3,081,971 results match your criteria development article


Cell identity specification in plants: lessons from flower development.

J Exp Bot 2021 Apr 17. Epub 2021 Apr 17.

Plant Cell and Molecular Biology, Institute of Biology, Humboldt-Universitaet zu Berlin, Germany.

Multicellular organisms display a fascinating complexity of cellular identities and patterns of diversification. The concept of ''cell type'' aims to describe and categorize this complexity. In this review, we discuss the traditional concept of cell types and highlight the impact of single-cell technologies and spatial omics on the understanding of cellular differentiation in plants. Read More

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Feasibility of a voice-enabled medical diary app (SpeakHealth) with caregivers of children with special healthcare needs and healthcare providers: A mixed methods study.

JMIR Form Res 2021 Apr 17. Epub 2021 Apr 17.

The Abigail Wexner Research Institute, Nationwide Children's Hospital, 700 Children's Drive, Columbus, US.

Background: Children with special health care needs (CSHCN) require more than the usual care management and coordination efforts from caregivers and health care providers (HCP). Health information and communication technologies can potentially facilitate these efforts in order to increase the quality of care received by CSHCN.

Objective: In this study, we assessed the feasibility of a voice-enabled medical diary app (SpeakHealth) by investigating its potential use among caregivers and HCPs. Read More

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Osteocalcin promotes proliferation, differentiation, and survival of PC12 cells.

Biochem Biophys Res Commun 2021 Apr 14;557:174-179. Epub 2021 Apr 14.

Division of Applied Pharmacology, Department of Health Promotion, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu 803-8580, Japan. Electronic address:

Involvement of the bone matrix protein osteocalcin (OC) in the development of learning and memory, and the prevention of anxiety-like behaviors in mice. However, the direct effects of OC on neurons are still unknown comparing to the mechanism how OC affects systemic energy expenditure and glucose homeostasis. In this study, we investigated the effect of OC on proliferation, differentiation, and survival of neurons using the rat pheochromocytoma cell line PC12. Read More

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Exploring the changes of brain immune microenvironment in Alzheimer's disease based on PANDA algorithm combined with blood brain barrier injury-related genes.

Biochem Biophys Res Commun 2021 Apr 14;557:159-165. Epub 2021 Apr 14.

College of Information Engineering, Shanghai Maritime University, 1550 Haigang Ave., Shanghai, 201306, PR China. Electronic address:

Studies have shown that the specific entry of peripheral cells into the brain parenchyma caused by BBB injury and the imbalance of the immune microenvironment in the brain are closely related to the pathogenesis of Alzheimer's disease (AD). Because of the difficulty of obtaining data inside the brain, it is urgent to find out the relationship between the peripheral and intracerebral data and their influence on the development of AD by machine learning methods. However, in the actual algorithm design, it is still a challenge to extract relevant information from a variety of data to establish a complete and accurate regulatory network. Read More

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Stunting, IQ, and final school attainment in the Cebu Longitudinal Health and Nutrition Survey birth cohort.

Econ Hum Biol 2021 Apr 7;42:100999. Epub 2021 Apr 7.

USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines.

School attainment is an important aspect of human capital, and a key determinant of long-term health and well-being. Early life deprivation and poor nutritional status are well known predictors of school entry and progression. We examine the persistence of early life influences and subsequent socioeconomic disadvantage (SED) across the multiple school continuation decisions that lead to final school attainment. Read More

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Combining immunotherapy with an epidrug in squamous cell carcinomas of different locations: rationale and design of the PEVO basket trial.

ESMO Open 2021 Apr 14;6(3):100106. Epub 2021 Apr 14.

Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France; Inserm U900 Research Unit, Saint Cloud, France; Paris-Saclay University, Paris, France. Electronic address:

Squamous cell carcinomas (SCCs) are among the most frequent solid tumors in humans. SCCs, related or not to the human papillomavirus, share common molecular features. Immunotherapies, and specifically immune checkpoint inhibitors, have been shown to improve overall survival in multiple cancer types, including SCCs. Read More

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Atmospheric nitrogen deposition: A review of quantification methods and its spatial pattern derived from the global monitoring networks.

Ecotoxicol Environ Saf 2021 Apr 14;216:112180. Epub 2021 Apr 14.

College of Resources and Environmental Sciences; National Academy of Agriculture Green Development; Key Laboratory of Plant-Soil Interactions of MOE, China Agricultural University, Beijing 100193, China.

Atmospheric nitrogen (N) deposition is a vital component of the global N cycle. Excessive N deposition on the Earth's surface has adverse impacts on ecosystems and humans. Quantification of atmospheric N deposition is indispensable for assessing and addressing N deposition-induced environmental issues. Read More

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Investigation of protein-ligand complexes by ligand-based NMR methods.

Carbohydr Res 2021 Apr 9;503:108313. Epub 2021 Apr 9.

Dipartimento di Scienze Chimiche, Complesso Universitario Monte Sant'Angelo, Università di Napoli Federico II, Via Cintia 4, I-80126, Napoli, Italy; CNR, Institute for Polymers, Composites and Biomaterials, IPCB ss, Catania, Italy. Electronic address:

Molecular recognition is at the base of all biological events and its knowledge at atomic level is pivotal in the development of new drug design approaches. NMR spectroscopy is one of the most widely used technique to detect and characterize transient ligand-receptor interactions in solution. In particular, ligand-based NMR approaches, including NOE-based NMR techniques, diffusion experiments and relaxation methods, are excellent tools to investigate how ligands interact with their receptors. Read More

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Blood biomarkers for differential diagnosis and early detection of pancreatic cancer.

Cancer Treat Rev 2021 Mar 24;96:102193. Epub 2021 Mar 24.

Division of Functional Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.

Pancreatic cancer is currently the most lethal tumor entity and case numbers are rising. It will soon be the second most frequent cause of cancer-related death in the Western world. Mortality is close to incidence and patient survival after diagnosis stands at about five months. Read More

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Glycerol as a substrate for actinobacteria of biotechnological interest: Advantages and perspectives in circular economy systems.

Chemosphere 2021 Apr 7;279:130505. Epub 2021 Apr 7.

Planta Piloto de Procesos Industriales Microbiológicos (PROIMI-CONICET), Avenida Belgrano y Pasaje Caseros, 4000, San Miguel de Tucumán, Tucumán, Argentina; Facultad de Ciencias Naturales e Instituto Miguel Lillo, Universidad Nacional de Tucumán, Miguel Lillo 205, 4000, Tucumán, Argentina. Electronic address:

Actinobacteria represent a ubiquitous group of microorganisms widely distributed in ecosystems. They have diverse physiological and metabolic properties, including the production of extracellular enzymes and a variety of secondary bioactive metabolites, such as antibiotics, immunosuppressants, and other compounds of industrial interest. Therefore, actinobacteria have been used for biotechnological purposes for more than three decades. Read More

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Oxygen vacancy induced peroxymonosulfate activation by Mg-doped FeO composites for advanced oxidation of organic pollutants.

Chemosphere 2021 Apr 3;279:130482. Epub 2021 Apr 3.

Environmental Process Modelling Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 CleanTech Loop, 637141, Singapore; School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. Electronic address:

Oxygen vacancy engineering has emerged as an effective approach to improve the performance of catalysts for peroxymonosulfate (PMS) activation. Herein, we report a facile precipitation method followed by calcination to synthesize cost-effective and environmentally friendly magnesium-doped hematite (Mg/FeO) composites. Multiple characterization results reveal that the incorporation of Mg can significantly increase the oxygen vacancies and specific surface area of 5%Mg/FeO, leading to a significantly enhanced performance in degrading Rhodamine B (RhB) through PMS activation. Read More

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Beneficial role of biochar addition on the anaerobic digestion of food waste: A systematic and critical review of the operational parameters and mechanisms.

J Environ Manage 2021 Apr 14;290:112537. Epub 2021 Apr 14.

Université de Paris, Institut de Physique Du Globe de Paris, CNRS, UMR 7154, F-75238, Paris, France.

The generation of huge amounts of food waste due to the increasing population is a serious global issue. The inadequate management of food waste and lack of proper handling approaches have created adverse negative impacts on the environment and the society. The use of traditional disposal (i. Read More

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Seeking sustainable development policies at the municipal level based on the triad of city, economy and environment: evidence from Hunan province, China.

J Environ Manage 2021 Apr 15;290:112554. Epub 2021 Apr 15.

State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Beijing Normal University and Institute of Remote Sensing and Digital Earth of Chinese Academy of Sciences, Beijing, 100875, China; Beijing Engineering Research Center for Global Land Remote Sensing Products, Institute of Remote Sensing Science and Engineering, Faculty of Geographical Science, Beijing Normal University, Beijing, 100875, China.

Keeping urbanization, economy and eco-environment in harmony is a core issue for attaining Sustainable Development Goals (SDGs) in any complex geographical regions. Previous studies mainly focused on seeking the balance between urban expansion levels, eco-environment quality and socioeconomic degree. But the challenges still exist in solving the negative influence of urban expansion that affects eco-environmental and economic development. Read More

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Targeting of myeloid-derived suppressor cells by all-trans retinoic acid as host-directed therapy for human tuberculosis.

Cell Immunol 2021 Apr 8;364:104359. Epub 2021 Apr 8.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medical and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address:

Conventional anti-tuberculosis (TB) therapies comprise lengthy antibiotic treatment regimens, exacerbated by multi-drug resistant and extensively drug resistant mycobacterial strains. We assessed the ability of all-trans retinoic acid (ATRA), as repurposed compound serving as host-directed therapy (HDT), to counteract the suppressive effects of myeloid-derived suppressor cells (MDSCs) obtained from active TB cases (untreated or during week one of treatment) on T-cell responsiveness. We show for the first time that MDSCs suppress non-specific T-cell activation and production of interleukin (IL)-2, IL-4, IL-13 and GM-CSF via contact-dependent mechanisms. Read More

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Hotpots and trends of covalent organic frameworks (COFs) in the environmental and energy field: Bibliometric analysis.

Sci Total Environ 2021 Mar 31;783:146838. Epub 2021 Mar 31.

Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Covalent organic frameworks (COFs) have attracted extensive attention due to their low density, adjustable structure, functionalization, and good stability. This paper systematically and comprehensively describes to qualitatively and quantitatively the progress, trends, and hotspots of COFs in the environmental and energy fields from the perspective of bibliometrics. Herein, based on the Web of Science database, a total of 2589 articles from 2005 to October 6, 2020, were collected. Read More

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Green toxicology approach involving polylactic acid biomicroplastics and neotropical tadpoles: (Eco)toxicological safety or environmental hazard?

Sci Total Environ 2021 Apr 9;783:146994. Epub 2021 Apr 9.

Post-Graduate Program in Conservation of Cerrado Natural Resources, Goiano Federal Institute, Urutaí, GO, Brazil; Post-Graduate Program in Biodiversity and Biotechnology, Federal University of Goiás, Goiânia, Brazil.

Different and alternative renewable-source materials, commonly called bioplastics, have been proposed due to the high production and consumption of petroleum-derived plastics and to their high toxicity in the biota. However, their toxicological safety has not yet been assessed in a comprehensive way; therefore, their effects on several animal groups remain completely unknown. Thus, we aimed at testing the following hypothesis: the exposure of Physalaemus cuvieri tadpoles to polylaic acid biomicroplastic (PLA BioMP) at environmentally relevant concentrations (760 and 15,020 μg/L) induces physiological changes in them. Read More

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Visible-light induced activation of persulfate by self-assembled EHPDI/TiO photocatalyst toward efficient degradation of carbamazepine.

Sci Total Environ 2021 Apr 9;783:146996. Epub 2021 Apr 9.

State Key Laboratory of Hydraulics and Mountain River Engineering, College of Architecture and Environment, Sichuan University, Chengdu 610065, China; Sino-German Centre for Water and Health Research, Sichuan University, Chengdu 610065, China. Electronic address:

Removal of pharmaceutical and personal care products from wastewater is very important in water treatment process. Combining photocatalysis with persulfate (PS) could be a good solvent for this problem. Novel perylene diimide derivative (EHPDI) was designed and synthesized. Read More

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Responses of phytoplankton community structure and association to variability in environmental drivers in a tropical coastal lagoon.

Sci Total Environ 2021 Apr 1;783:146873. Epub 2021 Apr 1.

Wetland Research and Training Centre, Chilika Development Authority, Balugaon 752030, Odisha, India. Electronic address:

Spatial and seasonal heterogeneity in phytoplankton communities are governed by many biotic and abiotic drivers. However, the identification of long-term spatial and temporal trends in abiotic drivers, and their interdependencies with the phytoplankton communities' structure is understudied in tropical brackish coastal lagoons. We examined phytoplankton communities' spatiotemporal dynamics from a 5-year dataset (n = 780) collected from 13 sampling stations in Chilika Lagoon, India, where the salinity gradient defined the spatial patterns in environmental variables. Read More

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Climate-driven fluxes of organic-bound uranium to an alpine lake over the Holocene.

Sci Total Environ 2021 Apr 1;783:146878. Epub 2021 Apr 1.

Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie (IMPMC), UMR 7590, Sorbonne Université-CNRS-MNHN-IRD, Paris, France.

Uranium (U) isotopic signatures and concentration in sediments are widely used as paleo-redox proxies, as the behavior of U is often controlled by bottom water oxygenation. Here, we investigated the processes controlling U accumulation in the sediments of Lake Nègre (Mediterranean Alps, South-East France) over the past 9200 years. Exceptionally high natural U concentrations (350-1250 μg·g) allowed the measurement of U along with other elements by high-resolution X-Ray Fluorescence core-scanning. Read More

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Hydrologic and nutrient-driven regime shifts of cyanobacterial and eukaryotic algal communities in a large shallow lake: Evidence from empirical state indicator and ecological network analyses.

Sci Total Environ 2021 Apr 12;783:147059. Epub 2021 Apr 12.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.

The detection and prediction of lake ecosystem responses to environmental changes are pressing scientific challenge of major global relevance. Specifically, an understanding of lake ecosystem stability over long-term scales is urgently needed to identify impending ecosystem regime shifts induced by human activities and improve lake ecosystem protection. This study investigated regime shifts in cyanobacterial and eukaryotic algal communities in a large shallow lake over a century in response to nutrient enrichment and hydrologic regulation using evidence from empirical state indicators and ecological network analyses of sedimentary-inferred communities. Read More

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Modeling a gross motor curve of typically developing Dutch infants from 3.5 to 15.5 months based on the Alberta Infant Motor Scale.

Early Hum Dev 2021 Apr 1;157:105366. Epub 2021 Apr 1.

Faculty of Social and Behavioral Sciences, Department of Pedagogical and Educational Sciences, Utrecht University, Utrecht, the Netherlands.

Background: Interindividual variability in gross motor development of infants is substantial and challenges the interpretation of motor assessments. Longitudinal research can provide insight into variability in individual gross motor trajectories.

Purpose: To model a gross motor growth curve of healthy term-born infants from 3. Read More

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Complex renal cysts combined with hemorrhage during crizotinib treatment for ALK-rearranged lung adenocarcinoma.

Cancer Treat Res Commun 2021 Apr 9;27:100373. Epub 2021 Apr 9.

Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Xuhui District, West Huaihai Road No. 241, Shanghai, China. Electronic address:

The oral small-molecule tyrosine kinase inhibitor (TKI), crizotinib has been approved as a first-generation anaplastic lymphoma kinase (ALK) inhibitor in treatment of advanced ALK-positive non-small cell lung cancer (NSCLC). Recently, development of complex renal cysts has been reported with crizotinib usage, highlighting the importance of accurate differentiation between complex renal cysts and new metastasis in NSCLC. Here we describe a case study with confirmed EGFR wild-type and ALK-rearranged lung adenocarcinoma who developed complex renal cysts combined with hemorrhage during crizotinib treatment, with no abnormal clinical symptoms or kidney functions observed. Read More

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Does Ostmann's fat pad size correlate with development of chronic otitis media in children?

Int J Pediatr Otorhinolaryngol 2021 Apr 14;145:110710. Epub 2021 Apr 14.

Department of Otorhinolaryngology - Head and Neck Surgery, Meir Medical Center, Kfar Saba, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Objective: To compare Ostmann's fat pad (OFP) size between healthy ears and ears with chronic otitis media with cholesteatoma (COMwC) in children, to assess its role in the disease.

Methods: MRI scans of 29 children with unilateral COMwC with conductive hearing loss were used to measure OFP, represented by the maximal diameter of the high intensity area medial to the tensor veli palatini muscle (TVP): M1. A reference diameter was defined from the medial border of OFP reaching the medial border of the medial pterygoid muscle: M2. Read More

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Spatial distributions and sources of PAHs in soil in chemical industry parks in the Yangtze River Delta, China.

Environ Pollut 2021 Apr 10;283:117121. Epub 2021 Apr 10.

Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China. Electronic address:

The Yangtze River Delta (YRD) is one of the fastest developing areas in eastern China and contains many chemical industry parks. The profiles and sources of polycyclic aromatic hydrocarbons (PAHs) in soil in chemical industry parks and surrounding areas in the YRD were investigated by analyzing soil samples (n = 64) were collected in the YRD and Rudong chemical park (RD), a typical chemical park in the Yangtze River Delta. The total concentrations of 19 PAHs in the YRD soil samples were 16. Read More

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Prediction of eye, hair and skin colour in Latin Americans.

Forensic Sci Int Genet 2021 Apr 6;53:102517. Epub 2021 Apr 6.

UMR 7268 ADES, CNRS, Aix-Marseille Université, EFS, Faculté de Médecine Timone, Marseille 13005, France; Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London, London WC1E 6BT, UK; Ministry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Yangpu District, Shanghai, China. Electronic address:

Here we evaluate the accuracy of prediction for eye, hair and skin pigmentation in a dataset of > 6500 individuals from Mexico, Colombia, Peru, Chile and Brazil (including genome-wide SNP data and quantitative/categorical pigmentation phenotypes - the CANDELA dataset CAN). We evaluated accuracy in relation to different analytical methods and various phenotypic predictors. As expected from statistical principles, we observe that quantitative traits are more sensitive to changes in the prediction models than categorical traits. Read More

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Implementing practices focused on workplace health and psychological wellbeing: A systematic review.

Soc Sci Med 2021 Apr 1;277:113888. Epub 2021 Apr 1.

Employment Systems and Institutions Group, Norwich Business School, University of East Anglia, NR4 7TJ, United Kingdom.

Rationale: Workplace health and wellbeing practices (WHWPs) often fail to improve psychological health or wellbeing because of implementation failure. Thus, implementation should be evaluated to improve the effectiveness of WHWPs.

Objective: We conducted a systematic review to identify critical success factors for WHWP implementation and gaps in the evidence. Read More

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3D printing of PEEK and its composite to increase biointerfaces as a biomedical material- A review.

Colloids Surf B Biointerfaces 2021 Mar 26;203:111726. Epub 2021 Mar 26.

Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, UK.

Poly ether-ether-ketone (PEEK) is a polymer with better lignin biocompatibility than other polymers. It is good for biomedical engineering applications. This research summarises the outcomes of an evaluation conducted on PEEK material composites, such as cellular calcium hydroxyapatite (CHAp) for medical applications. Read More

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Reflecting on educational preparedness and professional development for early-career nurse faculty: A phenomenological study.

Nurse Educ Pract 2021 Apr 2;53:103052. Epub 2021 Apr 2.

Northcentral University, 11355 N. Torrey Pines Road, La Jolla, CA, United States. Electronic address:

Bedside nurses are assuming the faculty role without the necessary skill set to meet their role's rigorous expectations. The researchers sought to explore the lived experiences of early-career nursing faculty and what it feels to be unprepared to teach. A qualitative research design using semi-structured interviews served as the primary data collection method. Read More

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Active learning pedagogy transformation: A whole-of-school approach to person-centred teaching and nursing graduates.

Nurse Educ Pract 2021 Apr 2;53:103051. Epub 2021 Apr 2.

University of Wollongong, Northfields Ave, Wollongong, NSW 2522, Australia.

In contemporary higher education contexts, active learning pedagogy pervades in discourses around designing quality student experiences. Transposing student bodies from passive to active participants in learning experiences is widely considered best practice in curriculum and pedagogical design. While literature on active learning is vast and recommendations on how to transform into an active learning approach abounds, such advice is often prescribed to individual teachers or courses. Read More

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Remodelling of trabecular bone in human distal tibia: A model based on an in-vivo HR-pQCT study.

J Mech Behav Biomed Mater 2021 Apr 14;119:104506. Epub 2021 Apr 14.

Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.

An abnormal remodelling process of bones can lead to various bone disorders, such as osteoporosis, making them prone to fracture. Simulations of load-induced remodelling of trabecular bone were used to investigate its response to mechanical signal. However, the role of mechanostat in trabecular-bone remodelling has not yet been investigated in simulations underpinned by a longitudinal in-vivo study in humans. Read More

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