42,678 results match your criteria diagnosis canadian

Rethinking autism spectrum disorder assessment for children during COVID-19 and beyond.

Autism Res 2021 Sep 22. Epub 2021 Sep 22.

Department of Clinical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA.

The COVID-19 pandemic has posed unique challenges for families and caregivers, as well as for autism-focused clinicians, who are faced with providing a thorough and accurate evaluation of children's specific needs and diagnoses in the absence of in-person assessment tools. The shift to telehealth assessments has challenged clinicians to reconsider approaches and assumptions that underlie the diagnostic assessment process, and to adopt new ways of individualizing standard assessments according to family and child needs. Mandates for physical distancing have uncovered deficiencies in diagnostic practices for suspected autism and have illuminated biases that have posed obstacles preventing children and families from receiving the services that they truly need. Read More

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September 2021

Assessment, diagnosis, and management of developmental coordination disorder.

Paediatr Child Health 2021 Oct 17;26(6):375-378. Epub 2021 Sep 17.

Canadian Paediatric Society, Developmental Paediatrics Section, Ottawa, Ontario, Canada.

Developmental coordination disorder (DCD) is a neurodevelopmental condition that affects 5% to 6% of school-aged children. DCD can significantly impact early development and life-long functioning. Evidence supports promising interventions for DCD, but the disorder continues to be under-recognized and under-diagnosed. Read More

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October 2021

FASD prevalence among children and youth: results from the 2019 Canadian Health Survey on Children and Youth.

Health Promot Chronic Dis Prev Can 2021 09;41(9):272-276

Public Health Agency of Canada, Ottawa, Ontario, Canada.

Introduction: The lack of national fetal alcohol spectrum disorder (FASD) prevalence estimates represents an important knowledge gap.

Methods: Using data from the 2019 Canadian Health Survey on Children and Youth, the prevalence of FASD was examined by age, sex and Indigenous identity. Median age of diagnosis and comorbid long-term health conditions were also assessed. Read More

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September 2021

Clinical application of fetal genome-wide sequencing during pregnancy: position statement of the Canadian College of Medical Geneticists.

J Med Genet 2021 Sep 20. Epub 2021 Sep 20.

Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

Purpose And Scope: The aim of this position statement is to provide recommendations for Canadian healthcare professionals regarding the use of genome-wide sequencing (GWS) in the context of diagnostic testing of the fetus during pregnancy. This statement was developed to facilitate clinical translation of GWS as a prenatal diagnostic test and the development of best practices in Canada, but the applicability of this document is broader and aims to help professionals in other healthcare systems.

Methods Of Statement Development: A multidisciplinary group was assembled to review existing literature on fetal GWS for genetic diagnosis in the context of suspected monogenic diseases and to make recommendations relevant to the Canadian context. Read More

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September 2021

Factors affecting participant recruitment and retention in borderline personality disorder research: a feasibility study.

Pilot Feasibility Stud 2021 Sep 20;7(1):178. Epub 2021 Sep 20.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1280 Main Street West, Hamilton, ON, Canada.

Background: Previous studies have shown that stigma is a major barrier to participation in psychiatric research and that individuals who participate in psychiatric research may differ clinically and demographically from non-participants. However, few studies have explored research recruitment and retention challenges in the context of personality disorders.

Aim: To provide an analysis of the factors affecting participant recruitment and retention in a study of borderline personality disorder among general psychiatric inpatients. Read More

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September 2021

The Safety of Agalsidase Alfa Enzyme Replacement Therapy in Canadian Patients with Fabry Disease Following Implementation of a Bioreactor Process.

Drugs R D 2021 Sep 20. Epub 2021 Sep 20.

Division of Nephrology, Department of Medicine, Dalhousie University, Rm 5090 ACC, QE II Health Sciences Centre, 5820 University Ave, Halifax, NS, B3H 1V8, Canada.

Background And Objective: Fabry disease, an X-linked lysosomal storage disorder characterized by absent or reduced alpha-galactosidase activity, is a lifelong disease that impairs patients' quality of life. Patients with Fabry disease have a considerably shortened lifespan, with mortality being mainly due to renal failure, cardiovascular disease, or cerebrovascular disease. Enzyme replacement therapy with agalsidase alfa has been shown to attenuate the renal, cardiovascular, and neuropathic disease progression associated with Fabry disease. Read More

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September 2021

Adenotonsillectomy, bronchoscopy and bronchoalveolar lavage in the management of preschool children with severe asthma: pilot study.

Eur Arch Otorhinolaryngol 2021 Sep 20. Epub 2021 Sep 20.

Division of Respiratory Medicine, Department of Paediatrics, and Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Canada.

Purpose: This is a pilot study that describes the feasibility and clinical course of a cohort of preschool children with severe asthma undergoing a combined adenotonillectomy (TA), bronchoscopy (B), and bronchoalveolar lavage (BAL) procedure.

Methods: A retrospective cohort study of preschool patients with severe asthma who underwent a combined TA-B-BAL procedure between 2012 and 2019. Subjects were treated at a tertiary care asthma clinic and had a diagnosis of preschool asthma according to the Canadian Thoracic Society Guidelines. Read More

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September 2021

Management of Peritonsillar Abscesses in Adults: Survey of Otolaryngologists in Canada and the United States.

OTO Open 2021 Jul-Sep;5(3):2473974X211044081. Epub 2021 Sep 13.

Division of Otolaryngology-Head & Neck Surgery, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada.

Objective: The management of peritonsillar abscess (PTA) has evolved over time. We sought to define contemporary practice patterns for the diagnosis and treatment of PTA.

Study Design: Cross-sectional survey. Read More

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September 2021

Impact of a cancer diagnosis on the income of adult cancer survivors: a scoping review protocol.

BMJ Open 2021 Sep 16;11(9):e047315. Epub 2021 Sep 16.

Cancer Control Research, BC Cancer, Vancouver, British Columbia, Canada.

Introduction: While the socioeconomic impact of a cancer diagnosis on cancer survivors has gained some attention in the literature, to our knowledge, a review of the evidence on changes in income due to cancer has yet to be undertaken. In this paper, we describe a scoping review protocol to review the evidence on the effect of a cancer diagnosis on the income of individuals diagnosed with cancer during adulthood (≥18 years). The purpose is to summarise existing evidence, identify gaps in current research and highlight priority areas for future research. Read More

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September 2021

Establishing Benchmarks for Antimicrobial Use in Canadian Children's Hospitals: Results From 2 National Point Prevalence Surveys.

Pediatr Infect Dis J 2021 Oct;40(10):899-905

Division of Infectious Diseases, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.

Background: Point prevalence surveys (PPS) are potentially useful to measure antimicrobial use across institutions. The objectives of the study were to describe and compare antimicrobial use between pediatric hospitals in Canada.

Methods: Fifteen pediatric hospitals all with pediatric infectious diseases service participated in 2 single-day PPS in 2018/19. Read More

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October 2021

Deciphering the low abundance microbiota of presumed aseptic hip and knee implants.

PLoS One 2021 14;16(9):e0257471. Epub 2021 Sep 14.

Department of Surgery, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.

16S rRNA gene sequencing of DNA extracted from clinically uninfected hip and knee implant samples has revealed polymicrobial populations. However, previous studies assessed 16S rRNA gene sequencing as a technique for the diagnosis of periprosthetic joint infections, leaving the microbiota of presumed aseptic hip and knee implants largely unstudied. These communities of microorganisms might play important roles in aspects of host health, such as aseptic loosening. Read More

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September 2021

Established and Emerging Regulatory Roles of Eukaryotic Translation Initiation Factor 5B (eIF5B).

Front Genet 2021 27;12:737433. Epub 2021 Aug 27.

Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB, Canada.

Translational control (TC) is one the crucial steps that dictate gene expression and alter the outcome of physiological process like programmed cell death, metabolism, and proliferation in a eukaryotic cell. TC occurs mainly at the translation initiation stage. The initiation factor eIF5B tightly regulates global translation initiation and facilitates the expression of a subset of proteins involved in proliferation, inhibition of apoptosis, and immunosuppression under stress conditions. Read More

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Perspectives of Canadian Rural Consultant Pediatricians on Diagnosing Autism Spectrum Disorder: A Qualitative Study.

J Dev Behav Pediatr 2021 Sep 10. Epub 2021 Sep 10.

Division of Developmental Pediatrics, Department of Pediatrics, University of Toronto, Toronto, ON, Canada; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada; Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, ON, Canada; Developmental Pediatrics, Orillia Soldiers Memorial Hospital, Orillia, ON, Canada; Pediatric Medicine, Hospital for Sick Children, Toronto, ON, Canada.

Background: Consultant pediatricians represent a potential resource for increasing autism spectrum disorder (ASD) diagnostic capacity; however, little is known about how they perceive their roles in ASD diagnosis.

Objective: The objective of this study was to examine the perspectives of rural consultant pediatricians regarding their perceived roles, facilitators, and barriers in ASD diagnosis.

Methods: We performed a qualitative study using thematic analysis. Read More

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September 2021

The incidence and prevalence of cardiac amyloidosis in a large community-based cohort in Alberta, Canada.

J Card Fail 2021 Sep 9. Epub 2021 Sep 9.

Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Background: Despite the improved awareness of cardiac amyloidosis among clinicians, its incidence and prevalence is not well described in a community setting.

Objective:  To investigate the incidence and prevalence of cardiac amyloidosis in the community.

Methods: In the adult population of Alberta, we examined 3 cohorts: 1) Probable cases of cardiac amyloidosis: the presence of physician-assigned diagnosis of amyloidosis (ICD-10 E85; ICD-9 277. Read More

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September 2021

Epidemiology and risk factors for pyogenic liver abscess in the Calgary Health Zone revisited: a population-based study.

BMC Infect Dis 2021 Sep 10;21(1):939. Epub 2021 Sep 10.

Department of Medicine, University of Calgary, Calgary, Canada.

Background: Pyogenic liver abscess (PLA), although uncommon in North America, is associated with significant morbidity and mortality. We sought to re-examine the epidemiology, risk factors, and outcomes of PLA in a large, diverse Canadian health zone.

Methods: All Calgary Health Zone (CHZ) residents aged ≥20 with PLA between 2015 and 2017 were identified. Read More

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September 2021

Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC).


Lancet 2021 Sep 7. Epub 2021 Sep 7.

Background: The European Atherosclerosis Society Familial Hypercholesterolaemia Studies Collaboration (FHSC) global registry provides a platform for the global surveillance of familial hypercholesterolaemia through harmonisation and pooling of multinational data. In this study, we aimed to characterise the adult population with heterozygous familial hypercholesterolaemia and described how it is detected and managed globally.

Methods: Using FHSC global registry data, we did a cross-sectional assessment of adults (aged 18 years or older) with a clinical or genetic diagnosis of probable or definite heterozygous familial hypercholesterolaemia at the time they were entered into the registries. Read More

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September 2021

Integrating Reverse Transcription Recombinase Polymerase Amplification with CRISPR Technology for the One-Tube Assay of RNA.

Anal Chem 2021 09 10;93(37):12808-12816. Epub 2021 Sep 10.

Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2G3, Canada.

CRISPR-Cas systems integrated with nucleic acid amplification techniques improve both analytical specificity and sensitivity. We describe here issues and solutions for the successful integration of reverse transcription (RT), recombinase polymerase amplification (RPA), and CRISPR-Cas12a nuclease reactions into a single tube under an isothermal condition (40 °C). Specific detection of a few copies of a viral DNA sequence was achieved in less than 20 min. Read More

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September 2021

Development of Acute Myocardial Infarction Mortality and Readmission Models for Public Reporting on Hospital Performance in Canada.

CJC Open 2021 Aug 1;3(8):1051-1059. Epub 2021 May 1.

Canadian Institute for Health Information, Toronto, Ontario, Canada.

Background: Given changes in the care and outcomes of acute myocardial infarction (AMI) patients over the past several decades, we sought to develop prediction models that could be used to generate accurate risk-adjusted mortality and readmission outcomes for hospitals in current practice across Canada.

Methods: A Canadian national expert panel was convened to define appropriate AMI patients for reporting and develop prediction models. Preliminary candidate variable evaluation was conducted using Ontario patients hospitalized with a most responsible diagnosis of AMI from April 1, 2015 to March 31, 2018. Read More

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Calvarial doughnut lesions with bone fragility in a French-Canadian family; case report and review of the literature.

Bone Rep 2021 Dec 25;15:101121. Epub 2021 Aug 25.

Medical Genetics Division, Department of Pediatrics, CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.

Calvarial Doughnut Lesions with Bone Fragility (CDL) is an autosomal dominant genetic disease, characterized by low bone mineral density, multiple fractures starting in childhood, and sclerotic doughnut-shaped lesions in the cranial bones. Aubé and colleagues described in 1988 a French-Canadian family of 12 affected members who had a clinical diagnosis of doughnut lesions of the skull, with pathological fractures, osteopenia, "bone in bone" in the vertebral bodies and squaring of metatarsal and metacarpal bones. Herein we study new members of this family. Read More

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December 2021

A Phase II Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy, Safety, and Tolerability of Arbaclofen Administered for the Treatment of Social Function in Children and Adolescents With Autism Spectrum Disorders: Study Protocol for AIMS-2-TRIALS-CT1.

Front Psychiatry 2021 24;12:701729. Epub 2021 Aug 24.

Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Autism Spectrum Disorder (ASD or autism) is characterized by difficulties in social communication and interaction, which negatively impact on individuals and their families' quality of life. Currently no pharmacological interventions have been shown to be effective for improving social communication in autism. Previous trials have indicated the potential of arbaclofen for improving social function among autistic children and adolescents with fluent speech. Read More

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Molecular Diagnosis of Pompe Disease in the Genomic Era: Correlation with Acid Alpha-Glucosidase Activity in Dried Blood Spots.

J Clin Med 2021 Aug 28;10(17). Epub 2021 Aug 28.

Department of Pediatrics, Université de Sherbrooke, Sherbrooke, QC J1H 5H3, Canada.

Measurement of alpha-glucosidase activity on dried blood spots has been the main method to screen for Pompe disease, but a paradigm shift has been observed in recent years with the incorporation of gene panels and exome sequencing in molecular diagnostic laboratories. An 89-gene panel has been available to Canadian physicians since 2017 and was analyzed in 2030 patients with a suspected muscle disease. Acid alpha-glucosidase activity was measured in parallel in dried blood spots from 1430 patients. Read More

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CARDEA study protocol: investigating early markers of cardiovascular disease and their association with lifestyle habits, inflammation and oxidative stress in adolescence using a cross-sectional comparison of adolescents with type 1 diabetes and healthy controls.

BMJ Open 2021 09 8;11(9):e046585. Epub 2021 Sep 8.

Department of Pediatrics, Université de Montréal, Montréal, Québec, Canada.

Introduction: Little is known regarding associations between potentially modifiable lifestyle habits and early markers of cardiovascular disease (CVD) in pediatric type 1 diabetes (T1D), hindering early prevention efforts. Specific objectives are: (1) compare established risk factors (dyslipidemia, hypertension) with novel early markers for CVD (cardiac phenotype, aortic distensibility, endothelial function) in adolescents with T1D and healthy age-matched and sex-matched controls; (2) examine associations between these novel early markers with: (i) lifestyle habits; (ii) adipokines and measures of inflammation; and (iii) markers of oxidative stress among adolescents with T1D and controls, and determine group differences in these associations; (3) explore, across both groups, associations between CVD markers and residential neighbourhood features.

Methods And Analyses: Using a cross-sectional design, we will compare 100 participants aged 14-18 years with T1D to 100 healthy controls. Read More

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September 2021

Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials.

BMJ 2021 09 8;374:n1034. Epub 2021 Sep 8.

Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.

Objective: To determine the benefits and harms of medical cannabis and cannabinoids for chronic pain.

Design: Systematic review and meta-analysis.

Data Sources: MEDLINE, EMBASE, AMED, PsycInfo, CENTRAL, CINAHL, PubMed, Web of Science, Cannabis-Med, Epistemonikos, and trial registries up to January 2021. Read More

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September 2021

Eight Cases of Hb Winnipeg [: c.226G>T (or )]: A Detailed Study.

Hemoglobin 2021 Sep 8:1-3. Epub 2021 Sep 8.

National Haemoglobinopathy Reference Laboratory, Oxford Radcliffe Hospitals National Health Service Trust, Oxford, Oxfordshire, United Kingdom.

Hb Winnipeg [α75(EF4)Asp→Tyr (α2); : c.226G>T (or )] is a stable α-globin chain variant described in a few articles. The majority of reported cases in older articles were clustered in Canada. Read More

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September 2021

Impact of COVID-19 on the Diagnosis and Management of Multiple Myeloma: Experience from a Canadian Center.

Rev Invest Clin 2021 Sep 8. Epub 2021 Sep 8.

Department of Medical Oncology and Hematology, Tom Baker Cancer Center, Calgary, Alberta; Charbonneau Cancer Research Institute, Calgary, Alberta, Canada.

Background: The impact of coronavirus disease-19 on the management of multiple myeloma (MM) has been recognized. However, the real effect on clinical outcomes remains poorly understood.

Objective: We describe a local experience of the management of MM patients and report their outcomes during the current pandemic. Read More

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September 2021

Evaluating the diagnostic accuracy of point-of-care ultrasound for cholelithiasis and cholecystitis in a canadian emergency department.

CJEM 2021 Sep 14;23(5):626-630. Epub 2021 Jan 14.

Department of Medicine, Division of Emergency Medicine and Critical Care, McMaster University, 237 Barton St East, 2nd Floor McMaster Wing, Room 252, Hamilton General Hospital, Hamilton, ON, L8L 2X2, Canada.

Objectives: Cholelithiasis and cholecystitis are common conditions that frequently require patients to come to the Emergency Department (ED) and undergo diagnostic imaging. The purpose of this study was to evaluate the test characteristics of emergency physician performed point-of-care ultrasound (POCUS) to diagnose cholelithiasis and cholecystitis in a Canadian ED.

Methods: A health records review was performed on all ED patients > 17 years of age for whom POCUS was performed to diagnose cholelithiasis and cholecystitis in a Canadian academic ED over a 5-year period. Read More

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September 2021

Alterations in Urine Metabolomics Following Sport-Related Concussion: A H NMR-Based Analysis.

Front Neurol 2021 19;12:645829. Epub 2021 Aug 19.

Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Millions of sport-related concussions (SRC) occur annually in North America, and current diagnosis of concussion is based largely on clinical evaluations. The objective of this study was to determine whether urinary metabolites are significantly altered post-SRC compared to pre-injury. Outpatient sports medicine clinic. Read More

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Characterising fetal alcohol spectrum disorder in Canada: a national database protocol study.

BMJ Open 2021 09 6;11(9):e046071. Epub 2021 Sep 6.

The Canada FASD Research Network, Edmonton, Alberta, Canada.

Introduction: Fetal alcohol spectrum disorder (FASD) is one of the most common neurodevelopmental disorders in North America. It is a complex disability, associated with challenges in cognitive, behavioural and socialemotional functioning, as well as an increased risk of physical and mental health comorbidities, and difficulties in daily living across the lifespan. Previous attempts to characterise the profile of this population have been hampered by differences in data collected across studies, regional discrepancies in terminology and definitions, and a lack of tools to integrate comprehensive datasets. Read More

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September 2021

Protocol for a multi-phase, mixed methods study to develop and evaluate culturally adapted CBT to improve community mental health services for Canadians of south Asian origin.

Trials 2021 Sep 6;22(1):600. Epub 2021 Sep 6.

Department of Psychiatry, University of Toronto, Toronto, Canada.

Background: Canadians of South Asian (SA) origin comprise the largest racialized group in Canada, representing 25.6% of what Statistics Canada terms "visible minority populations". South Asian Canadians are disproportionately impacted by the social determinants of health, and this can result in high rates of mood and anxiety disorders. Read More

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September 2021

Visual Impairment, Eye Disease, and 3-Year Cognitive Decline: The Canadian Longitudinal Study on Aging.

Ophthalmic Epidemiol 2021 Sep 5:1-9. Epub 2021 Sep 5.

School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.

Purpose: To examine the longitudinal association between vision-related variables and the 3-year change in cognitive test scores in a community-dwelling sample of adults and to explore whether sex, education, or hearing loss act as effect modifiers.

Methods: Data came from two waves of a 3-year population-based prospective cohort study (Canadian Longitudinal Study on Aging), which consisted of 30,097 randomly selected people aged 45-85 years from 7 Canadian provinces. Visual impairment (VI) was defined as binocular presenting visual acuity worse than 20/40. Read More

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September 2021