48,456 results match your criteria developed recurrence

Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer.

NPJ Genom Med 2021 Jun 11;6(1):45. Epub 2021 Jun 11.

Departments of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Predicting the risk of metastasis before starting prostate cancer (PCa) treatment can minimize the overtreatment of indolent cases and help choosing appropriate treatment. The levels of circulating microRNAs (miRNAs) from body fluids can be used as noninvasive prognostic biomarkers. In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR-142-3p, miR-451, and miR-636. Read More

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Impact of skeletal muscle mass in patients with recurrent gastric cancer.

World J Surg Oncol 2021 Jun 11;19(1):170. Epub 2021 Jun 11.

Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan.

Background: We retrospectively examined the relationship among skeletal muscle mass index (SMI), prognosis, and chemotherapy side effects in patients with recurrent gastric cancer (RGC).

Methods: Sixty-seven patients who developed recurrence after undergoing curative gastrectomy for gastric cancer at Tottori University Hospital and received palliative chemotherapy were included in this study. Pretreatment computed tomography was performed to measure the skeletal muscle mass (SMM) and cross-sectional SMM at the third lumbar vertebra. Read More

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Long-term outcomes of single-incision versus multiport laparoscopic totally extra-peritoneal inguinal hernia repair: a single-institution experience of 186 consecutive cases.

Surg Today 2021 Jun 11. Epub 2021 Jun 11.

Department of Gastroenterological Surgery, Osaka Police Hospital, Tennoji-Ku Kitayamacho 10-31, Osaka, Osaka, 543-0035, Japan.

Purpose: This retrospective study was conducted to compare the long-term outcomes of single-incision totally extraperitoneal (S-TEP) inguinal hernia repair and conventional multiport totally extraperitoneal (M-TEP) inguinal hernia repair.

Methods: The study population included 186 consecutive patients (S-TEP, n = 149; M-TEP, n = 37) who underwent elective surgery for inguinal hernia at Osaka Police Hospital between 2011 and 2013.

Results: No significant between-group difference was found in patient or hernia characteristics or in perioperative outcomes, with the exception of age (S-TEP group vs. Read More

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Redefining postmastectomy radiation contouring in the era of immediate breast reconstruction: An accurate assessment of local recurrence risk.

Clin Transl Radiat Oncol 2021 Jul 6;29:33-39. Epub 2021 May 6.

Dept. Oncology, London Regional Cancer Program, London, ON, Canada.

Introduction: Most studies report post-mastectomy local recurrences as chest wall recurrences without clarifying whether the recurrence is in the subcutaneous tissue, muscle or underlying rib. Post-mastectomy chest wall radiation is recommended in patients at increased risk of locoregional recurrence. Chest wall radiation-related fibrosis has become an important clinical consideration in the era of immediate implant-based breast reconstruction. Read More

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Recurrent uncomplicated urinary tract infections: definitions and risk factors.

Tommaso Cai

GMS Infect Dis 2021 27;9:Doc03. Epub 2021 May 27.

Department of Urology, Santa Chiara Hospital, Trento, Italy.

Recurrent uncomplicated urinary tract infections (UTI) have a high impact on patients' quality of life and high direct and indirect costs for public health. Therefore, optimal management should be of high priority. Current international guidelines were reviewed, and a systematic literature search was performed in Medline, Cochrane, and Embase. Read More

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Establishment and Evaluation of a Predictive Model for Early Postoperative Recurrence of Hepatocellular Carcinoma in Patients with Microvascular Invasion.

Int J Gen Med 2021 3;14:2259-2274. Epub 2021 Jun 3.

Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, 100021, People's Republic of China.

Objective: The present study aimed to identify the risk factors for early postoperative recurrence of hepatocellular carcinoma (HCC) in patients with microvascular invasion (MVI) and develop a predictive model.

Inclusion Population And Methods: Patients who underwent surgery for HCC with pathological identification of MVI at the Cancer Hospital of the Chinese Academy of Medical Sciences from January 2014 to June 2019 were consecutively enrolled in this study. A total of 416 patients were included, divided into an early recurrence group (N = 169) and a non-early recurrence group (N = 247), taking 12 months as the cut-off point for early recurrence. Read More

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Amnion epithelial cells are an effective source of factor H and prevent kidney complement deposition in factor H-deficient mice.

Stem Cell Res Ther 2021 Jun 10;12(1):332. Epub 2021 Jun 10.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via GB Camozzi 3, 24020, Ranica, Bergamo, Italy.

Complement factor H (FH) is the main plasma regulator of the alternative pathway of complement. Genetic and acquired abnormalities in FH cause uncontrolled complement activation amplifying, with the consequent accumulation of complement components on the renal glomeruli. This leads to conditions such as C3 glomerulopathy (C3G) and atypical hemolytic uremic syndrome (aHUS). Read More

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A conservative treatment for chronic obstructive sialoadenitis by intraductal instillation of mucolytic, steroids and antibiotic solution.

Eur Arch Otorhinolaryngol 2021 Jun 10. Epub 2021 Jun 10.

Unit of Otorhinolaringology, Department of Biomedicina, Neuroscienze E Diagnostica Avanzata, Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone", University of Palermo, Via del Vespro, 133, 90127, Palermo, Italy.

Purposes: Reporting our experience in treating chronic obstructive sialadenitis with a protocol consisting of sialoendoscopy and intraductal instillation of antibiotics, steroids and n-acetyl-cysteine (NAC) solution.

Methods: Prospective study of patients with chronic obstructive sialadenitis with no apparent lithiasic obstructions, with recurrent non-lithiasic sialoadenitis and patients with lithiasic sialoadenitis not solved with sialoendoscopy. In all cases, a sialoendoscopy was performed. Read More

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A versatile nanoagent for multimodal imaging-guided photothermal and anti-inflammatory combination cancer therapy.

Biomater Sci 2021 Jun 10. Epub 2021 Jun 10.

Department of Ultrasonography, The Third Affiliated Hospital of Southern Medical University, Academy of Orthopedics, Guangzhou 510515, Guangdong Province, P. R. China.

Photothermal therapy (PTT) has drawn great attention in cancer treatment because of its minimal invasiveness and high spatiotemporal selectivity, but it still encounters severe obstacles like heat-resistance, metastasis and recurrence. A key reason for the treatment failure is the highly inflammatory tumor microenvironment caused by hyperthermia. A simultaneous anti-inflammatory therapy alongside the PTT has great potential for overcoming the drawbacks of PTT; however, it has been less reported and further study is urgently needed. Read More

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Evaluation of peripheral nodal recurrence in patients with endometrial cancer.

J Turk Ger Gynecol Assoc 2021 Jun 10. Epub 2021 Jun 10.

Clinic of Gynecologic Oncology, University of Health Sciences Turkey, Etlik Zübeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey.

Objective: We aimed to evaluate the clinico-pathological patient features, prognostic factors, treatment options and outcomes of peripheral nodal recurrence (PNR) of endometrial cancer (EC).

Material And Methods: The data of 9 patients with PNR of EC from two institutions were reviewed. The electronic literature was reviewed from 1972 to May 2018 to identify articles about PNR in EC. Read More

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Treatment and outcome of spontaneous pneumothorax secondary to suspected migrating vegetal foreign body in 37 dogs.

Vet Rec 2021 Jun 9:e22. Epub 2021 Jun 9.

Surgical Department, Centre Hospitalier Vétérinaire Languedocia, Montpellier, France.

Background: The aim of this study is to describe surgical findings, treatment and outcome of spontaneous pneumothorax (SP) secondary to suspected migrating vegetal foreign body (MVFB).

Methods: This retrospective study included dogs with computed tomography (CT) consistent with SP suspected to be secondary to MVFB that underwent thoracic surgery. They were divided into two groups according to whether CT identified (group 1) or only suspected (group 2) an MVFB. Read More

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Rare Fetus-in-Fetu: Experience From a Large Tertiary Pediatric Referral Center.

Front Pediatr 2021 24;9:678479. Epub 2021 May 24.

Department of Pediatric Surgery, Maternal and Child Health Hospital of Hubei, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Fetus-in-fetu (FIF) is an extremely rare disease, and most prior publications are single case reports. Here, we describe the clinical characteristics, imaging manifestations, and the treatment and related complications of FIF from a large tertiary pediatric referral center. After institutional review board approval, patients with a diagnosis of FIF between January 2010 and November 2019 were further selected and reexamined. Read More

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An Evaluation of the Use of Corticosteroids for the Management of Immune-Mediated Adverse Events in Cancer Patients Treated With Immune Checkpoint Inhibitors.

J Adv Pract Oncol 2021 Mar 1;12(2):137-145. Epub 2021 Mar 1.

Allegheny Health Network, Kittanning, Pennsylvania.

Immune checkpoint inhibitors (ICIs) have gained prominence for the treatment of a variety of malignancies. However, they are associated with the development of immune-mediated adverse events (IMAEs). Appropriate management of IMAEs and subsequent rechallenging of patients with ICI therapy remains an important area of research. Read More

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Outcomes of Immune Checkpoint Inhibitor-related Diarrhea or Colitis in Cancer Patients With Superimposed Gastrointestinal Infections.

Am J Clin Oncol 2021 Jun 9. Epub 2021 Jun 9.

Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province Department of Oncology, The Second Xiangya Hospital of Central South University, Changsha, Hunan Province, People's Republic of China Departments of Gastroenterology, Hepatology, and Nutrition Infectious Diseases, Infection Control, and Employee Health Melanoma Medical Oncology Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center Department of Biosciences, Rice University Department of Internal Medicine, Baylor College of Medicine, Houston, TX Department of Internal Medicine, Saint Joseph Hospital, Chicago, IL Department of Internal Medicine, University of Missouri, Kansas City, MO Department of Gastroenterology, Sibley Memorial Hospital, Johns Hopkins University, Washington, DC.

Background And Objective: Immune-mediated diarrhea and colitis (IMDC) is a common adverse event in cancer patients receiving immune checkpoint inhibitors (ICIs). Gastrointestinal (GI) infections can co-occur with IMDC, and its impact on the course and outcome of IMDC remains unclear.

Patients And Methods: We retrospectively reviewed cancer patients who received ICIs and developed IMDC between January 2015 and September 2019. Read More

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Proper assignation of reactivation in a COVID-19 recurrence initially interpreted as a reinfection.

J Infect Dis 2021 Jun 9. Epub 2021 Jun 9.

Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.

A 77-year-old-male (Case R) who had had a previous diagnosis of mild COVID-19 episode, was hospitalized 35 days later. On Day 23 post-admission, he developed a second COVID-19 episode, now severe, and finally died. Initially, Case R COVID-19 recurrence was interpreted as a reinfection due to the exposure to a SARS-CoV-2 RT-PCR-positive room-mate. Read More

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A novel Filobacterium sp can cause chronic bronchitis in cats.

PLoS One 2021 9;16(6):e0251968. Epub 2021 Jun 9.

Centre for Veterinary Education, University of Sydney, Sydney, NSW, Australia.

Background: Cilia-associated respiratory bacillus (CARB; now known as Filobacterium rodentium gen. nov., sp. Read More

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Role of F-18 FDG PET/CT in the follow-up of asymptomatic renal cell carcinoma patients for postoperative surveillance: based on conditional survival analysis.

J Cancer Res Clin Oncol 2021 Jun 9. Epub 2021 Jun 9.

Department of Urology, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea.

Purpose: This study investigated the clinical usefulness of F-18 fluorodeoxylucose (FDG) positron emission tomography/computed tomography (PET/CT) for postoperative surveillance in the RCC patients in terms of detectability of recurrence and radiation exposure.

Methods: Three-hundred-and-forty- three RCC patients who underwent surgery and postoperative surveillance were retrospectively included. Conditional recurrent free survival (CRFS) was investigated and diagnostic performance of conventional imaging (CI) which include abdominopelvic CT or/and chest CT was compared to the FDG PET/CT. Read More

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[Efficacy and Relapse Prediction Model of Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Acute Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):696-702

Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China,E-mail:

Objective: To observe the clinical efficacy of allogeneic peripheral blood stem cell transplantation(allo-HSCT) on the treatment of adult acute leukemia patients, moreover, to establish and evaluate a Logistic model to predict the risk of relapse in adult acute leukemia patients after allo-HSCT.

Methods: The clinical data of 145 adult acute leukemia patients treated by peripheral blood stem cell transplantation in the First Affiliated Hospital of Xi'an Jiaotong University from January 2010 to December 2019 was enrolled and analyzed retrospectively. Complications and survival of patients were observed. Read More

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The prognostic value of sarcopenia combined with preoperative fibrinogen-albumin ratio in patients with intrahepatic cholangiocarcinoma after surgery: A multicenter, prospective study.

Cancer Med 2021 Jun 8. Epub 2021 Jun 8.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Background: To explore the prognostic value of the fibrinogen-albumin ratio (FAR) combined with sarcopenia in intrahepatic cholangiocarcinoma (ICC) patients after surgery and to develop a nomogram for predicting the survival of ICC patients.

Materials And Methods: In this prospective cohort study, 116 ICC patients who underwent radical surgery were enrolled as the discovery cohort and another independent cohort of 68 ICC patients was used as the validation cohort. Kaplan-Meier method was used to analyze prognosis. Read More

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Sequence-Defined Nanotubes Assembled from IR780-Conjugated Peptoids for Chemophototherapy of Malignant Glioma.

Research (Wash D C) 2021 16;2021:9861384. Epub 2021 May 16.

School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, USA.

Near-infrared (NIR) laser-induced phototherapy through NIR agents has demonstrated the great potential for cancer therapy. However, insufficient tumor killing due to the nonuniform heat or cytotoxic singlet oxygen (O) distribution over tumors from phototherapy results in tumor recurrence and inferior outcomes. To achieve high tumor killing efficacy, one of the solutions is to employ the combinational treatment of phototherapy with other modalities, especially with chemotherapeutic agents. Read More

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Metachronous Sporadic Desmoid Tumors Arisen in the Stomach and the Cecum.

Cureus 2021 May 4;13(5):e14847. Epub 2021 May 4.

Department of Surgery, Ako City Hospital, Ako City, JPN.

Desmoid-type fibromatosis (DF) is a rare soft-tissue tumor demonstrating fibroblastic to myofibroblastic differentiation, recognized as a biologically intermediate, locally aggressive tumor; however, it can be clinically lethal due to its infiltrative growth and risk of locoregional recurrence. Desmoid-type fibromatoses can arise from any part of the body, however, intra-abdominal DFs comprise only 8% of all DFs. We report a case of a male in his 60s who presented with the metachronous occurrence of DF: gastric DF followed by cecal DF with two years of clinical interval. Read More

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Laparoscopic cryoablation for small renal masses: Oncological outcomes at 5-year follow-up.

Arab J Urol 2020 Dec 17;19(2):159-165. Epub 2020 Dec 17.

Department of Urology, Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, The Netherlands.

: To evaluate the oncological outcome at 5-year follow-up after laparoscopic cryoablation (LCA) for small renal masses (SRMs), as there is an increasing interest in ablative therapy for cT1a renal tumours due to the rising incidence of SRMs, the trend towards minimally invasive nephron-sparing treatments, and the ageing population. : Between 2004 and 2015, 233 consecutive LCA were performed in 219 patients for SRMs at two referral centres. We only included those patients with ≥5 years of follow-up ( = 165) in a prospectively maintained database. Read More

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December 2020

Development and Validation of a Prognostic Nomogram for Postoperative Recurrence-Free Survival of Ameloblastoma.

Cancer Manag Res 2021 1;13:4403-4416. Epub 2021 Jun 1.

Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510055, People's Republic of China.

Purpose: Ameloblastoma is a benign odontogenic neoplasm with a high local recurrence rate if the operation is not thorough. However, a useful clinical tool for the quantitative assessment of the prognosis and risk of postoperative recurrence of ameloblastoma has not yet been constructed. This study aims to develop a prognostic nomogram model for ameloblastoma of the jaw to assist surgeons in surgical decision-making. Read More

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Georgian Med News 2021 Apr(313):26-33

4Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Russian Federation.

The aim of the study is to substantiate the surgical treatment tactics of recurrence varicose veins after endovenous interventions. Early and long-term results of the treatment, quality of life of patients with recurrence of varicose veins were studied. Among the admitted patients, there were 55 (65. Read More

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Prognosis of variceal and non-variceal upper gastrointestinal bleeding in already hospitalised patients: Results from a French prospective cohort.

United European Gastroenterol J 2021 Jun 8. Epub 2021 Jun 8.

Groupe Hospitalier Intercommunal Le Raincy-Montfermeil, Montfermeil, France.

Objectives: Patients who develop upper gastrointestinal bleeding (UGIB) while in hospital appear to have a poor prognosis. Our study aims at analysing the difference in outcome between in-patients (IPs) and out-patients presenting with variceal and non-variceal UGIB.

Methods: We conducted a multicentre prospective study by collecting data about variceal and non-variceal UGIB cases through 46 hospitals in France between November 2017 and October 2018. Read More

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Neutropenia, Thrombocytopenia, and Eosinophilia: An Unusual Triad in a Patient on Long-Term Vancomycin Therapy.

Am J Case Rep 2021 Jun 8;22:e931647. Epub 2021 Jun 8.

School of Medicine, Saint Louis University, Saint Louis, MO, USA.

BACKGROUND Vancomycin is an antibiotic commonly used for management of severe gram-positive infections. It is infrequently associated with hematologic adverse effects, ranging from isolated thrombocytopenia or neutropenia to pancytopenia. Although the mechanism is poorly understood, it is considered an immune-mediated phenomenon. Read More

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Evaluation of endocrine resistance using ESR1 genotyping of circulating tumor cells and plasma DNA.

Breast Cancer Res Treat 2021 Jun 8. Epub 2021 Jun 8.

Cancer Center, Massachusetts General Hospital, Bldg 149, 13th Street, Charlestown, MA, 02129, USA.

Purpose: Therapeutic efficacy of hormonal therapies to target estrogen receptor (ER)-positive breast cancer is limited by the acquisition of ligand-independent ESR1 mutations, which confer treatment resistance to aromatase inhibitors (AIs). Monitoring for the emergence of such mutations may enable individualized therapy. We thus assessed CTC- and ctDNA-based detection of ESR1 mutations with the aim of evaluating non-invasive approaches for the determination of endocrine resistance. Read More

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Development of CD133 Targeting Multi-Drug Polymer Micellar Nanoparticles for Glioblastoma - In Vitro Evaluation in Glioblastoma Stem Cells.

Pharm Res 2021 Jun 7. Epub 2021 Jun 7.

Department of Radiology and Imaging, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Purpose: Glioblastoma (GBM) is a malignant brain tumor with a poor long-term prognosis due to recurrence from highly resistant GBM cancer stem cells (CSCs), for which the current standard of treatment with temozolomide (TMZ) alone will unlikely produce a viable cure. In addition, CSCs regenerate rapidly and overexpress methyl transferase which overrides the DNA-alkylating mechanism of TMZ, leading to resistance. The objective of this research was to apply the concepts of nanotechnology to develop a multi-drug therapy, TMZ and idasanutlin (RG7388, a potent mouse double minute 2 (MDM2) antagonist), loaded in functionalized nanoparticles (NPs) that target the GBM CSC subpopulation, reduce the cell viability and provide possibility of in vivo preclinical imaging. Read More

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Nodular fasciitis of the breast: clinicopathologic and molecular characterization with identification of novel USP6 fusion partners.

Mod Pathol 2021 Jun 7. Epub 2021 Jun 7.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

Nodular fasciitis is a benign, self-limited, pseudosarcomatous neoplasm that can mimic malignancy due to its rapid growth, cellularity, and mitotic activity. Involvement of the breast is rare and diagnosis on biopsy can be challenging. In this largest series to date, we examined the clinicopathologic and molecular characteristics of 12 cases of nodular fasciitis involving the breast/axilla. Read More

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Radium-223 in patients with prostate specific antigen (PSA) progression and without clinical metastases following maximal local therapy: A pilot study.

Urol Oncol 2021 Jun 4. Epub 2021 Jun 4.

Department of Urology, University Hospitals Leuven, Leuven, Belgium; Department of development and regenaration, Leuven, Belgium.

Background: Despite the curative intent of radical prostatectomy (RP) (+/- radiotherapy (RT)), 30% of the clinically localized prostate cancer (CaP) patients will develop rising PSA (prostate specific antigen). In absence of clinical recurrence, there is a lack of effective treatment strategies in order to control the disease at its earliest (micro)metastatic stage. The aim of this study was to assess safety, tolerability, and biochemical response of off-label Radium-223 (Xofigo) treatment in CaP patients with PSA relapse following maximal local therapy. Read More

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