3,510 results match your criteria development bronchopulmonary


Can high-flow nasal cannula reduce the risk of bronchopulmonary dysplasia compared with CPAP in preterm infants? A systematic review and meta-analysis.

BMC Pediatr 2021 Sep 16;21(1):407. Epub 2021 Sep 16.

Physiotherapy Department, Postgraduate Program in Rehabilitation and functional performance, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Campus JK - Diamantina/MG, Rodovia MGT 367 - Km 583, n° 5.000 Alto da Jacuba, Diamantina, Minas Gerais, 39100-000, Brazil.

Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects the premature lung, and to reduce its incidence has been used non-invasive ventilatory support, such as continuous positive airway (CPAP) and high-flow nasal cannula (HFNC). Thus, the objective of this review was to assess whether the use of high flow nasal cannula (HFNC) compared to continuous positive airway pressure (CPAP) decreases the risk of bronchopulmonary dysplasia (BPD) in premature newborns.

Methods: The protocol was registered (Prospero: CRD42019136631) and the search was conducted in the MEDLINE, PEDro, Cochrane Library, CINAHL, Embase, and LILACS databases, and in the clinical trials registries, until July 2020. Read More

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September 2021

Extracellular Vesicle-Shuttling MicroRNAs Regulate the Development of Inflammatory Lung Responses.

Ann Pulm Crit Care Med 2018 Oct 23;1(2):1-4. Epub 2018 Dec 23.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University, Boston, MA 02118, USA.

MicroRNAs are small single-stranded, non-coding RNAs which have a known role in post-transcriptional regulation of gene expression. Recent studies have reported that extracellular vesicles are capable of specific delivery of miRNAs to a target cell or tissue from a host cell. MiRNAs are generated by host cells, selectively packaged into EVs, and then delivered to nearby target cells with full functionality. Read More

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October 2018

An Experimental Model of Bronchopulmonary Dysplasia Features Long-Term Retinal and Pulmonary Defects but Not Sustained Lung Inflammation.

Front Pediatr 2021 30;9:689699. Epub 2021 Aug 30.

Leukocyte Signalling Laboratory, Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.

Bronchopulmonary dysplasia (BPD) is a severe lung disease that affects preterm infants receiving oxygen therapy. No standardized, clinically-relevant BPD model exists, hampering efforts to understand and treat this disease. This study aimed to evaluate and confirm a candidate model of acute and chronic BPD, based on exposure of neonatal mice to a high oxygen environment during key lung developmental stages affected in preterm infants with BPD. Read More

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Genetic and Epidemiological Similarities, and Differences Between Postoperative Intraperitoneal Adhesion Development and Other Benign Fibro-proliferative Disorders.

Reprod Sci 2021 Sep 13. Epub 2021 Sep 13.

Department of Obstetrics and Gynecology, Augusta University, 1120 15th Street, CJ-1036, Augusta, GA, 30912, USA.

Intraperitoneal adhesions complicate over half of abdominal-pelvic surgeries with immediate, short, and long-term sequelae of major healthcare concern. The pathogenesis of adhesion development is similar to the pathogenesis of wound healing in all tissues, which if unchecked result in production of fibrotic conditions. Given the similarities, we explore the published literature to highlight the similarities in the pathogenesis of intra-abdominal adhesion development (IPAD) and other fibrotic diseases such as keloids, endometriosis, uterine fibroids, bronchopulmonary dysplasia, and pulmonary, intraperitoneal, and retroperitoneal fibrosis. Read More

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September 2021

Profiles of Functioning in 5.5-Year-Old Very Preterm Born Children in France: The EPIPAGE-2 Study.

J Am Acad Child Adolesc Psychiatry 2021 Sep 7. Epub 2021 Sep 7.

Objective: Very preterm born children are at risk for impairments in multiple neurodevelopmental domains, but outcomes vary between individuals. The present study aimed to distinguish subgroups with distinct profiles of functioning across motor, cognitive, behavioral, and psychosocial domains. These profiles were related to neonatal and social/environmental factors. Read More

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September 2021

Adrenomedullin Deficiency Potentiates Lipopolysaccharide-Induced Experimental Bronchopulmonary Dysplasia in Neonatal Mice.

Am J Pathol 2021 Sep 8. Epub 2021 Sep 8.

Section of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA. Electronic address:

Lung inflammation interrupts alveolarization and causes bronchopulmonary dysplasia (BPD). Besides mechanical ventilation and hyperoxia, sepsis contributes to BPD pathogenesis. Adrenomedullin (Adm) is a multifunctional peptide that exerts anti-inflammatory effects in the lungs of adult rodents. Read More

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September 2021

Complicated Intubations are Associated with Bronchopulmonary Dysplasia in Very Low Birth Weight Infants.

Am J Perinatol 2021 Sep 9. Epub 2021 Sep 9.

Department of Pediatrics, Division of Neonatology, UH Rainbow Babies and Children's Hospital, Cleveland, Ohio.

Objective:  This study aimed to evaluate the association between desaturation <60% (severe desaturation) during intubation and a total number of intubation attempts in the first week of life in very low birth weight (VLBW) infants with adverse long-term outcomes including bronchopulmonary dysplasia (BPD) and severe periventricular/intraventricular hemorrhage grade 3 or 4 (PIVH).

Study Design:  A retrospective chart review was performed on VLBW infants intubated in the neonatal intensive care unit during the first week of life between January 2017 and July 2020. Descriptive tables were generated for two outcomes including BPD and PIVH. Read More

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September 2021

Development of a Nomogram for Moderate-to-Severe Bronchopulmonary Dysplasia or Death: Role of N-Terminal Pro-brain Natriuretic Peptide as a Biomarker.

Front Pediatr 2021 23;9:727362. Epub 2021 Aug 23.

Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

This study aimed to explore the clinical value of N-terminal pro-brain natriuretic peptide (NT-proBNP) in predicting moderate-to-severe bronchopulmonary dysplasia (BPD)/death, and to establish an effective clinical predictive nomogram. We retrospectively analyzed very low birth weight infants (VLBWs) with gestational age ≤ 32 weeks. The NT-proBNP values were determined on the 1st, 3rd, 7th, 14th, 21st, and 28th days after birth. Read More

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Clinical Characteristics and Outcomes Until 2 Years of Age in Preterm Infants With Typical Chest Imaging Findings of Bronchopulmonary Dysplasia: A Propensity Score Analysis.

Front Pediatr 2021 23;9:712516. Epub 2021 Aug 23.

Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China.

The goal of the current study was to assess the associations of typical chest imaging findings of bronchopulmonary dysplasia (BPD) in preterm infants with clinical characteristics and outcomes until 2 years of age. This retrospective cohort study enrolled 256 preterm infants with BPD who were admitted between 2014 and 2018. A propensity score analysis was used to adjust for confounding factors. Read More

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The Effect of Severe Intraventricular Hemorrhage on the Biorhythms of Feeding in Premature Infants.

Front Pediatr 2021 23;9:673152. Epub 2021 Aug 23.

Division of Neonatology, Department of Pediatrics, University of Kentucky School of Medicine, Lexington, KY, United States.

Suck-swallow rhythmicity and the integration of breathing into infant feeding are developmentally regulated. Neurological injury and breathing abnormalities can both impact feeding in preterm infants. To determine the effects of neurologic injury independent of effects of disordered breathing on feeding biorhythms in premature infants. Read More

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PRMT7 targets of Foxm1 controls alveolar myofibroblast proliferation and differentiation during alveologenesis.

Cell Death Dis 2021 Sep 8;12(9):841. Epub 2021 Sep 8.

Department of Health Sciences, Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, P.R. China.

Although aberrant alveolar myofibroblasts (AMYFs) proliferation and differentiation are often associated with abnormal lung development and diseases, such as bronchopulmonary dysplasia (BPD), chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF), epigenetic mechanisms regulating proliferation and differentiation of AMYFs remain poorly understood. Protein arginine methyltransferase 7 (PRMT7) is the only reported type III enzyme responsible for monomethylation of arginine residue on both histone and nonhistone substrates. Here we provide evidence for PRMT7's function in regulating AMYFs proliferation and differentiation during lung alveologenesis. Read More

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September 2021

Crystal structure of Aspergillus fumigatus AroH, an aromatic amino acid aminotransferase.

Proteins 2021 Sep 8. Epub 2021 Sep 8.

Department of Biochemical Sciences, Sapienza University of Rome, Rome.

Aspergillus fumigatus is a saprophytic ubiquitous fungus whose spores can trigger reactions such as allergic bronchopulmonary aspergillosis or the fatal invasive pulmonary aspergillosis. To survive in the lungs, the fungus must adapt to a hypoxic and nutritionally restrictive environment, exploiting the limited availability of aromatic amino acids (AAAs) in the best possible way, as mammals do not synthesize them. A key enzyme for AAAs catabolism in A. Read More

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September 2021

Association between blood carboxyhemoglobin level and bronchopulmonary dysplasia in extremely low birthweight infants.

J Investig Med 2021 Sep 7. Epub 2021 Sep 7.

Keck School of Medicine/Pediatrics/Division of Neonatology, USC, Los Angeles, California, USA.

Carboxyhemoglobin (CO-Hb) can be endogenously formed in the presence of oxidative stress and may be elevated in inflammatory lung disease. There is lack of evidence of its relationship with the development of bronchopulmonary dysplasia (BPD) in extremely low birthweight (ELBW) infants. The objective of the study is to evaluate the relationship between blood CO-Hb levels in the first 14 days of life (DOL) in ELBW infants and the development of BPD at 36 weeks postmenstrual age (PMA). Read More

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September 2021

Predictive Ability of the New Bronchopulmonary Dysplasia Definition on Pulmonary Outcomes at 20 to 24 months' Corrected Age of Preterm Infants.

Am J Perinatol 2021 Sep 7. Epub 2021 Sep 7.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Objective:  This study aimed to determine the predictive abilities of the National Institute of Child Health and Human Development (NICHD) 2018 definition of bronchopulmonary dysplasia (BPD) on mortality and pulmonary outcomes of preterm infants at 20 to 24 months' corrected age and compare them with the National Institutes of Health (NIH) 2001 definition.

Study Design:  A retrospective cohort study was conducted in a level III neonatal intensive care unit (NICU) in Bangkok, Thailand. Data from 502 infants less than 32 weeks of gestation born between 2011 and 2017 were reviewed. Read More

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September 2021

Bibliometric Analysis of Bronchopulmonary Dysplasia in Extremely Premature Infants in the Web of Science Database Using CiteSpace Software.

Front Pediatr 2021 20;9:705033. Epub 2021 Aug 20.

Department of Neonatology, Hangzhou Children's Hospital, Hangzhou, China.

To review the literature related to bronchopulmonary dysplasia in extremely pre-mature infants, summarize research direction, and report trends. CiteSpace is a Java application which supports visual exploration with knowledge discovery in bibliographic databases. Relevant articles from 2008 to 2020 were retrieved from the Web of Science Core Collection database, and we extracted the following data: title, abstract, year, keywords, author, organization, journal and cited literature. Read More

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and Its Role in Adverse Perinatal Outcomes: A Review.

Neoreviews 2021 Sep;22(9):e574-e584

NICU Quality Improvement, Comer Children's Hospital, The University of Chicago, Chicago, IL.

Human species are the most common microbes found in amniotic fluid and in the placenta after preterm birth, and have previously been correlated with chorioamnionitis, preterm labor, and bronchopulmonary dysplasia, among other adverse birth and neonatal outcomes. Although these correlations exist, there still remains little explanation as to whether plays a pathogenic role in the development of neonatal disease. In addition, species are not usually identified on routine culture as they require special culture methods because of their fastidious growth requirements. Read More

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September 2021

PREDICTORS OF BRONCHOPULMONARY DYSPLASIA DEVELOPMENT AND COMORBIDITIES OF PREMATURITY ASSOCIATED WITH RESPIRATORY SUPPORT TECHNIQUES IN PREMATURE NEONATES.

Wiad Lek 2021 ;74(7):1699-1706

DNIPROPETROVSK MEDICAL ACADEMY OF MINISTRY OF HEALTH OF UKRAINE, DNIPRO, UKRAINE.

Objective: The aim of the study was to analyze and identify risk factors for the development of moderate and severe bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis in preterm neonates in intensive care unit and during any kind of respiratory support.

Patients And Methods: Materials and methods: A simple retrospective-prospective blind controlled non-randomised study included 28-32 weeks of gestational age 122 newborns with respiratory distress syndrom, who were treated in the neonatal intensive care units of two medical institutions of Dnipro from 2016 to 2020. Among 122 children neonates were divided into two groups according to particularities of respiratory support, prior type of noinvasive ventilation and infusion volume per day. Read More

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September 2021

Seminars in perinatology: Brain imaging in the premature neonate the dimensions of white matter injury in preterm neonates.

Semin Perinatol 2021 Aug 20:151469. Epub 2021 Aug 20.

Department of Pediatrics (Neurology), University of Toronto and the Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Toronto M5G 1X8, Canada. Electronic address:

White matter injury (WMI) represents a frequent form of parenchymal brain injury in preterm neonates. Several dimensions of WMI are recognized, with distinct neuropathologic features involving a combination of destructive and maturational anomalies. Hypoxia-ischemia is the main mechanism leading to WMI and adverse white matter development, which result from injury to the oligodendrocyte precursor cells. Read More

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Association between Term Equivalent Brain MRI and 2 Year Outcomes in Extremely Preterm Infants: A Report from the PENUT Trial Cohort.

J Pediatr 2021 Aug 26. Epub 2021 Aug 26.

Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA.

Objectives: To compare the term equivalent) brain MRI findings between erythropoietin (Epo) treated and placebo control groups in infants 24-0/7 to 27-6/7 weeks' gestational age (GA) and to assess the associations between MRI findings and neurodevelopmental outcomes at 2 years corrected age (CA).

Study Design: The association between brain abnormality scores and Bayley Scales of Infant Development (BSID-III) at 2 years CA was explored in a subset of infants enrolled in the Preterm Erythropoietin Neuroprotection Trial. Potential risk factors for neurodevelopmental outcomes such as treatment assignment, recruitment site, GA, inpatient complications and treatments were examined using Generalized Estimating Equation models. Read More

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Macrophage-derived IL-6 trans-signaling as a novel target in the pathogenesis of bronchopulmonary dysplasia.

Eur Respir J 2021 Aug 26. Epub 2021 Aug 26.

Department of Pediatric and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics - Experimental Pulmonology, Koln, Germany

Rationale: Premature infants exposed to oxygen are at risk for bronchopulmonary dysplasia (BPD), which is characterised by lung growth arrest. Inflammation is important, but the mechanisms remain elusive. Here, we investigated inflammatory pathways and therapeutic targets in severe clinical and experimental BPD. Read More

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Cellular Therapy for the Treatment of Paediatric Respiratory Disease.

Int J Mol Sci 2021 Aug 18;22(16). Epub 2021 Aug 18.

Research and Development, Science and Emerging Technologies, Aerogen Limited, Galway Business Park, H91 HE94 Galway, Ireland.

Respiratory disease is the leading cause of death in children under the age of 5 years old. Currently available treatments for paediatric respiratory diseases including bronchopulmonary dysplasia, asthma, cystic fibrosis and interstitial lung disease may ameliorate symptoms but do not offer a cure. Cellular therapy may offer a potential cure for these diseases, preventing disease progression into adulthood. Read More

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Effects of Total Enteral Nutrition on Early Growth, Immunity, and Neuronal Development of Preterm Infants.

Nutrients 2021 Aug 11;13(8). Epub 2021 Aug 11.

The Novel Drug and Vaccine Delivery Systems Facility, Department of Chemistry and Biochemistry, Laurentian University, Sudbury, ON P3E 2C6, Canada.

The feeding of colostrum and mother's transitional milk improves immune protection and neurodevelopmental outcomes. It also helps with gut maturation and decreases the risks of infection. The supply of nutrients from human milk (HM) is not adequate for preterm infants, even though preterm mother's milk contains higher concentrations of protein, sodium, zinc, and calcium than mature HM. Read More

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Intrauterine Hypoxia and Epigenetic Programming in Lung Development and Disease.

Biomedicines 2021 Aug 2;9(8). Epub 2021 Aug 2.

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Clinically, intrauterine hypoxia is the foremost cause of perinatal morbidity and developmental plasticity in the fetus and newborn infant. Under hypoxia, deviations occur in the lung cell epigenome. Epigenetic mechanisms (e. Read More

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Structural lung disease following allergic bronchopulmonary aspergillosis complicating pediatric cystic fibrosis.

Pediatr Pulmonol 2021 Aug 24. Epub 2021 Aug 24.

Department of Paediatrics, The University of Melbourne, Melbourne, Australia.

Background: Allergic bronchopulmonary aspergillosis (ABPA) complicating cystic fibrosis (CF) is frequently associated with significant structural lung damage as assessed by computed tomography (CT) scanning.

Methods: Using a validated CF scoring system (structural lung disease [SLD] score) we examined the degree of structural lung disease in a group of 25 children with CF who had received steroid therapy for ABPA (CF-ABPA) and compared our findings to a matched group of CF patients without ABPA (CF-CON) using both cross-section and longitudinal analysis. Further, we examined the structure-function correlation between CT findings and lung function. Read More

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An Update on the Prevention and Management of Bronchopulmonary Dysplasia.

Pediatric Health Med Ther 2021 11;12:405-419. Epub 2021 Aug 11.

Department of Pediatrics, Duke University, Durham, NC, USA.

Bronchopulmonary dysplasia (BPD) is a common morbidity affecting preterm infants and is associated with substantial long-term disabilities. There has been no change in the incidence of BPD over the past 20 years, despite improvements in survival and other outcomes. The preterm lung is vulnerable to injuries occurring as a result of invasive ventilation, hyperoxia, and infections that contribute to the development of BPD. Read More

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Association of time of first corticosteroid treatment with bronchopulmonary dysplasia in preterm infants.

Pediatr Pulmonol 2021 Aug 11. Epub 2021 Aug 11.

Children's Mercy Kansas City, University of Missouri, Kansas, Missouri, USA.

Objective: To evaluate the association between the time of first systemic corticosteroid initiation and bronchopulmonary dysplasia (BPD) in preterm infants.

Study Design: A multi-center retrospective cohort study from January 2010 to December 2016 using the Children's Hospitals Neonatal Database and Pediatric Health Information System database was conducted. The study population included preterm infants <32 weeks' gestation treated with systemic corticosteroids after 7 days of age and before 34 weeks' postmenstrual age. Read More

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High Frequency of Allergic Bronchopulmonary Aspergillosis in Bronchiectasis-COPD Overlap.

Chest 2021 Aug 5. Epub 2021 Aug 5.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Republic of Singapore. Electronic address:

Background: Allergic bronchopulmonary aspergillosis (ABPA) is associated with frequent exacerbations and poor outcomes in chronic respiratory disease, but remains underdiagnosed. The role of fungal sensitization in bronchiectasis-COPD overlap (BCO) is unknown.

Research Question: What is the occurrence and clinical relevance of Aspergillus sensitization and ABPA in BCO when compared with individuals with COPD or bronchiectasis without overlap?

Study Design: Prospective, observational, cross-sectional study. Read More

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The Association between Early Gram-Negative Bacteria in Tracheal Aspirate Cultures and Severe Bronchopulmonary Dysplasia among Extremely Preterm Infants Requiring Prolonged Ventilation.

Am J Perinatol 2021 Aug 6. Epub 2021 Aug 6.

Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan.

Objective:  The study aimed to evaluate the association between bronchopulmonary dysplasia (BPD) development at 36 weeks' postmenstrual age (PMA) and Gram-negative bacteria in tracheal aspirate cultures among extremely preterm infants.

Study Design:  This study has a retrospective cohort. Patients were 155 infants aged less than or equal to 26 gestational weeks who were admitted to the neonatal intensive care unit of Osaka Women's and Children's Hospital from 2009 to 2018. Read More

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Thermosensory Transient Receptor Potential Ion Channels and Asthma.

Biomedicines 2021 Jul 14;9(7). Epub 2021 Jul 14.

Far Eastern Scientific Center of Physiology and Pathology of Respiration, 675000 Blagoveshchensk, Russia.

Asthma is a widespread chronic disease of the bronchopulmonary system with a heterogeneous course due to the complex etiopathogenesis. Natural-climatic and anthropogenic factors play an important role in the development and progression of this pathology. The reception of physical and chemical environmental stimuli and the regulation of body temperature are mediated by thermosensory channels, members of a subfamily of transient receptor potential (TRP) ion channels. Read More

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Bilateral lung transplantation in a 9-year-old girl with bronchopulmonary dysplasia with pulmonary hypertension.

Pediatr Pulmonol 2021 Aug 5. Epub 2021 Aug 5.

Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University Hospital, Sendai, Japan.

Background: Bronchopulmonary dysplasia (BPD) is a chronic respiratory disease that occurs in premature infants and the prognosis is variable depending on the comorbidities including fibrosis, emphysema, or pulmonary hypertension (PH). We present a case of a 9-year-old girl who developed PH associated with severe BPD (BPD-PH) and underwent bilateral lung transplantation (BLTx). Case description A 9-year-old girl was admitted to our department to undergo BLTx. Read More

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