575,722 results match your criteria diagnostic biomarkers


Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio are associated with a 2-year relapse in patients with multiple sclerosis.

Mult Scler Relat Disord 2022 Jan 10;58:103514. Epub 2022 Jan 10.

Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Background: The association between increased neutrophil-to-lymphocyte ratio (NLR) and multiple sclerosis has been demonstrated in several studies. The monocyte-to-lymphocyte ratio (MLR) is an emerging biomarker for disease monitoring. Moreover, there has not been a published Taiwanese study to date. Read More

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January 2022

Commonly expressed key transcriptomic profiles of sepsis in the human circulation and brain via integrated analysis.

Int Immunopharmacol 2022 Jan 12;104:108518. Epub 2022 Jan 12.

Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province 410013, PR China. Electronic address:

Background: Sepsis is the leading cause of death in intensive care units and is characterized by multiple organ failure, including dysfuction of the immune system and brain. This study aims to determine the differential effect of sepsis on specific circulating immune cell subsets compared with brain transcriptome and identify the genes co-expressed by them, so as to identify key genes and regulatory factors involved in the pathogenesis of sepsis induced brain injury and identify novel therapeutic targets.

Methods: The GSE133822 and GSE135838 datasets were obtained from the Gene Expression Omnibus (GEO) database and utilized for bioinformatics analyses. Read More

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January 2022

Elevated basal serum tryptase: disease distribution and variability in a regional health system.

J Allergy Clin Immunol Pract 2022 Jan 12. Epub 2022 Jan 12.

Allergy & Immunology Service, Walter Reed National Military Medical Center, Bethesda MD; Department of Medicine, Uniformed Services University, Bethesda, MD. Electronic address:

Background: Hereditary-alpha tryptasemia (HαT) is the most common etiology for elevated basal serum tryptase (BST). However, the utility of tryptase genotyping of individuals with elevated BST in general clinical practice remains undefined. Moreover, studies showing associations between elevated BST and chronic kidney disease (CKD), myelodysplastic syndrome (MDS), rheumatoid arthritis (RA), or eosinophilic esophagitis (EoE) did not include tryptase genotyping. Read More

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January 2022

Tumour- associated autoantibodies as prognostic cancer biomarkers- a review.

Autoimmun Rev 2022 Jan 12:103041. Epub 2022 Jan 12.

Centre for Precision Health, , Edith Cowan University, Joondalup, Perth, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Perth, WA, Australia.

Throughout the process of carcinogenesis, autologous cells are transformed into cancer cells, leading to changes in their protein expression profiles. It has been suggested that mutations, protein misfolding, overexpression and aberrant post-translational modifications, changes in protein abundance or location can render tumour-associated antigens immunogenic. Subsequent changes in the tumour microenvironment may lead to humoral immune responses and therefore the production of tumour-associated autoantibodies. Read More

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January 2022

Urinary Proteomics in Kidney Transplantation.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2021 Dec 30;42(3):7-16. Epub 2021 Dec 30.

Macedonian Academy of Sciences and Arts Skopje, N. Macedonia.

Although kidney transplantation is the best treatment option for end stage kidney disease, it is still associated with long-term graft failure. One of the greater challenges for transplant professionals is the ability to identify grafts with a high risk of failure before initial decline of eGFR with irreversible graft changes. Transplantation medicine is facing an emerging need for novel disease end point-specific biomarkers, with practical application in preventive screening, early diagnostic, and improved prognostic and therapeutic utility. Read More

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December 2021

Diagnostic and Prognostic Markers of Periodontal Disease.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2021 Dec 30;42(3):89-95. Epub 2021 Dec 30.

Ss. Cyril and Methodius University in Skopje, Faculty of Dentistry - Skopje, Department of Oral and Periodontal Diseases, Skopje, N. Macedonia.

The aim of this study is to determine the values of salivary enzyme biomarkers (alkaline phosphatase - ALP, aspartate aminotransferase - AST and lactate dehydrogenase - LDH) in subjects with healthy and diseased periodontium and to investigate the possibility of using these salivary enzymes as diagnostic and prognostic markers. We collected saliva with the spitting method from all examinees in the morning, using the recommendations provided by The values of the enzymes in saliva were determined spectro-photometrically, with the following methods: ALP-IFCC, AST-IFCC, LDH-PYRUVATE. IGI Silness-Löe was used to determine the presence of gingival inflammation, and to determine the presence of clinically manifest periodontitis, we determined the clinical loss of periodontal attachment with a graduated periodontal probe. Read More

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December 2021

Plasma metabolomic profiles for colorectal cancer precursors in women.

Eur J Epidemiol 2022 Jan 15. Epub 2022 Jan 15.

Department of Nutrition, Harvard T.H. Chan School of Public Health, 667 Huntington Avenue, Kresge 906A, Boston, MA, 02115, USA.

How metabolome changes influence the early process of colorectal cancer (CRC) development remains unknown. We conducted a 1:2 matched nested case-control study to examine the associations of pre-diagnostic plasma metabolome (profiled using LC-MS) with risk of CRC precursors, including conventional adenomas (n = 586 vs. 1141) and serrated polyps (n = 509 vs. Read More

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January 2022

Clinical issues of surgery for uterine endometrial cancer in Japan.

Jpn J Clin Oncol 2022 Jan 15. Epub 2022 Jan 15.

Objective: The mainstay of treatment for uterine endometrial cancer is surgery, and recurrent-risk cases require multidisciplinary treatment, including surgery, chemotherapy and radiation therapy.

Methods: The standard surgery for uterine endometrial cancer is hysterectomy and bilateral salpingooophorectomy, with additional retroperitoneal lymph node dissection and omentectomy, depending on the case. The appropriate treatment is determined based on the risk classification, such as the depth of invasion into the myometrium, diagnosis of histological type and grade, and risk assessment of lymph node metastasis. Read More

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January 2022

Kinases and therapeutics in pathogen mediated gastric cancer.

Mol Biol Rep 2022 Jan 15. Epub 2022 Jan 15.

Infectious Bioengineering Lab, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, Madhya Pradesh, 453552, India.

Introduction: Many pathogens have coexisted with humans for millennia and can cause chronic inflammation which is the cause of gastritis. Gastric cancer (GC) is associated with 8.8% of cancer related deaths, making it one of the leading causes of cancer related deaths worldwide. Read More

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January 2022

A review of prognostic and predictive biomarkers in breast cancer.

Clin Exp Med 2022 Jan 15. Epub 2022 Jan 15.

Radiation Applications Research School, Nuclear Science and Technology Research Institute, P.O. Box: 14395-836, Tehran, Iran.

Breast cancer (BC) is a common cancer all over the world that affects women. BC is one of the leading causes of cancer mortality in women, which today has decreased with the advancement of technology and new diagnostic and therapeutic methods. BCs are histologically divided into in situ and invasive carcinoma, and both of them can be divided into ductal and lobular. Read More

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January 2022

Capability of intravoxel incoherent motion and diffusion tensor imaging to detect early kidney injury in type 2 diabetes.

Eur Radiol 2022 Jan 15. Epub 2022 Jan 15.

Department of Radiology, Xiang'an Hospital of Xiamen University, Xiamen, 361005, China.

Objectives: To prospectively investigate the capability of intravoxel incoherent motion (IVIM) and conventional diffusion tensor imaging (DTI) to identify early kidney function injury in type 2 diabetes.

Methods: Forty-one diabetes patients (normoalbuminuria: n = 27; microalbuminuria: n = 14) and 28 volunteers were recruited. All participants were examined using DTI and IVIM with 3. Read More

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January 2022

Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer.

Br J Cancer 2022 Jan 14. Epub 2022 Jan 14.

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

Background: CA125 is the best available yet insufficiently sensitive biomarker for early detection of ovarian cancer. There is a need to identify novel biomarkers, which individually or in combination with CA125 can achieve adequate sensitivity and specificity for the detection of earlier-stage ovarian cancer.

Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we measured serum levels of 92 preselected proteins for 91 women who had blood sampled ≤18 months prior to ovarian cancer diagnosis, and 182 matched controls. Read More

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January 2022

Functional nucleic acids in glycobiology: A versatile tool in the analysis of disease-related carbohydrates and glycoconjugates.

Int J Biol Macromol 2022 Jan 11. Epub 2022 Jan 11.

School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China. Electronic address:

As significant components of the organism, carbohydrates and glycoconjugates play indispensable roles in energy supply, cell signaling, immune modulation, and tumor cell invasion, and function as biomarkers since aberrance of them has been proved to be associated with the emergence and development of certain diseases. Functional nucleic acids (FNAs) have properties including easy-to-synthesize, good stability, good biocompatibility, low cost, and high programmability, they have attracted significant research attention and been incorporated into biosensors for detecting disease-related carbohydrates and glycoconjugates. This review summarizes the construction strategies and biosensing applications of FNAs-based biosensors in glycobiology in terms of target recognition and signal transduction. Read More

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January 2022

Systematic Review of Cost-Effectiveness Models in Prostate Cancer: Exploring New Developments in Testing and Diagnosis.

Value Health 2022 Jan 22;25(1):133-146. Epub 2021 Sep 22.

Health Economics Bristol, Bristol Medical School, University of Bristol, Bristol, England, UK.

Objectives: Recent innovations in prostate cancer diagnosis include new biomarkers and more accurate biopsy methods. This study assesses the evidence base on cost-effectiveness of these developments (eg, Prostate Health Index and magnetic resonance imaging [MRI]-guided biopsy) and identifies areas of improvement for future cost-effectiveness models.

Methods: A systematic review using the National Health Service Economic Evaluation Database, MEDLINE, Embase, Health Technology Assessment databases, National Institute for Health and Care Excellence guidelines, and United Kingdom National Screening Committee guidance was performed, between 2009 and 2021. Read More

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January 2022

The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis.

Crit Care 2022 Jan 14;26(1):21. Epub 2022 Jan 14.

Thrombosis and Atherosclerosis Research Institute (TaARI), McMaster University, DBRI C5-106, 237 Barton St East, Hamilton, ON, L8L 2X2, Canada.

Background: Sepsis, the dysregulated host response to infection, triggers abnormal pro-coagulant and pro-inflammatory host responses. Limitations in early disease intervention highlight the need for effective diagnostic and prognostic biomarkers. Protein C's role as an anticoagulant and anti-inflammatory molecule makes it an appealing target for sepsis biomarker studies. Read More

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January 2022

Development of a europium nanoparticles lateral flow immunoassay for NGAL detection in urine and diagnosis of acute kidney injury.

BMC Nephrol 2022 Jan 14;23(1):30. Epub 2022 Jan 14.

Jilin Collaborative Innovation Center for Antibody Engineering, Jilin Medical University, 132013, Jilin, PR China.

Background: AKI is related to severe adverse outcomes and mortality with Coronavirus Disease 2019 (COVID-19) patients, that early diagnosed and intervened is imperative. Neutrophil gelatinase-associated lipocalin (NGAL) is one of the most promising biomarkers for detection of acute kidney injury (AKI), but current detection methods are inadequacy, so more rapid, convenient and accuracy methods are needed to detect NGAL for early diagnosis of AKI. Herein, we established a rapid, reliable and accuracy lateral flow immunoassay (LFIA) based on europium nanoparticles (EU-NPS) for the detection of NGAL in human urine specimens. Read More

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January 2022

tRF-19-W4PU732S promotes breast cancer cell malignant activity by targeting inhibition of RPL27A (ribosomal protein-L27A).

Bioengineered 2022 Feb;13(2):2087-2098

Department of Dermatology, Yijishan Hospital, First Affiliated Hospital of Wannan Medical College, Wuhu, China.

Breast cancer (BC) is a serious threat to female health. tRNA-derived fragments (tRFs) are popular biomarkers for the diagnosis and treatment of cancer. The purpose of this study was to identify tRFs related to BC and to explore the function and regulatory mechanism of crucial tRFs in BC cells. Read More

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February 2022

Test-retest reliability of mismatch negativity and gamma-band auditory steady-state response in patients with schizophrenia.

Schizophr Res 2022 Jan 11;240:165-174. Epub 2022 Jan 11.

Shanghai Med-X Engineering Research Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China; Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai 200030, China. Electronic address:

Patients with schizophrenia show widespread impairments in clinical, cognitive and psychosocial functioning. Mismatch negativity (MMN) and gamma-band auditory steady-state response (ASSR) are two neurophysiological biomarkers widely used to inform diagnosis, guide treatments and track response to interventions in schizophrenia. However, evidence for the test-retest reliability of these indices across multiple sessions in schizophrenia patients remains scarce. Read More

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January 2022

Platelet-to-lymphocyte ratio differs between MS and NMOSD at disease onset and predict disability.

Mult Scler Relat Disord 2022 Jan 8;58:103507. Epub 2022 Jan 8.

Centro de esclerosis múltiple de Buenos Aires, Buenos Aires, Argentina; Servicio de Neurología, Hospital Universitario de CEMIC, Buenos Aires, Argentina.

Background: We aimed to assess platelet-to-lymphocyte (PLR) and neutrophil-to-lymphocyte ratios (NLR) for differentiating multiple sclerosis (MS) from aquaporin-4-antibody-positive neuromyelitis optica spectrum disorders (NMOSD) at disease onset.

Methods: We retrospectively enrolled and reviewed the medical records of patients with MS (N = 50) and NMOSD (N = 33) followed in specialized MS/NMOSD centers from Argentina. Demographical and clinical (manifestation and disability) data and neuroradiological features (new/enlarging or contrast-enhancing lesions) were assessed at baseline, 1 and 2 years. Read More

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January 2022

Apoptotic protease activating factor-1 gene and MicroRNA-484: A possible interplay in relapsing remitting multiple sclerosis.

Mult Scler Relat Disord 2022 Jan 6;58:103502. Epub 2022 Jan 6.

Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Background: Emerging evidence suggests that dysregulated apoptosis might be implicated in the pathogenesis of multiple sclerosis (MS). The aim of the current study was to evaluate the expression of Apoptotic protease activating factor-1 (APAF1) mRNA and its potential regulator miR-484 in relapsing remitting MS patients (RRMS) and to investigate their role as potential disease biomarkers.

Methods: After Bioinformatic analysis was conducted and revealed miR-484 involvement in the regulation of APAF-1 gene expression. Read More

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January 2022

Use of a Cytosponge biomarker panel to prioritise endoscopic Barrett's oesophagus surveillance: a cross-sectional study followed by a real-world prospective pilot.

Lancet Oncol 2022 Jan 11. Epub 2022 Jan 11.

MRC Cancer Unit, Hutchison-MRC Research Centre, University of Cambridge, Cambridge, UK. Electronic address:

Background: Endoscopic surveillance is recommended for patients with Barrett's oesophagus because, although the progression risk is low, endoscopic intervention is highly effective for high-grade dysplasia and cancer. However, repeated endoscopy has associated harms and access has been limited during the COVID-19 pandemic. We aimed to evaluate the role of a non-endoscopic device (Cytosponge) coupled with laboratory biomarkers and clinical factors to prioritise endoscopy for Barrett's oesophagus. Read More

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January 2022

Spatial Confinement-Derived Double-Accelerated DNA Cascade Reaction for Ultrafast and Highly Sensitive Monitoring of Exosomal miRNA and Exosome Tracing.

Anal Chem 2022 Jan 14. Epub 2022 Jan 14.

College of Chemistry, Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications, Institute of Analytical Chemistry for Life Science, Zhengzhou 450001, China.

Exosomal microRNAs (miRNAs) are reliable biomarkers of disease progression, allowing for non-invasive detection. However, detection of exosomal miRNAs remains a challenge due to low abundance, poor permeability of the lipid bilayers, and slow kinetics of previous methods. Herein, an accelerated DNA nanoprobe was implemented for fast, monitoring of miRNA in exosomes by employing a spatial confinement strategy. Read More

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January 2022

Updates on breast biomarkers.

Virchows Arch 2022 Jan 14. Epub 2022 Jan 14.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Recent advancements in breast cancer treatment have ushered in a new era of precision medicine. Novel trials have led to the approval of a growing list of personalized therapies and corresponding biomarkers. These advancements have shifted the pathologist's practice into a leading role in the management breast cancer. Read More

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January 2022

CEST MRI provides amide/amine surrogate biomarkers for treatment-naïve glioma sub-typing.

Eur J Nucl Med Mol Imaging 2022 Jan 14. Epub 2022 Jan 14.

Box65, Lysholm Department of Neuroradiology, The National Hospital for Neurology & Neurosurgery, University College London Hospitals NHS Foundation Trust, 8-11 Queen Square, London, WC1N 3BG, UK.

Purpose: Accurate glioma classification affects patient management and is challenging on non- or low-enhancing gliomas. This study investigated the clinical value of different chemical exchange saturation transfer (CEST) metrics for glioma classification and assessed the diagnostic effect of the presence of abundant fluid in glioma subpopulations.

Methods: Forty-five treatment-naïve glioma patients with known isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion status received CEST MRI (B = 2μT, T = 3. Read More

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January 2022

The central vein sign helps in differentiating multiple sclerosis from its mimickers: lessons from Fabry disease.

Eur Radiol 2022 Jan 14. Epub 2022 Jan 14.

Department of Advanced Biomedical Sciences, University "Federico II", Via Pansini, 5, 80131, Naples, Italy.

Objectives: Although the use of specific MRI criteria has significantly increased the diagnostic accuracy of multiple sclerosis (MS), reaching a correct neuroradiological diagnosis remains a challenging task, and therefore the search for new imaging biomarkers is crucial. This study aims to evaluate the incidence of one of the emerging neuroradiological signs highly suggestive of MS, the central vein sign (CVS), using data from Fabry disease (FD) patients as an index of microvascular disorder that could mimic MS.

Methods: In this retrospective study, after the application of inclusion and exclusion criteria, MRI scans of 36 FD patients and 73 relapsing-remitting (RR) MS patients were evaluated. Read More

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January 2022

The Development and Validation of Anti-Paratuberculosis-Nocardia Polypeptide Antibody [anti-pTNP] for the Diagnosis of Crohn's Disease.

J Crohns Colitis 2022 Jan 13. Epub 2022 Jan 13.

Center for Inflammatory Bowel Disease Research, Department of Gastroenterology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Background And Aims: Non-invasive biomarkers in sera of patients with inflammatory bowel disease [IBD] are not currently available for rapidly and accurately diagnosing the disease. We aimed to investigate and validate the potential roles of anti-paratuberculosis-nocardia polypeptide antibodies [anti-pTNP] in the diagnosis of IBD.

Methods: Serum samples were collected from 502 patients with diagnosed Crohn's disease [CD], 141 patients with ulcerative colitis [UC] and 109 healthy donors, and the levels of anti-pTNPs and ASCAs were determined by enzyme-linked immunosorbent assay. Read More

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January 2022

High-Throughput, High-Multiplex Digital Protein Detection with Attomolar Sensitivity.

ACS Nano 2022 Jan 14. Epub 2022 Jan 14.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.

A major challenge in many clinical diagnostic applications is the measurement of low-abundance proteins and other biomolecules in biological fluids. Digital technologies such as the digital enzyme-linked immunosorbent assay (ELISA) have enabled 1000-fold increases in sensitivity over conventional protein detection methods. However, current digital ELISA technologies still possess insufficient sensitivities for many rare protein biomarkers and require specialized instrumentation or time-consuming workflows that have limited their widespread implementation. Read More

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January 2022

A panel of three serum microRNA can be used as potential diagnostic biomarkers for nasopharyngeal carcinoma.

J Clin Lab Anal 2022 Jan 14:e24194. Epub 2022 Jan 14.

Department of Urology, Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Clinical College of Anhui Medical University, Shenzhen, China.

Background: Nasopharyngeal carcinoma is cancer with unique epidemiological characteristics, showing obvious ethnicity, gender, and geographical prevalence. More and more evidence shows that microRNAs are stable in serum and are specific to different tumor types. Therefore, miRNA is a new non-invasive biomarker for cancer detection. Read More

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January 2022

Diagnostic panel of serum miR-125b-5p, miR-182-5p, and miR-200c-3p as non-invasive biomarkers for urothelial bladder cancer.

Clin Transl Oncol 2022 Jan 14. Epub 2022 Jan 14.

Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China.

Purpose: This study aimed to identify a diagnostic panel of serum microRNAs (miRNAs) for the early detection of bladder cancer (BC).

Methods: Serum samples were collected from 112 BC patients and 112 normal controls (NCs). A three-stage selection was conducted to identify differentially expressed miRNAs as candidates to construct the diagnostic panel. Read More

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January 2022

Application of diffusion-weighted whole-body MRI for response monitoring in multiple myeloma after chemotherapy: a systematic review and meta-analysis.

Eur Radiol 2022 Jan 14. Epub 2022 Jan 14.

School of Cancer & Pharmaceutical Sciences, King's College London, Strand, London, WC2R 2LS, UK.

Objective: Myeloma Response Assessment and Diagnosis System recently published provides a framework for the standardised interpretation of DW-WBMRI in response assessment of multiple myeloma (MM) based on expert opinion. However, there is a lack of meta-analysis providing higher-level evidence to support the recommendations. In addition, some disagreement exists in the literature regarding the effect of timing and lesion subtypes on apparent diffusion coefficient (ADC) value changes post-treatment. Read More

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January 2022