454 results match your criteria diagnosed crmo


Rare presentation of chronic recurrent multifocal osteomyelitis of the Iliac wing mimicking Ewing's sarcoma.

SA J Radiol 2021 18;25(1):2030. Epub 2021 Feb 18.

Department of Radiology, University of Texas Health, San Antonio, Texas, United States of America.

This report describes a case of chronic recurrent multifocal osteomyelitis (CRMO) in an 11-year-old girl, involving the iliac bone as an initial, solitary site. Atypical imaging features were suspicious of a bone tumour, such as Ewing's sarcoma. Chronic recurrent multifocal osteomyelitis is a great masquerader and can present atypically. Read More

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February 2021

Variability in phenotype and response to treatment in chronic nonbacterial osteomyelitis; the Irish experience of a national cohort.

Pediatr Rheumatol Online J 2021 Mar 25;19(1):45. Epub 2021 Mar 25.

UCD Centre for Arthritis Research, School of Medicine, University College Dublin, Dublin, Ireland.

Background: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory disease affecting bone with considerable phenotypic heterogeneity and variable association with other autoinflammatory conditions. Disease pathogenesis is incompletely understood, and treatment protocols vary between physicians with no clinical treatment guidelines available prior to 2017. Although CNO was previously considered benign, it is now clear that long-term sequelae do occur. Read More

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[SAPHO syndrome : An overview and nosological differentiation of 35 disease cases].

Z Rheumatol 2021 Mar 16. Epub 2021 Mar 16.

Abt. für Rheumatologie, klinische Immunologie, Osteologie und Physikalische Medizin, Kerckhoff-Klinik GmbH, Campus Kerckhoff der Justus-Liebig-Universität Gießen, Benekestr. 2-8, 61231, Bad Nauheim, Deutschland.

The SAPHO syndrome is not a single entity but an inhomogeneous, nosologically heterogeneous complex of symptoms with unknown etiology and heterogeneous pathogenesis. Clinically subacute, recurrent or chronic disease processes and a common skin-bone association (skibo disease) can be found. Under the acronym SAPHO, chronically recurrent multifocal osteomyelitis (CRMO) is the most common disease that can occur in youth as well as adolescence. Read More

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Whole-body MRI Imaging Is an Essential Tool in Diagnosing and Monitoring Patients With Sterile Osteomyelitis.

J Rheumatol 2021 Mar 1. Epub 2021 Mar 1.

TSS was supported by the University of Iowa's Department of Radiology and Divisions of Pediatric Radiology and Neuroradiology. PJF was supported by NIH/NIAMS R01AR059703 and The Marjorie K. Lamb Professorship at the University of Iowa Carver College of Medicine. T.S. Sato, Clinical Assistant Professor, Divisions of Pediatric Radiology and Neuroradiology, Department of Radiology, Carver College of Medicine, University of Iowa; P.J. Ferguson, Professor, Division of Pediatric Rheumatology, Allergy and Immunology, Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA. Address correspondence to Dr. P. Ferguson, University of Iowa, 200 Hawkins Dr., Iowa City, IA 52240, USA. Email:

From the first description in 1972 as "subacute and chronic recurrent osteomyelitis" to the currently recognized chronic recurrent multifocal osteomyelitis (CRMO) or chronic nonbacterial osteitis (CNO), diagnosis and monitoring of patients with this disease has been and continues to be a challenge While the most common presenting symptom is focal bone pain, its waxing and waning nature tends to contribute to the diagnostic odyssey that many patients must endure. Read More

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Assessing Knowledge and Promoting Awareness of Chronic Recurrent Multifocal Osteomyelitis Among Oral and Maxillofacial Surgeons.

J Oral Maxillofac Surg 2021 Jan 28. Epub 2021 Jan 28.

Professor of Oral and Maxillofacial Surgery, Harvard School of Dental Medicine, Leonard B. Kaban, DMD, MD Chair in Oral and Maxillofacial Surgery, Oral Surgeon-in-Chief, Department of Plastic and Oral Surgery, Boston Children's Hospital, Boston, MA. Electronic address:

Purpose: Chronic recurrent multifocal osteomyelitis (CRMO) is underdiagnosed and underreported because of a lack of awareness among providers. While patients with undiagnosed CRMO often present to oral and maxillofacial surgeons (OMSs) with a chief complaint of mandibular pain, to our knowledge, there is no literature regarding how well informed these providers are about this disease. Survey studies and educational efforts have been carried out among other specialists with the aim of raising awareness. Read More

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January 2021

Whole-body MRI in paediatric undefined inflammatory conditions.

Pediatr Int 2021 Feb 10. Epub 2021 Feb 10.

Department of Clinical Sciences and Community Health, University of Milan, Italy, Milano.

Background: Whole Body Magnetic Resonance Imaging (WBMRI) is a multiregional imaging technique suitable to investigate the extent of multisystemic diseases without exposure to radiation, with a high sensitivity to bone alterations. The aim of our study was to evaluate the role of WBMRI in the workup of children with non-specific musculoskeletal features, and non-indicative laboratory and instrumental data, suspected to have a rheumatologic disease.

Methods: We retrospectively analysed medical records, including laboratory tests and radiological data of 34 children who have been evaluated due to non-specific musculoskeletal manifestations, for which a WBMRI was prescribed. Read More

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February 2021

Paediatric bone lesions: diagnostic accuracy of imaging correlation and CT-guided needle biopsy for differentiating benign from malignant lesions.

Br J Radiol 2021 Apr 10;94(1120):20201234. Epub 2021 Feb 10.

Musculoskeletal Radiology Department, Royal National Orthopaedic Hospital, Stanmore, UK.

Objective: To determine the sensitivity, specificity and accuracy of CT-guided needle biopsy (CT-NB) for distinguishing benign and malignant lesions in children with suspected primary bone tumours, and to assess the correlation between imaging diagnosis and final diagnosis.

Methods: Retrospective review of children who underwent CT-NB of a suspected primary bone tumour between October 2016 and October 2019. Data collected included anatomical location, imaging diagnosis, type of needle, type of biopsy sample, CT-NB diagnosis, final diagnosis and post-procedural complications. Read More

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The multi-kinase inhibitor dasatinib suppresses autoinflammation and increases bone density in a mouse model for chronic recurrent multifocal osteomyelitis.

Cell Biochem Funct 2021 Feb 1. Epub 2021 Feb 1.

Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Japan.

Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease that presents with bone destruction and pain. Although genetic studies have identified signalling pathways involving CRMO, molecularly targeted drugs remain unavailable. We used an animal model of CRMO as an in vivo screening system for candidate therapeutic agents. Read More

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February 2021

Whole-body magnetic resonance imaging in inflammatory diseases: Where are we now? Results of an International Survey by the European Society of Musculoskeletal Radiology.

Eur J Radiol 2021 Mar 9;136:109533. Epub 2021 Jan 9.

Department of Radiology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

Purpose: To investigate the current role of WB-MRI for rheumatic inflammatory diseases in clinical practice using a survey addressed to musculoskeletal radiologists.

Methods: A survey composed of 61 questions, subdivided in three sections, demographics (five questions), application of WB-MRI for inflammatory musculoskeletal diseases in adults and children (28 questions: 7 open and 21 multiple choice for each subgroup) was distributed via the European Society of Musculoskeletal Radiology (ESSR) from July 2 to December 31, 2018 to radiologists working in academic, private, and public workplaces. Comparisons among the different workplaces were performed using the Chi-squared and the Kruskal-Wallis test for nominal and ordinal data, respectively (p < 0. Read More

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Biological therapy in refractory chronic nonbacterial osteomyelitis: A case series of 19 patients.

Joint Bone Spine 2021 Mar 17;88(2):105120. Epub 2020 Dec 17.

Department of Pediatric Rheumatology, University Hospital 12 de Octubre, Av Cordoba s/n, 28041 Madrid, Spain; Department of Public Health & Maternal and Child Health, Complutense University of Madrid, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.

Introduction: Chronic non-bacterial osteomyelitis (CNO) represents an autoinflammatory bone disorder. Currently there are no standardized diagnostic or treatment guidelines. The objective of the study is to describe our experience with biological therapy in children with the disease. Read More

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[Chronic multifocal osteomyelitis: A case report and literature review].

Authors:
Y W Hu R Liu L Luo

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Dec;52(6):1140-1145

Department of Rheumatology, the First Affiliated Hospital of Xinjiang Medical University, Urumchi 8300542, China.

A case of chronic multifocal osteomyelitis was described in terms of its clinical manifestations, serological and imaging examinations, diagnostic criteria, treatment options, and follow-up evaluation after discharge. The pathogenesis, diagnosis, differential diagnosis and treatment of chronic multifocal osteomyelitis were reviewed, and the characteristics of autoinflammatory osteopathy were reviewed. The patient with onset from youth had developed severe skin lesions, progressive arthralgia and rachialgia. Read More

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December 2020

Chronic recurrent multifocal osteomyelitis: diagnosis and treatment.

Curr Opin Pediatr 2021 Feb;33(1):90-96

Division of Pediatric Rheumatology, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, USA.

Purpose Of Review: The aim of this article is to review recent findings regarding the diagnosis and treatment of chronic recurrent multifocal osteomyelitis (CRMO).

Recent Findings: An adequate understanding of pathophysiology along with the new advances in MRI imaging make it possible to determine the extent of disease and establish early treatment. TNF-α inhibitors and bisphosphonates have shown to be a well-tolerated and efficient treatment for CRMO providing both symptomatic relief and normalization of bone morphology. Read More

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February 2021

[Extranodal B-cell lymphoma in the distal femur with pre-existing CRMO].

Z Rheumatol 2021 Feb 15;80(1):78-84. Epub 2020 Oct 15.

Abt. Rheumatologie und klinische Immunologie, Medizinische Klinik II, Universitätsklinikum Würzburg, Würzburg, Deutschland.

CRMO is a rare form of nonbacterial osteomyelitis, which is mainly found in children. The diagnosis is complex because bone tumors or lymphoma must also be excluded. The case report describes the development of a solitary femoral lymphoma on the basis of a known CRMO disease as well as the differential diagnostic pitfalls. Read More

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February 2021

Clinical characteristics of pediatric synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: the first Chinese case series from a single center.

Clin Rheumatol 2021 Apr 15;40(4):1487-1495. Epub 2020 Sep 15.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Introduction: Pediatric SAPHO syndrome is regarded as the equivalent of chronic recurrent multifocal osteomyelitis or chronic non-bacterial osteomyelitis. This study aimed to evaluate the clinical features and treatment options for Chinese pediatric patients with SAPHO syndrome.

Method: We conducted a single-center, retrospective study on a sample of 24 pediatric patients with SAPHO syndrome who were diagnosed at Peking Union Medical College Hospital from April 2014 to August 2018. Read More

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Acetabula Osteoid Osteoma Mimicking Juvenile Idiopathic Arthritis and Chronic Recurrent Multifocal Osteomyelitis.

Case Rep Rheumatol 2020 28;2020:8810735. Epub 2020 Aug 28.

Department of Pediatric Rheumatology, University at Buffalo, Oishei Children's Hospital, Buffalo, NY, USA.

Osteoid osteoma (OO) is a benign bone tumor that usually presents between 10 and 35 years of age. The metaphysis and diaphysis of the femur and tibia are the typical locations. The diagnosis is usually straightforward when images reveal a radiolucent nidus surrounded by reactive sclerosis. Read More

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[Chronic nonbacterial osteomyelitis : Imaging and differential diagnoses].

Radiologe 2020 Sep;60(9):863-876

Institut für Diagnostische und Interventionelle Radiologie, Kinder- und Neuroradiologie, Universitätsmedizin Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Deutschland.

Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease in childhood and adolescence with a preference for the female gender. It is manifested with multiple osseous lesions, with a predilection for the metaphyseal end zones of the long bones of the lower extremities. These bone lesions usually occur multifocally, can recur and develop a different appearance depending on the bone structure affected. Read More

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September 2020

The Many Faces of Pediatric Chronic Recurrent Multifocal Osteomyelitis (CRMO): A Practical Location- and Case-Based Approach to Differentiate CRMO From Its Mimics.

J Magn Reson Imaging 2020 Aug 25:e27299. Epub 2020 Aug 25.

Department of Radiology, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, USA.

Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease of childhood and adolescence characterized by episodic bone pain. Diagnosis relies heavily on whole-body MRI and is made by excluding a wide variety of other disorders with overlapping imaging features, depending on location, marrow distribution, and the presence or absence of multifocality. We present an overview of the clinical and imaging features of CRMO and, through various clinical scenarios, provide tips for tailoring the differential diagnosis based on location and distribution of encountered abnormalities. Read More

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Chronic non-bacterial osteomyelitis: a retrospective international study on clinical manifestations and response to treatment.

Clin Exp Rheumatol 2020 Nov-Dec;38(6):1255-1262. Epub 2020 Aug 5.

Department of Clinical Sciences and Community Health, University of Milan, and Paediatric Rheumatology Unit, ASST G. Pini & CTO, Milan, Italy.

Objectives: Chronic non-bacterial osteomyelitis (CNO) is a rare non-infectious bone inflammatory disorder; when multifocal, it is referred to as Chronic Recurrent Multifocal Osteomyelitis (CRMO). This study evaluates the demographic, clinical and radiological characteristics of a multi-centre cohort of patients with CNO/CRMO.

Methods: Demographic and clinical data of patients with an established diagnosis of CNO/CRMO followed at paediatric rheumatology centres across Europe (Italy, France, Slovenia) and India were retrospectively collected. Read More

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December 2020

Whole-body MRI in the diagnosis of paediatric CNO/CRMO.

Rheumatology (Oxford) 2020 Oct;59(10):2671-2680

School of Clinical Sciences, Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, UHB Education Centre, Bristol.

Chronic recurrent multifocal osteomyelitis (CRMO) is an auto-inflammatory disorder affecting the skeleton of children and adolescents. Whole-body MRI (WBMRI) is key in the diagnosis and follow-up of CRMO. Imaging protocols should include sagittal short Tau inversion recovery of the spine, imaging of the hands and feet, and T1 images for distinguishing normal bone marrow. Read More

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October 2020

Radiographic changes of chronic recurrent multifocal osteomyelitis that persisted into adulthood.

BMJ Case Rep 2020 Jul 2;13(7). Epub 2020 Jul 2.

Clinical Medicine, New York Institute of Technology College of Osteopathic Medicine at Arkansas State University, Jonesboro, Arkansas, USA

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare non-infectious autoinflammatory disorder typically seen in young women. We describe the case of a young man who presented at 13 years of age with pain in the tibia, humerus, clavicle and hip. Worsening of the condition through clinical presentation and radiographic imaging was observed over 10 years. Read More

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Chronic recurrent multifocal osteomyelitis with myositis: A case report and review of the literature.

Pediatr Int 2020 05;62(5):644-645

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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Imaging features in patients with SAPHO/CRMO: a pictorial review.

Jpn J Radiol 2020 Jul 30;38(7):622-629. Epub 2020 Apr 30.

Department of Radiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome and chronic recurrent multifocal osteomyelitis (CRMO) have been described as disorders of chronic osteoarthritic inflammation frequently associated with skin manifestations, and SAPHO and CRMO (SAPHO/CRMO) are rare autoinflammatory disorders of unknown etiology. SAPHO tends to occur in adults and CRMO predominantly occurs in children and adolescents. SAPHO/CRMO can affect any skeletal region (e. Read More

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Diagnosing and treating native spinal and pelvic osteomyelitis in adolescents.

Spine Deform 2020 10 18;8(5):1001-1008. Epub 2020 Apr 18.

Department of Orthopedic Surgery, Boston Children's Hospital, Hunnewell 2, 300 Longwood Avenue, Boston, MA, 02115, USA.

Study Design: Retrospective case series.

Objectives: To describe how pediatric patients with spinal and pelvic osteomyelitis are diagnosed and treated and assess the diagnostic value of magnetic resonance imaging (MRI), needle aspiration biopsy (NAB), and blood cultures in this population. Spinal and pelvic osteomyelitis de novo are uncommon in children and minimal literature exists on the subject. Read More

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October 2020

New variant in the IL1RN-gene (DIRA) associated with late-onset, CRMO-like presentation.

Rheumatology (Oxford) 2020 Nov;59(11):3259-3263

Department of Immunology, University of Tuebingen, Tuebingen.

Objective: To report a chronic recurrent multifocal osteomyelitis (CRMO)-like clinical phenotype with multisystem inflammation associated with a novel gene variant in the spectrum of IL-1-mediated diseases.

Methods: A 3-year-old boy presented with recurrent episodes of fever, serositis, pancreatitis and high inflammatory markers with onset at age 13 months. At age 3 years, he started limping. Read More

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November 2020

Autoinflammatory diseases in childhood, part 2: polygenic syndromes.

Pediatr Radiol 2020 03 17;50(3):431-444. Epub 2020 Feb 17.

Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.

Autoinflammatory diseases are a family of disorders characterized by aberrant stimulation of inflammatory pathways without involvement of antigen-directed autoimmunity. They can be further divided in monogenic and polygenic types. Those without an identified genetic mutation are known as polygenic and include systemic-onset juvenile idiopathic arthritis, idiopathic recurrent acute pericarditis, Behçet syndrome, chronic recurrent multifocal osteomyelitis and inflammatory bowel disease among others. Read More

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Autoinflammatory diseases in childhood, part 1: monogenic syndromes.

Pediatr Radiol 2020 03 17;50(3):415-430. Epub 2020 Feb 17.

Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.

Autoinflammatory diseases constitute a family of disorders defined by aberrant stimulation of inflammatory pathways without involving antigen-directed autoimmunity. They may be divided into monogenic and polygenic types. Monogenic autoinflammatory syndromes are those with identified genetic mutations, such as familial Mediterranean fever, tumor necrosis factor receptor-associated periodic fever syndrome (TRAPS), mevalonate kinase deficiency or hyperimmunoglobulin D syndrome, cryopyrin-associated periodic fever syndromes (CAPS), pyogenic arthritis pyoderma gangrenosum and acne (PAPA) syndrome, interleukin-10 and interleukin-10 receptor deficiencies, adenosine deaminase 2 deficiency and pediatric sarcoidosis. Read More

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Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.

J Immunol 2020 03 5;204(6):1607-1620. Epub 2020 Feb 5.

Laboratory of Leukocyte Signalling, Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic;

Autoinflammatory diseases are characterized by dysregulation of the innate immune system, leading to spontaneous inflammation. mouse strain is a well-characterized model of this class of disorders. Because of the mutation leading to the lack of adaptor protein PSTPIP2, these animals suffer from autoinflammatory chronic multifocal osteomyelitis similar to several human syndromes. Read More

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Chronic recurrent multifocal osteomyelitis: a case report.

Turk Pediatri Ars 2019 25;54(4):272-276. Epub 2019 Dec 25.

Department of Pediatrics, Dr. Sami Ulus Women's and Children's Health Research and Training Hospital, Ankara, Turkey.

Chronic recurrent multifocal osteomyelitis is a rare autoinflammatory, immunologic disorder. It may involve recurrent inflammatory bone pain associated with aseptic osteomyelitis. If the diagnosis is delayed, it negatively influences quality of life by leading to persistent symptoms or joint damage. Read More

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December 2019

Pediatric chronic nonbacterial osteomyelitis of the mandible: Seattle Children's hospital 22-patient experience.

Pediatr Rheumatol Online J 2020 Jan 15;18(1). Epub 2020 Jan 15.

Pediatric Oral and Maxillofacial Surgery, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.

Background: Studies evaluating treatment responses for chronic nonbacterial osteomyelitis (CNO) are lacking. We aimed to measure and compare response rates of medical treatments, time to response of medical treatments among patients with CNO of the mandible, and describe bacterial contamination rates from biopsy.

Methods: We conducted a retrospective chart review of all patients diagnosed with CNO of mandible between 2003 and 2017 and extracted demographic, clinical, laboratory, imaging and surgical data. Read More

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January 2020