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Perforated Meckel's diverticulum in omphalocele in a newborn: A case report of an uncommon presentation from northern Tanzania.

Int J Surg Case Rep 2021 Jul 27;85:106246. Epub 2021 Jul 27.

Kilimanjaro Christian Medical University College, Faculty of Medicine, P O Box 2240, Moshi, Tanzania; Department of Pediatrics, Kilimanjaro Christian Medical Centre, P O Box 3010, Moshi, Tanzania.

Introduction And Importance: The concurrent existence of Omphalocele and Meckel's diverticulum is not unheard of but is relatively uncommon. A few cases of their coexistence have been reported. Due to the uncommon dual presentation, it is easy to delay or even miss the diagnosis, delaying management. Read More

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Challenges in replicating secondary analysis of electronic health records data with multiple computable phenotypes: A case study on methicillin-resistant Staphylococcus aureus bacteremia infections.

Int J Med Inform 2021 Jul 16;153:104531. Epub 2021 Jul 16.

Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address:

Background: Replication of prediction modeling using electronic health records (EHR) is challenging because of the necessity to compute phenotypes including study cohort, outcomes, and covariates. However, some phenotypes may not be easily replicated across EHR data sources due to a variety of reasons such as the lack of gold standard definitions and documentation variations across systems, which may lead to measurement error and potential bias. Methicillin-resistant Staphylococcus aureus (MRSA) infections are responsible for high mortality worldwide. Read More

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Multiple sclerosis incidence and prevalence in Poland: Data from administrative health claims.

Mult Scler Relat Disord 2021 Jul 22;55:103162. Epub 2021 Jul 22.

Department of Neurology, Jagiellonian University Medical College, Krakow, Poland; Department of Neurology, University Hospital in Krakow, Krakow, Poland.

Background: The detailed data concerning multiple sclerosis (MS) epidemiology in Poland are based on studies from few and less populated provinces. Therefore, we evaluated MS incidence and prevalence in Poland using electronic administrative health claims (AHCs) from the National Health Fund.

Methods: We retrospectively analyzed the AHC financial database collected from 2009 to 2019, encompassing all patients using public health resources. Read More

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Social Cognition and Interaction Training (SCIT) versus Training in Affect Recognition (TAR) in patients with schizophrenia: A randomized controlled trial.

J Psychiatr Res 2021 Jul 23;142:101-109. Epub 2021 Jul 23.

Department of Psychology and Neuroscience, University of North Carolina - Chapel Hill, USA; Australian Catholic University, School of Behavioural and Health Sciences, Melbourne, VIC, Australia.

Introduction: Training in Affect Recognition (TAR) is a "targeted" and computer-aided program that has been shown to effectively attenuate facial affect recognition deficits and improve social functioning in patients with schizophrenia. Social Cognition and Interaction Training (SCIT) is a group "broad-based" intervention, that has also been shown to improve emotion recognition, theory of mind (ToM), and social functioning. To date, no study has compared the efficacy of two different social cognitive interventions. Read More

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What do we know about non-epileptic seizures in adults with intellectual disability: A narrative review.

Seizure 2021 Jul 23;91:437-446. Epub 2021 Jul 23.

Academic Neurology Unit, University of Sheffield, UK. Electronic address:

Psychogenic non-epileptic seizures (PNES) superficially resemble epileptic seizures, but are not associated with abnormal electrical activity in the brain. PNES are a heterogeneous entity and while there is increasing interest in the characterisation of PNES sub-groups, little is known about individuals with PNES who have an intellectual disability (ID). ID is a lifelong condition characterised by significant limitations in cognitive, social and practical skills. Read More

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Tear metabolomics highlights new potential biomarkers for differentiating between Sjögren's syndrome and other causes of dry eye.

Ocul Surf 2021 Jul 28. Epub 2021 Jul 28.

Mitolab, MitoVasc Institute, CNRS, 6015, INSERM U1083, University of Angers, France; Department of Biochemistry and Molecular Biology, University Hospital, Angers, France.

Purpose: The lacrimal exocrinopathy of primary Sjögren's syndrome (pSS) is one of the main causes of severe dry eye syndrome and a burden for patients. Early recognition and treatment could prevent irreversible damage to lacrimal glands. The aim of this study was to find biomarkers in tears, using metabolomics and data mining approaches, in patients with newly-diagnosed pSS compared to other causes of dry eye syndrome. Read More

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NON-INVASIVE DIAGNOSIS AND FOLLOW-UP OF PRIMARY MALIGNANT LIVER TUMOURS.

Clin Res Hepatol Gastroenterol 2021 Jul 28:101766. Epub 2021 Jul 28.

Service d'hépatologie, Hôpital Avicenne, APHP, Université Sorbonne Paris Nord, Bobigny. Electronic address:

Among a wide range of malignant liver tumours, hepatocellular carcinoma (HCC) developed on a background of cirrhosis represents the most frequent clinical situation. In this setting, HCC is one of the rare solid tumours for which histological confirmation is not mandatory. The convergence of multiple arguments obtained by non-invasive parameters using radiological findings allows to avoid liver biopsy in a large proportion of patients when a diagnosis of underlying cirrhosis is ascertained. Read More

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NON-INVASIVE DIAGNOSIS AND FOLLOW-UP OF CHRONIC INFECTION WITH HEPATITIS B VIRUS.

Clin Res Hepatol Gastroenterol 2021 Jul 28:101773. Epub 2021 Jul 28.

Service d'hépato-gastroentérologie, Hôpital Saint Joseph & INSERM UMR 1252 IRD SESSTIM Aix Marseille Université, Marseille.

Diagnosis of chronic hepatitis B virus (HBV) infection, initial staging of infection and monitoring of treated and untreated patients are mainly based on clinical, biological and imaging criteria allowing a complete non-invasive management for the majority of patients. Along to the conventional virological tools, rapid diagnostic tests and blotting paper tests for HBV DNA are validated alternatives. After diagnosis, the initial work-up should include HIV, HCV and HDV serologies, HBeAg status, and HBsAg and HBV DNA quantification. Read More

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NON-INVASIVE DIAGNOSIS AND FOLLOW-UP OF CHRONIC INFECTION WITH HEPATITIS C VIRUS.

Clin Res Hepatol Gastroenterol 2021 Jul 28:101771. Epub 2021 Jul 28.

Service d'hépato-gastroentérologie, Hôpital Haut-Lévêque, CHU Bordeaux, pessac & INSERM U1053, Université de Bordeaux, Bordeaux.

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease. Clinical care for patients with HCV-related liver disease has advanced considerably with developments in screening, diagnostic procedures to evaluate liver fibrosis and improvements in therapy with pangenotypic direct antivirals and prevention. These AFEF guidelines on the non-invasive diagnosis and follow up of chronic infection with HCV describe the optimal management of HCV positive patients with non-invasive methods in screening, in assessing viral disease and liver fibrosis and the follow-up of these patients according to the value of FibroScan®, Fibrotest® or Fibrometer®. Read More

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NON-INVASIVE DIAGNOSIS AND FOLLOW-UP OF RARE GENETIC LIVER DISEASES.

Clin Res Hepatol Gastroenterol 2021 Jul 28:101768. Epub 2021 Jul 28.

Service d'hépatologie, Hôpital Rangueil, CHU Toulouse, Toulouse.

Rare genetic liver diseases can result in multi-systemic damage, which may compromise the patient's prognosis. Wilson's disease, must be investigated in any patient with unexplained liver disease and/or unexplained neurological or neuropsychiatric disorders. The diagnosis is based on a combination of clinical, biological features, including copper balance. Read More

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NON-INVASIVE DIAGNOSIS AND FOLLOW-UP OF AUTOIMMUNE HEPATITIS.

Clin Res Hepatol Gastroenterol 2021 Jul 28:101772. Epub 2021 Jul 28.

Service d'hépato-gastroentérologie, Hôpital Saint Joseph & INSERM UMR 1252 IRD SESSTIM Aix Marseille Université, Marseille.

Autoimmune hepatitis (AIH) is a liver disease characterised by necrotico-inflammatory lesions of hepatocytes, the presence of specific autoantibodies and response to corticosteroid treatment. AIH must be considered in any patient with acute or chronic liver disease. As there is no pathognomonic sign of AIH, the diagnosis is based on a combination of clinical, biological, immunological and histological findings, after excluding other causes of liver disease. Read More

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Anterior Shoulder Instability Part I - Diagnosis, Non-Operative Management, and Bankart Repair - An International Consensus Statement.

Arthroscopy 2021 Jul 28. Epub 2021 Jul 28.

Purpose: The purpose of this study was to establish consensus statements via a modified Delphi process on the diagnosis, non-operative management, and Bankart repair for anterior shoulder instability.

Methods: A consensus process on the treatment utilizing a modified Delphi technique was conducted, with 65 shoulder surgeons from 14 countries across 5 continents participating. Experts were assigned to one of 9 working groups defined by specific subtopics of interest within anterior shoulder instability. Read More

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Strategies for Multivariate Analyses of Imaging Genetics Study in Alzheimer's disease.

Neurosci Lett 2021 Jul 28:136147. Epub 2021 Jul 28.

School of Computer Science and Technology, Hangzhou Dianzi University, Hangzhou, Zhejiang, 310018, China; Key Laboratory of Intelligent Image Analysis for Sensory and Cognitive Health, Ministry of Industry and Information Technology of China, Hangzhou, Zhejiang, 310018, China.

Alzheimer's disease (AD) is an incurable neurodegenerative disease primarily affecting the elderly population. Early diagnosis of AD is critical for the management of this disease. Imaging genetics examines the influence of genetic variants (i. Read More

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Exome sequencing versus targeted gene panels for the evaluation of nonimmune hydrops fetalis.

Am J Obstet Gynecol 2021 Jul 28. Epub 2021 Jul 28.

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco CA; Institute of Human Genetics, University of California, San Francisco, San Francisco, CA; Fetal Treatment Center, University of California, San Francisco, San Francisco, CA.

Background: Next generation sequencing is increasingly used in prenatal diagnosis. Targeted gene panels and exome sequencing are both available, but the comparative diagnostic yields of these approaches are not known.

Objective: We compared the diagnostic yield of exome sequencing with simulated application of commercial targeted gene panels in a large cohort of fetuses with nonimmune hydrops fetalis (NIHF). Read More

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Sialendoscopy: A 4-Year Single Center Experience.

J Oral Maxillofac Surg 2021 Jun 22. Epub 2021 Jun 22.

OMFS IMPATH research group, Faculty of Medicine, Clinical intern, Department of Imaging & Pathology, KU Leuven, Leuven, Belgium; Professor and Chairperson, Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.

Purpose: Sialendoscopy is a relatively new technique designed to diagnose and treat benign obstructive salivary gland disease using a minimally invasive approach. The purpose of this study is to present our experiences regarding the use of sialendoscopy in the form of a 4-year, single center experience and to demonstrate its usefulness in oral and maxillofacial practice.

Methods: We collected data on patients who underwent sialendoscopy at the Oral-Maxillofacial Surgery Department of UZ Leuven between November 2015 and August 2019, including age, gender, sex, initial clinical presentation and symptoms, gland involvement, type of diagnostic investigations, diagnosis, localization of the obstruction, therapeutic intervention, surgeon, type of anesthesia, materials used, complications, secondary treatment, duration of follow-up, and outcome. Read More

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Incidence of ocular hypertension in patients receiving intravitreal anti-VEGF injections: comparing filtered drug in plastic silicone-free syringes to nonfiltered drug in silicone-lined insulin plastic syringes.

Can J Ophthalmol 2021 Jul 28. Epub 2021 Jul 28.

From the Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, B.C.. Electronic address:

Objective: To examine the difference in incidence of ocular hypertension (OHT) following the introduction of filtered anti-vascular endothelial growth factor (anti-VEGF) medication in silicone-free syringes.

Design: Retrospective cohort study.

Methods: A retrospective review of consecutive treatment-naive patients receiving intravitreal anti-VEGF injections in a group practice was performed. Read More

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Current treatment for childhood arterial ischaemic stroke.

Lancet Child Adolesc Health 2021 Jul 28. Epub 2021 Jul 28.

Department of Radiology, University Hospital Munich, LMU Munich, Munich, Germany. Electronic address:

Paediatric arterial ischaemic stroke is an important cause of neurological morbidity in children, with consequences including motor disorders, intellectual impairment, and epilepsy. The causes of paediatric arterial ischaemic stroke are unique compared with those associated with stroke in adulthood. The past decade has seen substantial advances in paediatric stroke research and clinical care, but many unanswered questions and controversies remain. Read More

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Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review.

Cancer Commun (Lond) 2021 Jul 31. Epub 2021 Jul 31.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, P. R. China.

Pancreatic cancer is a highly malignant digestive system tumor with a poor prognosis. Most pancreatic cancer patients are diagnosed at an advanced stage or even metastasis due to its highly aggressive characteristics and lack of typical early symptoms. Thus, an early diagnosis of pancreatic cancer is crucial for improving its prognosis. Read More

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Clinical characteristics and sick leave associated with infectious mononucleosis in a real-world setting in Germany.

Int J Clin Pract 2021 Jul 31:e14690. Epub 2021 Jul 31.

IQVIA, Frankfurt, Germany.

Infectious mononucleosis (IM), mainly caused by the Epstein-Barr virus, can result in prolonged symptoms. The objective of this study was to look at the length of sick leave, diagnosis of IM, treatment, and comorbidities in a real-world setting in Germany. This retrospective, cross-sectional study used electronic medical record data from office-based practices in Germany and included patients with an initial confirmed diagnosis of IM between the January 1, 2016 and December 31, 2018. Read More

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Editorial: an elastography-based two-step approach to detect NAFLD with compensated advanced chronic liver disease-authors' reply.

Aliment Pharmacol Ther 2021 Aug;54(4):517-518

NAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

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The relationship between microscopic hematuria and hydronephrosis in urolithiasis.

Int J Clin Pract 2021 Jul 31:e14688. Epub 2021 Jul 31.

Department of Emergency Medicine, Aksaray University Medical School, Aksaray, Turkey.

Aim: The aim of this study was to investigate the relationship between the degree of hydronephrosis and the presence of microscopic hematuria in patients that presented to the emergency department (ED) with ureteral stones.

Methods: The records of patients who presented to our ED due to urolithiasis between January 2017 and December 2020 were retrospectively analyzed. Patients aged 18 years or older who underwent non-contrast computed tomography (CT abdomen/pelvis) and urinalysis (UA) and were diagnosed with ureteral stones were included in the study. Read More

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Role of electrodiagnosis in nerve transfers for focal neuropathies and brachial plexopathies.

Muscle Nerve 2021 Jul 31. Epub 2021 Jul 31.

Plastic & Reconstructive Surgery, University of Toronto, Toronto, Ontario, Canada.

Over the past 2 decades, the surgical treatment of brachial plexus and peripheral nerve injuries has advanced considerably. Nerve transfers have become an important surgical tool in addition to nerve repair and grafting. Electrodiagnosis has traditionally played a role in the diagnosis and localization of peripheral nervous system injuries, but a different approach is needed for surgical decision-making and monitoring recovery. Read More

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Kidney disease profile and encountered problems during follow-up in Syrian refugee children: a multicenter retrospective study.

Pediatr Nephrol 2021 Jul 31. Epub 2021 Jul 31.

Division of Pediatric Nephrology, Adnan Menderes University, Aydin, Turkey.

Background: Children are one of the most vulnerable groups in conflict zones, especially those with chronic diseases. This study aimed to investigate kidney disease profiles and problems during follow-up in a population of Syrian refugee children residing in Turkey.

Methods: Syrian refugee children aged between 0 and 18 years were included in the study. Read More

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Comparison of preoperative diagnostic accuracy of fine needle aspiration and core needle biopsy in parotid gland neoplasms.

Eur Arch Otorhinolaryngol 2021 Jul 31. Epub 2021 Jul 31.

Dept of Otorhinolaryngology, University of Medical Sciences, Bagcilar Training and Research Hospital, Merkez Mahallesi, 6. Sk. Bağcilar, 34100, Istanbul, Turkey.

Background: Fine needle aspiration (FNA) and core needle biopsy (CNB) are two commonly used approaches for the diagnosis of suspected neoplastic parotid gland lesions. We aimed to compare the diagnostic efficiency of FNA and CNB performed with ultrasound guidance preoperatively for the diagnosis of parotid neoplasms.

Methods: We retrospectively analysed the preoperative specimens of 113 patients (66 FNA, 47 CNB) who underwent surgical excision at our institute between 2014 and 2017. Read More

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Neonatal diagnosis of biliary atresia: a practical review and update.

Pediatr Radiol 2021 Jul 31. Epub 2021 Jul 31.

Department of Radiology, Cleveland Clinic, 9500 Euclid Ave., Mail Code L10, Cleveland, OH, 44193, USA.

Biliary atresia is challenging to diagnose because many of the clinical and imaging features of this condition overlap with those of other causes of cholestasis in newborns. When jaundice persists beyond 2 weeks of age, the neonate should be evaluated for cholestasis, and biliary atresia - the most common cause of neonatal cholestasis - should be considered. It is critical to diagnose biliary atresia early because failure to treat can result in hepatic fibrosis and death in less than 1 year. Read More

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Bortezomib plus dexamethasone as first-line therapy for patients with POEMS syndrome.

Ann Hematol 2021 Jul 31. Epub 2021 Jul 31.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.

POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare plasma cell dyscrasia without standard front-line treatment. Merely, few studies have reported the responses and outcomes of bortezomib plus dexamethasone (BDex) in POEMS syndrome. In this study, a total of 69 patients (40 males) treated with front-line BDex were included. Read More

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Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.

Cancer Chemother Pharmacol 2021 Jul 31. Epub 2021 Jul 31.

Núcleo de Pesquisas Em Oncologia, Universidade Federal Do Pará, Belém, Pará, Brazil.

Purpose: Fluoropyrimidines are one of the most used drug class to treat cancer patients, although they show high levels of associated toxicity. This study analyzed 33 polymorphisms in 17 pharmacogenes involved with the pharmacogenomics of fluoropyrimidines, in gastrointestinal cancer patients undergoing fluoropyrimidine-based treatment in the Brazilian Amazon.

Methods: The study population was composed of 216 patients, 92 of whom have an anatomopathological diagnosis of gastric cancer and 124 of colorectal cancer. Read More

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Surgical Outcome of Treatment of Tracheobronchial Foreign Bodies in Children: A Retrospective Analysis.

West Afr J Med 2021 Jul;38(7):684-688

Department of Surgery, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria.

Background: Foreign body aspiration is an important cause of morbidity and potential mortality in children. The diagnosis of foreign body aspiration may be difficult in children as they are unable to give a history and the condition mimics a host of other childhood illnesses. In this study, we present our experience with foreign body aspiration in children. Read More

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Non-neoplastic inflammatory pseudotumor of the lung after immunotherapy for melanoma: A diagnostic pitfall on fine needle aspiration biopsy of lung.

Diagn Cytopathol 2021 Jul 31. Epub 2021 Jul 31.

Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.

Nivolumab is commonly used as monotherapy or in combination therapy for management of locally advanced or metastatic melanoma; however, it is also associated with immunotherapy-related adverse events concerning for disease progression or tumor flare reaction. This report presents a case of a non-neoplastic pseudotumor of the lung initially mistaken for malignancy that occurred in a patient receiving adjuvant nivolumab therapy following complete resection of stage IIIB melanoma. The diagnosis was made by lung biopsy and confirmed by a wedge resection, with findings consistent with organizing pneumonia type of pulmonary inflammatory pseudotumor rather than malignancy. Read More

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