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Utility of multi-parametric quantitative magnetic resonance imaging of the lacrimal gland for diagnosing and staging Graves' ophthalmopathy.

Eur J Radiol 2021 Jun 8;141:109815. Epub 2021 Jun 8.

Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong Province, China. Electronic address:

Purpose: To explore radiological changes of the lacrimal gland (LG) in Graves' ophthalmopathy (GO) based on multi-parametric quantitative MRI and its clinical utility in LG diagnosis and activity in GO.

Methods: We enrolled 99 consecutive patients with GO (198 eyes) and 12 Graves' Disease (GD) patients (24 eyes) from July 2018 to June 2020. Clinical, laboratory, and MRI data were collected at the first visit. Read More

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Clinical characteristics and outcomes of community-acquired pneumonia in western Saudi Arabia: A four-year retrospective analysis of medical records.

J Infect Public Health 2021 May 27;14(7):960-966. Epub 2021 May 27.

Infection Prevention and Control, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background: Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality, especially for the elderly and people who suffer from chronic conditions. This study was conducted to assess the clinical and microbiological characteristics and disease outcomes associated with the occurrence of CAP.

Methods: This retrospective chart review was conducted at King Abdulaziz Medical City, Jeddah, Saudi Arabia. Read More

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Non-pharmacologic direct cost of a simplified strategy with glecaprevir/pibrentasvir for 8 weeks in naïve non-cirrhotic patients with hepatitis C implemented in clinical practice. The Just SIMPLE Study.

Gastroenterol Hepatol 2021 Jun 12. Epub 2021 Jun 12.

Digestive Diseases, Hospital La Paz, Madrid.

Background And Objective: The emergence of highly tolerable, effective, and shorter duration direct-acting antivirals (DAAs) regimens offers the opportunity to simplify hepatitis C virus management but medical costs are unknown. Thus, we aimed to determine the direct medical costs associated with a combo-simplified strategy (one-step diagnosis and low monitoring) to manage HCV infection within an 8-week glecaprevir/pibrentasvir (GLE/PIB) regimen in clinical practice in Spain.

Patients And Methods: Healthcare resources and clinical data were collected retrospectively from medical charts of 101 eligible patients at 11 hospitals. Read More

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Immune status changing helps diagnose osteoarticular tuberculosis.

PLoS One 2021 15;16(6):e0252875. Epub 2021 Jun 15.

Spine and Osteopathy Ward, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.

Objective: This study is aimed to develop a new nomogram for the clinical diagnosis of osteoarticular tuberculosis (TB).

Methods: xCell score estimation to obtained the immune cell type abundance scores. We downloaded the expression profile of GSE83456 from GEO and proceed xCell score estimation. Read More

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How do patients with borderline personality disorder experience Distress Tolerance Skills in the context of dialectical behavioral therapy?-A qualitative study.

PLoS One 2021 15;16(6):e0252403. Epub 2021 Jun 15.

Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany.

Distress Tolerance Skills (DTS) are an important component of Dialectical Behavioral Therapy (DBT), a therapy method frequently used for treating patients with Borderline Personality Disorder (BPD). However, little is known about how DTS-training is experienced by individuals with BPD. The aim of this study was to explore BPD patients' experiences with receiving DTS-training. Read More

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Comparison of Liver Condemnation and Bile Microscopy As Tools to Estimate Prevalence and Burden in the Anta Province of Cusco in Peru.

Vector Borne Zoonotic Dis 2021 Jun 14. Epub 2021 Jun 14.

Division of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.

Fascioliasis is a zoonotic infection linked to significant economic losses in the livestock industry. Infection prevalence and estimated financial burden vary across locations owing to different diagnostic tests used. The accuracy of liver condemnation to estimate the prevalence and costs of fascioliasis has seldom been evaluated. Read More

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LRH-1 high expression in the ovarian granulosa cells of PCOS patients.

Endocrine 2021 Jun 15. Epub 2021 Jun 15.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.

Purpose: Polycystic ovary syndrome (PCOS) is considered one of the most common endocrine disorders with heterogeneity. There are also reports that liver receptor homolog 1 [LRH-1 or nuclear receptor subfamily 5 group A member 2] plays an important role in the reproductive system. But up to now, there are no reports related to the link with PCOS and LRH-1. Read More

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Does margin width impact breast cancer recurrence rates in women with breast conserving surgery for ductal carcinoma in situ?

Breast Cancer Res Treat 2021 Jun 15. Epub 2021 Jun 15.

Division of Surgical Oncology, Department of Surgery, University of Wisconsin, 600 Highland Ave, Madison, WI, 53792, USA.

Purpose: Controversy remains regarding the optimal margin width for patients with ductal carcinoma in situ (DCIS) who undergo breast conserving surgery (BCS).

Methods: Women with a primary DCIS diagnosis were enrolled in a statewide population-based cohort from 1997 to 2006. Patients were surveyed every two years with follow-up data available through 2016. Read More

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Management of traumatic posterior fossa epidural hematomas in pediatrics: our experience and review of the literature.

Childs Nerv Syst 2021 Jun 15. Epub 2021 Jun 15.

Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.

Background And Aims: Conservative management of posterior fossa epidural hematoma in the pediatric age group has been increasingly considered in the last decade with good clinical outcomes and comparable results to surgical intervention in carefully selected patients. The purpose of this study is to evaluate the outcome of observation in the management of pediatric patients with posterior fossa epidural hematoma (PFEDH) in our tertiary hospital and present a literature review on PFEDH pediatric patients.

Methods: We conducted a retrospective observational study at King Abdullah University Hospital (KAUH), a tertiary hospital in North Jordan. Read More

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Awareness of thyroid cancer among medical students: A questionnaire-based study.

Sci Prog 2021 Apr-Jun;104(2):368504211023654

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

To investigate whether medical students acquire enough knowledge about thyroid cancer (TC). It was a cross-sectional study in a Chinese medical college based on a questionnaire about the knowledge of TC and thyroid self-examination. Medical students enrolled were grouped into preclinical medical students (PMS) and clinical medical students (CMS) according to their grades. Read More

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LA14 Alleviates Liver Injury.

mSystems 2021 Jun 15:e0038421. Epub 2021 Jun 15.

Key Laboratory of Nutrition of Zhejiang Province, Institute of Health Food, Hangzhou Medical College, Hangzhou, China.

Although the probiotic Lactobacillus acidophilus LA14 is used worldwide, its effect on liver diseases remains unelucidated. Here, 32 rats were divided into four groups, gavaged with L. acidophilus LA14 (3 × 10 CFU) or phosphate-buffered saline for 7 days, and then intraperitoneally injected with d-galactosamine or saline. Read More

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Hyperglycemia and Hypo-HDL-cholesterolemia Are Primary Risk Factors for Age-related Cataract, and a Korean-style Balanced Diet has a Negative Association, based on the Korean Genome and Epidemiology Study.

J Korean Med Sci 2021 Jun 14;36(23):e155. Epub 2021 Jun 14.

Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, Asan, Korea.

Background: The prevalence of cataracts is steadily increasing among the middle-aged and elderly worldwide. We hypothesized that adults aged > 50 years with age-related cataracts (ARCs) have an association with metabolic syndrome (MS) and its components, and MS has interactions with different dietary patterns and lifestyles that affect ARC risk. We examined the hypothesis using the Korean Genome and Epidemiology Study (KoGES; a large-scale hospital-based cohort study), which collected data between 2004-2013. Read More

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PMUC versus RPUC or SC in predicting SIRS and urosepsis after PCNL: A systematic review and meta-analysis.

J Endourol 2021 Jun 15. Epub 2021 Jun 15.

Xiangya Hospital Central South University, 159374, Department of Urology, The Xiangya Hospital, Central South University, Changsha, Hunan 410000, China., Changsha, China, 410008;

Purpose: To compare preoperative midstream urine cultures (PMUC) and renal pelvic urine culture (RPUC) or stone culture (SC) in predicting systemic inflammatory response syndrome (SIRS) and urosepsis after percutaneous nephrolithotomy (PCNL).

Methods: We searched PubMed, Web of Science and EMBASE databases up to September 1, 2020 for relevant published studies. Two authors independently confirmed whether the literatures met the inclusion criteria and collected the data from the selected literatures. Read More

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Clinically applicable artificial intelligence algorithm for the diagnosis, evaluation, and monitoring of acute retinal necrosis.

J Zhejiang Univ Sci B 2021 Jun;22(6):504-511

Eye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

The prompt detection and proper evaluation of necrotic retinal region are especially important for the diagnosis and treatment of acute retinal necrosis (ARN). The potential application of artificial intelligence (AI) algorithms in these areas of clinical research has not been reported previously. The present study aims to create a computational algorithm for the automated detection and evaluation of retinal necrosis from retinal fundus photographs. Read More

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Modeling the risk of radiation pneumonitis in esophageal squamous cell carcinoma treated with definitive chemoradiotherapy.

Esophagus 2021 Jun 15. Epub 2021 Jun 15.

State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangdong Esophageal Cancer Institute, Guangzhou, China.

Background: To develop and validate a nomogram for the prediction of symptomatic radiation pneumonitis (RP) in patients with esophageal squamous cell carcinoma (ESCC) who received definitive concurrent chemoradiotherapy.

Methods: Clinical factors, dose-volume histogram parameters, and pulmonary function parameters were collected from 402 ESCC patients between 2010 and 2017, including 321 patients in the primary cohort and 81 in the validation cohort. The end-point was the occurrence of symptomatic RP (grade ≥ 2) within the first 12 months after radiotherapy. Read More

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Risk factors for antibody formation in children with hemophilia: methodological aspects and clinical characteristics of the HEMFIL cohort study.

Blood Coagul Fibrinolysis 2021 Jun 11. Epub 2021 Jun 11.

Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands Hemocentro de Belo Horizonte, Fundação HEMOMINAS, Belo Horizonte, Brazil Center for Clinical Transfusion Research, Sanquin, Leiden, The Netherlands.

Up to 35% of patients with hemophilia A and 5% with hemophilia B develop neutralizing antibodies which can inhibit the therapeutic activity of factor replacement (inhibitors). Despite the clinical relevance of antifactor VIII and IX neutralizing antibodies, there is still a major gap on the knowledge of risk factors for their development. Furthermore, most of the studies on risk factors for inhibitor development come from Caucasian and Afro-American populations. Read More

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Diagnosis values of IL-6 and IL-8 levels in serum and bronchoalveolar lavage fluid for invasive pulmonary aspergillosis in chronic obstructive pulmonary disease.

J Investig Med 2021 Jun 14. Epub 2021 Jun 14.

Department of Respiratory and Critical Care Medicine, Cangzhou Central Hospital, Cangzhou, Hebei, China.

Among immunologically normal hosts, patients with chronic obstructive pulmonary disease (COPD) are considered to be at high risk of invasive pulmonary aspergillosis (IPA), and early diagnosis and treatment are the key to improving the prognosis of patients. Here we aimed to evaluate whether interleukin (IL)-6 and IL-8 might be used in the detection and diagnosis of IPA in patients with COPD. We prospectively collected 106 patients with COPD and divided them into non-IPA (n=74), probable/possible IPA (n=26) and proven IPA (n=6). Read More

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EGFR Exon 20 Insertion Mutations: Clinicopathological Characteristics and Treatment Outcomes in Advanced Non-Small Cell Lung Cancer.

Clin Lung Cancer 2021 May 16. Epub 2021 May 16.

Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia. Electronic address:

Background: Epidermal growth factor receptor gene (EGFR) exon 20 insertion (ex20-ins) mutations are an uncommon and heterogeneous group of non-small cell lung cancers (NSCLCs), resistant to conventional EGFR tyrosine kinase inhibitors (TKIs). Characteristics and outcomes of patients with EGFR ex20-ins have not been fully established; we sought to clarify them using a multinational patient database.

Patients And Methods: Patients with NSCLC from six Australian institutions with EGFR exon 20 mutations (ex20-mut), excluding T790M, were retrospectively reviewed. Read More

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Post-vaccination HPV seroprevalence among female sexual health clinic attenders in England.

Vaccine 2021 Jun 11. Epub 2021 Jun 11.

Blood Safety, Hepatitis, Sexually Transmitted Infections (STI) and HIV Service, Public Health England, London, UK.

Background: The National HPV Immunisation Programme was introduced in England in September 2008 using the HPV16/18 bivalent vaccine. We conducted serological surveillance to explore vaccination coverage levels. We also conducted a case-control study to investigate a hypothesised cross-protective effect of the HPV16/18 vaccine against genital warts. Read More

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Characterization and Treatment Goals of Patients on Long-Acting Injectable vs Oral Antipsychotics: Results from a Patient/Caregiver/Psychiatrist Survey.

CNS Spectr 2021 Apr;26(2):154

Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ, USA.

Background: Patient preferences in schizophrenia (SCZ), including identification of key goals and outcomes for treatment and relative importance of certain treatment goals to patients, have been assessed by several studies. However, there continues to be a lack of sufficient evidence on US patient attitudes and perceptions towards treatment goals and pharmacotherapy options in SCZ, especially taking into context long-acting injectable antipsychotics (LAIs) in this disease area. This lack of evidence is further pronounced in caregivers of individuals with SCZ. Read More

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Survival of patients with rare diseases: a population-based study in Tuscany (Italy).

Orphanet J Rare Dis 2021 Jun 14;16(1):275. Epub 2021 Jun 14.

Unit of Epidemiology of Rare Diseases and Congenital Anomalies, Institute of Clinical Physiology, National Research Council, via Moruzzi 1, 56124, Pisa, Italy.

Background: Rare diseases (RDs) encompass a heterogeneous group of life-threatening or chronically debilitating conditions that individually affect a small number of subjects but overall represent a major public health issue globally. There are still limited data on RD burden due to the paucity of large population-based epidemiological studies. The aim of this research was to provide survival estimates of patients with a RD residing in Tuscany, Italy. Read More

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Socioeconomic Status and Rurality Among Patients With Head and Neck Cancer.

Otolaryngol Head Neck Surg 2021 Jun 15:1945998211019278. Epub 2021 Jun 15.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Southern Illinois University, Springfield, Illinois, USA.

Objective: Describe the relationship among rurality, socioeconomic status (SES), and patient/tumor characteristics in patients presenting with head and neck cancer.

Study Design: Retrospective single-institution study.

Setting: Academic tertiary-level medical center. Read More

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More Than Just Adolescence: Differences in Fatigue Between Youth With Cerebral Palsy and Typically Developing Peers.

Ann Rehabil Med 2021 Jun 14. Epub 2021 Jun 14.

Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.

Objective: To quantify differences in fatigue and disordered sleep between adolescents with cerebral palsy (CP) and their typically developing peers. A secondary aim was to investigate the association between fatigue and disordered sleep in adolescents with CP.

Methods: A convenience sample of 36 youth with CP aged 10-18 years was matched for age and sex with 36 typically developing peers. Read More

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Trends and predictors of HIV positivity and time since last test at voluntary counselling and testing encounters among adults in Kilifi, Kenya, 2006-2017.

Wellcome Open Res 2019 4;4:127. Epub 2021 Jun 4.

Kenya Medical Research Institute (KEMRI) -Wellcome Trust Research Programme, Kilifi, Kenya.

Little is known about HIV retesting uptake among key populations (KP) and general populations (GP) in Kenya. We assessed trends and predictors of first-time testing (FTT), late retesting (previous test more than one year ago for GP or three months for KP), and test positivity at three voluntary counselling and testing (VCT) centres in coastal Kenya. : Routine VCT data covering 2006-2017 was collected from three VCT centres in Kilifi County. Read More

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Factors predicting high-dose and combined antipsychotic prescribing in New Zealand: High-dose antipsychotic prescribing.

Psychiatry Res 2021 May 14;302:113996. Epub 2021 May 14.

School of Pharmacy, University of Auckland, Grafton, Auckland, New Zealand; Department of Pharmacy, Auckland District Health Board, Grafton, Auckland, New Zealand. Electronic address:

Objective: Guidelines recommend using antipsychotic monotherapy at the lowest effective dose, however high-dose and antipsychotic polypharmacy prescribing (APP) remain commonplace. The aim of this study was to determine the prevalence and patterns of high-dose antipsychotic prescribing and APP among mental health service users in New Zealand (NZ).

Methods: A retrospective audit of service users discharged from inpatient (n=657), or registered with community (n=1560), mental health services at Auckland District Health Board was undertaken. Read More

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Anti-Müllerian hormone levels among contraceptive users: evidence from a cross-sectional cohort of 27,125 individuals.

Am J Obstet Gynecol 2021 Jun 11. Epub 2021 Jun 11.

Modern Fertility, San Francisco, CA. Electronic address:

Background: Anti-Müllerian Hormone has become the clinical biomarker-based standard to assess ovarian reserve. As anti-Müllerian hormone testing becomes more common, more individuals are seeking to interpret values obtained while using contraceptives. To appropriately counsel women, a better understanding of anti-Müllerian hormone levels in women using different contraceptives is needed. Read More

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Gut microbiome composition and serum metabolome profile among individuals with spinal cord injury and normal glucose tolerance or prediabetes/type 2 diabetes.

Arch Phys Med Rehabil 2021 Jun 11. Epub 2021 Jun 11.

Departments of Physical Medicine and Rehabilitation, the University of Alabama at Birmingham, Birmingham, Alabama. Electronic address:

Objective: To compare the gut microbiome composition and serum metabolome profile among individuals with spinal cord injury (SCI) and normal glucose tolerance (NGT) or prediabetes/type 2 diabetes (P/DM).

Design: Cross-sectional design.

Setting: Research university. Read More

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Low torcular Herophili position and large brain stem-tentorium angle in fetuses with open spinal dysraphism at 11-13 weeks of gestation.

Ultrasound Obstet Gynecol 2021 Jun 14. Epub 2021 Jun 14.

Center for Prenatal Diagnosis and Human Genetics, Berlin, Germany.

Objective: The aim of this study was to evaluate whether in fetuses with open spina bifida the tentorium is downward displaced and vertically oriented already at the 11-13 weeks scan and is reflected in an alteration of the Brainstem-Tentorium (BST) angle.

Patients And Methods: Two groups of patients were recruited in three Fetal Medicine referral Centers: the prospectively collected control group included singleton pregnancies with a normal sonographic examination after first trimester combined screening for chromosomal abnormalities and normal outcome. The study group was selected retrospectively and enclosed all cases with open spina bifida. Read More

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Expression of long non-coding RNA LUCAT1 in patients with chronic obstructive pulmonary disease and its potential functions in regulating cigarette smoke extract-induced 16HBE cell proliferation and apoptosis.

J Clin Lab Anal 2021 Jun 14:e23823. Epub 2021 Jun 14.

Department of Blood Transfusion, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: Chronic obstructive pulmonary disease (COPD), characterized by persistent airflow limitation, was a disease mediated by a combination of inflammatory factors, immune cells, and immune mediators. COPD was an inflammatory and autoimmune disease involving T-lymphocytes triggered by cigarette smoke and other factors that progressively affected the bronchi, lung parenchyma, and pulmonary blood vessels. LncRNAs were reported to be implicated in COPD pathogenesis and development. Read More

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Pyruvate kinase deficiency in children.

Pediatr Blood Cancer 2021 Jun 14:e29148. Epub 2021 Jun 14.

Dana-Farber/Boston Children's Cancer and Blood Disorder Center, Boston, Massachusetts, USA.

Background: Pyruvate kinase deficiency (PKD) is a rare, autosomal recessive red blood cell enzyme disorder, which leads to lifelong hemolytic anemia and associated complications from the disease and its management.

Methods: An international, multicenter registry enrolled 124 individuals younger than 18 years old with molecularly confirmed PKD from 29 centers. Retrospective and prospective clinical data were collected. Read More

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