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World Neurosurg 2022 Jun 22. Epub 2022 Jun 22.

University of Texas Southwestern Medical Center, Department of Neurological Surgery, Dallas, TX, USA.

Objective: Red blood cell (RBC) transfusion is commonly indicated in brain tumor surgery due to risk of blood loss. Current transfusion guidelines are based on evidence derived from critically ill patients and may not be optimal for brain tumor surgeries. Our study is the first to synthesize available evidence to suggest RBC transfusion thresholds in brain tumor patients undergoing surgery. Read More

Neuroimage 2022 Jun 22:119408. Epub 2022 Jun 22.

School of Medical Sciences (Neuroscience), Brain and Mind Centre, University of Sydney, Australia, 2006. Electronic address:

Over the past two decades, magnetic resonance imaging (MRI) studies have explored brain activation patterns during acute noxious stimuli. Whilst these human investigations have detailed changes in primarily cortical regions, they have generally not explored discrete changes within small brain areas that are critical in driving behavioural, autonomic, and endocrine responses to pain, such as within subregions of the hypothalamus, amygdala, and midbrain periaqueductal gray matter (PAG). Ultra-high field (7-Tesla) MRI provides enough signal-to-noise at high spatial resolutions to investigate activation patterns within these small brain regions during acute noxious stimulation in awake humans. Read More

J Shoulder Elbow Surg 2022 Jun 22. Epub 2022 Jun 22.

Department of Orthopaedics and Sports Medicine, University of Washington Medical Center, Seattle, WA, USA. Electronic address:

Background: Cuff tear arthropathy (CTA) can be successfully treated with various types of shoulder arthroplasty. While reverse total shoulder arthroplasty (RSA) is commonly used to treat CTA, CTA hemiarthroplasty (CTA-H, hemiarthroplasty with an extended humeral articular surface) can also be effective in patients with preserved glenohumeral elevation and an intact coracoacromial arch. As the value of arthroplasty is being increasingly scrutinized, cost containment has become a priority. Read More

J Ren Nutr 2022 Jun 22. Epub 2022 Jun 22.

Department of Population Health, Grossman School of Medicine, New York University; Department of Medicine, Grossman School of Medicine, New York University. Electronic address:

Biochim Biophys Acta Mol Basis Dis 2022 Jun 22:166472. Epub 2022 Jun 22.

BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China. Electronic address:

During the epidemic, the individuals with underlying diseases usually have a higher rate of mortality. Diabetes is highly prevalent worldwide, making it a frequent comorbidity in dengue fever patients. Therefore, understanding the relationship between dengue virus (DENV) infection and diabetes is important. Read More

Pharmacol Res 2022 Jun 22:106326. Epub 2022 Jun 22.

Department of Biochemistry, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, India. Electronic address:

Diabetes is a major public health disease that is globally approaching epidemic proportions. One of the major causes of type 2 diabetes is either a defect in insulin secretion or insulin action which is usually caused by a combination of genetic and environmental factors. Not only these factors but others such as deregulation of various pathways, and oxidative stress are also known to trigger the redox imbalance in diabetics. Read More

Eur J Pharmacol 2022 Jun 22:175117. Epub 2022 Jun 22.

Department of Biochemistry, German University in Cairo, Cairo, Egypt.

Diabetic nephropathy (DN) is one of the most serious consequences of diabetes and the most common reason for end-stage renal disease. The current study was set out to investigate the ability of olmesartan medoxomil (OM) to treat DN by evaluating the reno-protective effects of this drug on fat/fructose/streptozotocin (F/Fr/STZ)-induced diabetic rat model. This model was induced by feeding rats high F/Fr diet for 7 weeks followed by injection of a single sub-diabetogenic dose of STZ (35mg/kg; i. Read More

Phytochemistry 2022 Jun 22:113286. Epub 2022 Jun 22.

Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, India; Sophisticated Analytical Instrument Facility & Research, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, U.P., India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, U.P., India. Electronic address:

Bioactivity guided phytochemical investigation led to isolation of six undescribed furostanol saponins, furoasparoside A-F along with five known compounds, gallic acid, methyl gallate, quercetin-3-O-β-glucopyranoside, liquiritigenin 4-O-β-apiofuranosyl-(1 → 2)-β-glucopyranoside and β-glucogallin for the first time from the roots of Asparagus racemosus. Isolated saponins were screened for their antidiabetic potential in L6-GLUT4myc myotubes in vitro followed by an in vivo evaluation in streptozocin-induced diabetic rats and db/db mice. Furoasparoside E produced a notable decrease in the postprandial blood glucose profile, in leptin receptor-deficient db/db mice, type 2 diabetes model. Read More

Chemosphere 2022 Jun 22:135451. Epub 2022 Jun 22.

Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address:

Endocr Pract 2022 Jun 22. Epub 2022 Jun 22.

Departments of Endocrinology & Nutrition. Hospital Universitario Ramón y Cajal. Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS). Madrid. Spain.

In this commentary we propose a change of the nomenclature of non-functioning adrenal incidentalomas (NFAI) to adrenal lesions of undetermined secretion of adrenal steroids (ALUSAS) since there are mounting evidence suggesting that a substantial proportion of so-called NFAIs do actually secrete steroids in excess. In fact, it is known that some NFAIs develop ACS over time. In the commentary we justify the change of term by summarizing the evidence that shows that NFAIs present a higher cardiometabolic risk than the general population, and the metabolomics studies in which an increase in cortisol metabolites is observed in patients with NFAI. Read More

J Ethnopharmacol 2022 Jun 22:115498. Epub 2022 Jun 22.

Univ Coimbra, Faculty of Pharmacy, Laboratory of Pharmacology and Pharmaceutical Care, 3000-548, Coimbra, Portugal; Univ Coimbra, Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), 3000-548, Coimbra, Portugal; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology, 3000-548, Coimbra, Portugal. Electronic address:

Ethnopharmacological Relevance: Agrimonia eupatoria L., a plant which belongs to the Rosaceae family, is widespread in temperate regions, particularly throughout the northern hemisphere. In folk medicine, this plant species has been used for its astringent, anti-inflammatory, analgesic and hypotensive properties as well as in gastrointestinal disorders. Read More

Lancet Diabetes Endocrinol 2022 Jul;10(7):540-548

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

In the past 30 years, there has been a substantial rise in the detection of thyroid nodules. Largely asymptomatic, thyroid nodules are most often incidental findings that typically pose minimal risk. Data supporting these findings show a rapid rise in the incidental detection of thyroid nodules and cancer, but minimal effect on mortality rates, despite treatment. Read More

Lancet Diabetes Endocrinol 2022 Jul;10(7):533-539

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Thyroid nodules are common, usually asymptomatic, and often pose minimal risk to the affected patient. However, 10-15% prove malignant and serve as the rationale for diagnostic assessment. Safely identifying and treating a relevant thyroid cancer through a cost-effective process is the primary goal of the treating practitioner. Read More

Lancet Diabetes Endocrinol 2022 Jun 22. Epub 2022 Jun 22.

Lancet Diabetes Endocrinol 2022 Jun 22. Epub 2022 Jun 22.

Thorac Cardiovasc Surg 2022 Jun 25. Epub 2022 Jun 25.

Department of Cardiac Surgery, University Clinical Hospital Center Zagreb, University of Zagreb, Zagreb, Croatia.

Background:  Diabetic patients tend to have increased platelet reactivity after coronary artery bypass grafting (CABG). The aim of this study was to determine the association between hemoglobin A1c (HbA1c) values and platelet reactivity and to evaluate the consequent impact on clinical outcomes in patients undergoing CABG.

Methods:  This prospective observational trial consecutively enrolled 225 diabetic patients undergoing CABG, between February 2014 and October 2018. Read More

Phytomedicine 2022 Jun 13;104:154264. Epub 2022 Jun 13.

State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian road, Nanjing, China. Electronic address:

Background: Gut microbiota coupled with their metabolites (bile acids, BAs) get involved in diabetic pathogenesis. Simiao Wan is a famous traditional Chinese formula consisting on Phellodendron chinense C.K. Read More

Maturitas 2022 Jun 13;163:82-87. Epub 2022 Jun 13.

Quilín Clinic, Faculty of Medicine, University of Chile, Santiago de Chile, Chile.

Objective: To evaluate the association between premature ovarian insufficiency (POI) and mortality.

Materials And Methods: This was a secondary analysis of a long-term cohort of Chilean women who received preventive health care between 1990 and 1993. The exposure variable was POI and the outcome was death, and follow-up time was 30 years. Read More

Int J Surg Case Rep 2022 Jun 13;96:107299. Epub 2022 Jun 13.

Department of Head and Neck Surgery, Facial Plastic and Reconstructive Surgery, University of Texas Rio Grande Valley, United States of America.

Introduction: Mucormycosis is an opportunistic mycosis common in poorly-controlled insulin dependent diabetic patients particularly with ketoacidosis. Fungal osteomyelitis is a life-threatening condition affectation of the nose and paranasal sinuses within the orofacial region.

Presentation Of Case: We present a 63-year-old diabetic male patient with maxillary mucormycotic osteomyelitis threatening his better seeing eye and review the clinical symptoms, relevant imaging, and management. Read More

Asian J Psychiatr 2022 Jun 18;74:103192. Epub 2022 Jun 18.

Research Division, Institute of Mental Health, Singapore; Department of Psychosis, Institute of Mental Health, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Electronic address:

Introduction: Clozapine use is associated with higher risks of metabolic side effects and cardiovascular diseases (CVD). Thus, this study aims to establish and compare the cardiometabolic profiles between non-clozapine antipsychotic and clozapine users with schizophrenia.

Methods: Data from 88 non-clozapine and 166 clozapine users were extracted from existing databases - demographics, medications, smoking and medical histories, anthropometric parameters, serum lipid and fasting glucose levels. Read More

Life Sci 2022 Jun 22;304:120725. Epub 2022 Jun 22.

Department of Pharmacy, Lanzhou University, Lanzhou 730000, PR China; State Key Laboratory of Veterinary Etiological Biology, College of Veterinary Medicine, Lanzhou 730000, PR China. Electronic address:

Aims: Diabetes mellitus (DM) is a major global health threat characterized by insulin resistance. A new tactic to ameliorate insulin resistance, thereby reversing the exacerbation of DM, is urgently needed. The work is aiming to provide a new strategy for DM treatment as well as to identify new targets. Read More

Altern Ther Health Med 2022 Jun 24. Epub 2022 Jun 24.

Background: Lower limb ischemia due to arterial stenosis is a major complication in patients with diabetes mellitus (DM). Liraglutide is a long-acting analogue of a glucagon-like peptide 1 (GLP-1) receptor agonist used for lowering blood glucose in patients with DM, and is believed to possess cardiovascular protective effects. The aim of this study was to investigate whether liraglutide has a protective effect on blood vessels and alleviates vascular intimal hyperplasia in streptozotocin (STZ)-induced rabbits with DM and its molecular mechanism. Read More

Altern Ther Health Med 2022 Jun 24. Epub 2022 Jun 24.

Context: Diabetes mellitus (DM) represents an emerging epidemic, poses serious threats to human health, and can seriously compromise patients' quality of life (QoL). Currently, no cure exists for DM. Some studies have found that both liraglutide and dapagliflozin have great therapeutic potential in preventing and treating DM and its complications. Read More

Diabet Med 2022 Jun 25:e14906. Epub 2022 Jun 25.

Department of Metabolism, Digestion and Reproduction, Imperial College London, United Kingdom.

Background: With advances in technology, there is emerging concern that inequalities exist in provision and diabetes outcomes in areas of greater deprivation. We assess the relationship between socioeconomic status and deprivation with access to diabetes technology and their outcomes in adults with type 1 diabetes.

Methods: Retrospective, observational analysis of adults attending a tertiary centre, comprising three urban hospitals in the UK. Read More

Mol Nutr Food Res 2022 Jun 25:e2200125. Epub 2022 Jun 25.

Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and Biomedical Network Research Centre on Diabetes and Metabolic Diseases (CIBERDEM, ISCIII), Barcelona, Spain.

Scope: Low sex hormone-binding globulin (SHBG) levels are associated with higher risk of developing cardiovascular disease. Epidemiological studies have shown that red wine has beneficial effects on cardiovascular disease. In this work we explored if resveratrol content in red wine increases SHBG levels. Read More

Curr Cardiol Rep 2022 Jun 25. Epub 2022 Jun 25.

Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada.

Purpose Of Review: The current care model of type 2 diabetes (T2D) and its complications appears to be "asynchronous" with patient care divided by specialty. This model is associated with low use of guideline-directed medical therapies.

Recent Findings: The use of integrated care models has been well described in the management of patients with T2D; this usually includes an endocrinologist coupled with a nutritionist and nurse. Read More

Med Biol Eng Comput 2022 Jun 25. Epub 2022 Jun 25.

Department of Biochemistry, All India Institute of Medical Sciences Pin, Raipur, 492099, Chhattisgarh, India.

Early identification of the risk factors associated with development of diabetic foot ulcer (DFU) can be facilitated using machine learning techniques. The aim of this study is to find out the association of various clinical and biochemical risk factors with DFU and develop a prediction model using different machine learning algorithms. Eighty each of type 2 diabetes mellitus (T2DM) with DFU and (T2DM) without DFU were enrolled for this observational study. Read More

Endocrine 2022 Jun 25. Epub 2022 Jun 25.

Endocrinology & Nutrition Department, Ramón y Cajal University Hospital, Madrid, Spain.

Purpose: To compare the evolution of the cardiometabolic parameters in patients with nonfunctioning adrenal incidentalomas (NFAI) and autonomous cortisol secretion (ACS) who underwent adrenalectomy and those who were conservatively managed.

Methods: A retrospective study of all patients with NFAI and ACS submitted to surgery or in follow-up in our center between January 2011-October 2020. NFAI was defined as an adrenal incidentaloma with cortisol post-dexamethasone suppression test (DST) ≤ 50 nmol/L and ACS as values >50 nmol/L without specific clinical signs of overt Cushing´s syndrome. Read More

Endocrine 2022 Jun 25. Epub 2022 Jun 25.

Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.

Background: Somatostatin receptor (SSTR) positron emission tomography/computed tomography (PET/CT) is increasingly deployed in the diagnostic algorithm of patients affected with medullary thyroid carcinoma (MTC). We aimed to assess the role of SSTR-PET/CT for therapeutic decision making upon restaging.

Methods: 23 pretreated MTC patients underwent SSTR-PET/CT and were discussed in our interdisciplinary tumor board. Read More

Endocrine 2022 Jun 25. Epub 2022 Jun 25.

Department of Health Promoting Science, Sophiahemmet University, Stockholm, Sweden.

Purpose: Decreasing levels of serum insulin-degrading enzyme (IDE) have been associated with an increased risk for Alzheimer´s disease (AD) in patients with type 2 diabetes mellitus (T2DM). Research on serum IDE levels in patients with T2DM is sparse and the aim of this study was to explore serum levels of IDE in patients with T2DM.

Method: Blood serum samples were obtained from a biobank. Read More