1,216,876 results match your criteria development study


A Dollar Is a Dollar Is a Dollar, or Is It? Insights From Children's Reasoning About "Dirty Money".

Cogn Sci 2021 Apr;45(4):e12950

Department of Psychology, University of Michigan.

Money can take many forms-a coin or a bill, a payment for an automobile or a prize for an award, a piece from the 1989 series or the 2019 series, and so on-but despite this, money is designed to represent an amount and only that. Thus, a dollar is a dollar, in the sense that money is fungible. But when adults ordinarily think about money, they think about it in terms of its source, and in particular, its moral source (e. Read More

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Referential Form and Memory for the Discourse History.

Cogn Sci 2021 Apr;45(4):e12964

Department of Psychology and Human Development, Vanderbilt University.

The way we refer to things in the world is shaped by the immediate physical context as well as the discourse history. But what part of the discourse history is relevant to language use in the present? In four experiments, we combine the study of task-based conversation with measures of recognition memory to examine the role of physical contextual cues that shape what speakers perceive to be a part of the relevant discourse history. Our studies leverage the differentiation effect, a phenomenon in which speakers are more likely to use a modified expression to refer to an object (e. Read More

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Identification of Potential High-Risk Patients on the Basis of PROMs in a Certified Centre for Joint Replacement (EndoProthetikZentrum) Using the Example of Hip Arthroplasty.

Z Orthop Unfall 2021 Apr 19. Epub 2021 Apr 19.

Department of Orthopaedics, Rostock University Medical Centre, Germany.

Background: In addition to clinical parameters, the subjective assessment by the patient to evaluate the operative outcome of an arthroplasty is becoming increasingly important. Questionnaires are used to identify patients who have not achieved the treatment goal at an early stage so that further interventions can be indicated.

Material And Methods: A questionnaire consisting of different PROMs was completed pre- and 3 months postoperatively by patients who had been treated with a hip arthroplasty. Read More

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The Relationship between Psychoacoustic and Electrophysiological Assessments of Temporal Resolution.

J Am Acad Audiol 2021 Apr 19. Epub 2021 Apr 19.

Department of Audiology, School of Rehabilitation Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background:  Temporal resolution is essential to speech acoustic perception. However, it may alter in individuals with auditory disorders, impairing the development of spoken and written language. The envelope of speech signals contains amplitude modulation (AM) that has critical information. Read More

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Association between Temporary Housing Habitation after the 2011 Japan Earthquake and Mite Allergen Sensitization and Asthma Development.

Int Arch Allergy Immunol 2021 Apr 19:1-13. Epub 2021 Apr 19.

Department of Allergy and Respirology, Hiratsuka City Hospital, Hiratsuka, Japan.

Introduction: We previously reported an increased prevalence of asthma in adults who lived in temporary housing after the 2011 Great East Japan Earthquake. The goal of the current study was to investigate changes in asthma prevalence and mite-specific immunoglobulin E (IgE) titers in temporary housing residents during 2014-2019.

Methods: By using the Global Initiative for Asthma guidelines, we diagnosed asthma in Ishinomaki city temporary housing residents aged 15 years or older. Read More

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Personal dosimeter utilisation among South African Interventionalists.

J Radiol Prot 2021 Apr 19. Epub 2021 Apr 19.

Department of Medical Imaging, Prince of Wales Hospital and Community Health Services, Randwick, New South Wales, AUSTRALIA.

Ionising radiation (IR) is increasingly being used in diagnostic and therapeutic procedures and offers increased benefits to patients but poses an increased occupational health risk to operators. The consistent use and monitoring of radiation health care workers' dosimeters is an important part of the process for ensuring adequate monitoring and control of IR in the workplace. There is however often inconsistent dosimeter utilisation among these workers. Read More

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Weaker McGurk Effect for Rubin's Vase-Type Speech in People With High Autistic Traits.

Multisens Res 2021 Apr 16:1-17. Epub 2021 Apr 16.

School of Psychology, Chukyo University, 101-2 Yagoto Honmachi, Showa-ku, Nagoya-shi, Aichi, 466-8666, Japan.

While visual information from facial speech modulates auditory speech perception, it is less influential on audiovisual speech perception among autistic individuals than among typically developed individuals. In this study, we investigated the relationship between autistic traits (Autism-Spectrum Quotient; AQ) and the influence of visual speech on the recognition of Rubin's vase-type speech stimuli with degraded facial speech information. Participants were 31 university students (13 males and 18 females; mean age: 19. Read More

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May the Cleaning of Prescriptive Documents Using Best Evidence Reduce the Cost of Prescribed Healthcare?

Value Health Reg Issues 2021 Apr 16;25:108-111. Epub 2021 Apr 16.

National Research University Higher School of Economics, Moscow. Electronic address:

Objectives: Clinical practice is developing under influence of the evidence-based clinical practice guidelines (EBCPG). In Russia development of the documents prescribing the content of care is connected with the idea that they may be used as well for estimation of the cost of care. The outcome is the national healthcare legislation of 2011. Read More

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Bidirectional sensory neuron-immune interactions: a new vision in the understanding of allergic inflammation.

Curr Opin Immunol 2021 Apr 16;72:79-86. Epub 2021 Apr 16.

Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), Inserm UMR1291 CNRS UMR5051, University of Toulouse III, Toulouse, France. Electronic address:

Peripheral neurons (including sensory neurons) are ubiquitously distributed in all tissues, particularly at the interface with the environment. The primary function of sensory neurons is the transmission of sensations of temperature, pain and itch to elicit appropriate behavioral responses. More recently, sensory neurons have emerged as potent regulators of type 2 immune responses and allergic inflammation. Read More

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Detection of foot contact in treadmill running with inertial and optical measurement systems.

J Biomech 2021 Apr 9;121:110419. Epub 2021 Apr 9.

Department of Physical Therapy & Rehabilitation Sciences, Drexel University, Philadelphia, PA, United States.

In running assessments, biomechanics of the stance phase are often measured to understand external loads applied to the body. Identifying time of initial foot contact can be challenging in runners with different strike patterns. Peak downward velocity of the pelvis (PDVP) has been validated in a laboratory setting to detect initial contact. Read More

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Development of an in vitro test method to simulate intra-operative impaction loading on lumbar intervertebral body fusion devices.

J Biomech 2021 Apr 5;121:110412. Epub 2021 Apr 5.

U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Applied Mechanics, Silver Spring, MD 20993, USA.

Intervertebral body fusion devices (IBFDs) are commonly used in the treatment of various spinal pathologies. Intra-operative fractures of polyether-ether-ketone (PEEK) implants have been reported in the literature and to the FDA as device-related adverse events. The device and/or implant inserter failures typically occur during device impaction into the disc space and require implant removal and replacement. Read More

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Understanding adolescents' perceived social responsibility: The role of family cohesion, interdependent self-construal, and social trust.

J Adolesc 2021 Apr 16;89:55-62. Epub 2021 Apr 16.

Department of Early Childhood Education and Centre for Child and Family Science, The Education University of Hong Kong, Hong Kong SAR, China.

Introduction: Positive family interactions contribute to the development of social responsibility among adolescents. Interdependent self-construal and social trust, which reflect the perceived relatedness and beliefs towards others, may explain the relation between family cohesion and social responsibility. The present study tested the mediating mechanisms between family cohesion and adolescents' social responsibility via adolescents' interdependent self-construal and social trust. Read More

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Swine as biomedical animal model for T-cell research-Success and potential for transmittable and non-transmittable human diseases.

Authors:
Tobias Käser

Mol Immunol 2021 Apr 16;135:95-115. Epub 2021 Apr 16.

Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, 27607 Raleigh, NC, USA. Electronic address:

Swine is biologically one of the most relevant large animal models for biomedical research. With its use as food animal that can be exploited as a free cell and tissue source for research and its high susceptibility to human diseases, swine additionally represent an excellent option for both the 3R principle and One Health research. One of the previously most limiting factors of the pig model was its arguably limited immunological toolbox. Read More

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Employing metabolomic approaches to determine the influence of age on experimental autoimmune encephalomyelitis (EAE).

Mol Immunol 2021 Apr 16;135:84-94. Epub 2021 Apr 16.

Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST-School, Korea University of Science and Technology (UST), Seoul, 02792, Republic of Korea. Electronic address:

The immune system plays a critical role not only in homeostasis of the body but also in pathogenesis. Autoimmunity and dysregulation of the immune balance are closely related to age. To examine the influence of age on autoimmunity, the pathophysiological features of experimental autoimmune encephalomyelitis (EAE) induced at different ages were elucidated on the basis of plasma-level metabolic changes. Read More

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Identification and application of a neutralizing epitope within alpha-hemolysin using human serum antibodies elicited by vaccination.

Mol Immunol 2021 Apr 16;135:45-52. Epub 2021 Apr 16.

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, 400038, PR China. Electronic address:

Staphylococcus aureus (SA), especially the methicillin-resistant variant (MRSA), is becoming a serious threat to human health in hospitals and communities, making the development of an effective vaccine urgent. Alpha-hemolysin (Hla) is a key virulence factor and also a good target for the development of SA vaccines. However, the epitopes in Hla recognized by human immunity are not characterized in detail, which hinders the design of epitope-based human vaccines against SA. Read More

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Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA): Early diagnosis, treatment and outcomes.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 16;261:12-16. Epub 2021 Apr 16.

Department of Urology, Children's Medicine Affiliated to Chongqing Medical University, Chongqing, PR China; Paediatrics Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Centre for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, PR China; Chongqing Key Laboratory of Paediatrics, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, PR China. Electronic address:

Objective: To describe and summarize the early diagnosis, treatment and outcomes of obstructed hemivagina and ipsilateral renal anomaly (OHVIRA).

Methods: Data from patients with OHVIRA treated at the study centre over the last decade were analysed retrospectively, including demographic characteristics, symptoms, diagnosis, treatment and outcomes. Relevant published literature was also reviewed in this study. Read More

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Adrenergic signaling promotes the expansion of cancer stem-like cells of malignant peripheral nerve sheath tumors.

Biochem Biophys Res Commun 2021 Apr 16;557:199-205. Epub 2021 Apr 16.

Department of Cellular Physiology, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Malignant peripheral nerve sheath tumor (MPNST), a highly malignant tumor that arises in peripheral nerve tissues, is known to be highly resistant to radiation and chemotherapy. Although there are several reports on genetic mutations and epigenetic changes that define the pathogenesis of MPNST, there is insufficient information regarding the microenvironment that contributes to the malignancy of MPNST. In the present study, we demonstrate that adrenaline increases the cancer stem cell population in MPNST. Read More

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Simulation analysis of implementation effects of construction and demolition waste disposal policies.

Waste Manag 2021 Apr 16;126:684-693. Epub 2021 Apr 16.

China Railway 14TH Bureau Group Co., Ltd, PR China.

Urban development generates large amounts of construction and demolition waste, and the enactment of various policies is an important way to increase resource efficiency. It is urgent to analyse the choices and effects of construction and demolition waste disposal policies around the world. This study analyses and compares the implementation effects of various construction and demolition waste disposal policies and provides suggestions on the selection and formulation of different disposal method policies. Read More

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Case study of pipeline failure analysis from two automated vacuum collection system.

Waste Manag 2021 Apr 16;126:643-651. Epub 2021 Apr 16.

Departament de Ciència de Materials i Química Física, Universitat de Barcelona, C/ Martí i Franquès 1, 08028 Barcelona, Spain. Electronic address:

Conventional municipal waste management systems based on collecting and storing waste for future management are cost-effective and flexible. These systems present significant problems such as odours, plagues and hygiene problems caused by their storage and greenhouse gas emissions from garbage trucks used for the transport of waste. The Automated Waste Collection System (AWCS) and Automated Vacuum Waste Collection (AVWC) systems, in which waste is transported directly underground to the processing plants, are efficient collection systems and respectful of the environment as alternatives to traditional systems. Read More

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A unique view of SARS-COV-2 through the lens of ORF8 protein.

Comput Biol Med 2021 Apr 15;133:104380. Epub 2021 Apr 15.

School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, Northern Ireland, UK. Electronic address:

Immune evasion is one of the unique characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attributed to its ORF8 protein. This protein modulates the adaptive host immunity through down-regulation of MHC-1 (Major Histocompatibility Complex) molecules and innate immune responses by surpassing the host's interferon-mediated antiviral response. To understand the host's immune perspective concerning the ORF8 protein, a comprehensive study of the ORF8 protein and mutations possessed by it have been performed. Read More

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Detection and removal of pacing artifacts prior to automated analysis of 12-lead ECG.

Comput Biol Med 2021 Apr 16;133:104396. Epub 2021 Apr 16.

Oregon Health & Science University, Knight Cardiovascular Institute, Portland, OR, USA. Electronic address:

Background: Pacing artifacts must be excluded from the analysis of paced ECG waveform. This study aimed to develop and validate an algorithm to identify and remove the pacing artifacts on ECG and vectorcardiogram (VCG).

Methods: We developed a semi-automatic algorithm that identifies the onset and offset of a pacing artifact based on the VCG signal slope steepness and designed a graphical user interface that permits quality control and fine-tuning the constraining threshold values. Read More

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Autofluorescence spectroscopy and multivariate analysis for predicting the induced damages to other organs due to liver fibrosis.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Mar 24;257:119741. Epub 2021 Mar 24.

Division of Biophotonics and Imaging, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India. Electronic address:

When our liver does not work well, it can induce damage to other organs causing their dysfunction. With this background, we aim to study the effect of liver fibrosis on other organs such as heart, lungs, kidney and spleen by assessing the variations in the inherent emission property of the tissue, using fluorescence spectroscopy. Fluorescence emission spectra from excised organs of liver fibrosis induced rats were collected at excitation wavelengths 320 and 410 nm. Read More

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Using soil erosion to locate nonpoint source pollution risks in coastal zones: A case study in the Yellow River Delta, China.

Environ Pollut 2021 Apr 10;283:117117. Epub 2021 Apr 10.

School of Environment, Beijing Normal University, Beijing, 100875, China. Electronic address:

Soil erosion contributes greatly to nonpoint source pollution (NSP). We built a coastal NSP risk calculation method (CNSPRI) based on the Revised Universal Soil Loss Equation (RUSLE) and geospatial methods. In studies on the formation and transport of coastal NSP, we analysed the pollution impacts on the sea by dividing subbasins into the sea and monitoring the pollutant flux. Read More

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Components study on antitussive effect and holistic mechanism of Platycodonis Radix based on spectrum-effect relationship and metabonomics analysis.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Apr 2;1173:122680. Epub 2021 Apr 2.

Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA.

The antitussive effect of Platycodonis Radix is closely related to the components in saponins fraction of Platycodonis Radix extract (SFPRE); however, these active components and their holistic mechanism remain unknown. Hence, a new method by integrating spectrum-effect relationship analysis with metabolomics analysis was applied to study the active components and their holistic mechanism simultaneously. For spectrum-effect relationship analysis, chemical fingerprints of ten batches of SFPRE were developed using UHPLC-LTQ-Orbitrap MS; antitussive effect were evaluated using a classic mice-cough model induced by ammonia liquor. Read More

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Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth: The Hokkaido Study on Environment and Children's Health.

Sci Total Environ 2021 Apr 16;783:147035. Epub 2021 Apr 16.

Hokkaido University Center for Environmental and Health Sciences, Sapporo, Japan. Electronic address:

Prenatal exposure to phthalates negatively affects the offspring's health. In particular, epigenetic alterations, such as DNA methylation, may connect phthalate exposure with health outcomes. Here, we evaluated the association of di-2-ethylhexyl phthalate (DEHP) exposure in utero with cord blood epigenome-wide DNA methylation in 203 mother-child pairs enrolled in the Hokkaido Study on Environment and Children's Health, using the Illumina HumanMethylation450 BeadChip. Read More

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Continuous preparation of dual-responsive sensing fibers for smart textiles.

J Colloid Interface Sci 2021 Apr 9;597:215-222. Epub 2021 Apr 9.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.

Continuous preparation of sensing fibers that respond to multiple stimuli is of great significance to the development of smart textile and clothing. However, in most cases, the production of sensing fibers is restricted to laboratory scale by factors of equipment and technology, thus it is still challenging to achieve industrial-scale fibers. In this study, continuous preparation of dual-responsive sensing fibers (DRSF) by a set of process designs with custom-built equipment, which consists of core fibers, functional layers, parallel electrodes and protective layers are reported. Read More

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Suppression of NLRP3 inflammasome by Platycodin D via the TLR4/MyD88/NF-κB pathway contributes to attenuation of lipopolysaccharide induced acute lung injury in rats.

Int Immunopharmacol 2021 Apr 16;96:107621. Epub 2021 Apr 16.

Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, People's Republic of China. Electronic address:

Acute lung injury (ALI) is a common clinical condition with a high mortality rate and no specific treatment is available. An excessive inflammatory response contributes to the development of ALI and accelerates its progression, and the NLRP3 inflammasome and NF-κB signaling pathways are key players in inflammation. Platycodin D has been reported to have anti-oxidant and anti-stress properties in various diseases. Read More

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Bibliometric Analysis of the Scientific Literature on Adolescent Idiopathic Scoliosis.

World Neurosurg 2021 Apr 16. Epub 2021 Apr 16.

Daniel and Jane Och Spine Hospital, New York-Presbyterian Healthcare System, Columbia University Medical Center, New York, NY, USA.

Background: In recent years, there has been increasing research on adolescent idiopathic scoliosis (AIS), leading to a large number of publications on this topic. To our knowledge, there is no study focused on the research trend in this field yet.

Methods: Using the Web of Science Core Collection database for all publications on AIS. Read More

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Nanopriming with zero-valent iron synthesized using pomegranate peel waste: A "green" approach for yield enhancement in Oryza sativa L. cv. Gonindobhog.

Plant Physiol Biochem 2021 Apr 16;163:261-275. Epub 2021 Apr 16.

Centre of Advanced Study, Department of Botany, Calcutta University, 35, Ballygange Circular Road, Kolkata-19, India. Electronic address:

Nanopriming is a combination of nanoparticle treatment and a seed dressing technique that can increase seed quality, seedling vigour, yield and also imparts tolerance against biotic and abiotic stress. Here, nano-scale zero-valent iron (G-nZVI) was synthesized using fruit peel waste of Punica granatum L and their formation was validated from XRD and optical spectroscopic techniques. Later, the seeds were primed with G-nZVI at six different concentrations (0, 10, 20, 40, 80, and 160 mg L ) to determine the dose which is optimum for increasing germination percentage and seedling vigour of rice (Oryza sativa L. Read More

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Emergency upscaling of video consultation during the COVID-19 pandemic: Contrasting user experience with data insights from the electronic health record in a large academic hospital.

Int J Med Inform 2021 Apr 12;150:104463. Epub 2021 Apr 12.

Department of Surgery, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, the Netherlands. Electronic address:

Background: Video consultation (VC) has been scaled up at our academic centre attempting to facilitate and accommodate patient-provider interaction in times of social distancing during the recent and ongoing COVID-19 pandemic.

Objectives: This study evaluates qualitative outcomes with data insights from the electronic health record, to contrast satisfaction outcomes with the actual use of VC.

Methods: Healthcare providers and patients using VC during the COVID-19 pandemic at a large academic centre in the Netherlands were surveyed for user satisfaction and experiences with VC. Read More

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