9,799 results match your criteria development obstetric


Trophectoderm biopsy of blastocysts for a preimplantation genetic test does not affect serum β-hCG levels in early pregnancy: a study using propensity score matching.

J Ovarian Res 2021 Jun 11;14(1):78. Epub 2021 Jun 11.

Department of Obstetrics and Gynecology, Center for Reproductive Medicine/Department of Fetal Medicine and Prenatal Diagnosis/BioResource Research Center, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Although preimplantation genetic test (PGT) has been used worldwide, few studies investigated the effect of trophectoderm biopsy of blastocysts on early embryo development. This study aimed to investigate whether trophectoderm (TE) biopsy of blastocysts for a PGT affected serum β-human chorionic gonadotropin (hCG) levels 14 days after transfer.

Methods: This was a retrospective cohort study conducted at the Third Affiliated Hospital of Guangzhou Medical University. Read More

View Article and Full-Text PDF

SARS-CoV-2 in pregnancy and possible transfer of immunity: assessment of peripartal maternal and neonatal antibody levels and a longitudinal follow-up.

J Perinat Med 2021 Jun 11. Epub 2021 Jun 11.

University Department of Obstetrics and Gynecology at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.

Objectives: In the current Severe Acute Respiratory Distress Coronavirus 2 (SARS-CoV-2) pandemic there is still great uncertainty about the effects of an infection in pregnancy especially regarding a possible fetal transmission of antibodies to SARS-CoV-2 and the longevity of this immunity.

Methods: Sixteen women who were infected with SARS-CoV-2 during pregnancy and their offspring were included. The antibody response to SARS-CoV-2 was measured in mother and umbilical cord blood peripartum and in a follow-up examination 6-11 weeks after birth. Read More

View Article and Full-Text PDF

Phosphodiesterase-5 inhibitors in Pregnancy: Systematic review and meta-analysis of maternal and perinatal safety and clinical outcomes.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Mater Research Institute - University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, Queensland 4101, Australia; Faculty of Medicine, University of Medicine, Whitty Building, Annerley Road, South Brisbane, Queensland 4101, Australia; NHMRC Stillbirth Centre For Research Excellence, Mater Research Institute, South Brisbane, Queensland 4101, Australia. Electronic address:

Objective: Phosphodiesterase-5 inhibitors have recently been used for the treatment of severe early onset pre-eclampsia and fetal growth restriction. There are however concerns that they may increase the risk of neonatal morbidity and mortality. The aim of this systematic review was to assess the safety profile and clinical outcomes of phosphodiesterase-5 inhibitors use in pregnancy. Read More

View Article and Full-Text PDF

Pregnancy in a Unicornuate Uterus with Non-Communicating Rudimentary Horn: Diagnostic and Therapeutic Challenges.

Authors:
Ratko Delić

Acta Med Litu 2020 21;27(2):84-89. Epub 2020 Dec 21.

Department of Obstetrics and Gynecology, General and Teaching Hospital Celje, Slovenia.

Unicornuate uterus with non-communicating rudimentary horn is a type of congenital uterine abnormality that occurs as a consequence of the arrested development of one of the two Müllerian ducts. Patients with unicornuate uterus have increased incidence of obstetric and gynaecological complications. We present a report of a clinical case of a 28-years-old female, who was referred to the hospital for evaluation of her infertility. Read More

View Article and Full-Text PDF
December 2020

Development of the Practice Readiness to Evaluate and address Perinatal Depression (PREPD) assessment.

Psychiatry Res 2021 May 29;302:114032. Epub 2021 May 29.

University of Massachusetts Medical School, Worcester, MA, United States; UMass Memorial Health Care, Worcester, MA, United States. Electronic address:

Objective: Perinatal depression is a common pregnancy complication and universal screening is recommended. The Practice Readiness to Evaluate and address Perinatal Depression (PREPD) was developed to measure obstetric practice readiness to integrate depression care into workflows. Objectives were to describe: (1) the PREPD; (2) associated characteristics by readiness level; and (3) use of the assessment to measure change. Read More

View Article and Full-Text PDF

Prevalence of neonatal near miss and associated factors in Nepal: a cross-sectional study.

BMC Pregnancy Childbirth 2021 Jun 9;21(1):422. Epub 2021 Jun 9.

Women's Health Development Unit, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.

Background: The rate of neonatal mortality has declined but lesser than the infant mortality rate and remains a major public health challenge in low- and middle-income countries. There is an urgent need to focus on newborn care, especially during the first 24 h after birth and the early neonatal period. Neonatal near miss (NNM) is an emerging concept similar to that of maternal near miss. Read More

View Article and Full-Text PDF

Prevalence-pattern and risk factors of Cesarean section in a multiethnic cohort.

Pak J Med Sci 2021 May-Jun;37(3):711-715

Sajid Malik, Human Genetics Program, Department of Zoology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.

Objective: This study was aimed to elucidate the prevalence-pattern and determinant of cesarean section (CS) in a multiethnic cohort from Pakistan.

Methods: Through a cross-sectional study design, women delivering at a tertiary care center were recruited during 2013-2017. Data on socio-demographic variables, obstetric complications and birth outcome were obtained. Read More

View Article and Full-Text PDF

Vertical transmission of SARS-CoV2 during pregnancy: A high-risk cohort.

Prenat Diagn 2021 Jun 8. Epub 2021 Jun 8.

Disciplina de Obstetrícia - Departamento de Obstetrícia e Ginecologia da FMUSP, São Paulo, Brazil.

Objective: Identify the potential for and risk factors of SARS-CoV-2 vertical transmission.

Methods: Symptomatic pregnant women with COVID-19 diagnosis in whom PCR for SARS-CoV-2 was performed at delivery using maternal serum and at least one of the biological samples: cord blood (CB), amniotic fluid (AF), colostrum and/or oropharyngeal swab (OPS) of the neonate. The association of parameters with maternal, AF and/or CB positivity and the influence of SARS-CoV-2 positivity in AF and/or CB on neonatal outcomes were investigated. Read More

View Article and Full-Text PDF

Postpartum depression and family function in Chinese women within 1 year after childbirth: A cross-sectional study.

Res Nurs Health 2021 Jun 8. Epub 2021 Jun 8.

Department of Community Nursing, Xiangya School of Nursing, Central South University, Changsha, China.

Family-related factors are reported to influence the development of postpartum depression (PPD), but limited studies have considered the role of family function in this condition. This study aimed to describe the proportion of people with probable or suspected PPD and to determine the relationships among PPD, family function, and obstetric factors. A cross-sectional study was conducted with 630 women who attended six integrated teaching and scientific research communities in Changsha, China. Read More

View Article and Full-Text PDF

Association Between Prenatal Opioid Exposure and Neurodevelopmental Outcomes in Early Childhood: A Retrospective Cohort Study.

Drug Saf 2021 Jun 7. Epub 2021 Jun 7.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California, CA, USA.

Introduction: Several studies have reported increasing prevalence of prescription opioid use among pregnant women. However, little is known regarding the effects of maternal opioid use on neurodevelopmental disorders in early childhood in pregnant women with no evidence of opioid use disorders or drug dependence.

Objective: The aim of this study was to quantify the association between prenatal opioid exposure from maternal prescription use and neurodevelopmental outcomes in early childhood. Read More

View Article and Full-Text PDF

Effectiveness of the CenteringPregnancy program on maternal and birth outcomes: A systematic review and meta-analysis.

Int J Nurs Stud 2021 May 20;120:103981. Epub 2021 May 20.

Emory University Nell Hodgson Woodruff School of Nursing, 1520 Clifton Road, Atlanta, GA 30322, USA. Electronic address:

Background: The World Health Organization has emphasized the critical role of prenatal care in achieving the Millennium Development Goals to reduce child and maternal mortality. The CenteringPregnancy program is a widely recognized model of prenatal care. Several countries have attempted to implement the program in prenatal care practice; however, its effectiveness on maternal and birth outcomes has not been systematically evaluated and analyzed. Read More

View Article and Full-Text PDF

Characterizing the Spectrum of Bladder Health and Lower Urinary Tract Symptoms (LUTS) among Women: Results from the CARDIA Study.

Urology 2021 Jun 1. Epub 2021 Jun 1.

School of Public Health, Birmingham, AL. Electronic address:

Objectives: To operationalize a new definition for bladder health, we examined the distribution of lower urinary tract symptoms (LUTS) and impact, along with associated factors, among women in the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Methods: We performed cluster analyses using validated LUTS symptom burden and impact scales collected between 2005-06 and 2010-11. We performed multinomial logistic regression analyses to evaluate cardiovascular factors (metabolic syndrome, cardiovascular health behaviors, and inflammation) between clusters after adjusting for covariates (demographic, obstetric/gynecologic, co-morbidities). Read More

View Article and Full-Text PDF

Intrapartum synthetic oxytocin, behavioral and emotional problems in children, and the role of postnatal depressive symptoms, postnatal anxiety and mother-to-infant bonding: A Dutch prospective cohort study.

Midwifery 2021 May 20;100:103045. Epub 2021 May 20.

University of Groningen, University Medical Centre Groningen, Department of General Practice and Elderly Care Medicine, the Netherlands.

Objective: To examine the association between intrapartum synthetic oxytocin and child behavioral and emotional problems and to assess if maternal depressive or anxious symptoms or mother-to-infant bonding play a mediating role in this association.

Design: Prospective cohort study.

Setting: Population-based Pregnancy Anxiety and Depression Study. Read More

View Article and Full-Text PDF

Biosensors and biomarkers for determining gestational diabetes mellitus and jaundice in children.

Biotechnol Appl Biochem 2021 Jun 2. Epub 2021 Jun 2.

Department of Obstetric, Centre Hospital of Wuhan, Affiliated to Huazhong University of Science and Technology, Wuhan, China.

Gestational diabetes and jaundice are the correlated diseases predominantly found in mother and newborn child. Jaundice is a neonatal complication with an increased risk when mother has gestational diabetes. Mothers with diabetes at an early stage of gestational age are at higher risk for hyperbilirubinemia (jaundice) and hypoglycemia. Read More

View Article and Full-Text PDF

The effects of dietary and lifestyle interventions among pregnant women with overweight or obesity on early childhood outcomes: an individual participant data meta-analysis from randomised trials.

BMC Med 2021 Jun 2;19(1):128. Epub 2021 Jun 2.

The Robinson Research Institute, Discipline of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, South Australia, Australia.

Background: The impact of maternal obesity extends beyond birth, being independently associated with an increased risk of child obesity. Current evidence demonstrates that women provided with a dietary intervention during pregnancy improve their dietary quality and have a modest reduction in gestational weight gain. However, the effect of this on longer-term childhood obesity-related outcomes is unknown. Read More

View Article and Full-Text PDF

Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters.

Life (Basel) 2021 May 23;11(6). Epub 2021 May 23.

Department of Pathophysiology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.

The aims of the study were (i) to find predictive factors for early postpartum conversion of gestational diabetes mellitus (GDM) into persisting glucose intolerance (PGI), (ii) to evaluate potential differences in adverse perinatal outcomes in GDM women with and without early postpartum PGI and, finally, (iii) to establish a risk score to predict postpartum PGI. A cross-sectional study comprised 244 GDM patients with known age, parity, positive family history of diabetes, pre-gestational BMI, comorbidities, smoking history, results of mid-trimester oral glucose tolerance test, HbA1c, obstetric complications, neonatal outcomes and mode of delivery. A risk score was calculated using parameters with highest odds ratios in a statistic scoring model. Read More

View Article and Full-Text PDF

Clinical and Pathological Significance of Cellular Atypia in Endometriosis.

Medicina (Kaunas) 2021 May 7;57(5). Epub 2021 May 7.

Departament of Obstretics and Gynecology, University of Medicine and Pharmacies, Science and Technology George Emil Palade, 540139 Tîrgu Mureș, Romania.

: To highlight the most frequent localization of ovarian endometriosis, the presence of atypical endometriosis, and recurrences. Retrospective review of 259 patients diagnosed with ovarian endometriosis treated at Tîrgu-Mures Emergency County Hospital, Obstetric Gynecology Clinic, between January 2014 and December 2018. : Data were collected and analyzed for demographics, size of ovarian endometriotic cyst, and recurrences. Read More

View Article and Full-Text PDF

Gestational Diabetes Mellitus per Different Diagnostic Criteria, Risk Factors, Obstetric Outcomes and Postpartum Glycemia: A Prospective Study in Ghana.

Clin Pract 2021 May 7;11(2):257-271. Epub 2021 May 7.

Heidelberg Institute of Global Health, University Hospital Heidelberg Germany, Im Neuenheimer Feld 130.3, 60120 Heidelberg, Germany.

The surge in gestational diabetes mellitus (GDM) globally requires a health system tailored approach towards prevention, detection and management. We estimated the prevalence of GDM using diverse recommended tests and diagnostic thresholds, and also assessed the risk factors and obstetric outcomes, including postpartum glycemia. Using a prospective cohort design, 446 singleton pregnant women without pre-existing diabetes did GDM tests in five hospitals in Ghana from 20-34 weeks using fasting plasma glucose (FPG), one-hour and 2-h oral glucose tolerance test (OGTT). Read More

View Article and Full-Text PDF

The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk.

Nutrients 2021 May 11;13(5). Epub 2021 May 11.

Department of Pediatric Endocrinology, Emma Children's Hospital, Amsterdam University Medical Centers, location VUmc, 1081 HV Amsterdam, The Netherlands.

Background: Chronic stress is often accompanied by alterations in the diurnal rhythm of hypothalamus-pituitary-adrenal activity. However, there are limited data on the diurnal rhythmicity of breast milk glucocorticoids (GCs) among women with psychological distress. We compared mothers who sought consultation at an expertise center for pregnant women with an increased risk of psychological distress with control mothers for GC diurnal rhythmicity in milk and saliva obtained at the same time. Read More

View Article and Full-Text PDF

Bioinformatics Analysis of Oral, Vaginal, and Rectal Microbial Profiles during Pregnancy: A Pilot Study on the Bacterial Co-Residence in Pregnant Women.

Microorganisms 2021 May 11;9(5). Epub 2021 May 11.

Department of Pathophysiology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.

Preterm birth (PTB) and threatened preterm labor (TPL), an important pre-PTB state, are major obstetric complications during pregnancy. However, their triggers have not been fully elucidated. The vagina is dominated by species (categorized as community state types; CSTs I, II, III, and V) or by mixed anaerobes (CST IV). Read More

View Article and Full-Text PDF

TBX2, a Novel Regulator of Labour.

Medicina (Kaunas) 2021 May 21;57(6). Epub 2021 May 21.

Reproductive Biology Laboratory, Amsterdam Reproduction and Development, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

: Therapeutic interventions targeting molecular factors involved in the transition from uterine quiescence to overt labour are not substantially reducing the rate of spontaneous preterm labour. The identification of novel rational therapeutic targets are essential to prevent the most common cause of neonatal mortality. Based on our previous work showing that Tbx2 (T-Box transcription factor 2) is a putative upstream regulator preceding progesterone withdrawal in mouse myometrium, we now investigate the role of TBX2 in human myometrium. Read More

View Article and Full-Text PDF

Ineffective Pregnancy Prevention During Adolescence: Assisting Healthcare Providers in Portugal With Individualized Risk Assessment.

J Prim Prev 2021 May 31. Epub 2021 May 31.

Center for Research in Neuropsychology and Cognitive Behavioral Intervention, Faculty of Psychology and Education Sciences, University of Coimbra, Rua Do Colégio Novo, 3000-115, Coimbra, Portugal.

In this study, we describe the relative contributions of and interactions between individual risk factors associated with ineffective pregnancy prevention among female adolescents in Portugal. Our sample consisted of 856 sexually experienced female adolescents (10-19 years) who did not intend to become pregnant. Of these, 379 were pregnant, and the residual (477) had never been pregnant. Read More

View Article and Full-Text PDF

Racial and Ethnic Disparities in Adverse Perinatal Outcomes at Term.

Am J Perinatol 2021 May 31. Epub 2021 May 31.

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon.

Objective:  This study aimed to evaluate whether racial and ethnic disparities in adverse perinatal outcomes exist at term.

Study Design:  We performed a secondary analysis of a multicenter observational study of 115,502 pregnant patients and their neonates (2008-2011). Singleton, nonanomalous pregnancies delivered from 37 to 41 weeks were included. Read More

View Article and Full-Text PDF

Development and Validation of a Prediction Model for Postpartum Hemorrhage at a Single Safety Net Tertiary Care Center.

Am J Obstet Gynecol MFM 2021 May 25:100404. Epub 2021 May 25.

Denver Health Medical Center, Department of Obstetrics and Gynecology, University of Colorado School of Medicine. Electronic address:

Background: Postpartum hemorrhage (PPH) is a leading cause of pregnancy-related morbidity and mortality; yet, there is limited ability to identify women at risk for this obstetric complication.

Objective: To develop and validate a prediction model for postpartum hemorrhage (PPH) based on antenatal and intrapartum risk factors.

Study Design:  This was a retrospective cohort study of women who delivered between April 2016 and March 2019 at a single safety net hospital. Read More

View Article and Full-Text PDF

Profile of Obstetric Patients in Intensive Care Unit: A Retrospective Study from a Tertiary Care Center in North India.

Indian J Crit Care Med 2021 Apr;25(4):388-391

Department of Biochemistry, Government Medical College, Jammu, Jammu and Kashmir, India.

Background: Critically ill obstetric patients constitute a small number of intensive care unit (ICU) admissions. Physiological changes in pregnancy along with certain pregnancy-specific diseases may cause a rapid worsening of the health status of the patient necessitating ICU care. The present study aims to study the clinical profile of the obstetric patients requiring ICU care. Read More

View Article and Full-Text PDF

Prediction of vaginal birth after cesarean in term gestations: A calculator without race and ethnicity.

Am J Obstet Gynecol 2021 May 24. Epub 2021 May 24.

Ohio State University, Columbus.

Background: Investigators have attempted to derive tools that could provide clinicians with an easily-obtainable estimate of the chance of vaginal birth after cesarean (VBAC) for those who undertake trial of labor after cesarean (TOLAC). One tool that subsequently was validated externally was derived from data from the Maternal-Fetal Medicine Units (MFMU) Cesarean Registry. Concern has been raised, however, that this tool includes the socially-constructed variables of race and ethnicity. Read More

View Article and Full-Text PDF

Use of Patient-Reported Outcome Measures to Assess Outpatient Postpartum Recovery: A Systematic Review.

JAMA Netw Open 2021 May 3;4(5):e2111600. Epub 2021 May 3.

University of Illinois, Chicago.

Importance: Outpatient postpartum recovery is an underexplored area of obstetrics. There is currently no consensus regarding which patient-reported outcome measure (PROM) clinicians and researchers should use to evaluate postpartum recovery.

Objective: To evaluate PROMs of outpatient postpartum recovery using Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) guidelines. Read More

View Article and Full-Text PDF

Midwives must, obstetricians may: An ethnographic exploration of how policy documents organise intrapartum fetal monitoring practice.

Women Birth 2021 May 23. Epub 2021 May 23.

Transforming Maternity Care Collaborative; School of Nursing and Midwifery, Logan Campus, Griffith University, University Drive, Meadowbrook, 4131, Qld, Australia. Electronic address:

Background: The capacity for midwifery to improve maternity care is under-utilised. Midwives have expressed limits on their autonomy to provide quality care in relation to intrapartum fetal heart rate monitoring.

Aim: To explore how the work of midwives and obstetricians was textually structured by policy documents related to intrapartum fetal heart rate monitoring. Read More

View Article and Full-Text PDF

Mechanical stress influences the morphology and function of human uterosacral ligament fibroblasts and activates the p38 MAPK pathway.

Int Urogynecol J 2021 May 25. Epub 2021 May 25.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Introduction And Hypothesis: Pelvic organ prolapse (POP) is a common condition in older women that affects quality of life. Mechanical injury of the pelvic floor support system contributes to POP development. In our study, we aimed to examine the mechanical damage to human uterosacral ligament fibroblasts (hUSLFs) to preliminarily explore the mechanism of mechanical transduction in POP. Read More

View Article and Full-Text PDF

Epidemiologic Trends and Diagnostic Evaluation of Fecal Incontinence.

Gastroenterol Hepatol (N Y) 2020 Jun;16(6):302-309

Dr Sharma is an associate professor of medicine and Dr Rao is a professor of medicine and the J. Harold Harrison, MD, Distinguished University Chair in Gastroenterology in the Division of Gastroenterology and Hepatology in the Medical College of Georgia at Augusta University in Augusta, Georgia.

Fecal incontinence (FI) is a prevalent condition that occurs in up to 15% of the Western population and significantly impairs quality of life. The current understanding of the epidemiology of FI is shifting because of an increasing recognition of FI in men, better appreciation for the impact of changing obstetric practices on FI in women, and comprehension of the effect of modifiable risk factors on the development of FI over time. The pathophysiology of FI is complex and multifactorial, which necessitates the use of multiple diagnostic tests, including tests of anorectal sensorimotor function, peripheral nerve function, and anatomic structure. Read More

View Article and Full-Text PDF