A fluorescence aptasensor based on [email protected] and RGO for the detection of Glypican-3.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Dec 29;270:120798. Epub 2021 Dec 29.

National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, Guangxi Medical University, Nanning, Guangxi, 530021, China; School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, Guangxi 541004, People's Republic of China. Electronic address:

Glypican-3 (GPC3), a heparin sulfate proteoglycan, is a potential diagnostic and therapeutic target for hepatocellular carcinoma. In this paper, a novel fluorescent aptasensor for GPC3 detection is constructed via [email protected] quantum dots-labeled GPC3 aptamer ([email protected]) as a fluorescence probe. First, [email protected] is screened out with higher fluorescence intensity, which emits bright blue fluorescence under ultraviolet light. Read More

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December 2021

Tumor microenvironment mechanisms and bone metastatic disease progression of prostate cancer.

Cancer Lett 2022 Jan 17. Epub 2022 Jan 17.

Department for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland. Electronic address:

During disease progression from primary towards metastatic prostate cancer (PCa), and in particular bone metastases, the tumor microenvironment (TME) evolves in parallel with the cancer clones, altering extracellular matrix composition, vasculature architecture, and recruiting specialized tumor-supporting cells that favor tumor spread and colonization at distant sites. We introduce the clinical profile of advanced metastatic PCa in terms of common genetic alterations. Findings from recently developed models of PCa metastatic spread are discussed, focusing mainly on the role of the TME (mainly matrix and fibroblast cell types), at distinct stages: premetastatic niche orchestrated by the primary tumor towards the metastatic site and bone metastasis. Read More

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January 2022

Endpoints for extraintestinal manifestations in inflammatory bowel disease trials: the EXTRA consensus from the International Organization for the Study of Inflammatory Bowel Diseases.

Lancet Gastroenterol Hepatol 2022 Jan 17. Epub 2022 Jan 17.

The Dr Henry J Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Extraintestinal manifestations occur frequently in patients with inflammatory bowel disease (IBD) and remain a diagnostic and therapeutic challenge. The aim of the Endpoints for Extraintestinal Manifestations in Inflammatory Bowel Disease Trials (EXTRA) initiative was to achieve international expert consensus on how to assess these manifestations in IBD trials. A systematic literature review was done to identify methods to diagnose extraintestinal manifestations in patients with IBD and measure treatment outcomes. Read More

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January 2022

Results of a phase 1, randomized, placebo-controlled first-in-human trial of griffithsin formulated in a carrageenan vaginal gel.

PLoS One 2022 20;17(1):e0261775. Epub 2022 Jan 20.

Center for Biomedical Research, Population Council, New York, New York, United States of America.

HIV pre-exposure prophylaxis (PrEP) is dominated by clinical therapeutic antiretroviral (ARV) drugs. Griffithsin (GRFT) is a non-ARV lectin with potent anti-HIV activity. GRFT's preclinical safety, lack of systemic absorption after vaginal administration in animal studies, and lack of cross-resistance with existing ARV drugs prompted its development for topical HIV PrEP. Read More

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January 2022

Diagnostic accuracy of three commercially available one step RT-PCR assays for the detection of SARS-CoV-2 in resource limited settings.

PLoS One 2022 20;17(1):e0262178. Epub 2022 Jan 20.

Department of Microbial, Cellular and Molecular Biology, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: COVID-19 is an ongoing public health pandemic regardless of the countless efforts made by various actors. Quality diagnostic tests are important for early detection and control. Notably, several commercially available one step RT-PCR based assays have been recommended by the WHO. Read More

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January 2022

Superficial basal cell carcinoma, think deeper: Step sectioning of skin biopsy specimens yields 14% more aggressive subtypes.

PLoS One 2022 20;17(1):e0256149. Epub 2022 Jan 20.

Department of Pathology, University Medical Center Utrecht, University Utrecht, University Utrecht, Utrecht, The Netherlands.

Introduction: Because of different therapeutic regimens for superficial and non-superficial basal cell carcinomas (BCCs), accurate histopathological examination of a punch biopsy to determine its subtype is essential. The aim of the current study was to evaluate the additional yield of a more extensive step-section method to that of a standard histologic examination at 4 levels.

Material And Methods: Data for this prospective study was obtained from the Pathology department of a Dutch tertiary hospital. Read More

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January 2022

Psychometric Properties of the Multidimensional Pain Inventory: Japanese Language Version (MPI-J).

Pain Physician 2022 Jan;25(1):E105-E112

Department of Pain Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan; Pain Management Center, Hoshi General Hospital, Fukushima, Japan.

Background: Many self-report scales have been developed. Among them, are those clinically useful scales for quantifying chronic pain (such as the Numeric Rating Scale), which are useful for determining the effectiveness of treatment, and multifaceted and comprehensive pain assessment scales that are used to determine therapeutic strategies. The representative measure of the latter is the West Haven Yale Multidimensional Pain Inventory (WHY-MPI), which constitutes a system for classifying patients with chronic pain termed the multiaxial assessment of pain (MAP), proposed by Turk and Rudy. Read More

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January 2022

Outcomes of Cervical Therapeutic Medial Branch Blocks and Radiofrequency Neurotomy: Clinical Outcomes and Cost Utility are Equivalent.

Pain Physician 2022 Jan;25(1):35-47

Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Background: Cervical facet joint pain is often managed with either cervical radiofrequency neurotomy, cervical medial branch blocks, or cervical intraarticular injections. However, the effectiveness of each modality continues to be debated. Further, there is no agreement in reference to superiority or inferiority of facet joint nerve blocks compared to radiofrequency neurotomy, even though cervical facet joint radiofrequency neurotomy has been preferred by many and in fact, has been mandated by the Centers for Medicare and Medicaid Services (CMS), except when radiofrequency cannot be confirmed. Read More

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January 2022

Safety and Efficacy of Platelet Rich Plasma for Treatment of Lumbar Discogenic Pain: A Prospective, Multicenter, Randomized, Double-blind Study.

Pain Physician 2022 Jan;25(1):29-34

Neurological Associates - The Interventional Group, USA, Los Angeles, CA; Department of Neurology, University of California, Los Angeles, CA.

Background: Interventions for chronic discogenic spine pain are currently insufficient in lowering individual patient suffering and global disease burden. A 2016 study of platelet rich plasma (PRP) for chronic discogenic pain previously demonstrated clinically significant response among active group patients compared with controls.

Objectives: To replicate the previous research to move this intervention forward as a viable option for patient care. Read More

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January 2022

Toxin and Immunotoxin Based Therapeutic Approaches.

Toxins (Basel) 2022 Jan 17;14(1). Epub 2022 Jan 17.

Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum-University of Bologna, Via S. Giacomo 14, 40126 Bologna, Italy.

The concept of "magic bullets", i [... Read More

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January 2022

Snakebite Associated Thrombotic Microangiopathy and Recommendations for Clinical Practice.

Toxins (Basel) 2022 Jan 14;14(1). Epub 2022 Jan 14.

Clinical Toxicology Research Group, University of Newcastle, Newcastle 2308, Australia.

Snakebite is a significant and under-resourced global public health issue. Snake venoms cause a variety of potentially fatal clinical toxin syndromes, including venom-induced consumption coagulopathy (VICC) which is associated with major haemorrhage. A subset of patients with VICC develop a thrombotic microangiopathy (TMA). Read More

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January 2022

Evaluating sacubitril/valsartan as a treatment option for heart failure with reduced ejection fraction and preserved ejection fraction.

Expert Opin Pharmacother 2022 Jan 20:1-18. Epub 2022 Jan 20.

Cardiology Unit, IRCCS Azienda Ospedaliero-universitaria Di Bologna, Bologna, Italy.

Introduction: Sacubitril/valsartan is the first-in-class angiotensin-receptor neprilysin inhibitor approved in 2015 for the treatment of heart failure with reduced ejection fraction (HFrEF). On 16 February 2021, the Food and Drug Administration acknowledged that "Benefits are most clearly evident in patients with left ventricular ejection fraction below normal," thus potentially extending the use in subjects with heart failure and preserved ejection fraction (HFpEF).

Areas Covered: The authors outline the regulatory history, pharmacokinetics, pharmacodynamics, and risk-benefit profile of sacubitril/valsartan in HFrEF and HFpEF. Read More

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January 2022

Landscape of Genomic Alterations in Wild-Type Glioblastoma Identifies PI3K as a Favorable Prognostic Factor.

JCO Precis Oncol 2020 Nov;4:575-584

Vivian L. Smith Department of Neurosurgery, The University of Texas Health Science Center at Houston, Houston, TX.

Purpose: wild-type (WT) glioblastoma (GBM) is an aggressive tumor with poor survival despite current therapies. The aim of this study was to characterize its genomic profile and determine whether a particular molecular signature is associated with improved survival outcomes.

Patients And Methods: Tumor samples from 232 patients with -WT GBM were sequenced, and the landscape of genomic alterations was fully delineated. Read More

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November 2020

International Harmonization of Provisional Diagnostic Criteria for -Amplified Metastatic Colorectal Cancer Allowing for Screening by Next-Generation Sequencing Panel.

JCO Precis Oncol 2020 Nov;4:6-19

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Purpose: amplification (human epidermal growth factor receptor 2 positivity [HER2]) in metastatic colorectal cancer (mCRC) has important therapeutic implications that necessitate the need for accurate diagnostics. The study purpose was to establish and validate harmonized diagnostic criteria for HER2 mCRC among 3 groups (GI-SCREEN-Japan, NCTN-SWOG-USA, and Korea).

Patients And Methods: We assessed HER2 status by immunohistochemistry (IHC), ratio, gene copy number (GCN) by fluorescence in situ hybridization (FISH), and copy number variation (CNV) using two targeted next-generation sequencing (NGS) panels. Read More

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November 2020

Copy Number as a Quantitative Biomarker for Real-World Outcomes to Anti-Human Epidermal Growth Factor Receptor 2 Therapy in Advanced Gastroesophageal Adenocarcinoma.

JCO Precis Oncol 2022 Jan;6:e2100330

Foundation Medicine, Boston, MA.

Purpose: Human epidermal growth factor receptor 2 (HER2) overexpression or amplification (amp) are biomarkers for approved anti-HER2 therapies. amp may better predict response compared with immunohistochemistry or in situ hybridization, and quantitative copy number (CN) may further stratify patients. We characterized amp in advanced gastroesophageal adenocarcinomas (GEA) and hypothesized that increased CN was associated with better outcome to trastuzumab. Read More

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January 2022

Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations.

ACS Nano 2022 Jan 20. Epub 2022 Jan 20.

Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, 320003 Haifa, Israel.

Wound dressings based on nanomaterials play a crucial role in wound treatment and are widely used in a whole range of medical settings, from minor to life-threatening tissue injuries. This article presents an educational review on the accumulating knowledge in this multidisciplinary area to lay out the challenges and opportunities that lie ahead and ignite the further and faster development of clinically valuable technologies. The review analyzes the functional advantages of nanomaterial-based gauzes and hydrogels as well as hybrid structures thereof. Read More

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January 2022

Multicenter phase II study of trifluridine/tipiracil for esophageal squamous carcinoma refractory/intolerant to 5-fluorouracil, platinum compounds, and taxanes: the ECTAS study.

Esophagus 2022 Jan 20. Epub 2022 Jan 20.

Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: The standard treatment for unresectable advanced/recurrent esophageal cancer in Japan is 5-fluorouracil plus platinum-containing drugs as first-line chemotherapy and taxanes as second-line chemotherapy. However, the standard regimen after patients become refractory to these treatments remains to be established. Therefore, we investigated the efficacy of trifluridine/tipiracil (FTD/TPI) in patients with esophageal cancer who are refractory or intolerant to 5-fluorouracil, platinum-containing drugs, and taxanes. Read More

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January 2022

Multimodal molecular imaging evaluation for early diagnosis and prognosis of cholangiocarcinoma.

Insights Imaging 2022 Jan 20;13(1):10. Epub 2022 Jan 20.

Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, People's Republic of China.

Cholangiocarcinoma (CCA) is an aggressive and lethal malignancy with limited therapeutic options. Despite recent advances in diagnostic imaging for CCA, the early diagnosis of CCA and evaluation of tumor invasion into the bile duct and its surrounding tissues remain challenging. Most patients with CCA are diagnosed at an advanced stage, at which treatment options are limited. Read More

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January 2022

[Complications of permanent vascular access for haemodialysis].

Angiol Sosud Khir 2021 ;27(4):165-174

Department of Vascular Surgery, Republican Clinical Hospital of the Ministry of Public Health of the Republic of Tatarstan, Kazan, Russia.

Permanent vascular access is the basis of renal replacement therapy by the method of programmed haemodialysis, on whose stable functioning depends the life of patients with end-stage renal disease. At the present time, there is significant deficit of scientific and methodological Russian-language literature on this problem, with no Russian consensus documents concerned. This article is a review of the contemporary world literature dedicated to the problem of permanent vascular access, including currently in force European (2018) and North American (2019) guidelines for good clinical practice, also discussing the problems of strategy and tactics of creating a permanent vascular access, monitoring its dysfunction, pathophysiology of functioning of arteriovenous fistulas. Read More

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January 2021

Past Experiences for Future Applications of Metabolomics in Critically Ill Patients with Sepsis and Septic Shocks.

Metabolites 2021 Dec 21;12(1). Epub 2021 Dec 21.

Metabolomics Unit, Cardiac Electrophysiology Research and Training Center, Chiang Mai University, Chiang Mai 50200, Thailand.

A disruption of several metabolic pathways in critically ill patients with sepsis indicates that metabolomics might be used as a more precise tool for sepsis and septic shock when compared with the conventional biomarkers. This article provides information regarding metabolomics studies in sepsis and septic shock patients. It has been shown that a variety of metabolomic pathways are altered in sepsis and septic shock, including amino acid metabolism, fatty acid oxidation, phospholipid metabolism, glycolysis, and tricarboxylic acid cycle. Read More

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December 2021

Rapid Diagnosis of Central Nervous System Scedosporiosis by Specific Quantitative Polymerase Chain Reaction Applied to Formalin-Fixed, Paraffin-Embedded Tissue.

J Fungi (Basel) 2021 Dec 27;8(1). Epub 2021 Dec 27.

Centre for Neurovascular Diseases Tübingen, ZNET, University of Tübingen, 72076 Tübingen, Germany.

is a typical mold causing cerebral abscesses, often after near-drowning. Infections are associated with high morbidity and mortality due to diagnostic challenges including the need for prolonged incubation of cultures. In addition, histopathological differentiation from other filamentous fungi, including may not be possible, excluding early specific diagnosis and targeted therapy. Read More

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December 2021

Laboratory and Field Assessments of Oral Vaccine Indicate the Potential for Protection against Vibriosis in Cultured Marine Fishes.

Animals (Basel) 2022 Jan 7;12(2). Epub 2022 Jan 7.

Aquatic Animal Health and Therapeutics Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.

Vibriosis is one of the most common threats to farmed grouper; thus, substantial efforts are underway to control the disease. This study presents an oral vaccination against multiple spp. in a marine fish with double booster immunisation. Read More

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January 2022

Speech- and Language-Based Classification of Alzheimer's Disease: A Systematic Review.

Bioengineering (Basel) 2022 Jan 11;9(1). Epub 2022 Jan 11.

Instituto Superior de Engenharia do Porto, 4249-015 Porto, Portugal.

Background: Alzheimer's disease (AD) has paramount importance due to its rising prevalence, the impact on the patient and society, and the related healthcare costs. However, current diagnostic techniques are not designed for frequent mass screening, delaying therapeutic intervention and worsening prognoses. To be able to detect AD at an early stage, ideally at a pre-clinical stage, speech analysis emerges as a simple low-cost non-invasive procedure. Read More

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January 2022

Diagnostic and Therapeutic Challenges in a Patient with Synchronous Very High-Risk Prostate Adenocarcinoma and Anal Carcinoma.

Curr Oncol 2022 Jan 15;29(1):377-382. Epub 2022 Jan 15.

Veterans Affairs New York Harbor Healthcare System, State University of New York-Downstate Medical Center, New York, NY 11209, USA.

A 79-year-old HIV-negative Caucasian man with a medical history of smoking 20 pack-years (quit 40 years prior), early-stage non-small cell lung cancer status post-lobectomy 13 years earlier at an outside hospital without evidence of recurrence, and benign prostatic hypertrophy was diagnosed with synchronous very high-risk prostate adenocarcinoma and early-stage anal basaloid squamous cell carcinoma. He proceeded to undergo concurrent treatment for these tumors, consisting of androgen deprivation therapy, external beam radiation therapy, and a brachytherapy boost for the prostate adenocarcinoma; for the anal carcinoma, he was treated with definitive chemoradiation. Over 3. Read More

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January 2022

NIR-II Aggregation-Induced Emission Luminogens for Tumor Phototheranostics.

Biosensors (Basel) 2022 Jan 17;12(1). Epub 2022 Jan 17.

Shenzhen Institute of Aggregate Science and Technology, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China.

As an emerging and powerful material, aggregation-induced emission luminogens (AIEgens), which could simultaneously provide a precise diagnosis and efficient therapeutics, have exhibited significant superiorities in the field of phototheranostics. Of particular interest is phototheranostics based on AIEgens with the emission in the range of second near-infrared (NIR-II) range (1000-1700 nm), which has promoted the feasibility of their clinical applications by virtue of numerous preponderances benefiting from the extremely long wavelength. In this minireview, we summarize the latest advances in the field of phototheranostics based on NIR-II AIEgens during the past 3 years, including the strategies of constructing NIR-II AIEgens and their applications in different theranostic modalities (FLI-guided PTT, PAI-guided PTT, and multimodal imaging-guided PDT-PTT synergistic therapy); in addition, a brief conclusion of perspectives and challenges in the field of phototheranostics is given at the end. Read More

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January 2022

Long-Term Clinical and Psychiatric Complications of Young Adults Cured of a Pediatric Bone Tumor Diagnosed Between 1987 and 1999 in Rhône: Alpes Region (France).

J Adolesc Young Adult Oncol 2022 Jan 18. Epub 2022 Jan 18.

Department of Pediatric Hematology and Oncology, University Hospital of Saint-Etienne, Saint-Etienne, France.

The 5-year survival for children diagnosed with cancer is ∼85%. The constant increase in survival curves is evidence of therapeutic optimization. Clinical and psychological complications are rarely analyzed simultaneously in the literature for pediatric malignant bone tumors. Read More

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January 2022