690,386 results match your criteria diagnostic evidence

The Management of Orbital Roof Fractures and Defects: A Review.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Orbital and Oculoplastics Department, Sussex Eye Hospital, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom Department of Neurosurgery, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom Department of Radiology, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom Department of Head & Neck Prosthetics, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, United Kingdom.

Purpose: To explore the anatomy, etiopathogenesis, diagnosis and classification, current evidence on intervention and the surgical management of orbital roof fractures and defects (ORFD) for oculoplastic surgeons presented with such cases.

Methods: A review of the current literature through the MEDLINE database using the following search terms: "orbital roof fracture (+treatment/management)," "orbital roof defect (+treatment/management)," "orbital roof erosion (+treatment/management)," "orbital roof repair," "orbital roof," "orbital fracture," "pediatric orbital roof (defect/fracture/erosion)," "orbital anatomy," and "orbital roof anatomy" was conducted. As relatively little has been published on this topic, inclusion criteria were broad and peer-reviewed articles judged to be of clinical importance, relevant to the aims of this review, were included. Read More

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Sequencing of Circulating Microbial Cell-Free DNA Can Identify Pathogens in Periprosthetic Joint Infections.

J Bone Joint Surg Am 2021 Jul 22. Epub 2021 Jul 22.

Hospital for Special Surgery Research Institute, New York, NY.

Background: Over 1 million Americans undergo joint replacement each year, and approximately 1 in 75 will incur a periprosthetic joint infection. Effective treatment necessitates pathogen identification, yet standard-of-care cultures fail to detect organisms in 10% to 20% of cases and require invasive sampling. We hypothesized that cell-free DNA (cfDNA) fragments from microorganisms in a periprosthetic joint infection can be found in the bloodstream and utilized to accurately identify pathogens via next-generation sequencing. Read More

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The relationship between urinary phthalate metabolites and polycystic ovary syndrome in women undergoing in vitro fertilization: Nested case-control study.

Iman Al-Saleh

Chemosphere 2021 Jul 14;286(Pt 1):131495. Epub 2021 Jul 14.

Environmental Health Program, Research Centre, King Faisal Specialist Hospital and Research Centre, PO Box: 3354, Riyadh, 11211, Saudi Arabia. Electronic address:

Certain endocrine disruptor chemicals are involved in the pathogenesis of polycystic ovary syndrome (PCOS), a hormonal disease related to infertility in women. Phthalates are the most common plasticizers found in several consumer products. Experimental and epidemiologic evidence suggests that some phthalates disrupt endocrine functions in reproductive mechanisms and development. Read More

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Covid-19 and Risk of Venous Thromboembolism in Ethnically Diverse Populations.

Chest 2021 Jul 19. Epub 2021 Jul 19.

Department of Medicine, University of California, San Francisco, San Francisco, CA USA.

Background: Limited existing data suggest the novel coronavirus disease 2019 (Covid-19) may increase risk for venous thromboembolism (VTE) but information from large, ethnically diverse populations with appropriate controls are lacking.

Research Question: Does the rate of VTE among adults hospitalized with Covid-19 differ from matched hospitalized controls without Covid-19?

Study Design And Methods: We conducted a retrospective study among hospitalized adults with laboratory-confirmed Covid-19 and hospitalized adults without evidence of Covid-19 matched on age, gender, race/ethnicity, acute illness severity, and month of hospitalization between February-August 2020 from two integrated healthcare delivery systems with 36 hospitals. Outcomes included VTE (deep venous thrombosis or pulmonary embolism ascertained using diagnosis codes combined with validated natural language processing algorithms applied to electronic health records) and death from any cause at 30 days. Read More

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Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and associations with attention-deficit/hyperactivity disorder and autism spectrum disorder in children.

Environ Res 2021 Jul 19:111692. Epub 2021 Jul 19.

Division of Mental and Physical Health, Norwegian Institute of Public Health, PO Box 222, Skøyen, N-0213, Oslo, Norway.

Background: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may be a risk factor for neurodevelopmental deficits and disorders, but evidence is inconsistent.

Objectives: We investigated whether prenatal exposure to PFAS were associated with childhood diagnosis of attention-deficit/hyperactivity disorder (ADHD) or autism spectrum disorder (ASD).

Methods: This study was based on the Norwegian Mother, Father and Child Cohort Study and included n = 821 ADHD cases, n = 400 ASD cases and n = 980 controls. Read More

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Testosterone therapy and cardiovascular diseases.

Cardiovasc Res 2021 Jul 22. Epub 2021 Jul 22.

IRCCS SDN, Diagnostic and Nuclear Research Institute, Naples, Italy.

Since it was first synthesised in 1935, testosterone (T) has been viewed as the mythical Fountain of Youth, promising rejuvenation, restoring sexual appetites, growing stronger muscles, and quicker thinking. T is endowed with direct effects on myocardial and vascular structure and function, as well as on risk factors for cardiovascular (CV) disease. Indeed, low serum T levels are a risk factor for diabetes, metabolic syndrome, inflammation, and dyslipidaemia. Read More

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A mixed methods study on the readiness of dental, medical, and nursing students for interprofessional learning.

PLoS One 2021 22;16(7):e0255086. Epub 2021 Jul 22.

Institute of Education, Tokyo Medical and Dental University, Tokyo, Japan.

Background: Interprofessional education (IPE) is crucial in dentistry, medicine, and nursing. However, scant mixed methods studies have compared the IPE outcomes across these disciplines to develop evidence-based IPE. This study explored the differences in the readiness of dental, medical, and nursing students for interprofessional learning before and after IPE workshops and elucidated reasons for this disparity. Read More

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Trauma-focused treatments for depression. A systematic review and meta-analysis.

PLoS One 2021 22;16(7):e0254778. Epub 2021 Jul 22.

School of Psychology and Exercise Science, Murdoch University, Murdoch, WA, Australia.

Background: Trauma-focused treatments (TFTs) have demonstrated efficacy at decreasing depressive symptoms in individuals with PTSD. This systematic review and meta-analysis evaluated the effectiveness of TFTs for individuals with depression as their primary concern.

Methods: A systematic search was conducted for RCTs published before October 2019 in Cochrane CENTRAL, Pubmed, EMBASE, PsycInfo, and additional sources. Read More

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Association of dexmedetomidine with recovery room and hospital discharge times: a retrospective cohort analysis.

Paediatr Anaesth 2021 Jul 22. Epub 2021 Jul 22.

Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada.

Background: Dexmedetomidine is a useful anesthetic adjunct, increasingly popular during pediatric surgery and procedural sedation. Its half-life of 2-3 hours might prolong recovery and discharge times when compared with an un-supplemented propofol anesthetic. This may create an additional burden in a busy post-anesthetic care unit (PACU). Read More

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Patterns of psychiatric admission in Australian pregnant and childbearing women.

Soc Psychiatry Psychiatr Epidemiol 2021 Jul 22. Epub 2021 Jul 22.

Neuropsychiatric Epidemiology Research Unit, School of Population and Global Health, University of Western Australia, Nedlands, Australia.

Purpose: The early postnatal period is a time of increased risk for psychiatric admission. However, there is scope to further examine if this increase in risk extends to the entire perinatal period (pregnancy and first postnatal year), and how it compares to admission outside of the perinatal period.

Methods: Data were linked across birth and hospital admission registers from July 2000 to December 2009. Read More

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An ESPGHAN Position Paper on the Use of Breath Testing in Paediatric Gastroenterology.

J Pediatr Gastroenterol Nutr 2021 Jul 20. Epub 2021 Jul 20.

Department of Paediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany Department of Paediatric Gastroenterology, Great Ormond Street Hospital, London, UK Department of Paediatrics, University Medical Centre Maribor, Maribor, Slovenia Department of Paediatric Gastroenterology, Hepatology and Nutrition, Hospital Sant Joan de Déu, Barcelona, Spain Unité de Gastroentérologie, Hépatologie, Nutrition, Diabétologie et Maladies Héréditaires du Métabolisme, Hôpital des Enfants, CHU de Toulouse, Toulouse, France; IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France Department of Translational Medical Science, Section of Paediatrics, University of Naples "Federico", Naples, Italy Department of Paediatrics, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania Department of Paediatric Gastroenterology, Hepatology & Nutrition, La Fe University Hospital, Valencia, Spain Department of Paediatric Medicine, Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Norway Centre for Paediatric Gastroenterology, Sheffield Children's Hospital, Sheffield, UK Department of Paediatric Gastroenterology, Al Jalila Children's Specialty Hospital, Dubai, UAE Department of Paediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam University Medical Centres, Amsterdam, The Netherlands.

Objectives: Given a lack of a systematic approach to the use of breath testing in paediatric patients, the aim of this position paper is to provide expert guidance regarding the indications for its use and practical considerations to optimise its utility and safety.

Methods: Nine clinical questions regarding methodology, interpretation, and specific indications of breath testing and treatment of carbohydrate malabsorption were addressed by members of the Gastroenterology Committee (GIC) of the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN).A systematic literature search was performed from 1983 to 2020 using PubMed, the MEDLINE and Cochrane Database of Systematic Reviews. Read More

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Outcomes of Patients With Parkinson Disease Undergoing Cervical Spine Surgery for Radiculopathy and Myelopathy With Minimum 2-Year Follow-up.

Clin Spine Surg 2021 Jul 21. Epub 2021 Jul 21.

Department of Orthopaedic Surgery and Rehabilitation Medicine, State University of New York (SUNY) Downstate Medical Center, Brooklyn, New York Rothman Orthopaedic Institute Department of Orthopaedic Surgery, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA Department of Orthopaedic Surgery, NYU Langone Orthopedic Hospital Spine Service, Hospital for Special Surgery, New York, NY.

Study Design: This was a retrospective cohort analysis.

Objective: To identify the impact of Parkinson disease (PD) on 2-year postoperative outcomes following cervical spine surgery (CSS).

Summary Of Background Data: (PD) patients are prone to spine malalignment and surgical interventions, yet little is known regarding outcomes of CSS among PD patients. Read More

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Mast cell activation syndrome: is anaphylaxis part of the phenotype? A systematic review.

Curr Opin Allergy Clin Immunol 2021 Jul 20. Epub 2021 Jul 20.

University of Antwerp, Faculty of Medicine and Health Sciences, Department of Immunology, Allergology, Rheumatology and the Infla-Med Centre of Excellence AZ Jan Palfijn Gent, Department of Immunology and Allergology, Ghent, Belgium Laboratoire d'Immunologie, CHU de Nîmes, Nîmes Aix-Marseille Univ, IRD, APHM, MEPHI IHU Méditerranée Infection, Marseille Université de Paris, Centre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252, Faculté de Médecine site Bichat, Paris, France; Laboratoire d'Excellence Inflamex, Paris, France IDESP, INSERM UMR UA 11, Montpellier, France.

Purpose Of Review: Mast cell activation syndrome (MCAS) and anaphylaxis are the result of a spontaneous or triggered pathological degranulation of mast cells (MCs) and might have as substrate normal or pathological MCs (increased burden, aberrant MCs or both).

Recent Findings: This review summarizes the most recent evidence on immunoglobulin E (IgE)-mediated and non IgE-mediated mechanisms underlying MC activation and degranulation and highlights the importance of standardized diagnostic criteria for MCAS. Application of these criteria implies that in most cases the clinical presentation of MCAS meets the diagnostic criteria for anaphylaxis. Read More

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Eating disorder measures in a sample of military veterans: A focus on gender, age, and race/ethnicity.

Psychol Assess 2021 Jul 22. Epub 2021 Jul 22.

National Center for PTSD.

Early detection of eating disorders (EDs) is crucial for both prevention and treatment; however, few ED measures have been validated among older adults, men, and racially/ethnically diverse individuals, who may have varying symptom presentations. We examined the psychometric quality of three self-report ED measures within a diverse sample of U.S. Read More

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Molecular evidence suggesting the persistence of residual SARS-CoV-2 and immune responses in the placentas of pregnant patients recovered from COVID-19.

Cell Prolif 2021 Jul 22:e13091. Epub 2021 Jul 22.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Objectives: Recent studies have shown the presence of SARS-CoV-2 in the tissues of clinically recovered patients and persistent immune symptoms in discharged patients for up to several months. Pregnant patients were shown to be a high-risk group for COVID-19. Based on these findings, we assessed SARS-CoV-2 nucleic acid and protein retention in the placentas of pregnant women who had fully recovered from COVID-19 and cytokine fluctuations in maternal and foetal tissues. Read More

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Magnetic Resonance Imaging-Based Structural Covariance Changes of the Striatum in Lifelong Premature Ejaculation Patients.

J Magn Reson Imaging 2021 Jul 22. Epub 2021 Jul 22.

Life Sciences Research Center, School of Life Science and Technology, Xidian University, Xi'an, China.

Background: The striatum has been reported to be implicated in various neurological diseases, including lifelong premature ejaculation (LPE). Altered striatum-related functional connectivity was investigated in LPE patients in previous studies; however, structural abnormalities in the striatum have been less studied in LPE.

Purpose: To identify the gray matter volume (GMV) and structural covariance patterns of the striatum between LPE patients and healthy controls (HCs). Read More

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Disseminated intravascular coagulation complicating diagnosis of ROS1-mutant non-small cell lung cancer: A case report and literature review.

Thorac Cancer 2021 Jul 22. Epub 2021 Jul 22.

Department of Medical Oncology, St George Cancer Care Centre, Kogarah, New South Wales, Australia.

Disseminated intravascular coagulation (DIC) is a rare paraneoplastic complication in advanced solid malignancies, with success of treatment and survival dependent on treatment of the underlying malignancy. Best estimates suggest an incidence of 1.6-6. Read More

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A forward search algorithm for detecting extreme study effects in network meta-analysis.

Stat Med 2021 Jul 21. Epub 2021 Jul 21.

Evidence Synthesis Method Team, Department of Primary Education, University of Ioannina School of Education, Ioannina, Greece.

In a quantitative synthesis of studies via meta-analysis, it is possible that some studies provide a markedly different relative treatment effect or have a large impact on the summary estimate and/or heterogeneity. Extreme study effects (outliers) can be detected visually with forest/funnel plots and by using statistical outlying detection methods. A forward search (FS) algorithm is a common outlying diagnostic tool recently extended to meta-analysis. Read More

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[Plasma determination of neurofilaments as biomarkers in multiple sclerosis: conclusions of the EMotion Forum].

Rev Neurol 2021 Aug;73(3):101-110

Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.

Introduction: In the management of multiple sclerosis (MS) there is still a need to identify biomarkers of disease progression, and clinical and subclinical activity. Among them, determination of neurofilament light chain plasma levels (NfL-PM) has shown a possible correlation with clinical course and assessment of therapeutic response in MS patients. However, the determination of NfL-PM has to overcome several obstacles that hinder its integration into healthcare practice, such as the absence of normalised values and standardised protocols. Read More

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MiRNAs and lncRNAs in NK cell biology and NK/T-cell lymphoma.

Genes Dis 2021 Sep 31;8(5):590-602. Epub 2020 Aug 31.

Department of Immunology, Chongqing Medical University, Chongqing, 400010, PR China.

The important role of lncRNAs and miRNAs in directing immune responses has become increasingly clear. Recent evidence conforms that miRNAs and lncRNAs are involved in NK cell biology and diseases through RNA-protein, RNA-RNA, or RNA-DNA interactions. In this view, we summarize the contribution of miRNAs and lncRNAs to NK cell lineage development, activation and function, highlight the biological significance of functional miRNAs or lncRNAs in NKTL and discuss the potential of these miRNAs and lncRNAs as innovative biomarkers/targets for NKTL early diagnosis, target treatment and prognostic evaluations. Read More

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September 2021

Beyond Colonoscopy: Exploring New Cell Surface Biomarkers for Detection of Early, Heterogenous Colorectal Lesions.

Front Oncol 2021 5;11:657701. Epub 2021 Jul 5.

Department of Diagnostic and Biomedical Sciences, The University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX, United States.

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths among both men and women in the United States. Early detection and surgical removal of high-risk lesions in the colon can prevent disease from developing and spreading. Despite implementation of programs aimed at early detection, screening colonoscopies fail to detect a fraction of potentially aggressive colorectal lesions because of their location or nonobvious morphology. Read More

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Risk factors and oncological outcomes of pulmonary metastasis in patients with giant cell tumor of bone.

J Clin Orthop Trauma 2021 Sep 9;20:101499. Epub 2021 Jul 9.

Department of Orthopaedic Surgery, Menoufia University Faculty of Medicine, Shebin El-Kom, Menoufia, Egypt.

Background: Giant cell tumor (GCT) of bone has a rare potential for metastatic spread. This study aimed at evaluating the incidence of chest metastases in GCT and their oncological outcome and identifying possible risk factors.

Methods: Medical records of 466 (313 de novo and 153 recurrent) patients with primary GCT of bone were retrospectively reviewed. Read More

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September 2021

Prolonged Self-Resolving Neutropenia Following Asymptomatic COVID-19 Infection.

Cureus 2021 Jul 18;13(7):e16451. Epub 2021 Jul 18.

Hematology and Oncology, Captain James A. Lovell Federal Health Care Center, North Chicago, USA.

Multiple hematologic complications have been reported as a result of the novel coronavirus disease 2019 (COVID-19) infection. These include leukopenia, lymphopenia, thrombocytopenia as well as increased risk of venous thromboembolism. Neutropenia is a relatively uncommon finding, especially in asymptomatic patients with no other evidence of systemic infection. Read More

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Anomalous Presentation of Venous Malformations in an Adolescent Male.

Cureus 2021 Jun 19;13(6):e15756. Epub 2021 Jun 19.

Division of Plastics, Hand, Reconstructive & Burn Surgery, Department of Surgery, University of New Mexico School of Medicine, Albuquerque, USA.

Venous malformations (VMs) may manifest clinically in a broad spectrum. Most VMs are sporadic with previous studies reporting less than 1.2% to be inherited. Read More

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Opportunistic diagnosis of osteoporosis, fragile bone strength and vertebral fractures from routine CT scans; a review of approved technology systems and pathways to implementation.

Ther Adv Musculoskelet Dis 2021 10;13:1759720X211024029. Epub 2021 Jul 10.

University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, NIHR Cambridge Biomedical Research Centre, Cambridge, CB2 0QQ, UK.

Osteoporosis causes bones to become weak, porous and fracture more easily. While a vertebral fracture is the archetypal fracture of osteoporosis, it is also the most difficult to diagnose clinically. Patients often suffer further spine or other fractures, deformity, height loss and pain before diagnosis. Read More

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Thalamus Radiomics-Based Disease Identification and Prediction of Early Treatment Response for Schizophrenia.

Front Neurosci 2021 5;15:682777. Epub 2021 Jul 5.

The Second Medical Center, Chinese PLA General Hospital, Beijing, China.

Background: Emerging evidence suggests structural and functional disruptions of the thalamus in schizophrenia, but whether thalamus abnormalities are able to be used for disease identification and prediction of early treatment response in schizophrenia remains to be determined. This study aims at developing and validating a method of disease identification and prediction of treatment response by multi-dimensional thalamic features derived from magnetic resonance imaging in schizophrenia patients using radiomics approaches.

Methods: A total of 390 subjects, including patients with schizophrenia and healthy controls, participated in this study, among which 109 out of 191 patients had clinical characteristics of early outcome (61 responders and 48 non-responders). Read More

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Acta Ortop Bras 2021 May-Jun;29(3):159-166

Universidade Federal do Paraná, Curitiba, PR, Brazil.

Objective: To translate into Brazilian Portuguese and conduct the cross-cultural adaptation of the "Injury Report Form for Rugby Union" questionnaire.

Methods: This is a cross-sectional study, level of evidence II, with following the steps: translation; synthesis; back-translation; review by a committee of experts and pre-final version; pre-test to verify comprehension; elaboration of the final version of the instrument and clinical application.

Results: The two versions resulting from the translation and adaptation process did not show great differences. Read More

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Acta Ortop Bras 2021 May-Jun;29(3):132-136

Universidade de São Paulo, Faculty of Medicine, Hospital das Clínicas, Institute of Orthopedics and Traumatology, HC-FMUSP, Grupo de Joelho, São Paulo, SP, Brazil.

Objective: This study aims to evaluate the sensitivity and specificity of the lever sign test in patients with and without chronic Anterior Cruciate Ligament (ACL) injuries in an outpatient setting and the inter-examiner agreement of surgeons with different levels of experience.

Methods: 72 consecutive patients with a history of previous knee sprains were included. The Lachman, anterior drawer, and Lever Sign tests were performed for all subjects in a randomized order by three blinded raters with different levels of experience. Read More

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Salivary Heme Oxygenase-1: A Potential Biomarker for Central Neurodegeneration.

J Cent Nerv Syst Dis 2021 7;13:11795735211029114. Epub 2021 Jul 7.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.

Background: Parkinson disease (PD) is the second most common neurodegenerative disease, affecting 2% of the population over 65 years of age. PD diagnosis is based on clinical examination and can only be confirmed during autopsy. In 2018, we reported that heme oxygenase-1 (HO-1), an inducible stress response protein important for heme catabolism and implicated in PD pathology, was higher in PD saliva relative to healthy controls, suggesting that salivary HO-1 may serve as a potential biomarker of PD. Read More

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Genetic association studies of alterations in protein function expose recessive effects on cancer predisposition.

Sci Rep 2021 Jul 21;11(1):14901. Epub 2021 Jul 21.

Department of Biological Chemistry, The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel.

The characterization of germline genetic variation affecting cancer risk, known as cancer predisposition, is fundamental to preventive and personalized medicine. Studies of genetic cancer predisposition typically identify significant genomic regions based on family-based cohorts or genome-wide association studies (GWAS). However, the results of such studies rarely provide biological insight or functional interpretation. Read More

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