388,707 results match your criteria diagnosis confirmed


COVID-19 in Argentine teriflunomide-treated multiple sclerosis patients: First national case series.

Mult Scler Relat Disord 2021 May 30;53:103049. Epub 2021 May 30.

Centro de Esclerosis Múltiple de Buenos Aires, CABA; Argentina; Servicio de Neurología, Hospital Universitario CEMIC, Buenos Aires, Argentina.

We report COVID-19 presentation, course and outcomes in teriflunomide-treated MS patients in Argentina.

Methods: descriptive, retrospective, multicentre, study that included MS patients receiving teriflunomide who developed COVID-19, with clinical follow-up at reference MS centres, also listed in a nationwide registry.

Results: Eighteen MS patients on teriflunomide treatment, from eight MS centres developed COVID-19. Read More

View Article and Full-Text PDF

Identification of Prognostic alternative splicing signatures and their clinical significance in uveal melanoma.

Exp Eye Res 2021 Jun 12:108666. Epub 2021 Jun 12.

Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. Electronic address:

As a posttranscriptional regulatory mechanism, alternative splicing (AS) has the potential to generate a large amount of protein diversity from limited genes. The purpose of our study was to assess the usefulness of prognostic splicing events as novel diagnostic and therapeutic signatures for uveal melanoma (UM). The datasets, clinical traits and AS data of UM were obtained from The Cancer Genome Atlas (TCGA) database and TCGA SpliceSeq database. Read More

View Article and Full-Text PDF

Differential Clinical Diagnosis and Prevalence Rate of Allergic Rhinitis, Asthma, and Chronic Obstructive Pulmonary Disease among COVID-19 Patients.

Int J Clin Pract 2021 Jun 15:e14532. Epub 2021 Jun 15.

Clinical Pharmacy Department, Faculty of Pharmacy, Beni-suef University, Beni-suef, Egypt.

Background: There is a great need to make a rapid differential clinical diagnosis of COVID-19 among respiratory disease patients and determining the prevalence rate of these diseases among the COVID-19 population.

Method: Approximately 522 patients with allergic rhinitis, asthma, COPD, and COVID-19 were analyzed for demographic and clinical features. Radiological features were analyzed only for COVID-19 patients. Read More

View Article and Full-Text PDF

Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study.

PLoS One 2021 15;16(6):e0253257. Epub 2021 Jun 15.

Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea.

Tooth loss is closely associated with suboptimal oral care. Suboptimal oral care can facilitate local infections. These can lead to systemic inflammation and endothelial dysfunction, which are important pathological mechanisms of hypertension. Read More

View Article and Full-Text PDF

Caseous calcification of the mitral annulus mimicking benign cardiac tumour of the mitral valve.

Cardiovasc J Afr 2021 May 7;32:1-4. Epub 2021 May 7.

Echocardiography and Vascular Ultrasound Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. Email:

Caseous calcification of the mitral annulus (CCMA) is a rare subtype of mitral annular calcification. It usually appears as a large, round, mass-like calcification with an echolucent core, which may be misdiagnosed as an intracardiac mass, cyst, thrombus or abscess of the mitral valve. We present a case report of CCMA that was misdiagnosed by echocardiography as a benign tumour due to its atypical imaging. Read More

View Article and Full-Text PDF

The use of cisplatin in patients after kidney transplantation with chronic renal insufficiency: Is the benefit higher than potential risks in therapy of non-seminomatous germ cell tumors?

Medicine (Baltimore) 2021 Jun;100(24):e26381

Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute.

Rationale: The use of cisplatin in patients with chronic kidney disease (CKD) is risky and depends on a number of factors. The optimal procedure in stage I of a non seminomatous germ cell tumor without proven lymphangioinvasion after orchiectomy is controversial and is the subject of a number of discussions due to the lack of randomized studies assessing individual treatment options. The adjuvant method of choice is surveillance or application of cisplatin-based chemotherapy with the risk of treatment related nephrotoxicity. Read More

View Article and Full-Text PDF

Mycobacterium avium complex peritonitis in a pediatric patient on peritoneal dialysis: A case report.

Medicine (Baltimore) 2021 Jun;100(24):e26321

Division of Nephrology and Rheumatology.

Introduction: Peritonitis due to Mycobacterium avium complex (MAC) is a rare but life-threatening complication in patients on peritoneal dialysis (PD). However, optimal therapeutic regimen, treatment duration, and appropriate timing of kidney transplantation (KT) after treatment are unknown.

Symptoms: We herein report a 4-year-old boy on PD due to end-stage kidney disease resulting from bilateral hypoplastic kidneys. Read More

View Article and Full-Text PDF

Lymphedema complicated by protein-losing enteropathy with a 22q13.3 deletion and the potential role of CELSR1: A case report.

Medicine (Baltimore) 2021 Jun;100(24):e26307

Department of Lymphatic Surgery, Beijing Shijitan Hospital, Capital Medical University.

Introduction: 22q13.3 deletion syndrome is a well-known syndrome characterized by typical clinical findings including neonatal hypotonia, absent or severely delayed speech, intellectual disability, and other various features, and detection of a heterozygous deletion of chromosome 22q13.3 with the involvement of at least part of SHANK3. Read More

View Article and Full-Text PDF

A case report of prenatal diagnosis of fetal alloimmune thrombocytopenia: A CARE-compliant article.

Medicine (Baltimore) 2021 Jun;100(24):e26092

Department of Obstetrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Rationale: Fetal alloimmune thrombocytopenia (FAIT) is a serious life-threatening disease caused by platelet-antigen incompatibility between the mother and fetus. FAIT can lead to fetal thrombocytopenia, intracranial hemorrhage (ICH), fetal death and severe neurological disorders after birth. Noninvasive prenatal diagnosis technology has not been widely used in China, and thus few cases of FAIT can be diagnosed prenatally. Read More

View Article and Full-Text PDF

LA14 Alleviates Liver Injury.

mSystems 2021 Jun 15:e0038421. Epub 2021 Jun 15.

Key Laboratory of Nutrition of Zhejiang Province, Institute of Health Food, Hangzhou Medical College, Hangzhou, China.

Although the probiotic Lactobacillus acidophilus LA14 is used worldwide, its effect on liver diseases remains unelucidated. Here, 32 rats were divided into four groups, gavaged with L. acidophilus LA14 (3 × 10 CFU) or phosphate-buffered saline for 7 days, and then intraperitoneally injected with d-galactosamine or saline. Read More

View Article and Full-Text PDF

Fibroblast-associated protein-α expression and BPV nucleic acid distribution in equine sarcoids.

Vet Pathol 2021 Jun 15:3009858211022696. Epub 2021 Jun 15.

Department of Veterinary Medical Sciences, 9296University of Bologna, Italy.

Sarcoids are the most common cutaneous tumor of equids and are caused by bovine papillomavirus (BPV). Different clinical subtypes of sarcoids are well characterized clinically but not histologically, and it is not known whether viral activity influences the clinical or histological appearance of the tumors. The aim of this study was to verify whether the development of different clinical types of sarcoids or the presence of certain histological features were associated with BPV distribution within the tumor. Read More

View Article and Full-Text PDF

PMUC versus RPUC or SC in predicting SIRS and urosepsis after PCNL: A systematic review and meta-analysis.

J Endourol 2021 Jun 15. Epub 2021 Jun 15.

Xiangya Hospital Central South University, 159374, Department of Urology, The Xiangya Hospital, Central South University, Changsha, Hunan 410000, China., Changsha, China, 410008;

Purpose: To compare preoperative midstream urine cultures (PMUC) and renal pelvic urine culture (RPUC) or stone culture (SC) in predicting systemic inflammatory response syndrome (SIRS) and urosepsis after percutaneous nephrolithotomy (PCNL).

Methods: We searched PubMed, Web of Science and EMBASE databases up to September 1, 2020 for relevant published studies. Two authors independently confirmed whether the literatures met the inclusion criteria and collected the data from the selected literatures. Read More

View Article and Full-Text PDF

Carcinomatous meningitis from recurrent glassy cell carcinoma of the uterine cervix-A case report.

J Obstet Gynaecol Res 2021 Jun 14. Epub 2021 Jun 14.

Department of Obstetrics and Gynecology, St. Mary's Hospital, Kurume, Japan.

Carcinomatous meningitis presents with a variety of neurological symptoms and has a poor prognosis. We encountered a case of carcinomatous meningitis from cervical cancer. A 30-year-old patient was diagnosed with cervical cancer (glassy cell carcinoma), stage IIB. Read More

View Article and Full-Text PDF

Myoepithelial Carcinoma Ex-Pleomorphic Adenoma: A Rare Pathology Misdiagnosed as Pleomorphic Adenoma; With a Novel TERT Promoter Mutation and High PD-L1 Expression.

Head Neck Pathol 2021 Jun 14. Epub 2021 Jun 14.

Department of Pathology, University of New Mexico School of Medicine, University of New Mexico, MSC08 4640, Albuquerque, NM, 87131, USA.

Myoepithelial carcinoma (MECA) is a rare salivary gland (SG) neoplasm (0.1-0.45% of all SG tumors) that often presents with bland cytomorphology and can be misclassified as cellular pleomorphic adenoma (PA) or myoepithelioma. Read More

View Article and Full-Text PDF

Non-invasive SERS serum detection technology combined with multivariate statistical algorithm for simultaneous screening of cervical cancer and breast cancer.

Anal Bioanal Chem 2021 Jun 14. Epub 2021 Jun 14.

First Affiliated Hospital of Xinjiang Medical University, Xinjiang, 830046, Urumqi, China.

Surface-enhanced Raman scattering (SERS), as a rapid, reliable and non-destructive spectral detection technology, has made a series of breakthrough achievements in screening and pre-diagnosis of various cancerous tumors. In this paper, high-performance gold nanoparticles/785 porous silicon photonic crystals (Au NPs/785 PSi PhCs) active SERS substrates were specially designed for serum testing, and realized highly sensitive detection of serum from healthy people, patients with cervical cancer and breast cancer. Based on the SERS spectra of the three groups of serum, the significant differences between the healthy group and cancer group at 1030 cm and 1051 cm were analyzed, and the similar but different serum SERS spectra of cervical cancer and breast cancer patients were compared. Read More

View Article and Full-Text PDF

Sarcoidosis associated pulmonary hypertension: an update.

Curr Opin Pulm Med 2021 Jun 11. Epub 2021 Jun 11.

National Pulmonary Hypertension Service, Royal Brompton Hospital National Lung and Heart Institute, Imperial College London, London, UK.

Purpose Of Review: Sarcoidosis associated pulmonary hypertension (SAPH) is a well-recognised complication, associated with a seven-fold increase in mortality. This comprehensive review will summarise these recent developments and proposes the use of a phenotype-based management approach in SAPH.

Recent Findings: Recent registry-based studies have highlighted the adverse outcomes associated with SAPH and shown that reduced 6-min walk distance and diffusion capacity for carbon monoxide are predictive of poor prognosis. Read More

View Article and Full-Text PDF

Newborn screening for cystic fibrosis: Role of primary care providers in caring for infants with positive screening results.

Can Fam Physician 2021 Jun;67(6):e144-e152

Clinician scientist in the Division of Pediatric Medicine at the Hospital for Sick Children, Chief Science Officer and Senior Scientist at ICES, and Professor of Pediatrics with a cross appointment at the Institute of Health Policy, Management and Evaluation and the Epidemiology Division of the Dalla Lana School of Public Health at the University of Toronto.

Objective: To explore primary care providers' (PCPs') preferred roles and confidence in caring for infants receiving a positive cystic fibrosis (CF) newborn screening (NBS) result, as well as management of CF family planning issues, given that expanded NBS has resulted in an increase in positive results.

Design: Mailed questionnaire.

Setting: Ontario. Read More

View Article and Full-Text PDF

Artificial neural network and logistic regression modelling to characterize COVID-19 infected patients in local areas of Iran.

Biomed J 2021 Feb 25. Epub 2021 Feb 25.

Graduate Student, Dept. of Civil Engineering, Lakehead University, Thunder Bay, ON, Canada.

Background: COVID-19 is an infectious disease that started spreading globally at the end of 2019. Due to differences in patient characteristics and symptoms in different regions, in this research, a comparative study was performed on COVID-19 patients in 6 provinces of Iran. Also, multilayer perceptron (MLP) neural network and Logistic Regression (LR) models were applied for the diagnosis of COVID-19. Read More

View Article and Full-Text PDF
February 2021

CT as a first-line modality in elderly patients with stable blunt chest trauma.

Chin J Traumatol 2021 Apr 1. Epub 2021 Apr 1.

Department of Surgery A, Emek Medical Center, Afula, 18101, Israel; Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 31096, Israel.

Purpose: Blunt thoracic injuries are common among elderly patients and may be a common cause of morbidity and death from blunt trauma injuries. We aimed to examine the impact of chest CT on the diagnosis and change of management plan in elderly patients with stable blunt chest trauma. We hypothesized that chest CT may play an important role in providing optimal management to this subgroup of trauma patients. Read More

View Article and Full-Text PDF

The Rapid Mood Screener: A Novel and Pragmatic Screener Tool for Bipolar I Disorder.

CNS Spectr 2021 Apr;26(2):167-168

University Health Network, Toronto, Ontario, Canada.

Introduction: Approximately 70% of patients with bipolar disorder (BPD) are initially misdiagnosed, resulting in significantly delayed diagnosis of 7-10 years on average. Misdiagnosis and diagnostic delay adversely affect health outcomes and lead to the use of inappropriate treatments. As depressive episodes and symptoms are the predominant symptom presentation in BPD, misdiagnosis as major depressive disorder (MDD) is common. Read More

View Article and Full-Text PDF

A Longitudinal Study to Assess Antidepressant Treatment Patterns and Outcomes in Individuals with Depression in the General Population.

CNS Spectr 2021 Apr;26(2):180

Centre d'évaluation et de Statistique (CES), Montreal, Canada.

Study Objectives: Depression is an important cause of disability in the United States (US). The care experience of major depressive disorder (MDD) is highly variable and has only been documented to a limited degree. This study examines the prevalence incidence and treatment patterns for MDD in the US general population. Read More

View Article and Full-Text PDF

Mood symptoms Associated with CADASIL Syndrome: A Case Report.

CNS Spectr 2021 Apr;26(2):144

Resident.

Objective: To discuss the psychiatric symptoms that are associated with CADASIL syndrome Abstract Cerebral:Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare type of hereditary disease involving the small cerebral vessels. The clinical symptoms are various and include recurrent ischemic strokes, migraine with aura, seizures with epilepsy, psychiatric problems such as mood disturbances, and progressive cognitive decline leading to dementia. This disease needs awareness amongst the psychiatrists even though it is discussed much more in neurology literature. Read More

View Article and Full-Text PDF

Clinical application of noninvasive prenatal testing in the detection of fetal chromosomal diseases.

Mol Cytogenet 2021 Jun 14;14(1):31. Epub 2021 Jun 14.

Affiliated Maternity and Child Health Hospital of Anhui Medical University, Hefei, China.

Objective: To assess the detection efficiency of noninvasive prenatal testing (NIPT) for fetal autosomal aneuploidy, sex chromosome aneuploidy (SCA), other chromosome aneuploidy, copy number variation (CNV), and to provide further data for clinical application of NIPT.

Materials And Methods: 25,517 pregnant women who underwent NIPT testing in Anhui Province Maternity and Child Health Hospital from September 2019 to September 2020 were selected, and samples with high-risk test results were subjected to karyotype analysis for comparison by using amniotic fluid, with some samples subjected to further validation by chromosomal microarray analysis, and followed up for pregnancy outcome.

Results: A total of 25,517 pregnant women who received NIPT, 25,502 cases were tested successfully, and 294 high-risk samples (1. Read More

View Article and Full-Text PDF

Usefulness of SS18-SSX antibody as a diagnostic marker for pulmonary metastatic synovial sarcoma.

Diagn Pathol 2021 Jun 14;16(1):54. Epub 2021 Jun 14.

Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Background: The novel SS18-SSX fusion-specific antibody is reported to have high sensitivity and specificity for the diagnosis of primary synovial sarcoma (SS), which often metastasizes to the lung. Thus far, no study has validated the diagnostic efficacy of SS18-SSX antibody for pulmonary metastatic SS. Therefore, we aimed to investigate the usefulness of the SS18-SSX antibody in the diagnosis of pulmonary metastatic SS. Read More

View Article and Full-Text PDF

Hospital utilization rates for influenza and RSV: a novel approach and critical assessment.

Popul Health Metr 2021 Jun 14;19(1):31. Epub 2021 Jun 14.

Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA.

Background: Influenza and respiratory syncytial virus (RSV) contribute significantly to the burden of acute lower respiratory infection (ALRI) inpatient care, but heterogeneous coding practices and availability of inpatient data make it difficult to estimate global hospital utilization for either disease based on coded diagnoses alone.

Methods: This study estimates rates of influenza and RSV hospitalization by calculating the proportion of ALRI due to influenza and RSV and applying this proportion to inpatient admissions with ALRI coded as primary diagnosis. Proportions of ALRI attributed to influenza and RSV were extracted from a meta-analysis of 360 total sources describing inpatient hospital admissions which were input to a Bayesian mixed effects model over age with random effects over location. Read More

View Article and Full-Text PDF

Brachial muscle injury resulting in acute compartment syndrome of the upper arm: a case report and literature review.

BMC Musculoskelet Disord 2021 Jun 14;22(1):545. Epub 2021 Jun 14.

Department of Orthopedic Trauma, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China.

Background: Acute compartment syndrome (ACS) is a potentially devastating condition. ACS is rare in the upper arm.

Case Presentation: We report a case of acute compartment syndrome of the anterior compartment of the upper arm due to brachial muscle injury. Read More

View Article and Full-Text PDF

[A Case of Rapidly Growing Sarcomatoid Urothelial Carcinoma of the Renal Pelvis and Ureter].

Hinyokika Kiyo 2021 May;67(5):191-195

The Department of Diagnostic Pathology, Tenri Hospital.

75 year-old man followed up regularly for the treatment of lung cancer came to our hospital with a chief complaint of general malaise. Blood test results showed deterioration in the renal function, and computed tomography (CT) confirmed left hydronephrosis. He was admitted to the hospital with the diagnosis of obstructive pyelonephritis. Read More

View Article and Full-Text PDF

Diagnostic accuracy of the interferon-gamma release assay (IGRA) for cases of feline mycobacteriosis.

Prev Vet Med 2021 Jun 8;193:105409. Epub 2021 Jun 8.

The Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, United Kingdom.

The aim of this study was to evaluate the sensitivity and specificity of the interferon-gamma release assay (IGRA) for diagnosing infections with members of the Mycobacterium (M.) tuberculosis-complex (MTBC) and non-tuberculous mycobacteria (NTM) in domestic cats, and to generate defined feline-specific cut-off values using receiver operating characteristic (ROC) curve analysis to improve test performance. Records of 594 cats that had been tested by IGRA were explored to identify individuals that had a culture and/or polymerase chain reaction (PCR)-confirmed case of mycobacterial disease, and those that had a final diagnosis of non-mycobacterial disease. Read More

View Article and Full-Text PDF

Aberrant splicing and transcriptional activity of TPP1 result in CLN2-like disorder.

Eur J Med Genet 2021 Jun 11:104259. Epub 2021 Jun 11.

Murdoch Children's Research Institute, The Royal Children's Hospital, Victoria, Australia; Institute for Molecular Bioscience, The University of Queensland, Queensland, Australia. Electronic address:

RNA sequencing (RNAseq) is emerging as a complementary tool to DNA sequencing, providing utility in diagnosis for disorders such as neuronal ceroid lipofuscinosis CLN2 disease. We describe an individual with a presentation suggestive of an attenuated CLN2 phenotype, including a history of regression, recent-onset microcephaly and spasticity from age five years. Exome sequencing revealed two variants inherited in trans in TPP1, NM_000391. Read More

View Article and Full-Text PDF

Safety, Tolerability, and Activity of ALXN1830 Targeting the Neonatal Fc Receptor in Chronic Pemphigus.

J Invest Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Department of Dermatology, Duke University Medical Center, Durham, NC USA.

Pemphigus is a debilitating immunoglobulin G (IgG)-mediated autoimmune disease in need of better tolerated, more targeted and rapid onset therapies. ALXN1830 is a humanized IgG4 antibody that blocks neonatal Fc receptor (FcRn) interactions with IgG. A multicenter, open-label safety and tolerability phase 1b/2 trial (NCT03075904) was conducted in North America from July 2017 to January 2019 and included patients aged ≥ 18 years with a confirmed diagnosis of pemphigus (vulgaris or foliaceus) and active disease. Read More

View Article and Full-Text PDF