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A Case of Hypophosphatemia due to Oncogenic Osteomalacia in a Patient with Natural Killer T-Cell Lymphoma.

Kidney Blood Press Res 2021 Jul 22:1-5. Epub 2021 Jul 22.

Ochsner Clinical School/The University of Queensland, Brisbane, Queensland, Australia.

Introduction: Oncogenic osteomalacia (Onc-Ost) is a paraneoplastic phenomenon characterized by hypophosphatemia due to elevated fibroblast growth factor-23 (FGF-23). Onc-Ost has been previously reported in patients with germ line mesenchymal tumors and solid organ malignancies. This is the first report of aggressive natural killer (NK) T-cell lymphoma presenting as Onc-Ost. Read More

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Cytokine storm syndrome in a young patient with cystic fibrosis.

Pediatr Pulmonol 2021 Jul 22. Epub 2021 Jul 22.

Cystic Fibrosis Regional Reference Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

We report the case of a patient with cystic fibrosis (CF) presenting with a full-blown cytokine storm syndrome probably triggered by infection. This condition is rare and the diagnosis can be particularly difficult in patients with a complex chronic disease such as CF. However, timely recognition and appropriate treatment in the early stages are key to avoiding a potentially fatal course. Read More

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cVEMP and VAT for the diagnosis of vestibular migraine.

Eur J Clin Invest 2021 Jul 22:e13657. Epub 2021 Jul 22.

Department 4 of Neurology, Cangzhou Central Hospital, Cangzhou, 061000, Hebei, China.

Background: Although the diagnostic criteria of vestibular migraine (VM) have already been defined, various clinical manifestations of VM and the lack of pathognomonic biomarker result in high rate of misdiagnosis and mismanagement. A timely and accurate diagnosis tool for evaluation of VM is highly needed.

Objective: The current study aims to investigate the potential feasibility of cervical vestibular evoked myogenic potential (cVEMP) and vestibular autorotation test (VAT) as a diagnosis tool for VM. Read More

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Sputum-Based Tumor Fluid Biopsy: Isolation and High-Throughput Single-Cell Analysis of Exfoliated Tumor Cells for Lung Cancer Diagnosis.

Anal Chem 2021 Jul 22. Epub 2021 Jul 22.

College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China.

Timely and effective diagnosis is of great significance for improving the survival rate of lung cancer patients. Although histopathology is the main diagnostic tool among the existing methods for lung cancer diagnosis, it is not suitable for high-risk groups, early lung cancer patients, patients with advanced-stage disease, and other situations wherein tumor tissues cannot be obtained. In view of this, we proposed an innovative lung cancer diagnosis method employing for the first time a microfluidic technology for high-efficiency isolation and high-throughput single-cell analysis of exfoliated tumor cells (ETCs) in sputum. Read More

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The Diagnostic Value of Coagulation Indicators and Inflammatory Markers in Distinguishing Between Strangulated and Simple Intestinal Obstruction.

Surg Laparosc Endosc Percutan Tech 2021 Jul 21. Epub 2021 Jul 21.

Prenatal Diagnosis Center Departments of Emergency Radiological Clinical Laboratory, Boai Hospital of Zhongshan Affiliated to Southern Medical University, Zhongshan, Guangdong, China.

Background: Intestinal obstruction with strangulation can be life-threating, and it is critical to make an accurate and timely diagnosis for emergency surgery.

Objective: This was aimed to investigate the value of coagulation indicators and inflammatory markers in distinguishing between strangulated and simple intestinal obstruction.

Materials And Methods: Fifty-four patients with intestinal obstruction were retrospectively studied. Read More

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Posterior Reversible Encephalopathy Syndrome and brain haemorrhage as COVID-19 complication: a review of the available literature.

J Neurol 2021 Jul 21. Epub 2021 Jul 21.

Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, Viale Alvaro del Portillo, 21, 00128, Rome, Italy.

Background: SARS-CoV-2 infection has been associated with various neurological manifestations. Since patients affected by SARS-CoV-2 infection present coagulation and immune system dysregulation, ischemic or haemorragic stroke is not uncommon, irrespective of respiratory distress. However, the occurrence of focal neurological deficits together with other symptoms like headache, cortical blindness, seizure and altered mental status should prompt the diagnosis of Posterior Reversible Encephalopathy Syndrome (PRES). Read More

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Biochemical composition, transmission and diagnosis of SARS-CoV-2.

Biosci Rep 2021 Jul 22. Epub 2021 Jul 22.

Apeejay Stya University, Gurugram, Haryana, India.

Coronavirus disease 2019 (COVID-19) is a life-threatening respiratory infection caused by SARS-CoV-2, a novel human coronavirus.  COVID-19 was declared a pandemic by World Health Organization in March 2020 for its continuous and rapid spread worldwide. Rapidly emerging COVID-19 epicenters and mutants of concerns have created mammoth chaos in healthcare sectors across the globe. Read More

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Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot.

Front Public Health 2021 5;9:691163. Epub 2021 Jul 5.

Clinical Microbiology Department, Andrija Štampar Teaching Institute of Public Health, Zagreb, Croatia.

Respiratory viral infections are the leading cause of morbidity and mortality in the world; however, there are several groups of viruses that are insufficiently routinely sought for, and can thus be considered neglected from a diagnostic and clinical standpoint. Timely detection of seasonality of certain respiratory viruses (e.g. Read More

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Acute myocardial infarction associated with severe malaria.

J Vector Borne Dis 2020 Apr-Jun;57(2):193-196

Department of Cardiology, Popular Superspeciality Hospital, Varanasi, UP, India.

Malaria is still a major public health problem, even after many preventive strategies. Plasmodium vivax is also a major health concern now due to the addition of new unusual manifestations day by day in its clinical profile. Herewith, we report a case of a 15-yr-old male of severe P. Read More

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Postinfantile giant cell hepatitis in the setting of autoimmune hepatitis: exclusively a histological pattern or a prognosis predictor?

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Department of Internal Medicine, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Autoimmune hepatitis (AIH) is a rare chronic liver disease with a non-specific clinical presentation. Its physiopathology is not fully understood and, if untreated, can progress to cirrhosis and even fulminant liver failure. Here, we describe a case of a 73-year-old patient with an 11-month history suggestive of liver disease, who was concomitantly diagnosed with AIH and the extremely rare postinfantile giant cell hepatitis (PIGCH). Read More

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[Clinical practice guideline for lympoma in China (2021 Edition)].


Zhonghua Zhong Liu Za Zhi 2021 Jul;43(7):707-735

Lymphoma is one of the most common malignancies in China. In China, there were 6 829 new Hodgkin lymphoma cases and 2 807 deaths in 2020, with 92 834 new non-Hodgkin lymphoma cases and 54 351 deaths. Due to the complicated pathological subtypes and heterogeity, the treatment strategies for lymphoma vary largely. Read More

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Molecular epidemiology of SARS-CoV-2 in Cyprus.

PLoS One 2021 21;16(7):e0248792. Epub 2021 Jul 21.

Molecular Virology Department, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.

Whole genome sequencing of viral specimens following molecular diagnosis is a powerful analytical tool of molecular epidemiology that can critically assist in resolving chains of transmission, identifying of new variants or assessing pathogen evolution and allows a real-time view into the dynamics of a pandemic. In Cyprus, the first two cases of COVID-19 were identified on March 9, 2020 and since then 33,567 confirmed cases and 230 deaths were documented. In this study, viral whole genome sequencing was performed on 133 SARS-CoV-2 positive samples collected between March 2020 and January 2021. Read More

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Two Cases Presenting With Unilateral Adduction Deficit Associated With Human Adenosine Deaminase 2 Deficiency.

J Pediatr Ophthalmol Strabismus 2021 Jul-Aug;58(4):e22-e26. Epub 2021 Jul 1.

Deficiency of human adenosine deaminase 2 (DADA2) is an auto-inflammatory inborn error of immunity caused by biallelic deleterious mutations in the gene encoding ADA2. The purpose of this article is to raise awareness among ophthalmologists and pediatricians to consider DADA2 as a possible diagnosis for patients with acute onset of diplopia. The authors describe two pediatric patients who presented with double vision due to uni-lateral adduction deficit, and discuss the importance of recognizing this clinically as an ophthalmologist. Read More

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Application progress of multiple imaging modalities in Takayasu arteritis.

Int J Cardiovasc Imaging 2021 Jul 21. Epub 2021 Jul 21.

Department of Cardiology, West China Hospital of Sichuan University, Guo Xue Xiang No.37, Chengdu, Sichuan, 610041, China.

Takayasu arteritis (TA) is a chronic, idiopathic, granulomatous large vessel vasculitis of unknown etiology. The clinical manifestations of TA are incredibly variable, mainly depending on the location of the lesions. In the light of its insidious progress and the diversity of clinical manifestations, a substantial proportion of patients might experience a considerable delay in diagnosis, which leads to irreversible malignant complications, highlighting the importance of early diagnosis. Read More

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Subacute combined degeneration of the spinal cord with concomitant autoimmune disease: report of 2 cases.

Braz J Med Biol Res 2021 16;54(10):e11355. Epub 2021 Jul 16.

Department of Neurology, Shanghai Eighth People's Hospital Affiliated to Jiang Su University, Shanghai, China.

The etiology of subacute combined degeneration (SCD) of the spinal cord is closely associated with vitamin B12 (VitB12) deficiency. The clinical manifestations of SCD are complex and vary substantially. Due to some SCD patients with atypical manifestations and concomitant autoimmune disorders, the probability of misdiagnosis and missed diagnosis is still relatively high in the early stage. Read More

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Using the Multi-Theory Model (MTM) of Health Behavior Change to Explain the Correlates of Mammography Screening among Asian American Women.

Pharmacy (Basel) 2021 Jul 15;9(3). Epub 2021 Jul 15.

School of Health and Applied Human Sciences, University of North Carolina Wilmington, Wilmington, NC 28403, USA.

Globally, breast cancer is the most common malignancy affecting women. The incidence of breast cancer has been growing among Asian American women. Mammography is a screening procedure that provides early diagnosis for the timely treatment to reduce premature mortality due to breast cancer. Read More

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Shock caused by spontaneous rupture uterine vessels during puerperal period: a case report and literature review.

Eur Rev Med Pharmacol Sci 2021 Jul;25(13):4451-4455

Tianjin Third Central Hospital, Obstetrics & Gynecology Department, Hedong District, China; Technology Research Central of Public Health Ministry, Tianjin, China.

Hemoperitoneum caused by spontaneous rupture of uterine vessels during delivery is relatively rare in obstetric hemorrhage, and even rarer during the puerperal period. It can be life-threatening without timely diagnosis and treatment; therefore, the literature on this topic is very scarce. To explore its etiology and identify its diagnosis and treatment principle, we are reporting a case of shock caused by spontaneous rupture of uterine vessels admitted in our hospital. Read More

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Congenital tooth-bearing tumor of the eyelid leading to lacrimal system obstruction.

Am J Ophthalmol Case Rep 2021 Sep 30;23:101157. Epub 2021 Jun 30.

Division of Plastic and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, USA.

Purpose: We present an unusual case of a congenital lesion presenting with concomitant chronic dacryocystitis. The clinical presentation, examination, management, and histopathology are reviewed.

Observations: A healthy male infant born at 37 weeks gestation presented with an isolated painless 5mm congenital mass of the left medial lower eyelid. Read More

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September 2021

Identification of serum microRNA signatures associated with autism spectrum disorder as promising candidate biomarkers.

Heliyon 2021 Jul 3;7(7):e07462. Epub 2021 Jul 3.

Department of Plant Physiology and Molecular Biology, "Paisii Hilendarski" University of Plovdiv, 24 Tzar Assen Street, Plovdiv, Bulgaria.

Background: MicroRNAs (miRNAs) are short non-coding RNA molecules with a well-recognized role in gene expression mostly at the post-transcriptional level. Recently, dysregulation of miRNAs and miRNA-mRNA interactions has been associated with CNS diseases, including numerous psychiatric disorders. Dynamic changes in the expression profiles of circulating miRNA are nowadays regarded as promising non-invasive biomarkers that may facilitate the accurate and timely diagnosis of complex conditions. Read More

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Current and Emerging Strategies for Prediction and Diagnosis of Prelabour Rupture of the Membranes: A Narrative Review.

Saadia Ghafoor

Malays J Med Sci 2021 Jun 30;28(3):5-17. Epub 2021 Jun 30.

Kakshal Hospital, Kakshal, Peshawar, Khyber Pakhtunkhwa, Pakistan.

Prelabour rupture of membranes (PROM) refers to the disruption of foetal membranes before the onset of labour, resulting in the leakage of amniotic fluid. PROM complicates 3% and 8% of preterm and term pregnancies, respectively. Accurate and timely diagnosis is crucial for effective management to prevent adverse maternal- and foetal-outcomes. Read More

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A Neonatal Hip Septic Arthritis Caused by Klebsiella pneumonia at Hawassa University Comprehensive Specialized Hospital Neonatal Unit, Hawassa, Sidama, Ethiopia.

Int Med Case Rep J 2021 13;14:471-474. Epub 2021 Jul 13.

Department of Pediatrics and Child Health, College of Health Sciences, Hawassa University, Hawassa, Ethiopia.

Background: Neonatal hip septic arthritis is one of the rarest clinical conditions epidemiologically but with momentous long-term sequelae. Early detection and proper intervention have a paramount role in alleviating the shattering long-term effects. The clinical presentation of neonatal hip septic arthritis is very non-specific, with limited movement of the extremities and excessive crying during manipulations such as diaper changing. Read More

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Acta Clin Croat 2020 Dec;59(4):605-614

1University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; 2Department of Psychiatry, Clinical Centre of Vojvodina, Novi Sad, Serbia; 3Department of Neurosurgery, Clinical Centre of Vojvodina, Novi Sad, Serbia; 4Clinical Centre of Vojvodina, Novi Sad, Serbia; 5Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 6University of Health Applied Sciencies, Zagreb, Croatia; 7University of Belgrade, Faculty of Medicine, Belgrade, Serbia; 8Division of Peripheral Nerve Surgery, Functional Neurosurgery and Pain Management Surgery, Department of Neurosurgery, Clinical Center of Serbia, Belgrade, Serbia.

The aim of this study was to analyze risk factors present in schizophrenic patients with depressive symptomatology. The sample comprised of 76 respondents diagnosed with schizophrenia. In the study, we used the Positive and Negative Syndrome Scale (PANSS) and Calgary Depression Scale for Schizophrenia. Read More

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December 2020

Enhancing the weighted voting ensemble algorithm for tuberculosis predictive diagnosis.

Sci Rep 2021 Jul 20;11(1):14806. Epub 2021 Jul 20.

Department of Computer and Information Sciences, College of Science and Technology (CST), Covenant University, Ota, Ogun State, Nigeria.

Tuberculosis has the most considerable death rate among diseases caused by a single micro-organism type. The disease is a significant issue for most third-world countries due to poor diagnosis and treatment potentials. Early diagnosis of tuberculosis is the most effective way of managing the disease in patients to reduce the mortality rate of the infection. Read More

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Validation of real-time RT-PCR for detection of SARS-CoV-2 in the early stages of the COVID-19 outbreak in the Republic of Korea.

Sci Rep 2021 07 20;11(1):14817. Epub 2021 Jul 20.

Division of Viral Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Diseases Control and Prevention Agency, 187 Osongsaengmyeong2-ro, Osong-eup, Heungdeok-gu, Cheongju-si, 28159, Republic of Korea.

A real-time reverse transcription polymerase chain reaction (RT-qPCR) assay that does not require Emergency Use Authorization (EUA) reagents was tested and validated for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the early stages of the outbreak of coronavirus disease 2019 (COVID-19) in the Republic of Korea. Early diagnosis of COVID-19 enables timely treatment and the implementation of public health measures. We validated the sensitivity, specificity, precision, linearity, accuracy, and robustness of the RT-qPCR assay for SARS-CoV-2 detection and compared its performance with that of several EUA-approved kits. Read More

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Challenges in management of atypical hemolytic uremic syndrome: bottle neck in resource limited settings.

Transfus Clin Biol 2021 Jul 17. Epub 2021 Jul 17.

Government Medical College and Hospital, Chandigarh, India. Electronic address:

Treatment of atypical hemolytic uremic syndrome cases is challenging right from establishing correct and timely diagnosis to execution of management protocol. A seven-year-old male child from poor socioeconomic status was admitted with chief complaints of fever, 3 episodes of vomiting and passage of cola coloured urine. Based on clinical and laboratory findings, diagnosis was established. Read More

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[Models of clinical and social management of patients with autism spectrum disorders].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(6):13-20

Mental Health Research Center, Moscow, Russia.

Objective: To develop clinical and social models and management routes for patients with autism spectrum disorders (ASD).

Material And Methods: A clinical follow-up study was performed for 254 patients, aged 4-17 years (average age 7.3 years), who represented the main forms of ASD. Read More

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Prevalence and risk factors of seizure in children with acute bacterial meningitis: updating previous evidence using an epidemiological design.

Iran J Child Neurol 2021 ;15(3):47-54

Infection Control &Hand Hygiene Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: The current study aimed to investigate the prevalence and risk factors of seizure in acute bacterial meningitis.

Materials & Methods: In the present study, a total of 180 children (age range, 2 months to 14 years) with acute bacterial meningitis, were separated into two groups based on the diagnosis of seizure. The study was conducted in Mashhad (Iran) from 2002 to 2016. Read More

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January 2021

Ultrasound evaluation of dialysis access-related distal ischaemia.

J Vasc Access 2021 Jul 20:1129729820932420. Epub 2021 Jul 20.

Third Department of Internal Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.

Dialysis access-related distal ischaemia is a rare yet potentially rather risky complication of haemodialysis angioaccess. Timely diagnosis is crucial to target both the goals of the access team: first of all to preserve the function of the hand ideally along with angioaccess patency. Unfortunately for some patients, urgent access ligation and central vein catheter insertion would be needed to save the hand. Read More

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Merkel cell carcinoma metastatic to the testis: report of a rare diagnosis and review of the literature.

Autops Case Rep 2021 8;11:e2020198. Epub 2020 Dec 8.

Instituto Português de Oncologia do Porto, Serviço de Anatomia Patológica, Porto, Portugal.

Merkel cell carcinoma is an aggressive malignancy that frequently recurs/disseminates, but metastases to the genitourinary tract are rare. Only eight cases of Merkel cell carcinoma metastatic to the testis are reported. We describe the ninth case of this event and provide a review of the literature. Read More

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December 2020