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Long-Term Quality of Life in Patients Following Minimally Invasive Conjunctivodacryocystorhinostomy With StopLoss Jones Tube.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Department of Ophthalmology, Jozef Strus City Hospital, Poznan, Poland Department of Ophthalmology, Military Institute of Medicine, Warsaw, Poland Govindram Seksaria Institute of Dacryology, L.V. Prasad Eye Institute, Hyderabad, India.

Purpose: To assess the long-term quality of life outcomes of minimally invasive conjunctivodacryocystorhinostomy with StopLoss Jones tubes.

Methods: A retrospective interventional case series was performed on all patients diagnosed with proximal bicanalicular obstruction who underwent a minimally invasive conjunctivodacryocystorhinostomy with StopLoss Jones tubes over a period of 5 years from October 2014 to September 2019. The procedure was performed as per standard published protocols of minimally invasive conjunctivodacryocystorhinostomy and StopLoss Jones tubes. Read More

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Spheno-Orbital Dermoid Masquerading as Recurrent Orbital Abscess.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

phthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, U.S.A. Ophthalmic Plastic Surgery, Department of Ophthalmology, Yale University, New Haven, Connecticut, U.S.A.

A 10-month-old girl presented with eyelid edema and erythema that did not improve with systemic antibiotics. Due to a lack of improvement, MRI was performed to avoid ionizing radiation from CT. An orbital abscess was recognized and drained. Read More

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Accelerated Progression of Diabetic Retinopathy in a Patient with Acquired Lipodystrophy Following Hematopoietic Stem Cell Transplantation.

Retin Cases Brief Rep 2021 Jul 16. Epub 2021 Jul 16.

Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan.

Purpose: To report a case of bilateral proliferative diabetic retinopathy and lipemia retinalis in a patient with acquired lipodystrophy.

Methods: A retrospective case report.

Results: A 23-year-old woman with a diagnosis of acquired lipodystrophy was referred for ophthalmic evaluation. Read More

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Risk Factors for Retinopathy of Prematurity in the Netherlands: A Comparison of Two Cohorts.

Neonatology 2021 Jul 22:1-8. Epub 2021 Jul 22.

Wilhelmina Children's Hospital, Utrecht, The Netherlands.

Introduction: Retinopathy of prematurity (ROP) remains an important cause for preventable blindness. Aside from gestational age (GA) and birth weight, risk factor assessment can be important for determination of infants at risk of (severe) ROP.

Methods: Prospective, multivariable risk-analysis study (NEDROP-2) was conducted, including all infants born in 2017 in the Netherlands considered eligible for ROP screening by pediatricians. Read More

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SOURCE-PANC: A Prediction Model for Patients With Metastatic Pancreatic Ductal Adenocarcinoma Based on Nationwide Population-Based Data.

J Natl Compr Canc Netw 2021 Jul 21. Epub 2021 Jul 21.

1Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam.

Background: A prediction model for overall survival (OS) in metastatic pancreatic ductal adenocarcinoma (PDAC) including patient and treatment characteristics is currently not available, but it could be valuable for supporting clinicians in patient communication about expectations and prognosis. We aimed to develop a prediction model for OS in metastatic PDAC, called SOURCE-PANC, based on nationwide population-based data.

Materials And Methods: Data on patients diagnosed with synchronous metastatic PDAC in 2015 through 2018 were retrieved from the Netherlands Cancer Registry. Read More

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Diagnostic potential of trace metals concentration in expressed prostatic secretion and serum of patients with category IV prostatitis.

J Trace Elem Med Biol 2021 Jul 8;68:126819. Epub 2021 Jul 8.

Scientific Research Center, Guilin Medical University, Guilin, Guangxi, China; Guangxi Health Commission Key Laboratory of Disease Proteomics Research, China. Electronic address:

Background: The National Institutes of Health (NIH) category IV prostatitis is a painless prostate gland inflammation, just as its name implies, this type of prostatitis is related with inflammation of the prostate, but most men are not conscious of it. However, category IV prostatitis is fairly common in general populations and reported having indirect relationships with prostate cancer.

Method: We analyzed the concentration of zinc (Zn), copper (Cu), calcium (Ca) and magnesium (Mg) in expressed prostatic secretion (EPS) and serum of patients with category IV prostatitis and healthy controls, investigating the diagnostic potential of different metals in category IV prostatitis using a flame atomic absorption spectrometer (FAAS). Read More

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Self-reported reasons for colonoscopy among adults aged 45-49 versus 50 years and older from 2010-2018.

Cancer Epidemiol 2021 Jul 19;74:101984. Epub 2021 Jul 19.

Department of Radiation Oncology, University of Texas Southwestern, Dallas, TX, USA. Electronic address:

Background: In May of 2018, the American Cancer Society lowered the age of colorectal cancer (CRC) screening initiation from 50 to 45 years and in October 2020, United States Preventive Services Task Force published draft guidelines also lowering age of screening initiation to 45 years. Evaluating guideline adherence is needed; however, the majority of prior research on cancer screening do not distinguish whether colonoscopy was performed for true screening purposes or for post-symptomatic diagnosis.

Methods: Using data from the National Health Interview Survey between 2010 to mid-2018, we assessed response to the question "What was the MAIN reason you had [last] colonoscopy?" stratified by age (45-49 versus 50+ years). Read More

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The Effects of Chronic Lymphocytic Thyroiditis on Clinicopathological Factors In Papillary Thyroid Cancer.

Endocr Pract 2021 Jul 19. Epub 2021 Jul 19.

Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

Introduction: This study evaluated the impact of chronic lymphocytic thyroiditis (CLT) on clinicopathological parameters, prognostic outcome and initial treatment responses in patients with papillary thyroid cancer (PTC).

Methods: A retrospective review was made of 1409 patients with PTC, comprising 443 pathology proven PTC patients with CLT and 447 PTC patients without CLT.

Results: The median follow-up time was 58 (8-380) months and the median age at the time of diagnosis was 43 years. Read More

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Association of periodontal disease with breed size, breed, weight, and age in pure-bred client-owned dogs in the United States.

Vet J 2021 Jul 19:105717. Epub 2021 Jul 19.

Waltham Petcare Science Institute, Freeby Lane, Waltham-on-the-Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK.

Despite periodontal disease (PD) being amongst the most common diagnoses in primary-care practice, the disease is generally underdiagnosed. However, the millions of clinical records generated by pet hospitals each year provide unique opportunities to generate insights about disease risk across large numbers of dogs. The objective of this study was to undertake a retrospective analysis of medical records to ascertain which sizes and breeds of dog are most frequently diagnosed with PD. Read More

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Sex Specific Long-Term Height and BMI Trajectories of Stimulant Treated Children Diagnosed with Attention-Deficit/Hyperactivity Disorder.

J Pediatr 2021 Jul 19. Epub 2021 Jul 19.

The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petach Tikva; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv. Electronic address:

Objectives: To evaluate the sex-specific effects of stimulants in children with Attention-Deficit/Hyperactivity Disorder (ADHD) on body mass index (BMI)-Z and Height-Z trajectories.

Study Design: A retrospective cohort study utilizing the database of Israel Clalit Health Services. Participants included 5-18-year-old insureds with documentation of at least two consecutive prescriptions of stimulant drugs for ADHD. Read More

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Influenza-Associated Neurologic Complications in Hospitalized Children.

J Pediatr 2021 Jul 19. Epub 2021 Jul 19.

Divisions of Neurology, The Children's Hospital of Philadelphia; Departments of Neurology, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address:

Objectives: To define the incidence and characteristics of influenza-associated neurologic complications in a cohort of children hospitalized at a tertiary care pediatric hospital with laboratory-confirmed influenza, and to identify associated clinical, epidemiologic, and virologic factors.

Study Design: Historical cohort study of children 0.5-18. Read More

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Covid-19 and Risk of Venous Thromboembolism in Ethnically Diverse Populations.

Chest 2021 Jul 19. Epub 2021 Jul 19.

Department of Medicine, University of California, San Francisco, San Francisco, CA USA.

Background: Limited existing data suggest the novel coronavirus disease 2019 (Covid-19) may increase risk for venous thromboembolism (VTE) but information from large, ethnically diverse populations with appropriate controls are lacking.

Research Question: Does the rate of VTE among adults hospitalized with Covid-19 differ from matched hospitalized controls without Covid-19?

Study Design And Methods: We conducted a retrospective study among hospitalized adults with laboratory-confirmed Covid-19 and hospitalized adults without evidence of Covid-19 matched on age, gender, race/ethnicity, acute illness severity, and month of hospitalization between February-August 2020 from two integrated healthcare delivery systems with 36 hospitals. Outcomes included VTE (deep venous thrombosis or pulmonary embolism ascertained using diagnosis codes combined with validated natural language processing algorithms applied to electronic health records) and death from any cause at 30 days. Read More

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Anti-microbial antibody response is associated with future onset of Crohn's disease independent of biomarkers of altered gut barrier function, subclinical inflammation, and genetic risk.

Gastroenterology 2021 Jul 19. Epub 2021 Jul 19.

Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: /Aim: Altered host immune reactivity to microbial antigens is hypothesized to trigger the onset of Crohn's disease (CD). We aimed to assess whether increased serum anti-microbial antibody response in asymptomatic first-degree relatives (FDR) of CD patients is an independent risk factor for future CD development.

Methods: We measured host serum antibody response to six microbial antigens at enrollment (Prometheus ELISA test: ASCA IgA/IgG, anti-OmpC, anti-A4-Fla2, anti-FlaX, anti-CBir1) and derived the sum of positive antibodies (AS). Read More

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Prevalence of hyperventilation in patients with asthma.

J Asthma 2021 Jul 22:1-11. Epub 2021 Jul 22.

Radboud university medical center, Radboud Institute for Health Sciences, Department of Respiratory Diseases, 6525 GA Nijmegen, The Netherlands.

Objective: Asthma is frequently accompanied by dysfunctional breathing of which hyperventilation has been recognized as a subtype. The prevalence of hyperventilation in stable asthma has been scantily studied using blood gas analysis. Hence, a reliable estimate of its prevalence is lacking. Read More

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Individual variability in human urinary metabolites identifies age-related, body mass index-related, and sex-related biomarkers.

Mol Genet Genomic Med 2021 Jul 22:e1738. Epub 2021 Jul 22.

Materia Medica Development Group, Institute of Medicinal Chemistry, Lanzhou University School of Pharmacy, Lanzhou, China.

Background: Metabolites present in human urine can be influenced by individual physiological parameters (e.g., body mass index [BMI], age, and sex). Read More

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Rapid Onset of Functional Tic-Like Behaviours in Young Adults during the COVID-19 Pandemic.

Eur J Neurol 2021 Jul 22. Epub 2021 Jul 22.

Department of Clinical Neurosciences, University of Calgary.

Background: Clinicians have reported an increase in functional tic-like behaviours in children and youth during the COVID-19 pandemic. We describe adults developing rapid onset of functional tic-like behaviours between May 2020 and June 2021.

Methods: Data were analysed from the Adult Tic Disorders Registry, a single-site,12-month prospective cohort study which began enrolment in January 2021. Read More

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Factors associated with the use and composition of two-drug regimens in a large single-centre HIV cohort.

J Antimicrob Chemother 2021 Jul 22. Epub 2021 Jul 22.

Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain.

Objectives: We aimed to assess the clinical characteristics associated with the use of two-drug regimens (2DRs) and the factors associated with specific antiretrovirals in 2DRs in a large single-centre HIV cohort.

Methods: Retrospective analysis of demographics, HIV characteristics and AIDS events, antiretroviral prescription, virological failure and genotypic resistance testing, and laboratory results from all adult people with HIV (PWH) prospectively followed at the Hospital Clinic of Barcelona who were receiving a 3DR or a 2DR in January 2020. We assessed factors associated with the probability of receiving 2DRs relative to three-drug regimens (3DRs) using a logistic regression model, controlling for age, sex and year of HIV diagnosis. Read More

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Clinical characteristics and management of olecranon and prepatellar septic bursitis in a multicentre study.

J Antimicrob Chemother 2021 Jul 22. Epub 2021 Jul 22.

Rheumatology Department, CHU Nantes, Nantes, France.

Background: No current guidelines are available for managing septic bursitis (SB).

Objectives: To describe the clinical characteristics and management of olecranon and prepatellar SB in five French tertiary care centres.

Methods: This is a retrospective observational multicentre study. Read More

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Reproducibility and Validity of Capillary Dried Blood Spot for Diagnosis of Vitamin A Deficiency and Anemia in Children <5 Years Old.

J Nutr 2021 Jul 22. Epub 2021 Jul 22.

Department of Social Nutrition, Nutrition Institute, Rio de Janeiro State University, Rio de Janeiro, Brazil.

Background: Vitamin A deficiency (VAD) and anemia are the most prevalent nutritional deficiency in children globally. The dried blood spot (DBS) method has been used in prevalence studies of VAD and anemia in different age groups. However, it has not yet been validated for children. Read More

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Both high and low pre-infection glucose levels associated with increased risk for severe COVID-19: New insights from a population-based study.

PLoS One 2021 22;16(7):e0254847. Epub 2021 Jul 22.

Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Importance: Patients with diabetes are known to be at increased risk for infections including severe coronavirus disease 2019 (COVID-19) but the relationship between COVID-19 severity and specific pre-infection glucose levels is not known.

Objective: To assess the differential effects of pre-infection glucose levels on the risk for severe COVID-19 amongst patients with and without diabetes.

Design: Population based historical cohort study. Read More

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Prospective screening of liver fibrosis in a primary care cohort using systematic calculation of fib-4 in routine results.

PLoS One 2021 22;16(7):e0254939. Epub 2021 Jul 22.

Hepato-Gastroenterology Department, Hôpital Saint-Joseph, Marseille, France.

Background & Aim: Liver fibrosis screening in primary care population is a major public health issue. The FIB-4 index is a simple non-invasive fibrosis test combining age, transaminases, platelets count, developed for the diagnosis of advanced fibrosis. The aim of our study was to evaluate the interest of liver fibrosis screening using systematic calculation of FIB-4 in routine blood analysis. Read More

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Mortality and associated risk factors of COVID-19 infection in dialysis patients in Qatar: A nationwide cohort study.

PLoS One 2021 22;16(7):e0254246. Epub 2021 Jul 22.

Hamad Medical Corporation, Doha, Qatar.

Context: Patients on maintenance dialysis are more susceptible to COVID-19 and its severe form. We studied the mortality and associated risks of COVID-19 infection in dialysis patients in the state of Qatar.

Methods: This was an observational, analytical, retrospective, nationwide study. Read More

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Factors associated with mortality in patients hospitalized with COVID-19: A prospective cohort in a Peruvian national referral hospital.

Medwave 2021 Jul 5;21(6):e8231. Epub 2021 Jul 5.

Escuela de Medicina, Universidad Científica del Sur, Lima, Perú. ORCID: 0000-0001-6386-6643.

Objectives: To describe and assess clinical characteristics and factors associated with mortality in adult patients with COVID-19 admitted to a national referral hospital in Peru.

Methods: We conducted a prospective cohort study that included hospitalized patients older than 18 years with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosis. Patients with a positive rapid serological test on admission but no respiratory symptoms nor compatible images were excluded. Read More

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Late onset of microbial keratitis after laser in situ keratomileusis surgery: case series.

J Cataract Refract Surg 2021 Aug;47(8):1044-1049

From the Sydney Eye Hospital (Garcerant, Cabrera-Aguas, Khoo, Watson); The University of Sydney (Cabrera-Aguas, Khoo, Watson), Save Sight Institute, Discipline of Ophthalmology, Faculty of Medicine and Health, Sydney, New South Wales, Australia.

Purpose: To report predisposing factors, clinical features, microbiology spectrum, antibiotic resistance, antimicrobial therapy, and outcomes of patients with a previous laser in situ keratomileusis (LASIK) surgery and diagnosed with presumed microbial keratitis.

Setting: Sydney Eye Hospital, Sydney, New South Wales, Australia.

Design: Retrospective case review. Read More

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Revision Total Joint Arthroplasty: Final Stop Tertiary Referral Center.

Orthopedics 2021 Jul-Aug;44(4):e477-e481. Epub 2021 Jul 1.

High complication rates associated with revision total knee arthroplasty (TKA) and total hip arthroplasty (THA) may unequally burden tertiary referral centers, which manage medically complex patients. The authors aimed to quantify TKA and THA referral patterns at a tertiary referral center based on travel distance and patient comorbidities. All patients who underwent primary or revision TKA or THA at the investigating institution from 2012 to 2016 were identified. Read More

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The Comparative Effect of Age on Clinical Outcomes Following Anatomic Total Shoulder Arthroplasty and Reverse Total Shoulder Arthroplasty.

Orthopedics 2021 Jul-Aug;44(4):e600-e606. Epub 2021 Jul 1.

At many institutions, the pendulum has swung toward reverse total shoulder arthroplasty (RTSA). Good results have been reported for patients older than 65 years with glenohumeral osteoarthritis with an intact rotator cuff, leading to questioning of the role of anatomic total shoulder arthroplasty (TSA) in the elderly. The purpose of this study was to compare outcome measures between TSA and RTSA patients using minimal clinically important difference (MCID) and substantial clinical benefit (SCB) as a function of age. Read More

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Risk of Late-Onset Breast Cancer in Genetically Predisposed Women.

J Clin Oncol 2021 Jul 22:JCO2100531. Epub 2021 Jul 22.

Fred Hutchinson Cancer Research Center, Seattle, WA.

Purpose: The prevalence of germline pathogenic variants (PVs) in established breast cancer predisposition genes in women in the general population over age 65 years is not well-defined. However, testing guidelines suggest that women diagnosed with breast cancer over age 65 years might have < 2.5% likelihood of a PV in a high-penetrance gene. Read More

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Spectrum of BCR-ABL Mutations and Treatment Outcomes in Ethiopian Imatinib-Resistant Patients With Chronic Myeloid Leukemia.

JCO Glob Oncol 2021 Jul;7:1187-1193

Fred Hutchinson Cancer Research Center, Seattle, WA.

Purpose: Despite the successes achieved in chronic myeloid leukemia (CML) with tyrosine kinase inhibitor (TKI) therapy, resistance remains an obstacle. The most common mechanism of resistance is the acquisition of a point mutation in the BCR-ABL kinase domain. Few studies have reported African patients with CML in regard to such mutations. Read More

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Prenatal stomach position and volume in relation to postnatal outcomes in left-sided congenital diaphragmatic hernia.

Prenat Diagn 2021 Jul 22. Epub 2021 Jul 22.

Department of Obstetrics and Gynecology, Division of Obstetrics and Fetal Medicine, Erasmus MC-Sophia Children's Hospital University Medical Center Rotterdam, Rotterdam, The Netherlands.

Objective: To examine the association between prenatal stomach position (SP) grade and stomach volume (SV) and the need for pulmonary hypertension (PH) treatment after birth in prenatally diagnosed left-sided congenital diaphragmatic hernia (CDH), live born >34 weeks.

Methods: In retrospect, SP grade and SV were determined in fetuses with isolated left-sided CDH from 19 weeks gestational age (GA) onwards at three different time periods (≤24 weeks' GA: US1, 24-30 weeks' GA: US2; ≥30 weeks' GA: US3). Primary outcome was need for treatment of PH after birth. Read More

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