129,562 results match your criteria diabetic patients

Understanding the increased risk of infections in diabetes: innate and adaptive immune responses in type 1 diabetes.

Metabolism 2021 May 7:154795. Epub 2021 May 7.

Department of Internal Medicine (463), Radboud University Medical Center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands.

Aims: Patients with diabetes have a higher incidence of infections with Candida albicans, Staphylococcus aureus and Mycobacterium tuberculosis, yet factors contributing to this increased risk are largely unknown. We hypothesize that altered innate and adaptive immune responses during diabetes contribute to an increased susceptibility to infections.

Materials And Methods: We studied cytokine responses to ex vivo pathogenic stimulations in a cohort with type 1 diabetes (n = 243) and non-diabetic healthy control subjects (n = 56) using isolated peripheral blood mononuclear cells (PBMCs). Read More

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Not so sweet and simple: impacts of SARS-CoV-2 on the β cell.

Islets 2021 May 10:1-14. Epub 2021 May 10.

Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, USA.

The link between COVID-19 infection and diabetes has been explored in several studies since the start of the pandemic, with associations between comorbid diabetes and poorer prognosis in patients infected with the virus and reports of diabetic ketoacidosis occurring with COVID-19 infection. As such, significant interest has been generated surrounding mechanisms by which the virus may exert effects on the pancreatic β cells. In this review, we consider possible routes by which SARS-CoV-2 may impact β cells. Read More

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Clinical and pathological analysis of renal biopsies of elderly patients in Northeast China: a single-center study.

Ren Fail 2021 Dec;43(1):851-859

The Department of Nephropathy, The Second Hospital of Jilin University, Changchun, China.

Purpose: To identify the clinical characteristics, histopathological features, and prognosis of kidney disease in a large cohort of elderly patients from Northeast China.

Methods: We retrospectively analyzed the renal disease spectrum in 7,122 patients who underwent renal biopsies at the Second Hospital of Jilin University from 2006 to 2020. Patients were grouped according to age: below 60 years (non-elderly group,  = 5923) and at least 60 years (elderly group,  = 1199). Read More

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December 2021

Disease related changes in vocal parameters of patients with type 2 diabetes mellitus.

Logoped Phoniatr Vocol 2021 May 10:1-7. Epub 2021 May 10.

Department of Otolaryngology, Gazi University, Ankara, Turkey.

Background: As the duration of diabetes progresses, various disease related complications might occur in patients. The main goal of this paper is to compare acoustic and aerodynamic measures of patients with type 2 diabetes mellitus (T2DM) with a control group of healthy subjects.

Methods: A total of 91 subjects, 51 individuals with type 2 diabetes mellitus (DM group) and 40 healthy volunteers (HV group) were participated in the study. Read More

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Diabetes: Device Therapy.

FP Essent 2021 May;504:28-33

University of Central Florida College of Medicine, 6850 Lake Nona Blvd, Orlando, FL 32827.

Insulin pumps, continuous glucose monitors (CGMs), and hybrid closed-loop insulin pumps with CGMs are available for the management of type 1 diabetes in patients of all ages and type 2 diabetes in patients treated with multiple daily injections of insulin. These devices have numerous benefits for patients, including improved diabetes control, fewer hypoglycemia and diabetic ketoacidosis events, and improved quality of life. Currently, there are seven insulin pumps on the US market, five CGMs, and four closed-loop systems. Read More

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Recent advances in the induced pluripotent stem cell-based skin regeneration.

Wound Repair Regen 2021 May 10. Epub 2021 May 10.

Department of Applied Biology, Council of Scientific & Industrial Research-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, India.

Skin regeneration has been a challenging clinical problem especially in cases of chronic wounds such as diabetic foot ulcers, and epidermolysis bullosa-related skin blisters. Prolonged non-healing wounds often lead to bacterial infections increasing the severity of wounds. Current treatment strategies for chronic wounds include debridement of wounds along with antibiotics, growth factors, and stem cell transplantation therapies. Read More

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Pre-operative glycaemic control and long-term survival in diabetic patients after coronary artery bypass grafting.

Eur J Cardiothorac Surg 2021 May 10. Epub 2021 May 10.

Surgical Services, Louis Stokes Cleveland VA Medical Center, VA Northeast Ohio Healthcare System, Cleveland, OH, USA.

Objectives: We analysed the Veteran Affairs data to evaluate the association of pre-operative glycated haemoglobin (HbA1c) and long-term outcome after isolated coronary artery bypass grafting (CABG).

Methods: Veterans with diabetes mellitus and isolated CABG (2006-2018) were divided into 4 groups (I: HbA1c <6.5%, II: HbA1c 6. Read More

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Adverse Events of Sodium-Glucose Cotransporter-2 Inhibitors in Chronic Kidney Disease: A Retrospective Chart Review.

Perm J 2021 May;25

Department of Nephrology, Kaiser Permanente West Los Angeles Medical Center, Los Angeles, CA.

Background: The renal benefits of sodium-glucose cotransporter-2 inhibitors (SGLT2) are now well established, and these agents are recommended by the American Diabetes Association and Kidney Disease: Improving Global Outcomes guidelines for patients with type 2 diabetes and chronic kidney disease. However, the safety profile of SGLT2 inhibitors in chronic kidney disease is not as clear. We describe the adverse event rates of SGLT2 inhibitors, primarily empagliflozin, in Kaiser Permanente Southern California members with diabetic kidney disease. Read More

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Prevalence and determinants of poor glycaemic control amongst patients with diabetes followed at Vanga Evangelical Hospital, Democratic Republic of the Congo.

Afr J Prim Health Care Fam Med 2021 Apr 30;13(1):e1-e6. Epub 2021 Apr 30.

Department of Family Medicine, Faculty of Medicine, Protestant University of Congo, Kinshasa.

Background: The prevalence of diabetes mellitus is increasing dramatically in developing countries, where diabetic patients usually present with poor glycaemic control, leading to complications and worsening the prognosis.

Aim: The aim of this study was to determine the extent of poor glycaemic control and its determinants in diabetic patients.

Setting: The study was conducted in a rural area of the province of Kwilu, Democratic Republic of the Congo. Read More

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Sodium-glucose co-transporter-2 inhibitor-associated euglycemic diabetic ketoacidosis that prompted the diagnosis of fulminant type-1 diabetes: A case report.

World J Clin Cases 2021 May;9(13):3163-3169

Department of Diabetes, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.

Background: Fulminant type 1 diabetes mellitus (FT1DM) is a subtype of type 1 diabetes mellitus characterized by an abrupt onset and a rapid and complete functional loss of islet β cells. It is a very rare disease generally associated with ketoacidosis and the absence of circulating pancreatic islet-related autoantibodies. Diabetic ketoacidosis with normal blood glucose levels has been reported during sodium-glucose co-transporter 2 (SGLT2) inhibitor therapy. Read More

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Successful endoscopic surgery for emphysematous pyelonephritis in a non-diabetic patient with autosomal dominant polycystic kidney disease: A case report.

World J Clin Cases 2021 Apr;9(12):2862-2867

Department of Surgery, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, Guangdong Province, China.

Background: Emphysema pyelonephritis (EPN) is a very dangerous type of urinary tract infection. It is a lethal disease that develops rapidly and causes the patient to deteriorate rapidly, and it can easily lead to systemic infections and even sepsis. The incidence is extremely low, and it is prevalent in patients with diabetes. Read More

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Single-Nucleus Transcriptomic Analysis Reveals Important Cell Cross-Talk in Diabetic Kidney Disease.

Front Med (Lausanne) 2021 21;8:657956. Epub 2021 Apr 21.

Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Diabetic kidney disease (DKD) leads to the loss of renal function and cell cross-talk is one of the crucial mechanisms participating in the pathogenesis of DKD. However, the mechanisms of cell communication were not fully elucidated in previous studies. In this study, we performed cell cross-talk analysis using CellPhoneDB based on a single-nucleus transcriptomic dataset (GSE131882) and revealed the associations between cell communication-related genes and renal function, providing overall insight into cell communication in DKD. Read More

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Role of Prucalopride in Treating Functional Constipation and Gastroparesis: A Systemic Review.

Cureus 2021 Apr 5;13(4):e14306. Epub 2021 Apr 5.

Anesthesiology, Bahawal Victoria Hospital, Quaid-E-Azam Medical College, Bahawalpur, PAK.

Prucalopride is a selective serotonin receptor agonist that can be used to treat chronic constipation. This article reviews the clinical efficacy side effects of prucalopride, assessing its role in constipation and gastroparesis. Relevant published medical literature was identified by using the search terms "constipation," "gastroparesis," and "prucalopride" from 2010 and onwards. Read More

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Post-Operative Euglycemic Diabetic Ketoacidosis in a Patient With SGLT-2 Inhibitor Use and Recent Sleeve Gastrectomy.

Cureus 2021 Apr 5;13(4):e14297. Epub 2021 Apr 5.

Department of Surgery, Ascension St. John Hospital, Detroit, USA.

A 51-year-old woman with type 2 diabetes mellitus developed euglycemic diabetic ketoacidosis (euDKA) in the post-operative setting after robotic-assisted sleeve gastrectomy. She developed tachycardia on post-operative day (POD) 1 before developing altered mental status and tachypnea on POD 2. The diagnosis was ultimately made by discovering ketonuria in the setting of anion gap metabolic acidosis despite repeatedly normal blood glucose levels. Read More

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A Novel Resolution of Diabetes: C-C Chemokine Motif Ligand 4 Is a Common Target in Different Types of Diabetes by Protecting Pancreatic Islet Cell and Modulating Inflammation.

Front Immunol 2021 23;12:650626. Epub 2021 Apr 23.

Department and Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Systemic inflammation is related to hyperglycemia in diabetes mellitus (DM). C-C chemokine motif ligand (CCL) 4 is upregulated in type 1 & type 2 DM patients. This study aimed to investigate if CCL4 could be a potential target to improve blood sugar control in different experimental DM models. Read More

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OCT Hyperreflective Retinal Foci in Diabetic Retinopathy: A Semi-Automatic Detection Comparative Study.

Front Immunol 2021 22;12:613051. Epub 2021 Apr 22.

IRCCS-Fondazione Bietti, Rome, Italy.

Optical coherence tomography (OCT) allows us to identify, into retinal layers, new morphological entities, which can be considered clinical biomarkers of retinal diseases. According to the literature, solitary, small (<30 µm), medium level hyperreflective (similar to retinal fiber layer) retinal foci (HRF) may represent aggregates of activated microglial cells and an biomarker of retinal inflammation. The identification and quantification of this imaging biomarker allows for estimating the level and possibly the amount of intraretinal inflammation in major degenerative retinal disorders, whose inflammatory component has already been demonstrated (diabetic retinopathy, age-related macular degeneration, radiation retinopathy). Read More

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Reduced Mortality Associated With the Use of Metformin Among Patients With Autoimmune Diseases.

Front Endocrinol (Lausanne) 2021 23;12:641635. Epub 2021 Apr 23.

Division of Rheumatology, Allergy, and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Objective: Metformin has been linked to anti-proliferative and anti-inflammatory mechanisms. In this study, we aimed to examine the long-term impact of metformin on mortality and organ damage in patients with autoimmune diseases and type 2 diabetes mellitus (T2DM).

Methods: We conducted a cohort study using the National Health Insurance Research Database in Taiwan between 1997 and 2013. Read More

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The Impact of Glycemic Control on Retinal Photoreceptor Layers and Retinal Pigment Epithelium in Patients With Type 2 Diabetes Without Diabetic Retinopathy: A Follow-Up Study.

Front Endocrinol (Lausanne) 2021 23;12:614161. Epub 2021 Apr 23.

Diabetes and Vascular Research Centre (DVRC), NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, United Kingdom.

Aims: To establish the sequential changes by glycemic control in the mean thickness, volume and reflectance of the macular photoreceptor layers (MPRLs) and retinal pigment epithelium in patients with type 2 diabetes without diabetic retinopathy.

Methods: Thirty-one poorly controlled (HbA1c > 8.0%) patients with type 2 diabetes without diabetic retinopathy undergoing glycemic control and 39 control subjects with normal HbA1c levels (< 5. Read More

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Therapeutic Effect of Epidermal Growth Factor Combined With Nano Silver Dressing on Diabetic Foot Patients.

Front Pharmacol 2021 23;12:627098. Epub 2021 Apr 23.

Department of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

To investigate the clinical efficacy of epidermal growth factor combined with nano silver dressing in the treatment of diabetic foot wounds. A total of 160 patients with diabetic foot ulcers admitted to the Second Affiliated Hospital of Nanchang University from 2015-06 to 2018-06 were selected to participate in the experiment. A randomized table method was used to randomly divide 160 patients into 4 groups: 40 in the epidermal growth factor group, 40 in the nano-silver dressing group, 40 in the combined group, and 40 in the saline control group (normal saline). Read More

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Rhinomaxillary mucormycosis presenting as palatal ulcer: A case report with comprehensive pathophysiology.

J Oral Maxillofac Pathol 2020 Sep-Dec;24(3):558-562. Epub 2021 Jan 9.

Department of Oral Medicine Geetanjali Dental and Research Institute, Udaipur, Rajasthan, India.

Mucormycosis is an emerging fungal infection which has exceptionally high mortality rates in immunocompromised patients and remains a life-threatening infection in uncontrolled diabetics. The reported cases in literature may be less in number due to its frequent misdiagnosis. Imaging techniques in the early stages are usually nondiagnostic and cytological smears are not very reliable, thus, the gold standard for definitive diagnosis remains with the histopathological examination. Read More

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January 2021

Acute fixation of displaced intra-articular calcaneus fractures is safe using the sinus tarsi approach.

J Orthop Trauma 2021 Mar 16. Epub 2021 Mar 16.

Department of Orthopaedic Surgery, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106.

Objective: Analyze the correlation between surgical timing and outcomes for calcaneus fractures treated using a sinus tarsi approach (STA).

Setting: Single level 1 Trauma Center.

Design: Retrospective. Read More

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Effect of advanced glycation end products on autophagic ability in osteoblasts.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Apr;46(4):361-367

Department of Orthodontics, Stomatological Hospital of Chongqing Medical University, Chongqing 401145.

Objectives: Excessive production of AGEs in diabetic patients will affect the normal function of osteoblasts, and this process may be related to autophagy of osteoblasts. This study aims to explore the effect of advanced glycation end products (AGEs) on autophagic activity during osteogenic differentiation in rat bone marrow mesenchymal stem cells (BMSCs).

Methods: BMSCs were isolated and cultured in vitro, treated with different concentrations (0, 50, 100, 200, and 400 mg/L) of AGEs for different time (3, 6, 12, 24, 48, and 72 h). Read More

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Ranibizumab for the treatment of diabetic retinopathy.

Expert Opin Biol Ther 2021 May 8. Epub 2021 May 8.

2 Department of Ophthalmology, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Introduction: Diabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus and the leading cause of blindness in young adults. Prior to anti-vascular endothelial growth factor (anti-VEGF) agents, the treatment of DR was based on control of systemic factors and laser photocoagulation. During the past decade, the use of anti-VEGF agents has revolutionized the treatment of DR, including diabetic macular edema (DME). Read More

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Contribution of rs3211938 polymorphism at CD36 to glucose levels, oxidized low-density lipoproteins, insulin resistance, and body mass index in Mexican mestizos with type-2 diabetes from western Mexico.

Nutr Hosp 2021 May 10. Epub 2021 May 10.

Facultad de Ciencias de la Salud. Universidad Juárez del Estado de Durango.

Background: type-2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia, insulin resistance (IR), and abnormal fatty acid metabolism in which the CD36 receptor has been implicated in glucose and lipid dysregulation.

Objective: to evaluate the contribution of polymorphism CD36 rs3211938 to metabolic profile in T2DM Mexican mestizos from western Mexico.

Methods: we included 115 individuals classified as non-T2DM (NT2DM) adults and T2DM patients. Read More

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The combined impact of ankle-brachial index and transcutaneous oxygen pressure on mortality in patients with type 2 diabetes and foot ulcers.

Acta Diabetol 2021 May 8. Epub 2021 May 8.

Clinical Sciences in Lund, Lund University, Lund, Sweden.

Aims: A diabetic foot ulcer (DFU) is associated with increased cardiovascular risk and mortality, independently of ulcer etiology (ischemic, neuro-ischemic or neuropathic). Ankle-brachial index (ABI) is the most commonly used test when diagnosing peripheral macrovascular disease and is a well-known marker for increased cardiovascular risk. Transcutaneous oxygen pressure (TcPO) is considered to better evaluate microvascular function and has in previous studies shown correlations with both wound healing and survival. Read More

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Staphylococcus aureus clones causing osteomyelitis; a literature review (2000-2020).

J Glob Antimicrob Resist 2021 May 6. Epub 2021 May 6.

Department of Infectious Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

Objectives: Staphylococcus aureus is the most common causative organism of osteomyelitis (OM). Nevertheless, the molecular epidemiology of S. aureus causing OM remains ill-defined. Read More

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Long-Term Administration of Metformin Ameliorates Age-Dependent Oxidative Stress and Cognitive Function in Rats.

Behav Brain Res 2021 May 6:113343. Epub 2021 May 6.

Department of Anatomy, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran; Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. Electronic address:

Background: Aging is an inevitable physiological process, associated with a decline in cognitive function. Recently, metformin, as the first-line treatment for type II diabetes, has been shown to increase the life expectancy of diabetic patients. Therefore, researchers are paying increasing attention to its anti-aging properties. Read More

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[Diabetes and COVID-19].

Therapie 2020 Apr 23. Epub 2020 Apr 23.

Département de pharmacologie médicale et toxicologie, Centre régional de pharmacovigilance Occitanie-Est, CHU Montpellier, 371, avenue du Doyen Gaston Giraud, 34295 Montpellier, France. Electronic address:

According to previous reports, diabetes seems to be associated with serious clinical events due to COVID-19. But is diabetes per se a risk factor of being infected by the virus? We discuss these points. Data about the antidiabetic drugs are scarce. Read More

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An investigation of the diet, exercise, sleep, BMI, and health outcomes of autistic adults.

Mol Autism 2021 May 8;12(1):31. Epub 2021 May 8.

Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18B Trumpington Road, Cambridge, England, CB2 8AH.

Background: Studies of autistic children suggest that restricted eating, reduced physical activity, and sleep disorders are common; however, no studies attempt to broadly describe the diet, exercise, and sleep patterns of autistic adults or consider relationships between lifestyle behaviors and the widely reported increased risks of obesity and chronic conditions. To address this, the authors developed the largest study of lifestyle patterns of autistic adults and assessed their relationships to body mass index, health outcomes, and family history.

Methods: We administered an anonymized, online survey to n = 2386 adults (n = 1183 autistic) aged 16-90 years of age. Read More

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Methylglyoxal Drives a Distinct, Nonclassical Macrophage Activation Status.

Thromb Haemost 2021 May 9. Epub 2021 May 9.

Institute for Diabetes and Cancer, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.

Metabolic complications in diabetic patients are driven by a combination of increased levels of nutrients and the presence of a proinflammatory environment. Methylglyoxal (MG) is a toxic byproduct of catabolism and has been strongly associated with the development of such complications. Macrophages are key mediators of inflammatory processes and their contribution to the development of metabolic complications has been demonstrated. Read More

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