Antibiotics (Basel) 2021 Feb 5;10(2). Epub 2021 Feb 5.
Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo 11884, Egypt.
Herein, a series of novel hybrid sulfaguanidine moieties, bearing 2-cyanoacrylamide -, pyridine-2-one -, and 2-imino-2-chromene-3-carboxamide , derivatives, were synthesized, and their structure confirmed by spectral data and elemental analysis. All the synthesized compounds showed moderate to good antimicrobial activity against eight pathogens. The most promising six derivatives, , , , , , and , revealed to be best in inhibiting bacterial and fungal growth, thus showing bactericidal and fungicidal activity. Read More