Spectrochim Acta A Mol Biomol Spectrosc 2021 Dec 29;270:120798. Epub 2021 Dec 29.
National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, Guangxi Medical University, Nanning, Guangxi, 530021, China; School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, Guangxi 541004, People's Republic of China. Electronic address:
Glypican-3 (GPC3), a heparin sulfate proteoglycan, is a potential diagnostic and therapeutic target for hepatocellular carcinoma. In this paper, a novel fluorescent aptasensor for GPC3 detection is constructed via [email protected] quantum dots-labeled GPC3 aptamer ([email protected]) as a fluorescence probe. First, [email protected] is screened out with higher fluorescence intensity, which emits bright blue fluorescence under ultraviolet light. Read More