376,050 results match your criteria development years


A diarylheptanoid compound from Alpinia officinarum Hance ameliorates high glucose-induced insulin resistance by regulating PI3K/AKT-Nrf2-GSK3β signaling pathways in HepG2 cells.

J Ethnopharmacol 2022 May 19:115397. Epub 2022 May 19.

Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University, 3 Xueyuan Road, Haikou, 571199, China. Electronic address:

Ethnopharmacological Relevance: Alpinia officinarum Hance, a perennial natural medicine-food herb, has been traditionally used to treat colds, stomachache, and diabetes for thousands of years. 1,7-Diphenyl-4E-en-3-heptanone (DPH5), a diarylheptanoid isolated from the rhizome of A. officinarum has been reported to be safe and to have antioxidant and hypoglycemic effects, suggesting its potential in the treatment of insulin resistance (IR). Read More

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Bidirectional relations between depression symptoms and chronic kidney disease.

J Affect Disord 2022 May 20. Epub 2022 May 20.

Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou 510515, China. Electronic address:

Background: Depression and chronic kidney disease (CKD) often coexist. However, both the relations of depression with CKD development and CKD with depression risk were still elusive. We aimed to investigate the bidirectional relations between renal function and depression in a cohort of young and middle-aged adults. Read More

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Safety and immunogenicity of heterologous boost immunisation with an orally administered aerosolised Ad5-nCoV after two-dose priming with an inactivated SARS-CoV-2 vaccine in Chinese adults: a randomised, open-label, single-centre trial.

Lancet Respir Med 2022 May 20. Epub 2022 May 20.

National Health Commission (NHC) Key laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China; School of Public Health, Nanjing Medical University, Nanjing, China; Institute of Global Public Health and Emergency Pharmacy, China Pharmaceutical University, Nanjing, China; School of Public Health, Southeast University, Nanjing, China. Electronic address:

Background: Due to waning immunity and protection against infection with SARS-CoV-2, a third dose of a homologous or heterologous COVID-19 vaccine has been proposed by health agencies for individuals who were previously primed with two doses of an inactivated COVID-19 vaccine.

Methods: We did a randomised, open-label, controlled trial to evaluate the safety and immunogenicity of heterologous boost immunisation with an orally administered aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in Chinese adults (≥18 years old) who had previously received two doses of an inactivated SARS-CoV-2 vaccine-Sinovac CoronaVac. Eligible participants were randomly assigned (1:1:1) to receive a heterologous booster vaccination with a low dose (1·0 × 10 viral particles per mL; 0·1 mL; low dose group), or a high dose (1·0 × 10 viral particles per mL; 0·2 mL; high dose group) aerosolised Ad5-nCoV, or a homologous intramuscular vaccination with CoronaVac (0·5 mL). Read More

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Optical and optoelectronic neuromorphic devices based on emerging memory technologies.

Nanotechnology 2022 May 23. Epub 2022 May 23.

ASIC and System State Key Lab, Fudan University, School of Microelectronics, Shanghai 200433, P.R.China, Shanghai, 200433, CHINA.

As artificial intelligence continues its rapid development, inevitable challenges arise for the mainstream computing hardware to process voluminous data (Big data). The conventional computer system based on von Neumann architecture with separated processor unit and memory is approaching the limit of computational speed and energy efficiency. Thus, novel computing architectures such as in-memory computing and neuromorphic computing based on emerging memory technologies have been proposed. Read More

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Predictive validity of ESSENCE Q screening tool for early detection of neurodevelopmental disorder in children.

Asian J Psychiatr 2022 May 13;73:103162. Epub 2022 May 13.

Department of Radiodiagnosis, All India Institute of Medical Sciences(AIIMS), Bhopal, India. Electronic address:

Introduction: Neurodevelopmental disorders (NDD) are a group of conditions that typically manifest early during the child's development with lifelong consequences. Early identification using efficient screening tools can positively modify the natural history of the disorder. ESSENCE Q is a simple questionnaire to detect ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations to reflect the co-existence of NDDs in children less than five years). Read More

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More efficient formation of longer-term representations for word forms at birth can be linked to better language skills at 2 years.

Dev Cogn Neurosci 2022 May 13;55:101113. Epub 2022 May 13.

Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Logopedics, Welfare Sciences, Faculty of Social Sciences, Tampere University, Finland.

Infants are able to extract words from speech early in life. Here we show that the quality of forming longer-term representations for word forms at birth predicts expressive language ability at the age of two years. Seventy-five neonates were familiarized with two spoken disyllabic pseudowords. Read More

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Emerging antibody-based therapies for the treatment of acute myeloid leukemia.

Cancer Treat Rev 2022 May 18;108:102409. Epub 2022 May 18.

Department of Medicine A, University Hospital Münster, Münster, Germany.

The development of antibody-based therapeutics for patients with acute myeloid leukemia (AML) has long been hampered due to the shared expression of antigens on leukemic blasts and hematopoietic stem and progenitor cells (HSPC). Nevertheless, the first antibody-drug conjugate has been approved for the treatment of AML in the recent years. In addition, multiple antibody-based therapeutics including antibody-drug conjugates, bispecific antibodies and immunocytokines are currently being developed in clinical trials with some of them demonstrating encouraging results alone and/or in combination with current standard therapies. Read More

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AlphaLogD determination: An optimized Reversed-Phase Liquid Chromatography method to measure lipophilicity on neutral and basic small and Beyond-Rule-of-Five compounds.

J Chromatogr A 2022 May 13;1674:463146. Epub 2022 May 13.

Analiza Inc, 3615 Superior Avenue E, Suite 4407B, Cleveland, OH, 44114-4139, USA.

Lipophilicity can be measured with different methods, such as Shake-Flask or liquid chromatography. HPLC presents the advantage of overcoming solubility issues and therefore extending the range of lipophilicity to high values. A specific HPLC method, called ELogD, had been developed 20 years ago on a C-amide stationary phase, enhancing hydrophobic and hydrogen bond interactions to mimic octanol-water partition. Read More

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Intentional binding and self-transcendence: Searching for pro-survival behavior in sense-of-agency.

Conscious Cogn 2022 May 20;102:103351. Epub 2022 May 20.

Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryocho, Aoba-ku, Sendai 980-8575, Japan; International Research Institute of Disaster Science, Tohoku University, 468-1 Aoba, Aramaki, Aoba-ku, Sendai 980-8572, Japan. Electronic address:

Sense-of-agency (SoA) is implicated in a wide range of pro-survival behavioral capacities from a classical psychological perspective. However, in recent years, SoA has primarily been considered a sensorimotor process indexed by intentional binding, and pro-survival behavioral capacity has been considered multifactorial. To revisit their association, considering such conceptual updates, we examined the relationship between intentional binding and eight factors of pro-survival behavioral capacity (as defined by the power-to-live questionnaire). Read More

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[Triggers and predictors of development and formation of sensorineural hearing loss].

Vestn Otorinolaringol 2022 ;87(2):34-43

Kuban State Medical University, Krasnodar, Russia.

The purpose of the study is to review the results of scientific researches in recent years in an expanded interdisciplinary view of the problem of etiopathogenesis of sensorineural hearing loss, as well as the role of comorbidities and triggers in the formation of persistent changes in the audio-receiving part of the auditory analyzer. Read More

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January 2022

CD19/22 CAR T-cells in Children and Young Adults with B-ALL: Phase I Results and Development of a Novel Bicistronic CAR.

Blood 2022 May 23. Epub 2022 May 23.

National Institutes of Health, Clinical Center, Bethesda, Maryland, United States.

Remission durability following single-antigen targeted chimeric antigen receptor (CAR) T-cells is limited by antigen modulation, which may be overcome with combinatorial targeting. Building upon our experiences targeting CD19 and CD22 in B-cell acute lymphoblastic leukemia (B-ALL), we report on the experiences and limitations of a novel MSCV-CD19/CD22-4-1BB bivalent CAR T-cell (CD19.22. Read More

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Promoting Family-Centered Care: A Provider Training Effectiveness Study.

Am J Occup Ther 2022 May;76(3)

Ayelet Ben-Sasson, ScD, OT, is Associate Professor, University of Haifa, Haifa, Israel.

Importance: Although family-centered care (FCC) is a best practice in pediatrics, health care providers report challenges in translating FCC from theory to practice.

Objective: To measure the effectiveness of the Better Together (BT) training to enhance providers' changes in FCC practice and self-efficacy.

Design: Pretest-posttest quasi-experimental design. Read More

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Development of a pharmacist-managed protocol for the transition from intravenous to subcutaneous insulin in critically ill adults.

Am J Health Syst Pharm 2022 May 23. Epub 2022 May 23.

Eskenazi Health, Indianapolis, IN, USA.

Disclaimer: In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Read More

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Behavioral features in child and adolescent huntingtin gene-mutation carriers.

Brain Behav 2022 May 23:e2630. Epub 2022 May 23.

Department of Psychiatry, University of Iowa Hospital and Clinics, Iowa City, Iowa, USA.

Introduction: We compared neuropsychiatric symptoms between child and adolescent huntingtin gene-mutation carriers and noncarriers. Given previous evidence of atypical striatal development in carriers, we also assessed the relationship between neuropsychiatric traits and striatal development.

Methods: Participants between 6 and 18 years old were recruited from families affected by Huntington's disease and tested for the huntingtin gene expansion. Read More

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Risk factors for development of long-term mood and anxiety disorder after pediatric traumatic brain injury: a population-based, birth cohort analysis.

Brain Inj 2022 May 23:1-11. Epub 2022 May 23.

Department of Physical Medicine and Rehabilitation, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.

Objectives: The objective of this study was to identify characteristics associated with an increased risk of anxiety and mood disorder prior to 25 years of age, in children who sustained a traumatic brain injury (TBI) prior to age 10.

Methods: This population-based study identified 562 TBI cases from a 1976-1982 birth cohort in Olmsted County, Minnesota. TBI cases were manually confirmed and classified by injury severity. Read More

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Seroprevalence of SARS-CoV-2 infection and associated factors among Bangladeshi slum and non-slum dwellers in pre-COVID-19 vaccination era: October 2020 to February 2021.

PLoS One 2022 23;17(5):e0268093. Epub 2022 May 23.

Health Systems and Population Studies Division, icddrb, Dhaka, Bangladesh.

Background: Seroprevalence studies have been carried out in many developed and developing countries to evaluate ongoing and past infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Data on this infection in marginalized populations in urban slums are limited, which may offer crucial information to update prevention and mitigation policies and strategies. We aimed to determine the seroprevalence of SARS-CoV-2 infection and factors associated with seropositivity in slum and non-slum communities in two large cities in Bangladesh. Read More

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What the snake leaves in its wake: Functional limitations and disabilities among snakebite victims in Ghanaian communities.

PLoS Negl Trop Dis 2022 May 23;16(5):e0010322. Epub 2022 May 23.

University of Groningen, Department of Internal Medicine/Infectious Diseases, University Medical Centre Groningen, Groningen, The Netherlands.

Background: The estimated five million snakebites per year are an important health problem that mainly affect rural poor populations. The global goal is to halve both mortality and morbidity from this neglected tropical disease by 2030. Data on snakebite morbidity are sparse and mainly obtained from hospital records. Read More

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Implementing Preoxygenation in Obese Patients Prior to Esophagogastroduodenoscopy Procedures in a Fast-Paced Ambulatory Gastrointestinal Endoscopy Center: A Quality Improvement Project.

AANA J 2022 Jun;90(3):197-205

has practiced as a CRNA for over 10 years. Her practice involves ambulatory surgery centers in the areas of plastics, urology, orthopedics, and GI. She received her MS in Anesthesia at the University of Tennessee at Chattanooga and most recently her DNP from the University of Alabama. After receiving her doctoral degree she was appointed to adjunct faculty at the University of Alabama.

Obese patients undergoing esophagogastroduodenoscopy procedures require sedation ranging between deep sedation and general anesthesia to tolerate the procedure which predisposes this patient population to hypoxemia development. A practical, cost-effective, and readily available means of preoxygenation that can be implemented by certified registered nurse anesthetists practicing in high-volume, fast-paced ambulatory gastrointestinal endoscopy centers is the use of a nonrebreathing face mask with reservoir bag and one-way exhalation valve, along with oxygen flow rates at 15 liters per minute, and instructing the patient in taking eight vital capacity deep breaths over 60 seconds prior to start of the procedure. The purpose of this quality improvement project was to reduce intraprocedural hypoxemic events, defined as intraprocedural SpO values ≤ 90%, in obese patients undergoing esophagogastroduodenoscopy procedures with deep sedation using propofol. Read More

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Adolescent Health Promotion Interventions Using Well-Care Visits and a Smartphone Cognitive Behavioral Therapy App: Randomized Controlled Trial.

JMIR Mhealth Uhealth 2022 May 23;10(5):e34154. Epub 2022 May 23.

National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Kodaira, Japan.

Background: Adolescent health promotion is important in preventing risk behaviors and improving mental health. Health promotion during adolescence has been shown to contribute to the prevention of late onset of the mental health disease. However, scalable interventions have not been established yet. Read More

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Self-reported executive function problems in adults born very low birthweight.

Paediatr Perinat Epidemiol 2022 May 23. Epub 2022 May 23.

Canterbury Child Development Research Group, University of Canterbury, Christchurch, New Zealand.

Background: Executive function difficulties are common among children born very preterm and/or very low birthweight (<1500 g; VLBW), but little is known about whether they persist into adulthood.

Objectives: Examine the nature and pattern of self-reported executive functioning at 23 and 28 years of age using data from a national cohort study of adults born VLBW and a comparison group of same-age full-term (FT) born adults. Also examined were associations between executive function difficulties and socio-economic outcomes. Read More

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Soluplus polymeric nanomicelles improve solubility of BCS-class II drugs.

Drug Deliv Transl Res 2022 May 23. Epub 2022 May 23.

Department of Drug and Health Sciences, University of Catania, 95125, Catania, Italy.

The issue of poor aqueous solubility is often a great hitch in the development of liquid dosage forms for those drugs that the Biopharmaceutics Classification System (BCS) includes in classes II and IV. Among the possible technological solutions, inclusion of the drug molecule within polymeric micelles, and particularly nanomicelles, has been proposed in the last years as a valid strategy. Our attention has been recently attracted by Soluplus, an amphiphilic polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer able to form small and stable nanomicelles. Read More

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Metamaterial Absorbers: from Tunable Surface to Structural Transformation.

Adv Mater 2022 May 23:e2202509. Epub 2022 May 23.

Frontiers Science Center for Flexible Electronics (FSCFE) & Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an, 710072, P. R. China.

Since the first demonstration, remarkable progress has been made in the theoretical analysis, structural design, numerical simulation, and potential applications of metamaterial absorbers (MAs). With the continuous advancement of novel materials and creative designs, the absorption of MAs has been significantly improved over a wide frequency spectrum from microwave to optical regime. Further, the integration of active elements into MAs design allows the dynamically manipulation of electromagnetic waves, opening a new platform to push the breakthrough in metadevices. Read More

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Does parity impact obstructed defecation in women with normal anorectal anatomy?

Int Urogynecol J 2022 May 23. Epub 2022 May 23.

Sydney Medical School Nepean, University of Sydney, Sydney, Australia.

Introduction And Hypothesis: Obstructed defecation (OD) is often associated with trauma to pelvic connective tissue and nerves sustained during pregnancy and childbirth. Although there are multiple potential etiologies of defecatory dysfunction, the pathophysiology of this symptom complex is not well understood. The purpose of this study is to determine the role of parity in the development of obstructed defecatory symptoms in women with normal anorectal anatomy in a search for evidence of a presumptive neuropathic effect of pregnancy and childbirth. Read More

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A mapping review of adolescent identity after TBI: what clinicians need to know.

Neuropsychol Rehabil 2022 May 23:1-36. Epub 2022 May 23.

School of Rehabilitation Science, McMaster University, 1400 Main Street West Institute for Applied Health Sciences (IAHS) Building - Room 403, Hamilton, ON, Canada.

Adolescence is a critical period for developing a sense of identity, an iterative process that relies on the development of skills such as self-reflection and self-appraisal. Outcomes of identity development include personal ethics, knowledge of one's strengths and challenges, and, ultimately, independence. Traumatic brain injury (TBI) affects these outcomes in adults, when identity has been established and may need to be redefined; but what happens when an injury occurs while identity is being formed? To answer this question, we used mapping review methodology to explore TBI effects on adolescent identity formation, mapping the evidence onto a biopsychosocial framework for rehabilitation. Read More

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'Nobody can take the stress away from me': a qualitative study on experiences of partners of patients with cancer regarding their work and health.

Disabil Rehabil 2022 May 23:1-9. Epub 2022 May 23.

Amsterdam UMC location Vrije Universiteit, Amsterdam, Department of Public and Occupational Health, Amsterdam, the Netherlands.

Purpose: To explore experienced health- and work-related problems of partners of patients with cancer, and their needs for support.

Materials And Methods: Semi-structured interviews were conducted with Dutch partners of patients with cancer. Interviews were transcribed verbatim. Read More

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Contractile force assessment methods for in vitro skeletal muscle tissues.

Elife 2022 May 23;11. Epub 2022 May 23.

University of Navarra, Tecnun School of Engineering, Manuel de Lardizábal, San Sebastian, Spain.

Over the last few years, there has been growing interest in measuring the contractile force (CF) of engineered muscle tissues to evaluate their functionality. However, there are still no standards available for selecting the most suitable experimental platform, measuring system, culture protocol, or stimulation patterns. Consequently, the high variability of published data hinders any comparison between different studies. Read More

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Rates of Return to Manual Labor After Arthroscopic Rotator Cuff Repair.

Am J Sports Med 2022 May 23:3635465221097102. Epub 2022 May 23.

Department of Orthopaedic Surgery, Carthage Area Hospital, Carthage, New York, USA.

Background: Rotator cuff tears represent a significant cause of shoulder pain and dysfunction in the United States. The development of these injuries is associated with older patient age and higher levels of physical activity; however, data regarding the rate of return to work after arthroscopic rotator cuff repair in patients older than 50 years of age who have physically strenuous jobs is inconclusive.

Purpose/hypothesis: The purpose of this study was to report short term outcomes and return to work rates after arthroscopic rotator cuff repair in a cohort of patients aged 50 to 60 years working in manual labor jobs. Read More

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Application of a composite scoring protocol to identify factors that contribute to the risk of overweight and obesity in Irish children.

Pediatr Obes 2022 May 23:e12922. Epub 2022 May 23.

UCD Institute of Food and Health, School of Agriculture and Food Science, University College Dublin, Dublin, Ireland.

Background: Investigations into the main drivers of childhood obesity are vital to implement effective interventions to halt the global rise in levels. The use of a composite score may help to identify children most at risk of overweight/obesity.

Objectives: To investigate the cumulative impact of factors associated with overweight/obesity risk in children. Read More

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Ultralow Set Voltage and Enhanced Switching Reliability for Resistive Random-Access Memory Enabled by an Electrodeposited Nanocone Array.

ACS Appl Mater Interfaces 2022 May 23. Epub 2022 May 23.

State Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.

Resistive random-access memory (RRAM) has been extensively investigated for 20 years due to its excellent advantages, including scalability, switching speed, compatibility with the complementary metal oxide semiconductor process, and neuromorphic computing application. However, the issue of memristor reliability for cycle to cycle and device to device resulting from the random ion drift and diffusion in solid-state thin films is still a great challenge for commercialization. Therefore, controlling the internal ionic process to improve the memristor performance and reliability is a primary and urgent task. Read More

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