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Outcomes of pericardiectomy for constrictive pericarditis following mediastinal irradiation.

J Card Surg 2021 Sep 21. Epub 2021 Sep 21.

Department of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Background: Pericardiectomy for postradiation constrictive pericarditis has been reported to generally have unfavorable outcomes. This study sought to evaluate surgical outcomes in a large cohort of patients undergoing pericardiectomy for radiation-associated pericardial constriction.

Methods: A retrospective analysis of all patients (≥18 years) who underwent pericardiectomy for a diagnosis of constrictive pericarditis with a prior history of mediastinal irradiation from June 2002 to June 2019 was conducted. Read More

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September 2021

Flexible sigmoidoscopy may be sufficient for initial evaluation of suspected immunotherapy-mediated colitis: a cross-sectional study.

J Gastroenterol Hepatol 2021 Sep 21. Epub 2021 Sep 21.

Division of Gastroenterology, Department of Medicine, City of Hope Medical Center.

Background And Aim: Immune checkpoint inhibitors (ICIs) have shown promise in treating a variety of cancers. Their increased use coincides with increased incidence of immunotherapy-mediated colitis (IMC), a common adverse effect. Optimal strategy for endoscopic evaluation of IMC (full colonoscopy or flexible sigmoidoscopy) is not well-defined. Read More

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September 2021

3D MRI of the Rheumatic Diseases.

Semin Musculoskelet Radiol 2021 Jun 21;25(3):425-432. Epub 2021 Sep 21.

Division of Musculoskeletal Radiology, Department of Radiology, UT Southwestern Medical Center, Dallas, Texas.

Magnetic resonance imaging (MRI) is commonly used to evaluate musculoskeletal pathologies due to its high spatial resolution and excellent tissue contrast. The diagnosis of rheumatic diseases can often be challenging. Investigation with conventional two-dimensional MRI is helpful for diagnosis and monitoring treatment. Read More

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Hereditary Breast and Ovarian Cancer Screening Syndrome Profile in Women Diagnosed with Breast Cancer from Paraná State Southwest.

Rev Bras Ginecol Obstet 2021 Aug 21;43(8):616-621. Epub 2021 Sep 21.

Laboratory of Tumor Biology, Universidade do Estado do Paraná, Francisco Beltrão, PR, Brazil.

Objective:  This study evaluated the risk of the hereditary breast and ovarian cancer (HBOC) syndrome in patients with breast cancer by using the Family History Screening 7 (FHS-7) tool, a validated low-cost questionnaire with high sensitivity able to screen the HBOC risk in the population.

Methods:  Women diagnosed with breast cancer ( = 101) assisted by the Unified Health System at the 8th Regional Health Municipal Office of the state of Paraná answered the FHS-7, and the results were analyzed using IBM SPSS Statistics for Windows, Version 25.0. Read More

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Concordance Between Clinical and Laboratory Diagnosis of Abnormal Vaginal Discharge in Chilean Women.

Rev Bras Ginecol Obstet 2021 Aug 21;43(8):600-607. Epub 2021 Sep 21.

Preclinical Sciences Department.

Objective:  To determine the concordance between the clinical diagnosis of women with abnormal vaginal discharge (AVD) and laboratory results using molecular detection and observation of the vaginal microbiota.

Methods:  Cross-sectional study conducted in 2018 in Temuco, Chile. A total of 25 midwives from 12 health centers participated. Read More

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Air embolism during lumbar surgery in the prone position.

Diving Hyperb Med 2021 Sep;51(3):303-305

Anesthésie Réanimation Hospices Civils de Lyon, France.

Only a few clinical cases of cerebral arterial gas embolism during spinal surgery are published. It seems important not to overlook this diagnosis in order to initiate rapid appropriate treatment. This was a suspected case of paradoxical gas embolism revealed postoperatively by neurological deficits and whose recovery was noted during hyperbaric oxygen treatment. Read More

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September 2021

Value of HSP90α in Lung Cancer Diagnosis and Recurrence Prediction: A Cohort Study.

Oncol Res Treat 2021 Sep 21:1-6. Epub 2021 Sep 21.

Department of Neurosurgery, University Medical Center Tuebingen, Tuebingen, Germany.

Purpose: In the current study, we tried to analyze the diagnostic value of HSP90α expression during the course of disease in patients treated with and without surgery.

Methods: Three hundred and twelve patients with lung cancer who referred to Qinhuangdao First Hospital from June 2016 to March 2021 were selected as the experimental group and 160 healthy individuals subjected as the control group in this cohort study. The ELISA method was used to detect the expression level of plasma HSP90α. Read More

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September 2021

Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression.

Aging (Albany NY) 2021 Sep 21;13(undefined). Epub 2021 Sep 21.

Faculty of Medicine and Biomedical Sciences (FMCB), University of Algarve, Campus de Gambelas, Faro 8005-139, Portugal.

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. This complex disease still holds severe problems concerning diagnosis due to the high invasiveness nature of colonoscopy and the low accuracy of the alternative diagnostic methods. Additionally, patient heterogeneity even within the same stage is not properly reflected in the current stratification system. Read More

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September 2021

Highly accurate diagnosis of lung adenocarcinoma and squamous cell carcinoma tissues by deep learning.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 14;265:120400. Epub 2021 Sep 14.

State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China.

Intraoperative detection of the marginal tissues is the last and most important step to complete the resection of adenocarcinoma and squamous cell carcinoma. However, the current intraoperative diagnosis is time-consuming and requires numerous steps including staining. In this paper, we present the use of Raman spectroscopy with deep learning to achieve accurate diagnosis with stain-free process. Read More

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September 2021

Nasopharyngeal cancer in monozygotic twins: A case report and review of the role of genetics and the environment.

Int J Surg Case Rep 2021 Sep 6;87:106371. Epub 2021 Sep 6.

Department of Otolaryngology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Introduction And Importance: Nasopharyngeal carcinoma (NPC) is considered a rare malignant head and neck tumour. However, the importance of genetics and environmental factors in the epidemiology of NPC is still unclear. Twins represent an excellent study population for genetic epidemiology; this is especially true of monozygotic-type twins because they are genetically identical. Read More

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September 2021

Hematologically important mutations: The autosomal forms of chronic granulomatous disease (third update).

Blood Cells Mol Dis 2021 Jul 28;92:102596. Epub 2021 Jul 28.

Dept of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Chronic granulomatous disease (CGD) is an immunodeficiency disorder affecting about 1 in 250,000 individuals. CGD patients suffer from severe, recurrent bacterial and fungal infections. The disease is caused by mutations in the genes encoding the components of the leukocyte NADPH oxidase. Read More

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WHO classification of soft tissue tumours 2020: An update and simplified approach for radiologists.

Eur J Radiol 2021 Aug 28;143:109937. Epub 2021 Aug 28.

Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India.

The WHO classification of soft tissue tumours categorizes the lesions based on histological differentiation. In the recent fifth edition (2020), many new entities have been introduced, based on their distinct biological behaviour, genetics and morphology. With the recent advances and better understanding of molecular genetics, several novel recurrent genetic alterations have been incorporated in this edition. Read More

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Role of GATA3 in tumor diagnosis: A review.

Pathol Res Pract 2021 Sep 13;226:153611. Epub 2021 Sep 13.

Department of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

GATA binding protein 3 (GATA3) belongs to a family of transcription factors comprising six members. These proteins identify G-A-T-A containing sequences in the target gene and bind to DNA target via two zinc-finger domains. The aim of this study was to evaluate the role of GATA3 in the diagnosis of tumors and its value as a prognostic marker. Read More

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September 2021

[The impact of COVID-19 on cancer diagnosis delay: possible consequences].

Aten Primaria 2021 Jun 16;53(9):102142. Epub 2021 Jun 16.

Sistemes d'Informació dels Serveis d'Atenció Primària (SISAP), Institut Català de la Salut (ICS), Barcelona, España.

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Do all patients with locoregionally advanced nasopharyngeal carcinoma benefit from the maintenance chemotherapy using S-1/capecitabine?

Oral Oncol 2021 Sep 18;122:105539. Epub 2021 Sep 18.

Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, 651 Dongfeng Road East, Guangzhou 510060, PR China; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, PR China. Electronic address:

Background: The goal of this study was to explore the benefits of S-1/capecitabine as maintenance therapy in locoregionally advanced nasopharyngeal carcinoma (NPC) patients with different risks of treatment failure.

Methods: A total of 2205 eligible, locoregionally advanced NPC patients were recruited for this retrospective study. Multivariate Cox regression analysis was performed to identify optimal predictors of overall survival (OS) and distant metastasis-free survival (DMFS) for constructing the nomograms. Read More

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September 2021

Association between vectorcardiographic QRS area and incident heart failure diagnosis and mortality among patients with left bundle branch block: A register-based cohort study.

J Electrocardiol 2021 Sep 4;69:30-35. Epub 2021 Sep 4.

Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Inova Heart and Vascular Institute, Fairfax, VA, United States.

Background: QRS duration and morphology including left bundle branch block (LBBB) are the most widely used electrocardiogram (ECG) markers for assessing ventricular dyssynchrony and predicting heart failure (HF). However, the vectorcardiographic QRS area may more accurately identify delayed left ventricular activation and HF development.

Objective: We investigated the association between QRS area and incident HF risk in patients with LBBB. Read More

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September 2021

Which is the best alternative to estimate muscle mass for sarcopenia diagnosis when DXA is unavailable?

Arch Gerontol Geriatr 2021 Sep 3;97:104517. Epub 2021 Sep 3.

FCNAUP - Faculdade de Ciências da Nutrição e Alimentação, Universidade do Porto, 4150-180 Porto, Portugal; LAETA-INEGI - Faculdade de Engenharia, Universidade do Porto, Porto, Portugal.

Background: Dual x-ray absorptiometry (DXA) is widely adopted to estimate muscle mass for research, but for daily practice is only available in a limited number of facilities.

Aim: To elucidate if it is anthropometry or bioelectrical impedance analysis (BIA) the method more concordant with DXA in estimating muscle mass for sarcopenia diagnosis among older adults, and to investigate the impact of several cut-off points in sarcopenia frequency.

Methods: 159 older adults (≥65 years) were included in a cross-sectional analysis. Read More

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September 2021

Deep neural network for early image diagnosis of Stevens-Johnson syndrome/toxic epidermal necrolysis.

J Allergy Clin Immunol Pract 2021 Sep 18. Epub 2021 Sep 18.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. Electronic address:

Background: Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) is a life-threatening cutaneous adverse drug reaction (cADR). However, distinguishing SJS/TEN from non-severe cADRS is difficult, especially in the early stages of the disease.

Objective: To overcome this limitation, we developed a computer-aided diagnosis system for the early diagnosis of SJS/TEN, powered by a deep convolutional neural network (DCNN). Read More

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September 2021

Gastric organoids: progress and remaining challenges.

Cell Mol Gastroenterol Hepatol 2021 Sep 18. Epub 2021 Sep 18.

Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University. Electronic address:

The stomach is a complex and physiologically necessary organ, yet large differences in physiology between mouse and human stomachs have impeded translation of physiological discoveries and drug screens performed using murine gastric tissues. Gastric cancer (GC) is a global health threat, with a high mortality rate and limited treatment options. The heterogeneous nature of gastric cancer makes it poorly suited for current "one size fits all" standard treatments. Read More

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September 2021

Evidence for and against subclinical disease activity and progressive disease in MOG antibody disease and neuromyelitis optica spectrum disorder.

J Neuroimmunol 2021 Aug 26;360:577702. Epub 2021 Aug 26.

Department of Neurology, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) and aquaporin-4 IgG seropositive neuromyelitis optica spectrum disorder (AQP4-IgG+ NMOSD) are generally considered to be relapsing disorders, without clinical progression or subclinical disease activity outside of clinical relapses, in contrast to multiple sclerosis (MS). With advances in the diagnosis and treatment of these conditions, prolonged periods of remission without relapses can be achieved, and the question of whether progressive disease courses can occur has re-emerged. In this review, we focus on studies exploring evidence for and against relapse-independent clinical progression and/or subclinical disease activity in patients with MOGAD and AQP4-IgG+ NMOSD. Read More

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Disease-modifying therapies and progressive multifocal leukoencephalopathy in multiple sclerosis: A systematic review and meta-analysis.

J Neuroimmunol 2021 Sep 15;360:577721. Epub 2021 Sep 15.

Department of Neurology, Wayne State University, Detroit, MI, USA.

Background High efficacy disease modifying therapies (DMT) in the management of Multiple Sclerosis (MS) have a favorable effect on relapse rate and disability progression; however, they can expose patients to significant risks, such as progressive multifocal leukoencephalopathy (PML). Objective The study aims to investigate prognostic factors that can determine outcome in MS-related PML patients. Methods We conducted a literature review and meta-analysis of 194 patients from 62 articles in PubMed, SCOPUS and EMBASE. Read More

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September 2021

Comparison of structural, functional, tonometric, and visual acuity testing for glaucoma: a prospective diagnostic accuracy study.

Ophthalmol Glaucoma 2021 Sep 18. Epub 2021 Sep 18.

Francis I Proctor Foundation, University of California, San Francisco; Department of Ophthalmology, University of California, San Francisco. Electronic address:

Objective: To determine the diagnostic accuracy of potential screening tests for moderate to advanced glaucoma.

Design: Prospective diagnostic test accuracy study.

Participants: The study enrolled a consecutive series of patients aged ≥ 50 years who presented to a glaucoma clinic in South India without ever having performed automated visual field testing. Read More

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September 2021

Characterizing the gene mutations associated with resistance to gatifloxacin in Mycobacterium tuberculosis through whole genome sequence.

Int J Infect Dis 2021 Sep 18. Epub 2021 Sep 18.

National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China. Electronic address:

Objectives: Gatifloxacin (GAT), as one of the representatives of the fourth-generation fluoroquinolones (FQs) has been used to treat drug-resistant tuberculosis. Although DNA gyrase mutations are the leading cause of FQs resistance, mutations conferring resistance to GAT remain inadequately characterized.

Methods: In the present study, GAT-resistant mutants were selected from 7H10 agar plates containing 0. Read More

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September 2021

Peripheral Blood Monocyte to Lymphocyte Ratio for Prediction of Tuberculous Pleuritis.

Int J Infect Dis 2021 Sep 18. Epub 2021 Sep 18.

Division of Pulmonary, Critical Care, and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Electronic address:

Objective: To examine the peripheral monocytes to lymphocytes ratio (ML ratio) of patients with tuberculous pleuritis and the ML ratio changes after treatment.

Methods: Clinical and laboratory information of patients with lymphocytic exudative pleural effusion admitted to Chiang Mai University Hospital from 2013 to 2019 were collected. We compared the ML ratios between tuberculous pleuritis and other diagnoses. Read More

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September 2021

PD-L1 is prognostic and a negative predictor of response to immunotherapy in gastric cancer.

Mol Ther 2021 Sep 18. Epub 2021 Sep 18.

Cancer Center, Daping Hospital, Army Medical University, Chongqing 400042, China; School of Medicine, Chongqing University, Chongqing 400030, China. Electronic address:

Cancer cells evade immune detection via programmed cell death 1/programmed cell death-ligand 1 (PD-1/PD-L1) interactions which inactivate T cells. PD-1/PD-L1 blockade has become an important therapy in the anti-cancer armamentarium. However, some patients do not benefit from PD-1/PD-L1 blockade despite expressing PD-L1. Read More

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September 2021

Comparative Study of Survival among Small Cell Lung Cancer Patients in the U.S. Military Health System and Those in the Surveillance, Epidemiology, and End Results (SEER) Program.

Ann Epidemiol 2021 Sep 18. Epub 2021 Sep 18.

John P. Murtha Cancer Center Research Program, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, Maryland; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland. Electronic address:

Purpose: The U.S. military health system (MHS) provides universal health care access to beneficiaries. Read More

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September 2021

Effects of 2,2',4,4'-tetrabromodiphenyl ether on the development of mouse embryonic stem cells.

Reprod Toxicol 2021 Sep 18. Epub 2021 Sep 18.

State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, 210029, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 210029, China. Electronic address:

2,2',4,4'-Tetrabromodiphenyl ether (BDE47) poses potential risks to reproduction and development, but the mechanism of its toxicity has not yet been elucidated. To explore the developmental toxicity of BDE47, mouse embryonic stem cells (mESCs), which are ideal models for testing the developmental toxicity of environmental contaminants in vitro, were exposed to BDE47 (0.04 μM, 1 μM, 25 μM, or 100 μM) for 24 h or 48 h in this study. Read More

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September 2021

Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations.

Diabetes Res Clin Pract 2021 Sep 18:109063. Epub 2021 Sep 18.

Faculty of Biology, Medicine and Health, University of Manchester and Manchester University Foundation Trust, Manchester, UK.

Diabetic sensorimotor polyneuropathy (DSPN) affects around one third of people with diabetes and accounts for considerable morbidity, increased risk of mortality, reduced quality of life, and increased health care costs resulting particularly from neuropathic pain and foot ulcers. Painful DSPN is encountered in 13-26% of diabetes patients, while up to 50% of patients with DSPN may be asymptomatic. Unfortunately, DSPN still remains inadequately diagnosed and treated. Read More

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September 2021