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Bioactive lipid mediators in the initiation and resolution of inflammation after spinal cord injury.

Neuroscience 2021 May 2. Epub 2021 May 2.

Departament de Biologia Cel·lular, Fisiologia i Inmunologia, Institut de Neurociències, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, 08193 Bellaterra, Catalonia, Spain.

Neuroinflammation is a prominent feature of the response to CNS trauma. It is also an important hallmark of various neurodegenerative diseases in which inflammation contributes to the progression of pathology. Inflammation in the CNS can contribute to secondary damage and is therefore an excellent therapeutic target for a range of neurological conditions. Read More

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Living well with kidney disease by patient and care-partner empowerment: kidney health for everyone everywhere.

Braz J Med Biol Res 2021 5;54(6):e11098. Epub 2021 Apr 5.

Sydney School of Public Health, The University of Sydney, Sydney, NSW, Australia.

Living with chronic kidney disease (CKD) is associated with hardships for patients and their care-partners. Empowering patients and their care-partners, including family members or friends involved in their care, may help minimize burden and consequences of CKD-related symptoms to enable life participation. There is a need to broaden the focus on living well with kidney disease and re-engagement in life, including emphasis on patients being in control. Read More

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Personalized analytics and wearable biosensor platform for early detection of COVID-19 decompensation (DeCODe: Detection of COVID-19 Decompensation): protocol for development of COVID-19 Decompensation Index.

JMIR Res Protoc 2021 May 4. Epub 2021 May 4.

University of Illinois Health, Chicago, US.

Background: During the COVID-19 pandemic, novel digital health technologies have the potential to improve our understanding of SARS Co-V2/ COVID-19, improve care delivery and produce better health outcomes. The National Institutes of Health called on digital health leaders to contribute to a high-quality data repository that will support the work of researchers to make discoveries not possible through small, limited data sets.

Objective: To this end, we seek to develop a COVID-19 digital biomarker that could provide early detection of a patient's physiologic worsening or decompensation. Read More

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Enhancing Dementia Education and Cognitive Screening in A Haitian Population: A Faith-based Approach.

J Community Health Nurs 2021 Apr-Jun;38(2):103-119

Louis and Anne Green Memory and Wellness Center FAU Memory Disorder Clinic Coordinator, Alzheimer's Disease Initiative Member, Federal Advisory Council on Alzheimer's Research, Care, and Services, Associate Professor of the Christine E. Lynn College of Nursing Assistant Professor of Clinical Biomedical Science (Secondary) Charles E. Schmidt College of Medicine Florida Atlantic University, Boca Raton, USA.

Ethnically diverse Americans experience 1.8-2.5 times higher risk of developing Alzheimer's disease than Whites (Mayeda, et al. Read More

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Nursing students' experiences of, and socialisation in, dementia care in the acute hospital setting.

Nurs Older People 2021 May 5. Epub 2021 May 5.

School of Health Sciences, University of Greenwich, London, England.

Background: An ageing population with a range of co-morbidities means the number of hospital admissions of older people with dementia is increasing. People with dementia can find acute hospital settings unsettling and they need to be cared for by a workforce skilled and knowledgeable in dementia care.

Aim: To explore nursing students' experiences of, and socialisation in, dementia care in the acute hospital setting in England through a secondary qualitative analysis of data from a phenomenological study of nursing students' cultural beliefs around, and understanding of, dementia. Read More

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Ripretinib and MEK inhibitors synergize to induce apoptosis in preclinical models of GIST and Systemic Mastocytosis.

Mol Cancer Ther 2021 May 4. Epub 2021 May 4.

Biology, Deciphera Pharmaceuticals, LLC

The majority of gastrointestinal stromal tumors (GIST) harbor constitutively activating mutations in KIT tyrosine kinase. Imatinib, sunitinib, and regorafenib are available as first, second, and third-line targeted therapies, respectively, for metastatic or unresectable KIT-driven GIST. Treatment of GIST patients with KIT kinase inhibitors generally leads to a partial response or stable disease but most patients eventually progress by developing secondary resistance mutations in KIT. Read More

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Barriers to postpartum diabetes screening: a qualitative synthesis of clinicians' views.

Br J Gen Pract 2021 Feb 3. Epub 2021 Feb 3.

Primary Care Unit, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge.

Background: Gestational diabetes mellitus (GDM) is an important risk factor for developing type 2 diabetes mellitus (T2DM) later in life. Postpartum screening provides an opportunity for early detection and management of T2DM, but uptake is poor.

Aim: To explore barriers to screening from clinicians' perspectives to guide future interventions to increase uptake of postpartum screening. Read More

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February 2021

Enhanced performance of gelatin 5-fluorouracil-containing nanoparticles against squamous cell carcinoma in simulated chronic wounds conditions.

Mater Sci Eng C Mater Biol Appl 2021 May 24;124:112073. Epub 2021 Mar 24.

Departament de Bioquímica i Fisiologia-Secció de Fisiologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Avda. Joan XXIII 27-31, 08028 Barcelona, Spain; Institut de Nanociència i Nanotecnologia-IN2UB, Universitat de Barcelona, Avda. Joan XXIII 27-31, 08028, Barcelona, Spain. Electronic address:

Chronic wounds are considered a silent epidemic affecting a significant fraction of the World population. Their treatment supposes a large fraction of the public spending on the health of developed countries. In chronic wounds secondary to burns, trauma, UV light radiation, and diabetes, among others, the development of squamous cell carcinoma (SCC) has been reported. Read More

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Secondary organizing pneumonia following occupational acute nitrogen oxide poisoning: a case report.

J Int Med Res 2021 May;49(5):3000605211010734

Department of Poisoning and Occupational Diseases, Emergency, Qilu Hospital, Shandong University, Jinan, Shandong, China.

Secondary organizing pneumonia (SOP) is a nonspecific inflammatory response towards acute lung injuries caused by various diseases. However, organizing pneumonia (OP) secondary to occupational acute nitrogen oxide poisoning has been reported rarely. We report a 49-year-old man who suffered from nitrogen oxide poisoning after inhaling mixed gas at work. Read More

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Becoming scholars in an online cohort of a PhD in nursing program.

Int J Nurs Educ Scholarsh 2021 May 4;18(1). Epub 2021 May 4.

Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada.

The goal of this descriptive qualitative study was to examine the views of students about their experience and development as scholars during the first two years of an online cohort nursing doctoral program. A secondary goal was to seek the views of faculty members very involved in the program. Semi-structured interviews were conducted with 10 of the 13 students of the first two online cohorts and five faculty members. Read More

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Tempering hope with Intimate Knowledge: Contrasting emergences of the concept 'uninfectious' in HIV.

Sociol Health Illn 2021 May 4. Epub 2021 May 4.

School for Policy Studies, University of Bristol, Bristol, UK.

In this paper, we contrast two emergences of the concept of 'uninfectious' (that pharmaceuticals can render someone living with HIV non-infectious) in HIV. First, using Novas' framing of 'political economies of hope', we describe the deployment of 'uninfectious' as part of global health campaigns. Second, we draw on Raffles' (International Social Science Journal, 2002, 54, 325) concept of 'intimate knowledge' to theorise our own account of 'uninfectious' through a re-analysis of qualitative data comprising the intimate experiences of people living with or around HIV collected at various points over the last 25 years. Read More

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Machine Learning and Natural Language Processing in Mental Health: Systematic Review.

J Med Internet Res 2021 May 4;23(5):e15708. Epub 2021 May 4.

URCI Mental Health Department, Brest Medical University Hospital, Brest, France.

Background: Machine learning systems are part of the field of artificial intelligence that automatically learn models from data to make better decisions. Natural language processing (NLP), by using corpora and learning approaches, provides good performance in statistical tasks, such as text classification or sentiment mining.

Objective: The primary aim of this systematic review was to summarize and characterize, in methodological and technical terms, studies that used machine learning and NLP techniques for mental health. Read More

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Early postoperative infection following lamellar keratoplasty: a review.

Br J Ophthalmol 2021 May 3. Epub 2021 May 3.

Cornea & Anterior Segment Service, LV Prasad Eye Institute, Bhubaneswar, Odisha, India

With the growing popularity of lamellar keratoplasty for selective replacement of diseased corneal tissue, it is important to understand the risk of developing an infection after the procedure. Although lesser than that postpenetrating keratoplasty, the reports on post lamellar keratoplasty infectious keratitis are not negligible. Trends of acute infections arising within 2 months of surgery are a subject of interest. Read More

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Rejection of Care and Aggression Among Older Veterans With Dementia: The Influence of Background Factors and Interpersonal Triggers.

J Am Med Dir Assoc 2021 Apr 30. Epub 2021 Apr 30.

Duke University School of Nursing, NC, USA; Geriatric Research, Education and Clinical Center, Durham Department of Veterans Affairs Medical Center, NC, USA.

Objectives: To test relationships among background factors, interpersonal triggers, rejection of care, and aggression among veterans living with dementia in residential long-term care settings, based on the need-driven dementia-compromised behavior model.

Design: A mixed methods secondary analysis of program evaluation data from the Staff Training in Assisted Living Residences-Veterans Health Administration intervention implemented by the US Department of Veterans Affairs healthcare system.

Setting And Participants: In total, 315 older veterans who participated in the 2013‒2016 Staff Training in Assisted Living Residences-Veterans Health Administration program at 76 Community Living Centers (Veterans Affairs-operated nursing homes). Read More

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Filler Use Among Trans Women: Correlates of Feminizing Subcutaneous Injections and Their Health Consequences.

Transgend Health 2021 Apr 15;6(2):82-90. Epub 2021 Apr 15.

San Francisco Department of Public Health, San Francisco, California, USA.

Subcutaneous injections, or "fillers," are used illicitly and in large quantities by trans women for feminization. They are associated with severe complications, but data on their use are limited, especially in places with widespread access to safe gender-affirming care. Our analysis seeks to assess the prevalence, correlates, and complications of filler use to inform prevention and treatment. Read More

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Policy Requirements for the Prevention and Management of Fetal Alcohol Spectrum Disorder in South Africa: A Policy Brief.

Front Public Health 2021 15;9:592726. Epub 2021 Apr 15.

Department of Social Work, University of the Western Cape, Cape Town, South Africa.

This policy brief is aimed to guide policymakers in developing a comprehensive and multi-sectoral policy for the prevention and management of fetal alcohol spectrum disorder (FASD). FASD is a leading source of non-genetic developmental and intellectual disability globally and is usually associated with primary and secondary disabilities. South Africa has been identified to have the highest reported prevalence of FASD in the world. Read More

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Risky Alcohol Drinking Pattern and Its Association with Educational Attainment and Wealth Index among Adult Men Population in Ethiopia: Further Analysis of 2016 Ethiopian Demographic Health Survey.

J Addict 2021 14;2021:6646085. Epub 2021 Apr 14.

Center for Disease Control Zonal Cordinator, Awi Zonal Health Department, Injibara, Ethiopia.

Risky alcohol drinking is one of the major public health problems and an important health risk factor for premature death and disability worldwide. Identifying the determinants of risky alcohol drinking patterns is crucial for developing and improving intervention on drinking behavior. In Ethiopia, the role of educational attainment and affluence in reducing risky alcohol drinking patterns among men remains unclear. Read More

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Drug Utilization Evaluation of Medications Used by Hypertensive Patients in Hospitals in Nigeria.

Hosp Top 2021 May 1:1-10. Epub 2021 May 1.

Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, Obafemi Awolowo University, Ife, Osun State, Nigeria.

Drug utilization studies in developing countries is evolving. Rising medication cost for hypertensive patients is a major cause of noncompliance to therapy. The study was a cross-sectional drug utilization review involving outpatients in two purposively selected hospitals (secondary and tertiary) in Abeokuta, Southwestern Nigeria. Read More

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Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis.

Authors:

Lancet 2021 May;397(10285):1625-1636

Background: The effects of pharmacological blood pressure lowering at normal or high-normal blood pressure ranges in people with or without pre-existing cardiovascular disease remains uncertain. We analysed individual participant data from randomised trials to investigate the effects of blood pressure lowering treatment on the risk of major cardiovascular events by baseline levels of systolic blood pressure.

Methods: We did a meta-analysis of individual participant-level data from 48 randomised trials of pharmacological blood pressure lowering medications versus placebo or other classes of blood pressure-lowering medications, or between more versus less intensive treatment regimens, which had at least 1000 persons-years of follow-up in each group. Read More

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The relationship among primary anatomic subsite and risk and distribution of second malignant neoplasms in patients with stage I/II diffuse large B-cell lymphoma: An analysis of the surveillance, epidemiology, and end results database.

Transl Oncol 2021 Apr 28;14(7):101106. Epub 2021 Apr 28.

Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology, Wuhan, China.

Background: Recent studies have reported that diffuse large B-cell lymphoma (DLBCL) involving different primary extranodal sites have distinct clinicopathological characteristics and prognosis. However, the risk of secondary malignant neoplasms (SMNs) in DLBCL survivors with different primary extranodal sites are unknown.

Methods: A total of 40,714 patients diagnosed with stage I/II DLBCL were included from the Surveillance, Epidemiology, and End Results (SEER) database from 1983 to 2015. Read More

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CsTCPs regulate shoot tip development and catechin biosynthesis in tea plant (Camellia sinensis).

Hortic Res 2021 May 1;8(1):104. Epub 2021 May 1.

State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, 230036, China.

The growth of leaves and biosynthesis of characteristic secondary metabolites are critically important for tea production and quality control. However, little is known about the coordinated regulation of leaf development and catechin biosynthesis in tea plants. Here, we reported that TCP TFs are involved in both catechin biosynthesis and leaf development. Read More

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Loop Diuretics in Infants with Heart Failure.

Neoreviews 2021 May;22(5):e309-e319

Departments of *Pediatrics and.

Tremendous advances have been made in the last 5 decades in the surgical management of congenital heart disease (CHD). Most infants affected by clinically significant CHD are at risk for developing heart failure (HF). Adult HF management is mostly evidence-based and our knowledge in this field has expanded significantly in the past decade. Read More

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Presentation, management and outcomes of pediatric urogenital tuberculosis: 20 years' experience from a tertiary center.

J Pediatr Urol 2021 Apr 8. Epub 2021 Apr 8.

Department of Urology, Sri Sathya Sai Institute of Higher Medical Sciences, Prashantigram, Puttaparthi, Andhra Pradesh, 515134, India. Electronic address:

Background: Urogenital tuberculosis (UGTB) has traditionally being a diagnosis of adulthood and is supposed to be rare in children, as it is believed that the symptoms of renal tuberculosis do not appear for 10 or more years after the primary infection. While this may be true in developed countries, where childhood pulmonary tuberculosis is a rarity nowadays. In developing countries, childhood pulmonary tuberculosis is still a major issue and hence, UGTB is not an uncommon diagnosis in younger children and adolescents in these countries. Read More

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Slowing Down Myopia Progression with Contact Lenses - Everyday Cases from the Clinic.

Klin Monbl Augenheilkd 2021 Apr 30;238(4):437-442. Epub 2021 Apr 30.

Ophthalmology, Universitätsspital Basel Augenklinik, Basel, Switzerland.

Background: An estimated 49.8% of the world population will be myopic by 2050. Multifocal contact lenses (MFCLs) and orthokeratology (OK) reduce peripheral retinal hyperopic defocus, which animal studies have shown to positively impact eye growth. Read More

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The Recruitment, Enlistment, and Deployment of HIV-Positive Military Service Members: An Evaluation of South African and U.S. National, Alongside International, Policies.

Mil Med 2021 Apr 30. Epub 2021 Apr 30.

Postgraduate Education Group, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, United Kingdom.

Introduction: Since its detection in the early 1980s, HIV and AIDS have claimed 32.7 million lives. The HIV epidemic continues to plague the world with its most devastating effects felt in Eastern and Southern Africa. Read More

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The relationship between serum uric acid level and uric acid / creatinine ratio with COPD severity (stable or acute exacerbation) and the development of cor pulmonale.

Int J Clin Pract 2021 Apr 30:e14303. Epub 2021 Apr 30.

Konya Provincial Health Directorate.

Background: There are studies reporting that uric acid elevation is a marker for hypoxemia and pulmonary hypertension secondary to some diseases.

Aim: The aim of this study is to investigate the relationship between serum uric acid level and uric acid/creatinine ratio with Chronic Obstructive Pulmonary Disease (COPD) exacerbation, hypoxemia in exacerbation and development of cor pulmonale.

Methods: A total of 96 COPD patients who were admitted to Ondokuz Mayıs University Faculty of Medicine emergency department and Chest Diseases outpatient clinic and whose written consent was obtained, were included in our study. Read More

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Neurologic Outcomes After Extracorporeal Cardiopulmonary Resuscitation: Recent Experience at a Single High-Volume Center.

ASAIO J 2021 Apr 21. Epub 2021 Apr 21.

From the Section of Neurocritical Care and Emergency Neurology, Department of Neurology, Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland Division of Thoracic Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland Division of Cardiac Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland University of Maryland School of Medicine, Baltimore, Maryland Division of Surgical Critical Care, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.

Extracorporeal cardiopulmonary resuscitation (ECPR)-veno-arterial extracorporeal membrane oxygenation (ECMO) for refractory cardiac arrest-has grown rapidly, but its widespread adoption has been limited by frequent neurologic complications. With individual centers developing best practices, utilization may be increasing with an uncertain effect on outcomes. This study describes the recent ECPR experience at the University of Maryland Medical Center from 2016 through 2018, with attention to neurologic outcomes and predictors thereof. Read More

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