52,076 results match your criteria diabetes young


A case of digenic maturity onset diabetes of the young with heterozygous variants in both HNF1Α and HNF1Β genes.

Eur J Med Genet 2021 Jun 20:104264. Epub 2021 Jun 20.

Diabetes Center, First Department of Paediatrics, "P. & A. Kyriakou" Children's Hospital, Athens, Greece.

Background: Maturity onset diabetes of the young (MODY) is the most commonly reported form of monogenic diabetes in the pediatric population. Only a few cases of digenic MODY have been reported up to now.

Case Report: A female patient was diagnosed with diabetes at the age of 7 years and was treated with insulin. Read More

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The impact of rotavirus vaccination in the prevalence of gastroenteritis and comorbidities among children after suboptimal rotavirus vaccines implementation in Taiwan: A population-based study.

Medicine (Baltimore) 2021 Jun;100(25):e25925

Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

Abstract: In Taiwan, rotavirus vaccination was implemented in 2006 in the private sector. The population-based impact of rotavirus vaccination on gastroenteritis and comorbidities of children remains under-investigated.We analyzed the annual prevalence of rotavirus-related disease, including gastroenteritis, convulsions, epilepsy, type I diabetes mellitus, intussusception, and biliary atresia among children under 5 years of age. Read More

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Type 1 diabetes mellitus presenting with diabetic ketoacidosis in a child with Patau syndrome (trisomy 13) and persistent fetal haemoglobin.

BMJ Case Rep 2021 Jun 22;14(6). Epub 2021 Jun 22.

Children and Young People's Diabetes Team, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

A 35-month-old boy with non-mosaic Patau syndrome presented in diabetic ketoacidosis and was diagnosed with type 1 diabetes mellitus. A decision to treat this unanticipated medical problem was made in conjunction with the child's parent, and he improved with fluid resuscitation and insulin treatment. Acute kidney injury with hypernatraemia complicated his treatment, but this resolved with careful intravenous fluid management. Read More

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Smoking status links habenular volume to glycated hemoglobin: Findings from the Human Connectome Project-Young Adult.

Psychoneuroendocrinology 2021 Jun 10;131:105321. Epub 2021 Jun 10.

Center for Depression Research and Clinical Care, UT Southwestern Medical Center, Dallas, TX, United States. Electronic address:

Background: The habenula-pancreas axis regulates the stimulatory effects of nicotine on blood glucose levels and may participate in the emergence of type 2 diabetes in human tobacco smokers. This secondary analysis of young adults from the Human Connectome Project (HCP-YA) evaluated whether smoking status links the relationship between habenular volume and glycated hemoglobin (HbA1c), a marker of long-term glycemic control.

Methods: Habenula segmentation was performed using a fully-automated myelin content-based approach in HCP-YA participants and the results were inspected visually (n = 693; aged 22-37 years). Read More

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Graves disease in infancy: a patient presentation and literature review.

Endocrinol Diabetes Metab Case Rep 2021 Jun 1;2021. Epub 2021 Jun 1.

Icahn School of Medicine, Mount Sinai Department of Pediatric Endocrinology, Kravis Children's Hospital, New York, NY, USA.

Summary: We describe a case of an infant who presented with clinical features of hyperthyroidism. The child was found to be tachycardic, hypertensive and diaphoretic, she was noted to have poor weight gain and difficulty in sleeping. The child was admitted to the pediatric intensive care unit for care. Read More

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SARS-CoV-2 Myocarditis Due to Severe Obesity.

Cureus 2021 May 17;13(5):e15074. Epub 2021 May 17.

Internal Medicine, Chicago Medical School Internal Medicine Residency Program at Northwestern Medicine McHenry Hospital, McHenry, USA.

Myocarditis is defined as a myocardial injury concomitant with myocardial dysfunction. Several causes are associated with it, including infectious versus inflammatory and inherited cardiomyopathies. It can be acute, subacute, or chronic, and it can present as focal versus diffuse myocardial dysfunction. Read More

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High fructose and streptozotocin induced diabetic impairments are mitigated by Indirubin-3-hydrazone via downregulation of PKR pathway in Wistar rats.

Sci Rep 2021 Jun 21;11(1):12924. Epub 2021 Jun 21.

Centre for Molecular Biology, Central University of Jammu, Jammu, UT of Jammu and Kashmir, 184311, India.

Metabolic disorders are becoming more common in young population due to increased consumption of carbohydrate rich diet, lack of physical activity and stress. Fructose is used as a sweetener in many carbonated beverages and is a known inducer of oxidative stress and hypertension. Up-regulation of the double-stranded RNA-dependent protein kinase (PKR) causes impairment in insulin signaling pathway and metabolic dysfunctions in type 2 diabetes mellitus. Read More

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Clinical characteristics of premature cardiovascular disease in our health area.

Rev Clin Esp (Barc) 2021 Jun 18. Epub 2021 Jun 18.

Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain; Servicio de Medicina Interna, Hospital Universitario Miguel Servet, Zaragoza, Spain. Electronic address:

Introduction And Objectives: Cardiovascular disease continues to be the main cause of mortality, but few data are available in the young population. The aim of our study was to know the incidence and clinical characteristics of premature cardiovascular disease in our health area.

Methods: Cross-sectional study of patients admitted for acute episode of premature cardiovascular disease in a referral hospital during 2018. Read More

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Epidemiological and clinical profile, management and outcomes of young patients (≤40 years) with acute coronary syndrome: A single tertiary care center study.

Indian Heart J 2021 May-Jun;73(3):295-300. Epub 2021 Jan 17.

Department of Cardiology, Post Graduate Institute of Medical Education & Research, Chandigarh, 160012, India. Electronic address:

Objective: To study the epidemiological and clinical profile, angiographic patterns, reasons for the delay in presentation, management, and outcomes of the acute coronary syndrome (ACS) in young patients (≤40yrs) presenting to a tertiary care hospital in North India.

Methods: We included a total of 182 patients aged ≤40 years and presenting with ACS to the cardiology critical care unit of our department from January 2018 to July 2019.

Results: The mean age of the study population was 35. Read More

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January 2021

Metabolic Syndrome and Related Inflammation, Prevalence, and Predictive Value of C-Reactive Protein in South Asian Youths.

Metab Syndr Relat Disord 2021 Jun 21. Epub 2021 Jun 21.

Centennial Medical Center, Nashville, Tennessee, USA.

Metabolic syndrome (MetS) is widely prevalent in the South Asian (SA) population. The syndrome leads to a high risk of premature atherosclerosis and diabetes. Obesity, specifically abdominal obesity, is a central pathological mechanism of disease in this population. Read More

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Update and harmonisation of guidance for the management of diabetic ketoacidosis in children and young people in the UK.

BMJ Paediatr Open 2021 4;5(1):e001079. Epub 2021 Jun 4.

Department of Women's and Children's Health, University of Liverpool, Liverpool, UK.

Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes mellitus. Careful and timely intervention is required to optimise glycaemic control and reduce the risk of mortality and devastating complications. Of these, cerebral oedema is the leading cause of death, with a mortality rate of approximately 25%. Read More

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Genome Editing Human Pluripotent Stem Cells to Model β-Cell Disease and Unmask Novel Genetic Modifiers.

Front Endocrinol (Lausanne) 2021 2;12:682625. Epub 2021 Jun 2.

Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.

A mechanistic understanding of the genetic basis of complex diseases such as diabetes mellitus remain elusive due in large part to the activity of genetic disease modifiers that impact the penetrance and/or presentation of disease phenotypes. In the face of such complexity, rare forms of diabetes that result from single-gene mutations (monogenic diabetes) can be used to model the contribution of individual genetic factors to pancreatic β-cell dysfunction and the breakdown of glucose homeostasis. Here we review the contribution of protein coding and non-protein coding genetic disease modifiers to the pathogenesis of diabetes subtypes, as well as how recent technological advances in the generation, differentiation, and genome editing of human pluripotent stem cells (hPSC) enable the development of cell-based disease models. Read More

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FKBPL and SIRT-1 Are Downregulated by Diabetes in Pregnancy Impacting on Angiogenesis and Endothelial Function.

Front Endocrinol (Lausanne) 2021 2;12:650328. Epub 2021 Jun 2.

The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Northern Ireland, United Kingdom.

Diabetes in pregnancy is associated with adverse pregnancy outcomes including preterm birth. Although the mechanisms leading to these pregnancy complications are still poorly understood, aberrant angiogenesis and endothelial dysfunction play a key role. FKBPL and SIRT-1 are critical regulators of angiogenesis, however, their roles in pregnancies affected by diabetes have not been examined before in detail. Read More

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Global Well-Being Is Associated With A1C and Frequency of Self-Monitoring of Blood Glucose in Predominately Latinx Youth and Young Adults With Type 1 Diabetes.

Diabetes Spectr 2021 May 21;34(2):202-208. Epub 2021 Dec 21.

Department of Pediatrics, Keck School of Medicine of the University of Southern California and the Los Angeles County + University of Southern California Medical Center, Los Angeles, CA.

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Characteristics of high-resolution magnetic resonance vessel wall imaging of cervicocerebral artery dissection and the influential factors of vascular recanalization.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 May;46(5):467-474

Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.

Objectives: Cervicocerebral artery dissection (CAD) is one of the important causes for ischemic stroke in young and middle-aged people. CAD is dangerous and untimely diagnosis and treatment are likely to result in severe disability. Early diagnosis and timely intervention can greatly improve the prognosis of patients. Read More

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Adverse Childhood Experiences are Associated with Cardiometabolic Risk among Hispanic American Adolescents.

J Pediatr 2021 Jun 17. Epub 2021 Jun 17.

Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL; Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL; Center for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, FL; WW International, Inc., New York, NY. Electronic address:

Objective: To assess the relationship between adverse childhood experiences (ACEs) and cardiometabolic risk among Hispanic adolescents.

Study Design: This cross-sectional study was conducted at an academic research center in Gainesville, Florida. Participants were locally recruited, and data were collected from 06/2016-07/2018. Read More

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Comparison of Outcomes of Coronary Artery Disease Treated by Percutaneous Coronary Intervention in 3 Different Age Groups (<45, 46-65, and >65 Years).

Am J Cardiol 2021 Jun 16. Epub 2021 Jun 16.

Department of Cardiology, Alfred Health, Victoria, Australia; Department of Medicine, University of Melbourne, Victoria, Australia; BakerIDI Heart and Diabetes Institute, Melbourne, Victoria, Australia; Monash University, Victoria, Australia. Electronic address:

There is paucity of data examining long-term outcomes of premature coronary artery disease (CAD). We aimed to investigate the short- and long-term clinical outcomes of patients with premature CAD treated by percutaneous coronary intervention (PCI) compared to older cohorts. We analyzed data from 27,869 patients who underwent PCI from 2005-2017 enrolled in a multicenter PCI registry. Read More

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[Economic burden and factors associated with Crohn's disease].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Jun;53(3):555-559

Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China.

Objective: To study the economic burden of Crohn's disease and its related factors, and to provide opinions for reducing personal burden and improving reimbursement policy.

Methods: Using a cross-sectional method, a self-created questionnaire based on the basic principles of health services research was used to survey Crohn's disease patients served by the Shanghai volunteer service foundation platform. Information collected included basic characteristics, therapy, and medical costs related to Crohn's disease in the past 12 months. Read More

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Chronic Kidney Disease after Snake Envenomation Induced Acute Kidney Injury.

Saudi J Kidney Dis Transpl 2021 Jan-Feb;32(1):146-156

Department of Nephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Snake bite is an important cause for acute kidney injury (AKI) in the tropics and the victims are often otherwise healthy young adults without conventional risk factors for chronic kidney disease (CKD). Available literature on long-term outcomes of AKI -snake envenomation is limited, with only two small retrospective studies with follow-up periods of two years or less. In a hospital-based prospective and retrospective follow-up study, all consecutive adult patients who developed AKI and discharged alive were recruited in the prospective group and for retrospective analysis, we retrieved medical records of patients hospitalized with snake bite from the digitized medical records. Read More

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Effects of a Life Skills-Based Intervention on Mental Health of Adolescents and Young Adults With Type 1 Diabetes.

J Psychosoc Nurs Ment Health Serv 2021 Jun 1:1-7. Epub 2021 Jun 1.

The current study examined the effectiveness of a life skills training intervention on the psychological health of adolescents and young adults with type 1 diabetes. This quasi-randomized controlled trial recruited 80 individuals from the West Azerbaijan Diabetes Community in Urmia, Iran. Participants were randomly allocated to intervention ( = 40) or control ( = 40) groups. Read More

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Pro-arrhythmic effects of elevated branched chain amino acid levels.

Cardiovasc Res 2021 Jun 17. Epub 2021 Jun 17.

Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.

Aim: Cardiac arrhythmias comprise a major health and economic burden and are associated with significant morbidity and mortality, including cardiac failure, stroke and sudden cardiac death (SCD). Development of efficient preventive and therapeutic strategies is hampered by incomplete knowledge of disease mechanisms and pathways. Our aim is to identify novel mechanisms underlying cardiac arrhythmia and SCD using an unbiased approach. Read More

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Prevalence and predictors of sleep deprivation and poor sleep quality and their associated perinatal outcomes during the third trimester of pregnancy.

J Taibah Univ Med Sci 2021 Jun 17;16(3):359-364. Epub 2020 Dec 17.

Department of Obstetrics and Gynaecology, St. Johns Medical College, Bengaluru, India.

Objectives: Maternal sleep deprivation not only affects the pregnant mother but also has profound effects on the well-being of the foetus. This study aims to assess the prevalence and predictors of excessive daytime sleepiness (EDS) and poor sleep quality (PSQ).

Methods: This was a cross-sectional study conducted among in-patient post-natal women of a tertiary care teaching hospital. Read More

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Care for health among Polish men, taking into account social and economic factors, as well as the type of work.

Med Pr 2021 Jun 1. Epub 2021 Jun 1.

Central Institute for Labour Protection - National Research Institute, Warsaw, Poland.

Background: Epidemiological studies show that an inappropriate healthy lifestyle is a major incidence factor, , for cardiovascular diseases, cancer, diabetes, obesity, as well as premature deaths, especially among men.

Material And Methods: In order to check the attitudes of men towards health and health behaviors, a questionnaire-based research was carried out among 600 men active on the labor market. Several standard questionnaire tools were used: the (PHBS), the for measuring the place of health in the value hierarchy; the , the, the , and the of the (COPSOQ II). Read More

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Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis?

Mol Psychiatry 2021 Jun 17. Epub 2021 Jun 17.

Zentrums für Apherese- und Hämofiltration am INUS Tagesklinikum, Cham, Germany.

As millions of patients have been infected by SARS-CoV-2 virus a vast number of individuals complain about continuing breathlessness and fatigue even months after the onset of the disease. This overwhelming phenomenon has not been well defined and has been called "post-COVID syndrome" or "long-COVID" [1]. There are striking similarities to myalgic encephalomyelitis also called chronic fatigue syndrome linked to a viral and autoimmune pathogenesis. Read More

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Comparison of Surgical Site Complications With Negative Pressure Wound Therapy vs Silver Impregnated Dressing in High-Risk Total Knee Arthroplasty Patients: A Matched Cohort Study.

J Arthroplasty 2021 May 24. Epub 2021 May 24.

Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN.

Background: Closed incision negative pressure wound therapy (ciNPWT) may reduce surgical site complications following total joint arthroplasty. Although unlikely necessary for all patients, the criteria for utilizing ciNPWT in primary total knee arthroplasty (TKA) remain poorly defined. This study's purpose was to compare the incidence of incisional wound complications, non-incisional complications (ie, dressing reactions), reoperations, and periprosthetic joint infections (PJIs) among a group of high-risk primary TKA patients treated with ciNPWT vs an occlusive silver impregnated dressing. Read More

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The prevalence of diabetes amongst young Emirati female adults in the United Arab Emirates: A cross-sectional study.

PLoS One 2021 17;16(6):e0252884. Epub 2021 Jun 17.

Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.

Aims: The prevalence of type 2 diabetes is rapidly increasing in the United Arab Emirates (UAE). The purpose of this study was to investigate the prevalence of prediabetes and diabetes using FPG and HbA1c and to examine their relationships with obesity and other risk factors in young female Emirati college students.

Methods: In this cross-sectional study we recruited 555 female college students aged 17-25, enrolled at United Arab Emirates University in Al Ain, UAE. Read More

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Predictive factors of polycystic ovary syndrome in girls with precocious pubarche.

Endocr Connect 2021 Jun 1. Epub 2021 Jun 1.

C Giordano, Dipartimento di Promozione della Salute, Materno-Infantile, Sezione di Malattie Endocrine, Palermo, Italy.

Objective: The aim of this study is to clarify, in girls with premature pubarche (PP), the influence of premature androgenization on the prevalence of polycystic ovary syndrome (PCOS).

Design And Patients: Ninety-nine PP girls, 63 who developed PCOS and 36 who did not develop PCOS, were cross-sectionally included. Clinical, anthropometric, and metabolic parameters were evaluated to find predictive factors of PCOS. Read More

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Insulin resistance and potential modulators of ovarian reserve in young reproductive-aged women with obesity and type 1 diabetes.

Gynecol Endocrinol 2021 Jun 17:1-8. Epub 2021 Jun 17.

Department of Pediatrics, "Vittore Buzzi" Children's Hospital, Milano, Italy.

Introduction: Both obesity and diabetes play a significant role in reproductive disorders in women and insulin resistance (IR) is a confirmed . We evaluated the relationship between IR and an established ovarian reserve biomarker such as anti-mullerian hormone (AMH) together with other potential modulators of ovarian physiology (adiponectin and kisspeptin) in young reproductive-aged group women with obesity and type 1 diabetes (T1D).

Patients And Methods: We recruited 32 female youths: 14 of them presented with T1D (14. Read More

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Prevalence of Depression and Sleep Disorders in Patients on Dialysis: A Cross-Sectional Study in Qatar.

Int J Nephrol 2021 26;2021:5533416. Epub 2021 May 26.

Department of Nephrology, Hamad Medical Corporation, Doha, ZIP/Post Code 3050, Qatar.

Patients with end-stage renal disease treated with dialysis have poor quality of life (QOL). Improving QOL in these patients with multiple comorbidities is a large challenge. We performed a cross-sectional study to evaluate the prevalence and associated factors of depression and sleep disorders in this population. Read More

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Influence of occupation type on the association between sleep duration and impaired fasting glucose: results from a Chinese population-based study.

BMJ Open 2021 06 16;11(6):e042066. Epub 2021 Jun 16.

Department of Epidemiology and Medical Statistics, Nantong University, Nantong, China

Objectives: Systematic evaluation of the influence of occupation type on the association between sleep-glucose metabolism DESIGN: A cross-sectional study.

Setting: The Nantong Metabolic Syndrome Study is a Chinese population-based study.

Participants: 20 502 participants aged 18-74 years old. Read More

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