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Clin Kidney J 2021 Apr 10;14(4):1190-1196. Epub 2020 Oct 10.

Department of Nephrology, Hospital del Mar, Barcelona, Catalunya, Spain.

Background: Ischaemia-reperfusion (I/R) damage is a relevant cause of delayed graft function (DGF). Complement activation is involved in experimental I/R injury, but few data are available from kidney transplant (KT) patients. We studied the dynamics of membrane attack complex (C5b-9) as a soluble fraction (SC5b-9) and the histological deposit pattern of C3b, complement Factor H (FH) and C5b-9 in DGF patients. Read More

PLoS One 2021 5;16(4):e0249552. Epub 2021 Apr 5.

Renal Transplant Center "A. Vercellone," Nephrology, Dialysis, and Renal Transplant Division, Department of Medical Sciences, "AOU Città Della Salute e Della Scienza di Torino" University Hospital, University of Turin, Turin, Italy.

Background: Pre-existing chronic hypotension affects a percentage of kidney transplanted patients (KTs). Although a relationship with delayed graft function (DGF) has been hypothesized, available data are still scarce and inconclusive.

Methods: A monocentric retrospective observational study was performed on 1127 consecutive KTs from brain death donors over 11 years (2003-2013), classified according to their pre-transplant Mean Blood Pressure (MBP) as hypotensive (MBP < 80 mmHg) or normal-hypertensive (MBP ≥ 80 mmHg, with or without effective antihypertensive therapy). Read More

J Clin Med 2021 Mar 2;10(5). Epub 2021 Mar 2.

Department of Nephrology, Parc de Salut Mar, 08003 Barcelona, Spain.

The role of C5a receptors (C5aR1 and C5L2) in renal ischemia-reperfusion injury (IRI) is uncertain. We generated an in vitro model of hypoxia/reoxygenation with human proximal tubule epithelial cells to mimic some IRI events. C5aR1, membrane attack complex (MAC) and factor H (FH) deposits were evaluated with immunofluorescence. Read More

Anaesthesist 2021 Apr 1. Epub 2021 Apr 1.

Klinik für Akut- und Notfallmedizin, St.-Antonius-Hospital gGmbH, Akademisches Lehrkrankenhaus der RWTH Aachen, Dechant-Deckers-Str. 8, 52249, Eschweiler, Deutschland.

Mechanical circulatory support using extracorporeal life support systems (ECLS) has significantly increased in recent years. These critically ill patients pose special challenges to the multiprofessional treatment team and require comprehensive, interdisciplinary and interprofessional concepts. For this reason, to ensure the best possible patient care a standardized ECLS training module has been created at national specialist society level, taking emergency and intensive care management into account. Read More

Med Klin Intensivmed Notfmed 2021 Apr 1. Epub 2021 Apr 1.

Klinik für Akut- und Notfallmedizin, St.-Antonius-Hospital gGmbH, Akademisches Lehrkrankenhaus der RWTH Aachen, Dechant-Deckers-Str. 8, 52249, Eschweiler, Deutschland.

Mechanical circulatory support using extracorporeal life support systems (ECLS) has significantly increased in recent years. These critically ill patients pose special challenges to the multiprofessional treatment team and require comprehensive, interdisciplinary and interprofessional concepts. For this reason, to ensure the best possible patient care a standardized ECLS training module has been created at national specialist society level, taking emergency and intensive care management into account. Read More

Transpl Immunol 2021 Mar 26;66:101388. Epub 2021 Mar 26.

Cardiff Transplant Unit, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, United Kingdom. Electronic address:

Aim: We aimed to analyse the efficacy of the Thymoglobulin dose used for induction in controlled DCD kidneys, and its initial impact on blood cell and CD3 count, as predictors of efficacy.

Methods: 140 DCD patients who received ATG induction, were analysed. Intended dose was 1. Read More

PLoS One 2021 25;16(3):e0249000. Epub 2021 Mar 25.

Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia.

Background: The need for kidney transplantation drives efforts to expand organ donation. The decision to accept organs from donors with acute kidney injury (AKI) can result in a clinical dilemma in the context of conflicting reports from published literature.

Material And Methods: This observational study included all deceased donor kidney transplants performed in Australia and New Zealand between 1997 and 2017. Read More

Iran J Kidney Dis 2021 Mar;1(2):148-154

1Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Pre-transplant serum phosphorus level is shown to be associated with some transplant outcomes in patients with chronic kidney disease. However, its association with Delayed graft function (DGF) has an aura of ambiguity. DGF means either the patient needs dialysis during the first week after transplantation or the creatinine level is ≥ 3. Read More

Am J Transplant 2021 Mar 23. Epub 2021 Mar 23.

Department of Nephrology and Transplantation, NHS Foundation Trust, Guy's and St Thomas, London, UK.

Kidneys from donation after circulatory death (DCD) donors are utilized variably worldwide, in part due to high rates of delayed graft function (DGF) and putative associations with adverse longer-term outcomes. We aimed to determine whether the presence of DGF, and its duration, were associated with poor longer-term outcomes after kidney transplantation from DCD donors. Using the UK transplant registry, we identified 4714 kidney-only transplants from controlled DCD donors to adult recipients between 2006-2016; 2832 recipients (60·1%) had immediate graft function and 1882 (39. Read More

Int J Oral Maxillofac Surg 2021 Mar 19. Epub 2021 Mar 19.

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China. Electronic address:

The aim of this retrospective study was to verify the three-dimensional morphological change in neocondyle bone growth after fibula free flap (FFF) reconstruction. The independent variables were age, sex, and diagnosis. Outcome variables included the direction and volume of neocondyle bone growth, and the time to a stable neocondyle following bone growth. Read More

Pharmacol Res 2021 Mar 17;167:105565. Epub 2021 Mar 17.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands.

Breakthrough cytomegalovirus (CMV) disease during valganciclovir prophylaxis is rare but may cause significant morbidity and even mortality. In order to identify patients at increased risk the incidence of CMV disease was studied in a large population of renal transplant recipients who underwent a kidney transplantation in the Radboud University Medical Center between 2004 and 2015 (n = 1300). CMV disease occurred in 31/1300 patients. Read More

Transpl Int 2021 Mar 19. Epub 2021 Mar 19.

Hospital do Rim, Fundação Oswaldo Ramos, São Paulo, SP, Brazil.

This retrospective multicenter (n=18) cohort study evaluated the incidence, risk factors, and the impact of delayed graft function (DGF) on 1-year kidney transplant (KT) outcomes. Of 3,992 deceased donor KT performed in 2014-2015, the incidence of DGF was 54%, ranging from 29.9% to 87. Read More

Int Urol Nephrol 2021 Mar 15. Epub 2021 Mar 15.

Urology Department, Centro Hospitalar Universitário São João, Alameda Prof. HernaniMonteiro, 4200-319, Porto, Portugal.

Purpose: To increase the pool of kidneys available for transplantation, a renewed interest in donation after circulatory death (DCD) has emerged. This study aims to determine the outcomes of kidney transplantation from DCD after abdominal normothermic oxygenated circulation (ANOR) support.

Methods: From January 2016 to December 2018, 58 kidneys were implanted from uncontrolled DCD after ANOR support. Read More

Ren Fail 2021 Dec;43(1):520-529

Tianjin First Central Hospital, Tianjin, China.

Background: Kidneys obtained from deceased donors increase the incidence of delayed graft function (DGF) after renal transplantation. Here we investigated the influence of the risk factors of donors with DGF, and developed a donor risk scoring system for DGF prediction.

Methods: This retrospective study was conducted in 1807 deceased kidney donors and 3599 recipients who received donor kidneys transplants in 29 centers in China. Read More

Ann Transl Med 2021 Feb;9(3):244

Department of Nephrology, Molecular Cell Laboratory for Kidney Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Monitoring allograft function during the early stages is crucial, and therefore requires biomarkers more sensitive than serum creatinine (Scr). Kidney injury molecular-1 (KIM-1) is a potent biomarker; however, disparities exist in the literature concerning its predictive value in allograft function. Therefore, this study aimed to evaluate its predictive value for the long-term prognosis of kidney transplantation patients. Read More

PLoS One 2021 8;16(3):e0247972. Epub 2021 Mar 8.

GlaxoSmithKline, Philadelphia, Pennsylvania, United States of America.

Introduction: Delayed graft function (DGF) following renal transplantation is a manifestation of acute kidney injury (AKI) leading to poor long-term outcome. Current treatments have limited effectiveness in preventing DGF. Interleukin-18 (IL18), a biomarker of AKI, induces interferon-γ expression and immune activation. Read More

Transplantation 2021 Feb 23. Epub 2021 Feb 23.

University of Minnesota, Department of Surgery, Transplantation Division, Minneapolis, MN; University of Minnesota, School of Public Health, Biostatistics Division, Minneapolis, MN; University of Alabama, Department of Medicine, Birmingham, AL; Hennepin Healthcare, Division of Nephrology, Minneapolis, MN; University of Manitoba, Department of Internal Medicine, Winnipeg, Manitoba. University of Iowa, Department of Internal Medicine, Iowa City, IA; Mayo Clinic, Division of Nephrology & Hypertension, Department of Internal Medicine, Rochester, MN; Mayo Clinic, Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Rochester, MN; University of California, UCLA Immunogenetics Center, Los Angeles, CA Univeristy of Nebraska Medical Center and Nebraska-Western Iowa Veterans Affairs Medical Center, Omaha, NE.

Background: Delayed graft function (DGF) of a kidney transplant results in increased cost and complexity of management. For clinical care or a DGF trial, it would be ideal to accurately predict individual DGF risk and provide preemptive treatment. A calculator developed by Irish et al has been useful for predicting population, but not individual risk. Read More

Kidney Res Clin Pract 2021 Mar 5;40(1):162-174. Epub 2021 Mar 5.

Transplant Research Center, Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: This study evaluated the impact of acute kidney injury (AKI) on posttransplant clinical outcomes for deceased donor (DD) kidney transplantation (KT) using the Kidney Donor Profile Index (KDPI) system.

Methods: Overall, 657 kidney transplant recipients (KTRs) receiving kidneys from 526 DDs from four transplant centers were included. We divided them into the high and low KDPI donor groups by 65%, the KDPI score, and both groups were subdivided into the AKI-DDKT and non-AKI-DDKT subgroups according to AKI in DDs. Read More

Transplantation 2021 Mar 1. Epub 2021 Mar 1.

Department of Pediatrics. University of Minnesota. Minneapolis, MN. United States Clinical and Translational Science Institute. University of Minnesota. Minneapolis, MN. United States.

Background: Kidneys donated after circulatory death (DCD) are increasingly being used for transplantation in adults to alleviate organ shortage. Pediatric data on survival benefits of DCD transplantation compared with remaining on the waitlist for a kidney donated after brain death (DBD) offer are lacking.

Methods: We used SRTR to identify 285 pediatric (< 18 years) DCD kidney transplants performed between 1987 and 2017. Read More

Stem Cell Res Ther 2021 Mar 1;12(1):158. Epub 2021 Mar 1.

Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

Objective: The aim of this meta-analysis was to evaluate the therapeutic effects of mesenchymal stromal cells (MSCs) versus traditional regimens for induction therapy in kidney transplantation (KT), especially the safety of MSC infusion, practicability of MSCs as induction therapy agents, and posttransplant complications.

Methods: PubMed, Embase, EBSCO, Ovid, and the Cochrane Library were searched for prospective clinical trials that compared MSCs with traditional regimens for induction therapy in KT.

Results: Four trials were included, including a total of 197 patients. Read More

Am J Med Sci 2021 Feb 25. Epub 2021 Feb 25.

Division of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC.

Background: Older kidney transplant recipients (OKTR) are vulnerable to infections and AKI, often prompting hospitalization. This study elucidates etiology of hospitalizations, AKI, and outcomes in OKTR.

Methods: Retrospective study of 500 patients age ≥ 60, who underwent kidney transplantation from 2005-2015. Read More

Kidney Int Rep 2021 Feb 13;6(2):296-303. Epub 2020 Nov 13.

Angion Biomedica, Uniondale, NY.

Introduction: One-third of kidney transplantation patients experience acute kidney injury (AKI) resulting in delayed graft function (DGF), associated with increased risk of graft failure and mortality. Preclinical and phase 2 data indicate that treatment with ANG-3777 (formerly BB3), a hepatocyte growth factor (HGF) mimetic, may improve long-term kidney function and reduce health care resource use and cost, but these data require validation in a phase 3 randomized controlled trial.

Methods: The Graft Improvement Following Transplant (GIFT) trial is a multicenter, double-blind randomized controlled trial, designed to determine the efficacy and safety of ANG-3777 in renal transplantation patients showing signs of DGF. Read More

Transplant Proc 2021 Feb 18. Epub 2021 Feb 18.

Department of Internal Medicine III/Collaborative Kidney Transplant Center, University Hospital Jena - Friedrich Schiller University, Jena, Germany. Electronic address:

Background: Delayed graft function (DGF) is a frequent complication after kidney transplantation affecting long-term outcome.

Patients And Methods: A total of 525 consecutive recipients (age 54.2 ± 13. Read More

Transplant Proc 2021 Mar 11;53(2):750-754. Epub 2021 Feb 11.

Sydney Medical School, University of Sydney, Sydney, Australia; Department of Surgery, Westmead Hospital, Westmead, Australia.

Background: Kidney transplantation is the optimum treatment for kidney failure in carefully selected patients. Technical surgical complications and second warm ischemic time (SWIT) increase the risk of delayed graft function (DGF) and subsequent short- and long-term graft outcomes including the need for post-transplant dialysis and graft failure. Intraoperative organ thermal regulation could reduce SWIT, minimizing surgical complications due to time pressure, and limiting graft ischemia-reperfusion injury. Read More

Transplant Proc 2021 Feb 9. Epub 2021 Feb 9.

Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI. Electronic address:

Delayed graft function (DGF) after kidney transplantation is associated with an increased risk of graft failure. We studied the histologic findings among adult kidney transplant recipients transplanted between January 2000 and June 2015 who had DGF and had a kidney biopsy within 14 days of transplant. Death censored graft failure (DCGF) and death at 1 and 3 years after transplant were examined. Read More

Transplant Proc 2021 Apr 10;53(3):1085-1090. Epub 2021 Feb 10.

Department of General, Oncological, Gastroenterological Surgery and Transplantation, University Hospital in Krakow, Poland.

Introduction: Delayed graft function (DGF) adversely affects graft survival and function. Machine perfusion (MP) improves DGF rate and may compensate for extended storage time.

Material And Methods: In this single-center cohort study, we included 193 consecutive kidney transplantations. Read More

Am J Transplant 2021 Feb 10. Epub 2021 Feb 10.

Division of Nephrology, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.

There are no prior studies assessing the risk factors and outcomes for kidney delayed graft function (K-DGF) in simultaneous heart and kidney (SHK) transplant recipients. Using the OPTN/UNOS database, we sought to identify risk factors associated with the development of K-DGF in this unique population, as well as outcomes associated with K-DGF. A total of 1161 SHK transplanted between 1998 and 2018 were included in the analysis, of which 311 (27%) were in the K-DGF (+) group and 850 in the K-DGF (-) group. Read More

Transplantation 2021 Feb 4. Epub 2021 Feb 4.

Department of Pathology and Laboratory Medicine, University of California, Davis School of Medicine, Sacramento, CA, USA. Division of Transplant Surgery, Department of Surgery, University of California, Davis School of Medicine, Sacramento, CA, USA. Section of Transplant Nephrology, Department of Medicine, University of California, Davis School of Medicine, Sacramento, CA, USA.

Background: Several groups have previously developed logistic regression models for predicting delayed graft function (DGF). In this study, we used an automated machine learning (ML) modeling pipeline to generate and optimize DGF prediction models en masse.

Methods: Deceased donor renal transplants at our institution from 2010-2018 were included. Read More

BMC Surg 2021 Feb 5;21(1):74. Epub 2021 Feb 5.

Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Introduction: Routine placement of surgical drains at the time of kidney transplant has been debated in terms of its prognostic value.

Objectives: To determine whether the placement of a surgical drain affects the incidence rate of developing wound complications and other clinical outcomes, particularly after controlling for other prognostic factors.

Methods: Retrospective analysis of 500 consecutive renal transplant cases who did not (Drain-free, DF) vs. Read More

Sci Rep 2021 Feb 1;11(1):2705. Epub 2021 Feb 1.

Department of Geophysics (DGF), University of Chile, Blanco Encalada 2002, Santiago, Chile.

The M 8.8 Maule earthquake is the largest well-recorded megathrust earthquake reported in South America. It is known to have had very few foreshocks due to its locking degree, and a strong aftershock activity. Read More