1,115 results match your criteria development sebaceous


Shifts in the Skin Bacterial and Fungal Communities of Healthy Children Transitioning through Puberty.

J Invest Dermatol 2021 Jul 10. Epub 2021 Jul 10.

Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA. Electronic address:

Previous cross-sectional studies have shown that skin microbiomes in adults are distinct from those in children. However, the human skin microbiome in individuals as they sexually mature has not been studied as extensively. We performed a prospective, longitudinal study to investigate the puberty-associated shifts in skin microbiota. Read More

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Case Report: A Frameshift Mutation in MSH2 Exon 2 in a Kidney Recipient With Muir-Torre Syndrome.

Front Oncol 2021 24;11:681780. Epub 2021 Jun 24.

Department of Pathology, Taicang Hospital of Traditional Chinese Medicine, Suzhou, China.

Muir-Torre syndrome (MTS), a rare subtype of Lynch syndrome, is mostly autosomal dominant, which is caused by germline mutations in DNA mismatch repair (MMR) genes, the resulting microsatellite instability (MSI) of which increases the risk of developing sebaceous and other visceral tumors. Several reports have showed an association between immunosuppressive agents and the progression of latent MTS. In this report, we described a 41-year-old man with a history of kidney transplantation, having a rapid growth of the nodule on the anterior chest under immunosuppressive therapy, which was histologically proved to be sebaceous carcinoma. Read More

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Serum resistin levels and resistin gene polymorphism in patients with acne vulgaris: does it correlate with disease severity?

Int J Dermatol 2021 Jul 7. Epub 2021 Jul 7.

Medical Biochemistry and Molecular Biology Department, Menoufia University, Shebin EL-Kom, Egypt.

Background: Acne vulgaris is a disease that inflames the sebaceous gland with multiple etiologies. Many proinflammatory adipokines contribute to this pathogenesis. Resistin is a proinflammatory mediator that activates kappa B, a nuclear factor, and c-Jun N-terminal kinases pathways inducing toll-like receptor-2, interleukin-1, 6, and tumor necrosis factor alpha. Read More

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Sex Hormones Related Ocular Dryness in Breast Cancer Women.

J Clin Med 2021 Jun 14;10(12). Epub 2021 Jun 14.

Breast Unit, University Campus Bio-Medico, 00128 Rome, Italy.

Background: Dry eye syndrome (DES) is strictly connected to systemic and topical sex hormones. Breast cancer treatment, the subsequent hormonal therapy, the subsequent hyperandrogenism and the early sudden menopause, may be responsible for ocular surface system failure and its clinical manifestation as dry eye disease. This local dryness is part of the breast cancer iatrogenic dryness, which affects overall mucosal tissue in the fragile population of those with breast cancer. Read More

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Preliminary efficiency evaluation of development methods applied to aged sebaceous latent fingermarks.

Sci Justice 2021 Jul 26;61(4):378-383. Epub 2021 Mar 26.

Rio Grande do Sul Technical and Scientific Division, Bioforensic Research Group, Brazilian Federal Police, Ipiranga Av., 1365, 90160-093 Porto Alegre, RS, Brazil.

Latent fingermarks are important trace evidence found in crime scenes mainly used for identification purposes. Once deposited, the composition of samples changes over time influencing the efficacy of latent fingermark development methods. In this sense, the aims of this work were to characterize the fatty acid (FA) profile of sebaceous latent fingermarks by GC-FID and to preliminarily evaluate the development efficiency of enhancement methods (powder dusting, iodine fuming and silver nitrate method) in a 30-day period of aging under controlled parameters of temperature, photoperiod and humidity. Read More

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Antibacterial Susceptibility Testing of in Acne Vulgaris Patients.

Clin Cosmet Investig Dermatol 2021 18;14:671-677. Epub 2021 Jun 18.

Riga Stradiņš University, Faculty of Medicine, Riga, LV-1007, Latvia.

Introduction: Combination therapy is widely used for the treatment of acne vulgaris (AV), including local anti-inflammatory drugs containing antimicrobials, such as clindamycin or erythromycin, to inhibit () growth and at the same time reduce the production of inflammatory mediators. The aim of the study is to compare the antibacterial susceptibility of to clindamycin and erythromycin in AV patients compared with healthy patients in the control group (CG).

Methods: The prospective study included 56 patients with clinically diagnosed AV symptoms and 12 patients were included in the CG who did not have AV. Read More

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A Janus-Faced Bacterium: Host-Beneficial and -Detrimental Roles of .

Front Microbiol 2021 31;12:673845. Epub 2021 May 31.

Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden.

The bacterial species (formerly known as ) is tightly associated with humans. It is the dominant bacterium in sebaceous regions of the human skin, where it preferentially colonizes the pilosebaceous unit. Multiple strains of that belong to phylogenetically distinct types can co-exist. Read More

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Anti-N-Methyl-D-Aspartate Receptor Encephalitis Associated with Ovarian Teratoma in South China-Clinical Features, Treatment, Immunopathology, and Surgical Outcomes of 21 Cases.

Dis Markers 2021 21;2021:9990382. Epub 2021 May 21.

Department of Gynecology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.

Objective: To study the clinical characteristics and surgical outcomes of anti-NMDAR encephalitis and the immunopathology of associated teratomas.

Methods: Twenty-one patients were enrolled in this retrospective study, who were diagnosed with anti-NMDAR encephalitis with ovarian teratoma and admitted to two tertiary hospitals in South China from July 2014 to December 2019. The clinical data of patients were reviewed. Read More

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Ferredoxin reductase regulates proliferation, differentiation, cell cycle and lipogenesis but not apoptosis in SZ95 sebocytes.

Exp Cell Res 2021 Aug 4;405(2):112680. Epub 2021 Jun 4.

Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China; Medical Cosmetic and Plastic Surgery Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:

Ferredoxin reductase (FDXR), a mitochondrial membrane-associated flavoprotein, is essential for electron transfer and modulates p53-dependent apoptosis in cancer cells.FDXR may be implicated in epidermal and sebocytic differentiation, but its explicit function in sebocytes remains to be elucidated. In the present study, immunohistochemistry revealed that FDXR expression was increased in sebaceous cells of acne lesions. Read More

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Fluorescent Cationic Conjugated Polymer-Based Adaptive Developing Strategy for Both Sebaceous and Blood Fingerprints.

ACS Appl Mater Interfaces 2021 Jun 3;13(23):27419-27429. Epub 2021 Jun 3.

Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.

Both latent sebaceous and blood fingerprints may provide valuable information for forensic investigation. To detect both types of fingerprints with no need to predistinguish them, a new adaptive developing strategy was proposed. A cationic conjugated polymer with poly[-(phenylene ethylene)--(thienylene ethynylene)] backbone (PPETE-NMe) was synthesized, which was dissolved in ,-dimethylformamide (DMF) to form the developing solution. Read More

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Skin Diseases in Elite Athletes.

Int J Sports Med 2021 May 11. Epub 2021 May 11.

Department of Sport Medicine Humboldt University and Charité University School of Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.

An athlete's skin has to cope with various stressors that influence skin integrity. This study investigated the effect of intense sporting activity at a competitive level on skin health, independent of the type of sport. The prevalence of dermatoses in elite athletes who exercise 8 or more hours per week was compared to recreational athletes. Read More

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Genetic analyses of a secondary poroma and trichoblastoma in a HRAS-mutated sebaceous nevus.

J Dermatol 2021 Aug 27;48(8):1268-1272. Epub 2021 Apr 27.

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

A sebaceous nevus is a congenital skin hamartoma caused by postzygotic HRAS or KRAS mosaic mutations. With age, affected individuals may develop secondary tumors within a sebaceous nevus. RAS mutations are harbored from the onset of sebaceous nevus, and further mutations can be expected to be required in order to explain the initiation of secondary tumors. Read More

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Effects of metformin on experimentally induced acne on rabbit ear.

Exp Dermatol 2021 Jul 13;30(7):966-972. Epub 2021 Apr 13.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Evidence for the effectiveness of metformin in the treatment of acne is limited. To assess its efficacy, comedones were experimentally induced in young New Zealand rabbit ear using Isopropyl Myristate (IM) followed by metformin treatment (30 mg/kg bodyweight) for 60 days with continued IM application. In another group, to check whether metformin pre-treatment affects subsequent comedone development by IM, metformin was given for 14 days and then withdrawn (14 days) followed by comedone development with IM and metformin treatment. Read More

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Normal and Premature Adrenarche.

Endocr Rev 2021 Mar 31. Epub 2021 Mar 31.

Emeritus of Pediatrics and Medicine, The University of Chicago Pritzker School of Medicine, Section of Adult and Pediatric Endocrinology, Metabolism, and Diabetes, Chicago, IL.

Adrenarche is the maturational increase in adrenal androgen production that normally begins in early childhood. It results from changes in the secretory response to ACTH that are best indexed by dehydroepiandrosterone sulfate (DHEAS) rise. These changes are related to the development of the zona reticularis (ZR) and its unique gene/enzyme expression pattern of low 3ß-hydroxysteroid dehydrogenase type 2 with high cytochrome b5A, sulfotransferase 2A1, and 17ß-hydroxysteroid dehydrogenase type 5. Read More

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A rare case of nevus sebaceous of the bilateral labia minora: A case report and review of literature.

Medicine (Baltimore) 2021 Mar;100(10):e25047

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital.

Rationale: Nevus sebaceous (NS) is a lesion caused by congenital hyperplastic disorder of the sebaceous glands. It commonly noted in the scalp and face and rarely in the trunk, neck, or oral mucosa. We present a rare case of a lesion arising in the genital region. Read More

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Stem and progenitor cells in sebaceous gland development, homeostasis and pathologies.

Exp Dermatol 2021 Apr 10;30(4):588-597. Epub 2021 Mar 10.

Center for Molecular Medicine Cologne, CMMC Research Institute, University of Cologne, Cologne, Germany.

Sebaceous glands (SGs), typically associated with hair follicles, are critical for the homeostasis and function of mammalian skin. The main physiological function of SGs is the production and holocrine secretion of sebum to lubricate and protect the skin. Defective SGs have been linked to a variety of skin disorders, including acne, seborrheic dermatitis and formation of sebaceous tumors. Read More

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Sex hormones and acne: State of the art.

J Dtsch Dermatol Ges 2021 04 12;19(4):509-515. Epub 2021 Feb 12.

Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany.

Acne is an androgen-dependent inflammatory disease of sebaceous follicles. Herein, we reviewed and discussed the underlying pathways of androgen biosynthesis and metabolism, non-genomic regulation of androgen receptor expression and function, posttranslational regulation of androgen excess in acne and acne-associated syndromes, such as polycystic ovary syndrome, and congenital adrenal hyperplasia. We provide insights into the involvement of sex hormones, particularly androgens, in skin homeostasis and acne pathogenesis, including comedogenesis, lipogenesis, microbiota, and inflammation. Read More

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Interfollicular epidermal stem-like cells for the recreation of the hair follicle epithelial compartment.

Stem Cell Res Ther 2021 01 15;12(1):62. Epub 2021 Jan 15.

3B's Research Group - Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Guimarães, Portugal.

Background: Hair follicle (HF) development and growth are dependent on epithelial-mesenchymal interactions (EMIs). Dermal papilla (DP) cells are recognized as the key inductive mesenchymal player, but the ideal source of receptive keratinocytes for human HF regeneration is yet to be defined. We herein investigated whether human interfollicular epidermal keratinocytes with stem-like features (EpSlKCs), characterized by a α6/CD71 expression, can replace human hair follicular keratinocytes (HHFKCs) for the recreation of the HF epithelium and respective EMIs. Read More

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January 2021

Glucocorticoid-Induced Skin Atrophy: The Old and the New.

Clin Cosmet Investig Dermatol 2020 30;13:1041-1050. Epub 2020 Dec 30.

Clinical Department, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University, Galati, Romania.

Glucocorticoids are major therapeutic agents highly used in the medical field. Topical glucocorticoids have biologic activities which make them useful in dermatology - anti-inflammatory, vasoconstrictive, immune suppressive and antiproliferative, in treating inflammatory skin disorders (allergic contact eczema, atopic hand eczema, nummular eczema, psoriasis vulgaris or toxic-irritative eczema). Unfortunately, the beneficial effects of topical glucocorticoids are shadowed by their potential for adverse effects - muscle or skin atrophy, striae distensae, rubeosis or acne. Read More

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December 2020

Systemic isotretinoin treatment in a renal transplant patient developing sebaceous hyperplasia due to cyclosporine.

North Clin Istanb 2020 22;7(6):628-630. Epub 2020 Jul 22.

Department of Dermatology, Haseki Training and Research Hospital, Istanbul, Turkey.

Sebaceous hyperplasia (SH) is a benign tumor with telangiectasia on it, yellowish or skin-colored, with papulosis. Besides genetic factors, aging, ultraviolet rays, sex hormones, calcineurin inhibitors, such as cyclosporin, tacrolimus and systemic steroids, play a role in the development of sebaceous hyperplasia. Cyclosporin is widely used in organ transplant patients. Read More

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An updated review of the sebaceous gland and its role in health and diseases Part 1: Embryology, evolution, structure, and function of sebaceous glands.

Dermatol Ther 2021 01 1;34(1):e14695. Epub 2021 Jan 1.

Veterans Affairs Hospital and SUNY Downstate Dermatology Service, Brooklyn, New York, USA.

Sebaceous glands are sebum-secreting components of pilosebaceous units. The embryological development of the sebaceous gland follows that of the hair follicle and epidermal tissue, beginning between weeks 13 and 16 of fetal development. New sebaceous glands do not normally develop following birth, but their size increases with age. Read More

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January 2021

Identification of KRAS mutation in a patient with linear nevus sebaceous syndrome: a case report.

BMC Med Genomics 2020 12 12;13(1):188. Epub 2020 Dec 12.

Department of Dermatologic Surgery, Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, Jiangsu, China.

Background: Linear nevus sebaceous syndrome (LNSS) is a rare genetic disease characterized by large linear sebaceous nevus typically on the face, scalp, or neck. LNSS could be accompanied by multisystem disorders including the central nervous system. Herein, we report gene mutational profile via whole exome sequencing of both lesional and non-lesional skin samples in a LNSS patient. Read More

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December 2020

Primary hypertrophic osteoarthropathy with severe arthralgia identified by gene mutation of .

Mod Rheumatol Case Rep 2021 Jul 18;5(2):404-408. Epub 2021 Jan 18.

Department of Maternal-Fetal Biology, National Center for Child Health and Development, Tokyo, Japan.

Male, 41 years old (yo) had been complaining of severe arthralgia. Past History indicated obstruction of intestinal tract at 12 yo and gastric ulcer at 13 yo. He had been suffered from polyarthralgia especially at PIP and MP joints of both hands from 38 yo. Read More

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Overall renewal of skin lipids with Vetiver extract for a complete anti-ageing strategy.

Int J Cosmet Sci 2021 Apr 28;43(2):165-180. Epub 2020 Dec 28.

Givaudan France SAS, Research and Development, Argenteuil, France.

Objective: Skin lipids are essential in every compartment of the skin where they play a key role in various biological functions. Interestingly, their role is central in the maintenance of hydration which is related to skin barrier function and in the skin structure through adipose tissue. It is well described today that skin lipids are affected by ageing giving skin sagging, wrinkles and dryness. Read More

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Effect of Genetic Polymorphisms of Human SLC22A3 in the 5'-flanking Region on OCT3 Expression and Sebum Levels in Human Skin.

J Dermatol Sci 2021 Jan 24;101(1):4-13. Epub 2020 Oct 24.

Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

Background: Human organic cation transporter 3 (OCT3,SLC22A3) mediates the uptake of many important endogenous substances and basic drugs, and has been identified as one of the transporters that are highly expressed in human skin. However, the mechanisms responsible for variability in mRNA expression, and the role of SLC22A3 in human skin is not clear.

Objective: We examined the effects of the single nucleotide polymorphisms ofSLC22A3 on the variability in SLC22A3 expression and sebum levels in humans. Read More

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January 2021

Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence.

Nat Commun 2020 11 6;11(1):5645. Epub 2020 Nov 6.

Laboratory of Stem Cell Dynamics, School of Life Sciences, Ecole Polytechnique Fédérale Lausanne, 1015, Lausanne, Switzerland.

The formation of hair follicles, a landmark of mammals, requires complex mesenchymal-epithelial interactions and it is commonly believed that embryonic epidermal cells are the only cells that can respond to hair follicle morphogenetic signals in vivo. Here, we demonstrate that epithelial stem cells of non-skin origin (e.g. Read More

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November 2020

The Pro-Differentiation Effect of Doxycycline on Human SZ95 Sebocytes.

Dermatology 2020 Oct 22:1-5. Epub 2020 Oct 22.

The UCD Charles Institute of Dermatology, University College Dublin, Dublin, Ireland.

Background: Despite their widespread clinical use in both acne vulgaris and rosacea, the effects of tetracyclines on sebocytes have not been investigated until now. Sebaceous glands are central to the pathogenesis of acne and may be important in the development of rosacea.

Objective: The aim of this study was to assess the effects of doxycycline on the immortalized SZ95 sebaceous gland cell line as a model for understanding possible effectiveness on the sebaceous glands in vivo. Read More

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October 2020

Advances in resolving the heterogeneity and dynamics of keratinocyte differentiation.

Curr Opin Cell Biol 2020 12 19;67:92-98. Epub 2020 Oct 19.

Department of Dermatology, Institute for Regenerative Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. Electronic address:

The mammalian skin is equipped with a highly dynamic stratified epithelium. The maintenance and regeneration of this epithelium is supported by basally located keratinocytes, which display stem cell properties, including lifelong proliferative potential and the ability to undergo diverse differentiation trajectories. Keratinocytes support not just the surface of the skin, called the epidermis, but also a range of ectodermal structures including hair follicles, sebaceous glands, and sweat glands. Read More

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December 2020

Genetic polymorphism of liver X receptor gene in vitiligo: Does it have an association?

J Cosmet Dermatol 2021 Jun 20;20(6):1906-1914. Epub 2020 Oct 20.

Medical Biochemistry and Molecular Biology Department, Menoufia University, Shebin El-Kom, Egypt.

Background: Vitiligo is an acquired depigmentation of the skin and the mucous membranes, exhibited as white macules and patches due to selective loss of melanocytes. Etiological theories of vitiligo include genetic, immunological, neurohormonal, cytotoxic, biochemical, oxidative stress, and newer theories of melanocytorrhagy and diminished melanocytes survival. It has been revealed that liver X receptor alpha gene is expressed in skin tissue such as sebaceous glands, hair follicle, keratinocytes, and fibroblasts and is linked to various skin disorders as acne vulgaris and psoriasis. Read More

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