36,759 results match your criteria diabetic nephropathy

USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells.

Biochem Pharmacol 2021 Apr 12:114562. Epub 2021 Apr 12.

Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou 510006, China. Electronic address:

Epithelial-to-mesenchymal transition (EMT) plays an important role in diabetic nephropathy (DN). Ubiquitin-specific protease 9X (USP9X/FAM) is closely linked to TGF-β and fibrosis signaling pathway. However, it remains unknown whether USP9X is involved in the process of EMT in DN. Read More

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Association of Nuclear Factor Erythroid-2-Related Actor 2 Gene Polymorphisms with Diabetic Nephropathy in Chinese Patients.

Int J Gen Med 2021 7;14:1231-1237. Epub 2021 Apr 7.

Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People's Republic of China.

Aim: Nuclear factor erythroid-2-related factor 2 (NRF2) has emerged as a therapeutic target in many diseases. To explore this further, we evaluated the relationships between the -617C/A (rs6721961) polymorphisms within the NRF2 promoter and diabetic nephropathy (DN) in Chinese Han patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 883 subjects with T2DM (500 without and 383 with DN) were enrolled in this study. Read More

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Could NAD Precursor Supplements Induce a Legacy of Protection against Diabetic Nephropathy?

J Am Soc Nephrol 2021 Apr 14. Epub 2021 Apr 14.

Regenerative Medicine Institute at CÚRAM Centre for Research in Medical Devices, School of Medicine, National University of Ireland Galway, Galway, Ireland.

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Long Noncoding RNAs and Their Therapeutic Promise in Diabetic Nephropathy.

Nephron 2021 Apr 14:1-11. Epub 2021 Apr 14.

Section of Nephrology, Division of Internal Medicine, The University of Texas at MD Anderson Cancer Center, Houston, Texas, USA.

Recent advances in large-scale RNA sequencing and genome-wide profiling projects have unraveled a heterogeneous group of RNAs, collectively known as long noncoding RNAs (lncRNAs), which play central roles in many diverse biological processes. Importantly, an association between aberrant expression of lncRNAs and diverse human pathologies has been reported, including in a variety of kidney diseases. These observations have raised the possibility that lncRNAs may represent unexploited potential therapeutic targets for kidney diseases. Read More

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Acute Kidney Injury Associated With Semaglutide.

Kidney Med 2021 Mar-Apr;3(2):282-285. Epub 2021 Jan 7.

VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM.

Case reports of acute kidney injury in patients taking the glucagon-like peptide 1 (GLP-1) receptor agonists exenatide and liraglutide have been reported. We report 2 patients with chronic kidney disease due to diabetic kidney disease who experienced rapid worsening of kidney function and increased proteinuria after being prescribed the GLP-1 receptor agonist semaglutide. In 1 patient, kidney biopsy showed advanced diffuse and nodular glomerulosclerosis accompanied by interstitial lymphoplasmacytic and eosinophilic infiltrate and evidence of acute tubular injury. Read More

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January 2021

Changes of serum advanced glycation end products (AGEs), matrix metalloprotein-2 (MMP-2), and urinary microalbuminuria (mALB) in diabetic nephropathy and their predictive value for heart failure.

Transl Androl Urol 2021 Mar;10(3):1279-1285

Department of Nephrology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Diabetic nephropathy is a common complication in diabetic patients, with a high rate of disability and mortality. This study aims to explore the changes in serum advanced glycation end products (AGEs), matrix metalloprotein-2 (MMP-2), and urinary microalbuminuria (mALB) in diabetic nephropathy and their predictive value for heart failure.

Methods: The 134 patients with diabetic nephropathy treated in our hospital from January 2014 to December 2017 were enrolled and divided into two groups resulting in 64 cases in an observation group with heart failure, and 70 cases without heart failure in a control group. Read More

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A Web of Science-based scientometric analysis about mammalian target of rapamycin signaling pathway in kidney disease from 1986 to 2020.

Transl Androl Urol 2021 Mar;10(3):1006-1017

Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Background: The mammalian target of rapamycin (mTOR) signaling pathway is vital for the regulation of cell metabolism, growth and proliferation in the kidney. This study aims to show current research focuses and predict future trends about mTOR pathway in kidney disease by the methods of scientometric analysis.

Methods: We referred to publications from the Web of Science Core Collection (WoSCC) Database. Read More

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Metformin attenuates diabetic renal injury via the AMPK-autophagy axis.

Exp Ther Med 2021 Jun 31;21(6):578. Epub 2021 Mar 31.

Department of Nephrology, General Hospital of Daqing Oil Field, Daqing, Heilongjiang 163001, P.R. China.

Diabetic nephropathy (DN) is a clinical condition characterized by kidney damage that is observed in patients with diabetes. DN is the main cause of end-stage renal disease (ESRD), which is the final stage of chronic kidney disease. Increasing evidence suggests that metformin, a characteristic oral hypoglycemic drug used for treating diabetes, exerts beneficial effects on various medical conditions and diseases, including cancer, cardiovascular diseases and thyroid-related disorders. Read More

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Urinary Growth Differentiation Factor-15 (GDF15) levels as a biomarker of adverse outcomes and biopsy findings in chronic kidney disease.

J Nephrol 2021 Apr 13. Epub 2021 Apr 13.

IIS-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Madrid, Spain.

Background: Growth Differentiation Factor-15 (GDF15) is a member of the TGF-β superfamily. Increased serum GDF15 has been associated with increased risk of chronic kidney disease (CKD) progression. However, no prior studies have addressed the significance of urinary GDF15 in adult CKD. Read More

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Ganoderma lucidum ameliorates the diabetic nephropathy via down-regulatory effect on TGFβ-1 and TLR-4/NFκB signalling pathways.

J Pharm Pharmacol 2021 Apr 13. Epub 2021 Apr 13.

Department of Biochemistry, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.

Objectives: Diabetic nephropathy (DN) is one of the most important complications of diabetes mellitus and it is considered as a principal cause for end-stage renal failure. Ganoderma lucidum (GL) has been studied for its reno-protective effect against different kidney injury models. The aim of our study is to investigate the mechanisms by which GL can improve kidney injury and consequent renal inflammation and fibrosis. Read More

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Rapidly destructive coxopathy due to dialysis amyloidosis: a case report.

Mod Rheumatol Case Rep 2021 Apr 15:1-5. Epub 2021 Apr 15.

Department of Orthopaedic Surgery and Rheumatology, Toho University Sakura Medical Center, Chiba, Japan.

Rapidly destructive coxopathy (RDC) is a disease that is sometimes seen in geriatric patients. A total hip arthroplasty (THA) is mostly chosen to treat the RDC, but few cases are known that received THAs due to RDC associated with dialysis amyloidosis. We report a case of RDC due to dialysis amyloidosis with special references to its pathophysiology. Read More

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An update on the role of miR-379 in human disorders.

Biomed Pharmacother 2021 Apr 10;139:111553. Epub 2021 Apr 10.

Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

miR-379 is a miRNA transcribed from the MIR379 locus on 14q32.31. This miRNA is located in an evolutionarily conserved miRNA cluster in an imprinted region that contains DLK1 and DIO3 genes. Read More

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Screening Tools Based on Nomogram for Diabetic Kidney Diseases in Chinese Type 2 Diabetes Mellitus Patients.

Diabetes Metab J 2021 Apr 13. Epub 2021 Apr 13.

ADR Monitoring Department, Henan Medical Products Administration & Center for ADR Monitoring of Henan, Zhengzhou, China.

Background: The influencing factors of diabetic kidney disease (DKD) in Chinese patients with type 2 diabetes mellitus (T2DM) were explored to develop and validate a DKD diagnostic tool based on nomogram approach for patients with T2DM.

Methods: A total of 2,163 in-hospital patients with diabetes diagnosed from March 2015 to March 2017 were enrolled. Specified logistic regression models were used to screen the factors and establish four different diagnostic tools based on nomogram according to the final included variables. Read More

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MiR-138 plays an important role in diabetic nephropathy through SIRT1-p38-TTP regulatory axis.

J Cell Physiol 2021 Apr 12. Epub 2021 Apr 12.

Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Diabetic nephropathy (DN) is the main cause of chronic kidney disease (CKD) and is one of the most common and serious complications of diabetes mellitus (DM). Sirtuin 1 (SIRT1) and tristetraprolin (TTP) are two important protective factors in DN; however, the regulatory relationship between SIRT1 and TTP, and the underneath mechanism are interesting but still unclear. Identifying the key factors that regulate SIRT1 or TTP may be of great value to the understanding and treatment of the DN. Read More

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Glomerular Endothelial Cell Crosstalk With Podocytes in Diabetic Kidney Disease.

Front Med (Lausanne) 2021 24;8:659013. Epub 2021 Mar 24.

Université de Paris, Paris Cardiovascular Center, Inserm, Paris, France.

Diabetes is the main cause of renal failure worldwide. Complications of the kidney micro-and macro-circulation are common in diabetic patients, leading to proteinuria and can progress to end-stage renal disease. Across the complex interplays aggravating diabetes kidney disease progression, lesions of the glomerular filtration barrier appear crucial. Read More

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miR-30a-5p targets Becn1 to ameliorate high-glucose-induced glomerular podocyte injury in immortalized rat podocyte cell line.

Am J Transl Res 2021 15;13(3):1516-1525. Epub 2021 Mar 15.

Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai, China.

Objective: Diabetic nephropathy (DN) is a serious kidney-based complication of diabetes, wherein podocyte injury is deemed crucial in the development of early stage. Various miRNAs, as report goes, is involved in the pathogenesis of varieties of kidney diseases including DN. In this study, we found a target relationship between miR-30a-5p and Becn1, of which there are few studies about the role in podocyte injury. Read More

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Association Between Lipoprotein (A) and Diabetic Nephropathy in Patients With Type 2 Diabetes Mellitus: A Meta-Analysis.

Front Endocrinol (Lausanne) 2021 24;12:633529. Epub 2021 Mar 24.

Department of Endocrinology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.

Background: Lipoprotein (a) [Lp (a)] has been well recognized as a risk factor of cardiovascular disease. However, the association between serum Lp (a) and diabetic nephropathy in patients with type 2 diabetes mellitus (T2DM) remains unknown. We performed a meta-analysis to comprehensively evaluate the above association. Read More

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Recurrent Glomerulonephritis in the Kidney Allograft.

Indian J Nephrol 2020 Nov-Dec;30(6):359-369. Epub 2020 Nov 30.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Renal transplantation is the preferred form of renal replacement therapy in patients who develop end-stage kidney disease (ESKD). Among the diverse etiologies of ESKD, glomerulonephritis is the third most common cause, behind hypertensive and diabetic kidney disease. Although efforts to prolong graft survival have improved over time with the advent of novel immunosuppression, recurrent glomerulonephritis remains a major threat to renal allograft survival despite concomitant immunosuppression. Read More

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November 2020

Role of dietary modifications in the management of type 2 diabetic complications.

Pharmacol Res 2021 Apr 7:105602. Epub 2021 Apr 7.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, India. Electronic address:

Diabetes is a chronic metabolic disorder with a high rate of morbidity and mortality. Insufficient insulin secretion and insulin action are two major causes for the development of diabetes, which is characterized by a persistent increase in blood glucose level. Diet and sedentary life style play pivotal role in development of vascular complications in type 2 diabetes. Read More

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Lower heart failure and chronic kidney disease risks associated with sodium-glucose cotransporter-2 inhibitor use in Japanese type 2 diabetes patients without established cardiovascular and renal diseases.

Diabetes Obes Metab 2021 Apr;23 Suppl 2:19-27

Cardiovascular, Renal, and Metabolism, Medical Affairs, AstraZeneca K.K., Osaka, Japan.

Aims: To examine heart failure (HF) and chronic kidney disease (CKD) risks reduction associated with sodium-glucose cotransporter-2 inhibitors (SGLT-2i) compared to other glucose-lowering drugs (oGLD) in the early stage of type 2 diabetes patients without established cardiovascular or renal diseases (CVRD-free T2D).

Materials And Methods: We performed an observational cohort study using a Japanese hospital claims registry, Medical Data Vision. CVRD-free T2D patients were identified between 1 April 2014 and 30 September 2018. Read More

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Fish oil replacement prevents, while docosahexaenoic acid-derived protectin DX mitigates end-stage-renal-disease in atherosclerotic diabetic mice.

FASEB J 2021 May;35(5):e21559

Quebec Heart and Lung Institute, Laval University, Quebec, QC, Canada.

Diabetic nephropathy (DN) remains the major cause of end-stage renal disease (ESRD). We used high-fat/high-sucrose (HFHS)-fed LDLr /ApoB mice with transgenic overexpression of IGFII in pancreatic β-cells (LRKOB100/IGFII) as a model of ESRD to test whether dietary long chain omega-3 polyunsaturated fatty acids LCω3FA-rich fish oil (FO) could prevent ESRD development. We further evaluated the potential of docosahexaenoic acid (DHA)-derived pro-resolving lipid mediators, 17-hydroxy-DHA (17-HDHA) and Protectin DX (PDX), to reverse established ESRD damage. Read More

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The Prevalence of Diabetic Microvascular Complications in China and the USA.

Curr Diab Rep 2021 Apr 9;21(6):16. Epub 2021 Apr 9.

Renal Division, Department of Medicine, Peking University First Hospital, 8 Xishiku Street, Xicheng District, Beijing, 100034, China.

Purpose Of Review: Diabetes can lead to development of devastating microvascular complications, such as nephropathy, retinopathy, and peripheral sensory and autonomic neuropathy. While China and the USA both face the threat of this major public health challenge, the literature is limited in describing similarities and differences in the prevalence, and risk factors for the development, of diabetic microvascular complications between these two countries.

Recent Findings: The current review discusses the following: (1) the most recent evidence on prevalence of diabetic microvascular complications in China and the USA (including downtrends of diabetes retinopathy and neuropathy in the USA); (2) differences in patient risk factors of these complications; (3) challenges and current knowledge gaps (such as lacking national epidemiological data of diabetic complications in China); and (4) potential future clinical and research opportunities (including needs in diabetes evaluation and management in remote areas and standardization of methods in evaluating diabetic complications across countries). Read More

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Pregnancy Outcomes in Women with Chronic Kidney Disease and Chronic Hypertension: A National Cohort Study.

Am J Obstet Gynecol 2021 Apr 3. Epub 2021 Apr 3.

School of Public Health, University College Cork, Cork, Ireland; INFANT Research Centre, University College Cork, Ireland.

Background: Maternal chronic kidney disease (CKD) and chronic hypertension (CH) have been linked with adverse pregnancy outcomes. We aimed to examine the association between these conditions and adverse pregnancy outcomes over the last three decades, and to examine if the risk was modified by parity, maternal age, and body mass index (BMI). We also investigated whether different subtypes of CKD had differing effects. Read More

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Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins.

Sci Rep 2021 Apr 5;11(1):7504. Epub 2021 Apr 5.

Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, Bangladesh.

Diabetes mellitus is a complex and heterogeneous metabolic disorder which is often pre- or post-existent with complications such as cardiovascular disease, hypertension, inflammation, chronic kidney disease, diabetic retino- and nephropathies. However, the frequencies of these co-morbidities vary among individuals and across populations. It is, therefore, not unlikely that certain genetic variants might commonly contribute to these conditions. Read More

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MicroRNAs in childhood nephrotic syndrome.

J Cell Physiol 2021 Apr 5. Epub 2021 Apr 5.

Department of Central Research Facility, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.

The discovery of microRNAs (miRNAs) has opened up new avenues of research to understand the molecular basis of a number of diseases. Because of their conservative feature in evolution and important role in the physiological function, microRNAs could be treated as predictors for disease classification and clinical process based on the specific expression. The identification of novel miRNAs and their target genes can be considered as potential targets for novel drugs. Read More

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Comparison of dipstick and quantitative tests for proteinuria and hematuria in middle-aged, male Japanese employees: A single-center study.

Health Sci Rep 2021 Jun 26;4(2):e267. Epub 2021 Mar 26.

Department of Hygiene and Health Promotion Medicine Graduate School of Medical and Dental Sciences, Kagoshima University Kagoshima Japan.

Background And Aims: The early and reliable detection of chronic kidney disease is important. In the present study, we aimed to compare the diagnostic results for proteinuria and hematuria between the dipstick test used in primary occupational health examinations and the quantitative tests used in more thorough examinations in clinics.

Methods: We conducted a single-center observational study of male staff (N = 573) at Kagoshima University who underwent a health examination in 2017. Read More

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MiR-30c-5p/ROCK2 axis regulates cell proliferation, apoptosis and EMT via the PI3K/AKT signaling pathway in HG-induced HK-2 cells.

Open Life Sci 2020 23;15(1):959-970. Epub 2020 Dec 23.

Department of Kidney Disease of Internal, Weihai Central Hospital, No. 3, Mishandong Road West, Wendeng District, 264400, Weihai, China.

Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus. Increasing evidence suggests that microRNA-30c-5p (miR-30c-5p) participates in the pathogenesis of DN, but the mechanism has not been clearly understood. Therefore, this study aimed to investigate the biological role of miR-30c-5p in human DN progression . Read More

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December 2020

MiR-203-3p inhibits the oxidative stress, inflammatory responses and apoptosis of mice podocytes induced by high glucose through regulating Sema3A expression.

Open Life Sci 2020 22;15(1):939-950. Epub 2020 Dec 22.

Department of Cardiovascular Medicine and Dongguan Cardiovascular Institute, The Third People's Hospital of Dongguan City, No. 1, Xianglong Road, Shi Long Town, Dongguan, China.

Diabetic nephropathy (DN) is the most serious long-term microvascular complication of diabetes, which mainly causes podocyte injury. Many studies have shown that microRNAs play a vital role in the development of DN. Studies have shown that miR-203-3p is involved in mesangial cell proliferation and apoptosis of DN mice. Read More

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December 2020

Mesenchymal Stem Cells: An Overview of Their Potential in Cell-Based Therapy for Diabetic Nephropathy.

Stem Cells Int 2021 16;2021:6620811. Epub 2021 Mar 16.

Institute of Translational Medicine, Shanghai University, Shanghai, China.

Diabetic nephropathy (DN) is a devastating complication associated with diabetes mellitus, and it is the leading cause of end-stage renal diseases (ESRD). Over the last few decades, numerous studies have reported the beneficial effects of stem cell administration, specifically mesenchymal stem or stromal cells (MSCs), on tissue repair and regeneration. MSC therapy has been considered a promising strategy for ameliorating the progression of DN largely based on results obtained from several preclinical studies and recent Phase I/II clinical trials. Read More

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Adipocyte Fatty Acid-Binding Protein, Cardiovascular Diseases and Mortality.

Front Immunol 2021 19;12:589206. Epub 2021 Mar 19.

Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong.

It has been increasingly recognized that inflammation plays an important role in the pathogenesis of cardiovascular disease (CVD). In obesity, adipose tissue inflammation, especially in the visceral fat depots, contributes to systemic inflammation and promotes the development of atherosclerosis. Adipocyte fatty acid-binding protein (AFABP), a lipid chaperone abundantly secreted from the adipocytes and macrophages, is one of the key players mediating this adipose-vascular cross-talk, in part its interaction with c-Jun NH2-terminal kinase (JNK) and activator protein-1 (AP-1) to form a positive feedback loop, and perpetuate inflammatory responses. Read More

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