Int J Antimicrob Agents 2021 Apr 12:106344. Epub 2021 Apr 12.
Division of Infectious Diseases, Department of Diagnostic and Public Health, University of Verona, P.Le L.A. Scuro 10, 37134, Verona, Italy; Division of Infectious Diseases, Department of Internal Medicine I, German Center for Infection Research, University of Tübingen, Otfried Müller Straße 12, 72074 Tübingen, Germany;; German Centre for Infection Research (DZIF), Clinical Research Unit for healthcare associated infections, Tübingen, Germany.. Electronic address:
Background: The superiority of combination therapy for carbapenem-resistant Gram-negative bacilli (CR-GNB) remains controversial. In vitro models may predict the efficacy of antibiotic regimens against CR-GNB.
Methods: A systematic review and meta-analysis were performed including pharmacokinetic/pharmacodynamic (PK/PD) and time-kill (TK) studies examining in vitro efficacy of antibiotic combinations against CR-GNB. Read More