229,599 results match your criteria diagnosis malignant


METTL3-Induced miR-222-3p Upregulation Inhibits STK4 and Promotes the Malignant Behaviors of Thyroid Carcinoma Cells.

J Clin Endocrinol Metab 2021 Sep 25. Epub 2021 Sep 25.

Department of Thyroid Surgery, The Sun Yat-Sen Memorial Hospital Sun Yat-Sen University, Guangzhou 510120, Guangdong Province, P. R. China.

Context: Abnormally high expression of N6-methyladenosine (m6A) methyltransferase-like 3 (METTL3) has been implied to accompany thyroid carcinoma (TC) development.

Objective: This study aimed to explore the protumorigenic role and downstream signaling axis of METTL3 in TC.

Methods: This study was conducted at the Sun Yat-Sen Memorial Hospital Sun Yat-Sen University. Read More

View Article and Full-Text PDF
September 2021

Genotypic characteristics of hepatoblastoma detected by next generation sequencing and its correlation with clinical efficacy.

APMIS 2021 Sep 24. Epub 2021 Sep 24.

Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, South road 2, Yizhuang Economic and Technological Development Zone, Beijing, 100176, P.R. China.

Background: Hepatoblastoma (HB) is the most common malignant embryonic liver tumor in children. In this study, we used the NGS method to detect the genotype characteristics of HB, summarized the correlation between common mutation genotypes of HB and clinical treatment and prognosis.

Methods: Firstly, DNA was extracted from tumor tissue specimens and peripheral blood of 19 children patients with HB. Read More

View Article and Full-Text PDF
September 2021

An unusual pediatric case of atypical spitzoid neoplasm.

Pediatr Dermatol 2021 Sep 24. Epub 2021 Sep 24.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

Spitzoid melanocytic lesions describe a spectrum of pediatric melanocytic proliferations ranging from benign Spitz nevi to malignant spitzoid melanomas typically arising within the first two decades of life. Atypical spitzoid neoplasm (ASN) is a poorly defined category within this spectrum that poses a unique diagnostic challenge due to histologic findings with insufficient atypical characteristics to make the diagnosis of melanoma. This report presents an exceptionally rare case of an ulcerative atypical spitzoid neoplasm mimicking an infantile hemangioma in a two-month-old girl treated with pulse dyed laser (PDL) and surgical excision. Read More

View Article and Full-Text PDF
September 2021

A Difficult Case of Pyrexia of Unknown Origin.

Indian J Pediatr 2021 Sep 25. Epub 2021 Sep 25.

Department of Microbiology, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, Maharashtra, India.

This is the case of a 15-y-old boy who presented with fever and back pain with MRI features of spondylitis. A CT-guided vertebral biopsy showed acute and chronic inflammatory cells and grew Pseudomonas aeruginosa on aerobic culture. The child was treated for 2 wk with antibiotics with no response. Read More

View Article and Full-Text PDF
September 2021

Ultrasonographic evaluation of ovarian mass for predicting malignancy in pregnant women.

Gynecol Oncol 2021 Sep 21. Epub 2021 Sep 21.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: The purpose of this study is to compare ultrasonographic ovarian mass scoring systems in pregnant women.

Study Design: This multicenter study included women with an ovarian mass during pregnancy who were evaluated using ultrasound and underwent surgery in 11 referral hospitals. The ovarian mass was evaluated and scored using three different scoring systems(International Ovarian Tumor Analysis Assessment of Different NEoplasias in the adnexa[IOTA ADNEX], Sassone, and Lerner). Read More

View Article and Full-Text PDF
September 2021

Multimodal imaging in the differential diagnosis of glioma recurrence from treatment-related effects: A protocol for systematic review and network meta-analysis.

Prog Brain Res 2021 13;265:377-383. Epub 2021 Aug 13.

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province Hospital of Chinese Medical, Guangzhou, China. Electronic address:

Background: Glioma is the most common malignant primary brain tumor and it will always recur. To date, various multimodal imaging including magnetic resonance imaging (MRI) and positron emission tomography computed tomography (PET/CT) was used to differentiate the diagnosis of true tumor recurrent (TuR) and treatment-related effects (TrE) in glioma patient but with no overall conclusion. In this study, SROC curve and Bayesian network meta-analysis will be used to conduct a comprehensive analysis of the results of different clinical reports, and assess the efficacy of multimodal imaging in difference TuR and TrE. Read More

View Article and Full-Text PDF

Combination of structural MRI, functional MRI and brain PET-CT provide more diagnostic and prognostic value in patients of cerebellar ataxia associated with anti-Tr/DNER: a case report.

BMC Neurol 2021 Sep 24;21(1):368. Epub 2021 Sep 24.

Department of Neurology, West China Hospital, Sichuan University, No. 37 GuoXue Alley, 610041, Chengdu, Sichuan, China.

Background: Brain magnetic resonance imaging (MRI) rarely reveals structural changes in patients with suspected anti-Tr/DNER encephalitis and thus provides very limited information. Here, we combined structural MRI, functional MRI, and positron emission tomography-computed tomography (PET-CT) findings to characterize this rare disorder in a patient.

Case Presentation: A 43-year-old woman presented with progressive cerebellar ataxia, memory impairment, anxiety, and depression. Read More

View Article and Full-Text PDF
September 2021

Pediatric Odontogenic and Maxillofacial Bone Pathology: A Global Analysis.

J Craniofac Surg 2021 Sep 23. Epub 2021 Sep 23.

Department of Plastic Surgery, University of Kansas Medical Center, University of Kansas School of Medicine, Kansas City, KS Keck School of Medicine Children's Hospital Los Angeles, Division of Plastic and Maxillofacial Surgery, Los Angeles, CA.

Background: Although pathology in the maxillary and mandibular bones is rare in young patients, the differential diagnosis is broad. The World Health Organization (WHO) updated its classification of maxillofacial bone pathology in 2017. Using these updated guidelines, a systematic review of common maxillofacial bone lesions in the pediatric population was performed. Read More

View Article and Full-Text PDF
September 2021

68Ga-DOTA-FAPI-04 PET/CT Imaging in a Case of SAPHO Syndrome.

Clin Nucl Med 2021 Sep 22. Epub 2021 Sep 22.

From the Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, PR China; and Academician (Expert) Workstation of Sichuan Province, PR China.

Abstract: A 66-year-old woman presented with anterior chest wall and knee joints pain and multiple skin lesions. 99mTc-MDP bone scintigraphy showed increased bone density in the sternal angle with abnormal bone metabolism. The patient was enrolled in a 68Ga-DOTA-FAPI-04 PET/CT tumor clinical trial, and it showed increased tracer uptake in the sternum and right knee joint. Read More

View Article and Full-Text PDF
September 2021

Hepatic hemangioendothelioma - A rare case report.

Int J Surg Case Rep 2021 Sep 20;87:106424. Epub 2021 Sep 20.

Pir Abdul Qadir shah Jeelani Institute of Medical Sciences, Gambat, Sindh, Pakistan.

Introduction And Importance: Hepatic hemangioendothelioma (HHE) is a very rare mild-moderate malignant tumor of the hepatic vascular endothelium. The etiology is yet not fully understood. Patients can be asymptomatic or may present with non-specific symptoms or hepatic insufficiency. Read More

View Article and Full-Text PDF
September 2021

Development of a novel ALK rearrangement screening test for non-small cell lung cancers.

PLoS One 2021 24;16(9):e0257152. Epub 2021 Sep 24.

Molecular Diagnosis Laboratory, Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan.

Approximately 5-7% of non-small cell lung cancer (NSCLC) cases harbor an anaplastic lymphoma kinase (ALK) fusion gene and may benefit from ALK inhibitor therapy. To detect ALK fusion genes, we developed a novel test using reverse transcription polymerase chain reaction (RT-PCR) for the ALK kinase domain (KD). Since ALK expression is mostly silenced in the adult with the exception of neuronal tissue, the normal lung tissue, mesothelial lining, and inflammatory cells are devoid of ALK transcript, making ALK KD RT-PCR an ideal surrogate test for ALK fusion transcripts in lung or pleural effusion. Read More

View Article and Full-Text PDF
September 2021

Epidemiologic profile and outcome of primary pediatric brain tumors in Iran: retrospective study and literature review.

Childs Nerv Syst 2021 Sep 24. Epub 2021 Sep 24.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.

Purpose: Primary pediatric tumors are the most common solid tumors in children. There are limited reports on the management and outcome of these tumors in the developing countries. In recent years, advances have been done in the diagnosis, treatment, and outcome of these tumors. Read More

View Article and Full-Text PDF
September 2021

Syncope as the initial presentation of pulmonary embolism in two patients with hepatocellular carcinoma: Two case reports and literature review.

Medicine (Baltimore) 2021 Sep;100(38):e27211

Department of Radiology, Jilin Provincial Cancer Hospital, Changchun, China.

Rationale: Pulmonary embolism (PE) has diverse clinical manifestations and syncope might be the first or only symptom of PE. Tumor disease usually presents with symptoms associated with the primary site, however, PE may be the first manifestation of occult tumors.

Patient Concerns: Here, we report 2 patients admitted to our hospital because of syncope. Read More

View Article and Full-Text PDF
September 2021

Malignant development of proliferative verrucous/multifocal leukoplakia: a critical systematic review, meta-analysis and proposal of diagnostic criteria.

J Oral Pathol Med 2021 Sep 24. Epub 2021 Sep 24.

Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group), Faculty of Medicine and Dentistry, University of Santiago de Compostela, A Coruña, Spain.

Background: Proliferative verrucous/multifocal leukoplakia (PVML) is an oral potentially malignant disorder (OPMD) that exhibits high rates of malignant development (MD). This study aimed to analyse the risk of MD of PVML, as well as to investigate the possible risk factors associated with its malignisation.

Methods: A bibliographical search of the Pubmed, Embase, Web of Science, and Scopus databases was conducted. Read More

View Article and Full-Text PDF
September 2021

SDHC phaeochromocytoma and paraganglioma: A UK-wide case series.

Clin Endocrinol (Oxf) 2021 Sep 24. Epub 2021 Sep 24.

Department of Clinical Genetics, Birmingham Women's Hospital, Birmingham, UK.

Objective: Phaeochromocytomas and paragangliomas (PPGL) are rare, but strongly heritable tumours. Variants in succinate dehydrogenase (SDH) subunits are identified in approximately 25% of cases. However, clinical and genetic information of patients with SDHC variants are underreported. Read More

View Article and Full-Text PDF
September 2021

The Place and Prognostic Value of TERT Promoter Mutation in Molecular Classification in Grade II-III Glial Tumors and Primary Glioblastomas.

Turk Patoloji Derg 2021 Sep 24. Epub 2021 Sep 24.

Department of Pathology, University of Health Sciences Gaziosmanpasa Research and Training Hospital, ISTANBUL, TURKEY.

Objective: Diffuse gliomas, the most common primary malignant brain tumors, have been classified by the World Health Organization as class II-IV gliomas. After 2016, two mutations in the promoter region of the telomerase reverse transcriptase (TERT) gene were identified in addition to the IDH, 1p / 19q, and ATRX status.

Material And Method: We identified 84 patients with grade II-IV glioma with IDH, ATRX, 1p / 19q and TERT status. Read More

View Article and Full-Text PDF
September 2021

Role of salt‑inducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells.

Mol Med Rep 2021 Nov 24;24(5). Epub 2021 Sep 24.

Department of General Surgery, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570105, P.R. China.

Colorectal cancer (CRC) is the third most common type of cancer worldwide. Currently, surgery, chemotherapy and radiation therapy are the conventional approaches used to treat CRC. However, these therapy strategies cause several side effects. Read More

View Article and Full-Text PDF
November 2021

Use of office based transnasal oesophagoscopy in management of Head & Neck conditions during the COVID-19 pandemic at the Royal Albert Edward Infirmary, Wigan, United Kingdom.

Med J Malaysia 2021 Aug;76(Suppl 4):14-19

The Royal Albert Edward Infirmary, Department of ENT, Wrightington Wigan and Leigh, NHS Foundation Trust, United Kingdom.

Objectives: To assess the clinical and cost effectiveness of transnasal oesophagoscopy (TNO) in cases of suspected upper aerodigestive tract malignancy and define its role as a safe alternative to panendoscopy. We have also analysed if the implementation of TNO during the COVID-19 pandemic was beneficial in order to provide uninterrupted care to the patients with the limited resources available in these challenging times.

Methods: All patients who underwent TNO guided biopsies or dilatation attempted over a 7 month period during COVID- 19 pandemic were included by searching the hospital and department database at The Royal Albert Edward Infirmary. Read More

View Article and Full-Text PDF

A rare case report of malignant peripheral nerve sheath tumor involving both the small bowel and large bowel.

Ann Afr Med 2021 Jul-Sep;20(3):228-231

Department of Gastroenterology, St. Michael's Medical Center, Newark, NJ, an Affiliate of New York Medical College, Westchester, NY, USA.

Malignant peripheral nerve sheath tumor (MPNST) contains properties and histologic markers of both neural crest cells and mesenchymal cells. It is a rare diagnosis, with an incidence of 1:100,000/year or 4%-10% of soft-tissue sarcomas. There are very few cases reported and studied. Read More

View Article and Full-Text PDF
September 2021

Primary thromboprophylaxis to prevent thrombotic events in pediatric oncology patients with a malignant mediastinal mass.

Pediatr Blood Cancer 2021 Sep 24:e29360. Epub 2021 Sep 24.

Department of Pediatrics, Zucker School of Medicine at Hofstra Northwell School of Medicine, Division of Hematology Oncology and Cellular Therapy, Steven and Alexandra Cohen Children's Medical Center, New York, New York, USA.

Children with malignant mediastinal masses have increased thrombotic events (TE). Eligible subjects with malignant mediastinal masses between January 2000 and December 2017 were evaluated for TE, with 19 among 76 subjects receiving enoxaparin thromboprophylaxis. There were 13 TEs among 76 subjects for an incidence of 17. Read More

View Article and Full-Text PDF
September 2021

Ependymosarcoma harboring C11orf95:RELA fusion transcript: Report of two cases and review of the literature.

Neuropathology 2021 Sep 23. Epub 2021 Sep 23.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Ependymoma is a relatively rare glial tumor of the central nervous system that arise from the cells lining the ventricles and central canal of the spinal cord. Ependymosarcoma (ES) is a newly introduced tumor entity of uncertain prognosis characterized by a rare phenomenon of a malignant mesenchymal transition arising within an ependymoma. ESs are surgically challenging tumors for diagnosis and therapy with a high incidence of morbidity and mortality. Read More

View Article and Full-Text PDF
September 2021

Changing epidemiology and age-specific incidence of cutaneous malignant melanoma in England: An analysis of the national cancer registration data by age, gender and anatomical site, 1981-2018.

Lancet Reg Health Eur 2021 Mar 6;2:100024. Epub 2021 Jan 6.

Institute of Health & Society, Newcastle University, UK.

Background: The incidence of cutaneous malignant melanoma, which is mostly attributable (86%) to UV radiation exposure, has been steadily increasing over the past four decades in predominantly fair-skinned populations. Although public health campaigns are increasing sun-protective behaviour in England, their effect on melanoma incidence is largely unknown. We conducted a retrospective population-based cohort study to examine whether there have been changes in the epidemiology of melanoma in England during the past four decades. Read More

View Article and Full-Text PDF

Osteochondroma Presenting Clinically with Carpal Tunnel Syndrome in a 12-Year-old Boy.

J Orthop Case Rep 2021 May;11(5):109-112

Department of Orthopaedics, D Y Patil University School of Medicine, Navi-Mumbai, Maharashtra. India.

Introduction: An exostosis is a benign growth of bone, which when capped with cartilage is called osteochondroma, which can appear as solitary or multiple, mostly affecting the long bones, pelvis, and shoulder region. The prevalence of known solitary exostosis is 1-2% in the general population. They are slow growing lesions with rare malignant transformation. Read More

View Article and Full-Text PDF

Myopericytoma Involving Proximal Phalanx of Index Finger: Masquerading as Tenosynovial Giant Cell Tumor - A Case Report.

J Orthop Case Rep 2021 May;11(5):88-91

Department of Orthopaedics, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra. India.

Introduction: Myopericytoma (MPC) is an uncommon benign smooth muscle cell neoplasm which frequently arises in lower extremities, sparsely they can be found in upper extremities and head and neck region. Very few case reports are available in the literature documenting hand localization of this tumor.

Case Presentation: In this report, we present a case of 83-year-old male individual with a mass lesion on the proximal phalanx of index finger of the right hand. Read More

View Article and Full-Text PDF

A Rare Case of Ewing's-like Adamantinoma of Tibia Managed by Limb Salvage Surgery Using Long Segment Ilizarov Bone Transport: A Case Report and Review of Literature.

J Orthop Case Rep 2021 May;11(5):61-67

Department of Plastic Surgery, Government Medical College, Kozhikode Kerala, India.

Introduction: Adamantinoma is a rare low-grade malignant tumor in young adults. Recent advances in molecular techniques have shown different variants with discordance between genotype and phenotype. This poses a challenge in diagnosis and management. Read More

View Article and Full-Text PDF

Clinicopathological value of long non-coding RNA profiles in gastrointestinal stromal tumor.

PeerJ 2021 3;9:e11946. Epub 2021 Sep 3.

Department of Gastrointestinal Surgery, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu Province, China.

Background: Long non-coding RNAs (lncRNAs) have been implicated in diagnosis and prognosis in various cancers. However, few lncRNA signatures have been established for prediction of gastrointestinal stromal tumors (GIST). We aimed to explore a lncRNA signature profile that associated with clinical relevance by mining data from Gene Expression Ominus (GEO) and Surveillance, Epidemiology, and End Results (SEER) Program. Read More

View Article and Full-Text PDF
September 2021

A rare case of thymoma with CA 19-9 production.

Respirol Case Rep 2021 Oct 17;9(10):e0844. Epub 2021 Sep 17.

Department of Thoracic and Cardiovascular Surgery Wakayama Medical University Wakayama Japan.

A 72-year-old man was diagnosed as having myasthenia gravis (MG). He underwent computed tomography which revealed an anterior mediastinal tumour. Laboratory examination revealed elevated levels (106. Read More

View Article and Full-Text PDF
October 2021

Evaluation of the Diagnostic Value of the Ultrasound ADNEX Model for Benign and Malignant Ovarian Tumors.

Int J Gen Med 2021 16;14:5665-5673. Epub 2021 Sep 16.

Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, 150080, People's Republic of China.

Objective: To investigate the diagnostic performance of the ADNEX model in the International Ovarian Tumor Analysis diagnostic models for ovarian tumors and further explore its application value in the staging of ovarian tumors.

Methods: A total of 224 patients who underwent ultrasound for evaluation of adnexal masses and were treated surgically owing to adnexal masses from January 2018 to June 2020 in our hospital were selected for research on the diagnostic accuracy of the ADNEX model. The clinical information and ultrasonographic findings of the patients were collected, and the pathological diagnosis was taken as the gold standard. Read More

View Article and Full-Text PDF
September 2021

Roles of N6-Methyladenosine Demethylase FTO in Malignant Tumors Progression.

Onco Targets Ther 2021 16;14:4837-4846. Epub 2021 Sep 16.

Department of Thoracic Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, People's Republic of China.

In 2007, the fat mass and obesity-associated (FTO) gene was discovered initially to regulate body mass index and obesity and was subsequently found to be the first mRNA N6-methyladenosine (m6A) demethylation enzyme, which can demethylate m6A. A growing body of evidence shows that m6A modification is involved in a variety of cell biological processes, including cell proliferation, apoptosis, and self-renewal through different regulatory mechanisms. In recent years, a large number of studies have found that m6A modification play key role in the occurrence and development of tumors, such as acute myeloid leukemia, breast cancer, lung cancer, etc. Read More

View Article and Full-Text PDF
September 2021

Magnetic Resonance Imaging of Uterine Cervix: A Pictorial Essay.

Indian J Radiol Imaging 2021 Apr 4;31(2):454-467. Epub 2021 Aug 4.

Department of Radiology, Lifescan Imaging Centre, Mumbai, Maharashtra, India.

Uterine cervix is the lower constricted part of uterus which is best evaluated by magnetic resonance imaging (MRI) due to its higher soft tissue and contrast resolution. The cervical cancer is a common gynecological cancer causing much morbidity and mortality especially in developing countries. Cervical carcinomas mainly occurs in reproductive age group with prognosis mainly depending on the extent of disease at the time of diagnosis, hence it is important to identify these cancerous lesions early and stage them accurately for optimal treatment. Read More

View Article and Full-Text PDF