Autoimmun Rev 2022 Jan 12:103041. Epub 2022 Jan 12.
Centre for Precision Health, , Edith Cowan University, Joondalup, Perth, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Perth, WA, Australia.
Throughout the process of carcinogenesis, autologous cells are transformed into cancer cells, leading to changes in their protein expression profiles. It has been suggested that mutations, protein misfolding, overexpression and aberrant post-translational modifications, changes in protein abundance or location can render tumour-associated antigens immunogenic. Subsequent changes in the tumour microenvironment may lead to humoral immune responses and therefore the production of tumour-associated autoantibodies. Read More