339,290 results match your criteria development low


A multi-motion bionic soft hexapod robot driven by self-sensing controlled twisted artificial muscles.

Bioinspir Biomim 2021 May 13. Epub 2021 May 13.

State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin Institute of Technology, Harbin, 150001, Heilongjiang Province, Harbin, 150001, CHINA.

Artificial muscles have unique advantages for driving bionic robots because their driving mode is similar to biological muscles. However, there is still a big gap between the existing artificial muscle and biological muscle in performance. The twisted artificial muscles (TAMs) from nylon 6,6 provides a low-cost, high integration, low hysteresis driving method. Read More

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A machine learning approach to inform developmental milestone achievement for children with autism.

JMIR Med Inform 2021 May 12. Epub 2021 May 12.

Ubicomp Lab, Department of Computer Science, Marquette University, 1422 W Kilbourn Ave102, Milwaukee, US.

Background: Care for children with autism spectrum disorder (ASD) can be challenging for families and medical care systems. This is especially true in Low-and-Middle-Income-countries (LMIC) like Bangladesh. To improve family-practitioner communication and developmental monitoring of children with ASD, [spell out] (mCARE) was developed. Read More

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Correlation study to identify the factors affecting COVID-19 case fatality rates in India.

Diabetes Metab Syndr 2021 May 10;15(3):993-999. Epub 2021 May 10.

Department of Geography, Banaras Hindu University, Varanasi, 221005, India.

Background And Aims: In India, COVID-19 case fatality rates (CFRs) have consistently been very high in states like Punjab and Maharashtra and very low in Kerala and Assam. To investigate the discrepancy in state-wise CFRs, datasets on various factors related to demography, socio-economy, public health, and healthcare capacity have been collected to study their association with CFR.

Methods: State-wise COVID-19 data was collected till April 22, 2021. Read More

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Hypofractionated versus single-fraction stereotactic radiosurgery for the treatment of brain metastases: A systematic review and meta-analysis.

Clin Neurol Neurosurg 2021 Apr 20;206:106645. Epub 2021 Apr 20.

Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia. Electronic address:

Objective: This systematic review and meta-analysis aimed to synthesize the latest evidence on the hypofractionated stereotactic radiosurgery (HF-SRS) compared to single-fraction stereotactic radiosurgery (SF-SRS) for the treatment of brain metastases.

Methods: We systematically searched PubMed, Scopus, EuropePMC, ProQuest, and Cochrane Central Databases. Original research articles investigating patients with brain metastasis receiving HF-SRS or SF-SRS reporting the local control/failure and/or radionecrosis during follow-up were included. Read More

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Fabricating multifunctional low-toxicity ratiometric fluorescent probe for individual detection of Cu/glutamate and continuous sensing for glutamate via Cu-based platform.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 1;259:119892. Epub 2021 May 1.

College of Chemistry, Liaoning University, 66 Chongshan Middle Road, Shenyang, Liaoning 110036, People's Republic of China. Electronic address:

Herein, a multifunctional ratiometric fluorescent (RF) probe Fe-MIL-88NH@RhB was fabricated for individual detection of CuGlu and continuous sensing of Glu based on unique coordination principle by encapsulating RhB into the porous of metal-organic-framework-Fe-MIL-88NH. Designed Fe-MIL-88NH@RhB platform could selectively identify Cu(II)/Glu accompanying a turn-off/turn-on fluorescent behavior with good linearity. Moreover, if the Fe-MIL-88NH@RhB/Cu is treated with Glu continuously, the quenching fluorescence of this platform (after Cu sensing at blue emission) would be further in turn restored. Read More

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Can the combination of TasP and PrEP eliminate HIV among MSM in British Columbia, Canada?

Epidemics 2021 Apr 6;35:100461. Epub 2021 Apr 6.

British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada; Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Introduction: In British Columbia (BC), the HIV epidemic continues to disproportionally affect the gay, bisexual and other men who have sex with men (MSM). In this study, we aimed to evaluate how Treatment as Prevention (TasP) and pre-exposure prophylaxis (PrEP), if used in combination, could lead to HIV elimination in BC among MSM.

Methods: Considering the heterogeneity in HIV transmission risk, we developed a compartmental model stratified by age and risk-taking behaviour for the HIV epidemic among MSM in BC, informed by clinical, behavioural and epidemiological data. Read More

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Evaluation of different strategic control protocols for Rhipicephalus microplus on cattle according to tick burden.

Ticks Tick Borne Dis 2021 May 1;12(4):101737. Epub 2021 May 1.

Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil; Departamento de Biociências e Tecnologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. Electronic address:

The development of a strategic protocol is fundamental to the control of Rhipicephalus microplus. The efficacy of different strategic tick control protocols (Day 1 to Day 119) using commercial acaricides according to R. microplus burden on bovines was evaluated. Read More

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Effects of alkali, enzymes, and ultrasound on monosodium glutamate byproduct for a sustainable production of Bacillus subtilis.

Food Chem 2021 Apr 27;360:129967. Epub 2021 Apr 27.

Institute of Food Science and Technology, College of Biological Science and Engineering, Fuzhou University, 350108 Fuzhou, China; Fujian Center of Excellence for Food Biotechnology, 350108 Fuzhou, China.

Due to the hindrance of flocculated polymers and bacterial cell wall, the production of Bacillus subtilis using monosodium glutamate byproduct (MSGB) was low. With the assistance of scanning electron microscope images, effects of alkali, lysozyme, papain, ultrasound, and their combinations on MSGB were evaluated using the results of soluble protein, carbohydrate, monosaccharides and peptidoglycans. Alkali could dissolve flocculated polymers increasing 21% soluble MSGB, and thus enhanced the subsequent treatments (ultrasound, lysozyme, or papain) to increase 14-17% soluble MSGB. Read More

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Development of anti-human IgM nanobodies as universal reagents for general immunodiagnostics.

N Biotechnol 2021 May 10. Epub 2021 May 10.

Department of Immunology, DEPBIO, Faculty of Chemistry, Hygiene Institute, UDELAR, Av. A. Navarro 3051, 11600, Montevideo, Uruguay. Electronic address:

Nanobodies are the smallest antibody fragments which bind to antigens with high affinity and specificity. Due to their outstanding physicochemical stability, simplicity and cost-effective production, nanobodies have become powerful agents in therapeutic and diagnostic applications. In this work, the advantages of nanobodies were exploited to develop generic and standardized anti-human IgM reagents for serology and IgM B-cell analysis. Read More

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Low-dose candesartan prevents schizophrenia-like behavioral alterations in a neurodevelopmental two-hit model of schizophrenia.

Prog Neuropsychopharmacol Biol Psychiatry 2021 May 10:110348. Epub 2021 May 10.

Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil; National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirão Preto, SP, Brazil. Electronic address:

Schizophrenia is a severe mental disorder with complex etiopathogenesis. Based on its neurodevelopmental features, an animal model induced by "two-hit" based on perinatal immune activation followed by peripubertal unpredictable stress was proposed. Sex influences the immune response, and concerning schizophrenia, it impacts the age of onset and symptoms severity. Read More

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Evaluation and comparison of in vitro intrinsic clearance rates measured using cryopreserved hepatocytes from humans, rats, and rainbow trout.

Toxicology 2021 May 10:152819. Epub 2021 May 10.

US Environmental Protection Agency, Office of Science Coordination and Policy (OSCP), William Jefferson Clinton Building, 1200 Pennsylvania Avenue NW, Washington, DC 20460 USA. Electronic address:

In vitro and in silico methods that can reduce the need for animal testing are being used with increasing frequency to assess chemical risks to human health and the environment. The rate of hepatic biotransformation is an important species-specific parameter for determining bioaccumulation potential and extrapolating in vitro bioactivity to in vivo effects. One approach to estimating hepatic biotransformation is to employ in vitro systems derived from liver tissue to measure chemical (substrate) depletion over time which can then be translated to a rate of intrinsic clearance (CL). Read More

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Diagnosis of Vertical Root Fractures by Cone Beam Computed Tomography in Root Filled Teeth with Confirmation by Direct Visualization- A Systematic Review and Meta-Analysis.

J Endod 2021 May 10. Epub 2021 May 10.

Department of Conservative Dentistry & Endodontics, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy Of Higher Education, Chennai 600095, Tamil Nadu, India. Electronic address:

Aim: The purpose of this review was to determine the diagnostic accuracy of CBCT in detecting vertical root fracture in root filled teeth when compared to a reference standard (direct visualization).

Methods: Electronic searches were performed in Medline, Scopus, Cochrane and Grey Literature for English language articles till June 2020. Prospective and retrospective clinical studies using CBCT to diagnose VRF in root filled teeth were included. Read More

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Deciphering the glioblastoma phenotype by Computed Tomography radiomics.

Radiother Oncol 2021 May 10. Epub 2021 May 10.

Department of Radiation Oncology (Maastro), GROW School for Oncology, Maastricht University Medical Centre+, Maastricht, The Netherlands.

Introduction: Glioblastoma (GBM) is the most common malignant primary brain tumour which has, despite extensive treatment, a median overall survival of 15 months. Radiomics is the high-throughput extraction of large amounts of image features from radiographic images, which allows capturing the tumour phenotype in 3D and in a non-invasive way. In this study we assess the prognostic value of CT radiomics for overall survival in patients with a GBM. Read More

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Preventing Memory Effects in Surface-Enhanced Raman Scattering Substrates by Polymer Coating and Laser-Activated Deprotection.

ACS Nano 2021 May 13. Epub 2021 May 13.

CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), 20014 San Sebastián, Spain.

The development of continuous monitoring systems requires sensors that are capable of screening multiple chemical species and providing real-time information. Such measurements, in which the sample is analyzed at the point of interest, are hindered by underlying problems derived from the recording of successive measurements within complex environments. In this context, surface-enhanced Raman scattering (SERS) spectroscopy appears as a noninvasive technology with the ability of identifying low concentrations of chemical species as well as resolving dynamic processes under different conditions. Read More

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Towards clinical application of tau PET tracers for diagnosing dementia due to Alzheimer's disease.

Alzheimers Dement 2021 May 13. Epub 2021 May 13.

Lund University, Clinical Memory Research Unit, Lund, Sweden.

The recent development of several tau positron emission tomography (PET) tracers represents a major milestone for the Alzheimer's disease (AD) field. These tau PET tracers bind tau neurofibrillary tangles, a key neuropathological characteristic of AD that is tightly linked to synaptic loss, brain atrophy, and cognitive decline. It is notable that these tau PET tracers show low uptake in most non-AD tauopathies and other neurodegenerative disorders, resulting in a diagnostic specificity that is superior to that of amyloid beta (Aβ) PET and biofluid markers, especially at an older age when incidental Aβ pathology is common. Read More

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Strawberry fruit skins are far more permeable to osmotic water uptake than to transpirational water loss.

PLoS One 2021 13;16(5):e0251351. Epub 2021 May 13.

Institute for Horticultural Production Systems, Leibniz-Universität Hannover, Hannover, Germany.

Water movements through the fruit skin play critical roles in many disorders of strawberry (Fragaria × ananassa Duch.) such as water soaking, cracking and shriveling. The objective was to identify the mechanisms of fruit water loss (dry skin, transpiration) and water uptake (wet skin, osmosis). Read More

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Long-term changes in body composition and their relationships with cardiometabolic risk factors: A population-based cohort study.

PLoS One 2021 13;16(5):e0251486. Epub 2021 May 13.

Child Health Big Data Research Center, Capital Institute of Pediatrics, Beijing, China.

The aim of the present study was to classify the latent body fat trajectories of Chinese adults and their relationships with cardiometabolic risk factors. Data were obtained from the China Health Nutrition Survey for 3,013 participants, who underwent six follow-up visits between 1993 and 2009. Skinfold thickness and other anthropometric indicators were used to estimate body composition. Read More

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Identification of recombinant Fabs for structural and functional characterization of HIV-host factor complexes.

PLoS One 2021 13;16(5):e0250318. Epub 2021 May 13.

Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America.

Viral infection and pathogenesis is mediated by host protein-viral protein complexes that are important targets for therapeutic intervention as they are potentially less prone to development of drug resistance. We have identified human, recombinant antibodies (Fabs) from a phage display library that bind to three HIV-host complexes. We used these Fabs to 1) stabilize the complexes for structural studies; and 2) facilitate characterization of the function of these complexes. Read More

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Differential Effects of Trichostatin A on Mouse Embryogenesis and Development.

Reproduction 2021 May 1. Epub 2021 May 1.

Q Zhou, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, Jilin University First Hospital, Changchun, China.

Trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, can significantly improve the reprogramming efficiency of somatic cells. However, whether TSA has detrimental effect on other kinds of embryos is largely unknown because of the lack of integrated analysis of TSA effect on natural fertilized embryos. To investigate the effect of TSA on mouse embryo development, we analyzed preimplantation and post-implantation development of in vivo, in vitro fertilized, and parthenogenetic embryos treated with TSA at different concentrations and durations. Read More

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Parent ethnic-racial socialization during childhood protects against increases in bedtime sleep problems in Black adolescents.

Am J Orthopsychiatry 2021 ;91(2):236-245

School of Social Work, University of Washington.

Racial disparities in sleep have been reported with Black adolescents showing the least amount of sleep relative to other youth. Yet, few within-group studies have examined factors that protect Black adolescents from sleep problems. To address this gap, we tested whether parent ethnic-racial socialization (i. Read More

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January 2021

Acoustic Droplet-Assisted Superhydrophilic-Superhydrophobic Microarray Platform for High-Throughput Screening of Patient-Derived Tumor Spheroids.

ACS Appl Mater Interfaces 2021 May 13. Epub 2021 May 13.

Key Laboratory of Artificial Micro/Nano-Structures, Ministry of Education School of Physics and Technology, Wuhan University, Wuhan 430072, China.

Cell-based high-throughput screening is a key step in the current disease-based research, drug development, and precision medicine. However, it is challenging to establish a rapid culture and screening platform for rare cells (patient-derived) due to the obvious differences between the traditional 2D cell model and the tumor microenvironment, as well as the lack of a low-consumption screening platform for low numbers of cells. Here, we developed an acoustic drop-assisted superhydrophilic-superhydrophobic microarray platform for the rapid culture and screening of a few cells. Read More

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RNA externalized by neutrophil extracellular traps promotes inflammatory pathways in endothelial cells.

Arthritis Rheumatol 2021 May 13. Epub 2021 May 13.

Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland, USA.

Objectives: Neutrophil extracellular traps (NETs) are extracellular lattices composed of nucleic material bound to neutrophil granule proteins. NETs may play pathogenic roles in development and severity of autoimmune diseases such as systemic lupus erythematosus (SLE), at least in part, through induction of type I interferon (IFN) responses via externalization of oxidized immunostimulatory DNA. A distinct subset of SLE proinflammatory neutrophils (low density granulocytes; LDGs) displays enhanced ability to form proinflammatory NETs that damage the vasculature. Read More

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In Situ TEM Studies of Sodium Polysulfides Electrochemistry in High Temperature Na-S Nanobatteries.

Small 2021 May 13:e2100846. Epub 2021 May 13.

Clean Nano Energy Center, State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, P. R. China.

Understanding polysulfide electrochemistry in high temperature sodium-sulfur (HT-Na-S) batteries is crucial for their practical applications. Currently the discharge capacity of commercial HT-Na-S battery achieves only one third of its theoretical capacity due to polysulfides formation, understanding of which is limited due to technical difficulty in direct imaging polysulfides. Herein, in situ transmission electron microscopy implemented with a microelectromechanical systems (MEMS) heating device is used to investigate the electrochemical reactions of HT-Na-S batteries. Read More

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Targeting Sphingosine-1-Phosphate Signaling in Immune-Mediated Diseases: Beyond Multiple Sclerosis.

Drugs 2021 May 13. Epub 2021 May 13.

San Diego VA Medical Center (SDVAMC), San Diego, CA, USA.

Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that exerts its actions by engaging 5 G-protein-coupled receptors (S1PR1-S1PR5). S1P receptors are involved in several cellular and physiological events, including lymphocyte/hematopoietic cell trafficking. An S1P gradient (low in tissues, high in blood), maintained by synthetic and degradative enzymes, regulates lymphocyte trafficking. Read More

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Current Biomarkers for Precision Medicine in Breast Cancer.

Adv Exp Med Biol 2021 ;1187:363-379

Center for Breast Cancer, National Cancer Center, Goyang-si, South Korea.

Breast cancer has become the prototypical solid tumor where targets have been identified within the tumor allowing for personalized approach for systemic therapy. Biomarkers are beginning to play an important role in preparing the way for precision treatment. Mandatory biomarkers for every newly diagnosed case of breast cancer are estrogen receptors and progesterone receptors in selecting patients for endocrine treatment and HER2 for identifying patients likely to benefit from antiHER2 therapy. Read More

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January 2021

Genetic analysis and screening of pyrethroid resistance mutations in Varroa destructor populations from Turkey.

Exp Appl Acarol 2021 May 13. Epub 2021 May 13.

Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000, Ghent, Belgium.

Varroa destructor is the most common ectoparasite of the Western honey bee (Apis mellifera L.) worldwide and poses a serious threat to bee health. Synthetic acaricides, particularly pyrethroids, are frequently used to control Varroa mites. Read More

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Improving virtual screening results with MM/GBSA and MM/PBSA rescoring.

J Comput Aided Mol Des 2021 May 13. Epub 2021 May 13.

Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia, 0014, Yerevan, Armenia.

Virtual screening (VS) based on molecular docking is one of the most useful methods in computer-aided drug design. By allowing to identify computationally putative ligands binding to the proteins of interest, VS dramatically reduces the time and expense of the development of novel therapeutics. Among the limitations of the VS approaches is the low accuracy of scoring functions implemented in docking methods for assessing binding affinity. Read More

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Effects of organic acid, Enterococcus faecalis strain EC-12 and sugar cane extract in feed against enterotoxigenic Escherichia coli-induced diarrhea in pigs.

AMB Express 2021 May 13;11(1):68. Epub 2021 May 13.

Research and Development Section, Institute of Animal Health, JA Zen-noh (National Federation of Agricultural Cooperative Associations), 7 Ohja-machi Sakura-shi, Chiba, 285-0043, Japan.

Diarrhea can lead to mortality and delayed growth in pigs and is a major economic loss in the pig industry. In this study, we evaluated non-antimicrobial materials that can prevent diarrhea to infection by enterotoxigenic Escherichia coli (ETEC) in weaned pigs and investigated biological changes. We confirmed the efficacy of fumaric acid, lactic acid, Enterococcus faecalis strain EC-12 (EC12) and sugar cane extract (SCE) in inhibiting diarrhea and investigated the biological changes by analyzing gut microbiota and plasma metabolites. Read More

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Clinical and Biochemical Features of Hypopituitarism Among Brazilian Children With Zika Virus-Induced Microcephaly.

JAMA Netw Open 2021 May 3;4(5):e219878. Epub 2021 May 3.

Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.

Importance: The Zika virus infects progenitor neuron cells, disrupts cerebral development, and, in mice, drives hypothalamic defects. Patients with microcephaly caused by congenital Zika infection present with midline cerebral defects, which may result in hypopituitarism.

Objective: To analyze postnatal growth and the presence of clinical and biochemical features associated with hypopituitarism in children with congenital Zika infections. Read More

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Development of the Three Antimicrobial Stewardship E's (TASE) framework and Association between Stewardship Interventions and intended Results (ASIR) analysis to identify key facility-specific interventions and strategies for successful antimicrobial stewardship.

Clin Infect Dis 2021 May 13. Epub 2021 May 13.

Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA.

Background: Successful antimicrobial stewardship (AS) interventions have been described previously. Currently, a uniform operational approach to planning and implementing successful AS interventions does not exist. From 2015 to 2019, concomitant vancomycin and piperacillin-tazobactam use (CVPTU) for >48 hours at Vanderbilt University Medical Center (VUMC) significantly decreased through AS efforts. Read More

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