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Assessing the differential sensitivities of wave-CAIPI ViSTa myelin water fraction and magnetization transfer saturation for efficiently quantifying tissue damage in MS.

Mult Scler Relat Disord 2021 Oct 4;56:103309. Epub 2021 Oct 4.

McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Montreal, QC, Canada; Department of Biomedical Engineering, McGill University, Montreal, QC, Canada; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.

Background: Wave-CAIPI Visualization of Short Transverse relaxation time component (ViSTa) is a recently developed, short-T-sensitized MRI method for fast quantification of myelin water fraction (MWF) in the human brain. It represents a promising technique for the evaluation of subtle, early signals of demyelination in the cerebral white matter of multiple sclerosis (MS) patients. Currently however, few studies exist that robustly assess the utility of ViSTa MWF measures of myelin compared to more conventional MRI measures of myelin in the brain of MS patients. Read More

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October 2021

European Society of Cardiology Quality Indicators for Cardiovascular Disease Prevention: developed by the Working Group for Cardiovascular Disease Prevention Quality Indicators in collaboration with the European Association for Preventive Cardiology of the European Society of Cardiology.

Eur J Prev Cardiol 2021 Oct 23. Epub 2021 Oct 23.

Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9LU, UK.

Aims: To develop a set of quality indicators (QIs) for the evaluation of the care and outcomes for atherosclerotic cardiovascular disease (ASCVD) prevention.

Methods And Results: The Quality Indicator Committee of the European Society of Cardiology (ESC) formed the Working Group for Cardiovascular Disease Prevention Quality Indicators in collaboration with Task Force members of the 2021 ESC Guidelines on Cardiovascular Disease Prevention in Clinical Practice and the European Association of Preventive Cardiology (EAPC). We followed the ESC methodology for QI development, which involved (i) the identification of the key domains of care for ASCVD prevention by constructing a conceptual framework of care, (ii) the development of candidate QIs by conducting a systematic review of the literature, (iii) the selection of the final set of QIs using a modified Delphi method, and (iv) the evaluation of the feasibility of the developed QIs. Read More

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October 2021

Using an Alternatives Assessment Framework to Evaluate Waterborne vs. Solventborne Basecoats used in Automotive Refinishing.

Integr Environ Assess Manag 2021 Oct 23. Epub 2021 Oct 23.

Hazardous Waste Management Program in King County, Seattle, Washington, USA.

We evaluated two types of automotive basecoats used in automotive refinishing (i.e., in auto body shops): waterborne and solventborne. Read More

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October 2021

Bar-cas12a, a novel and rapid method for plant species authentication in case of Phyllanthus amarus Schumach. & Thonn.

Sci Rep 2021 Oct 22;11(1):20888. Epub 2021 Oct 22.

Department of Biology, Faculty of Science, Research Center in Bioresources for Agriculture, Industry and Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Rapid and accurate species diagnosis accelerates performance in numerous biological fields and associated areas. However, morphology-based species taxonomy/identification might hinder study and lead to ambiguous results. DNA barcodes (Bar) has been employed extensively for plant species identification. Read More

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October 2021

An ELISA-based method for rapid genetic screens in .

Proc Natl Acad Sci U S A 2021 Oct;118(43)

Vollum Institute, Oregon Health and Science University, Portland, OR 97239.

is a powerful model in which to perform genetic screens, but screening assays that are both rapid and can be used to examine a wide variety of cellular and molecular pathways are limited. offer an extensive toolbox of GFP-based transcriptional reporters, GFP-tagged proteins, and driver lines, which can be used to express GFP in numerous subpopulations of cells. Thus, a tool that can rapidly and quantitatively evaluate GFP levels in tissue would provide a broadly applicable screening platform. Read More

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October 2021

Magnetic Guiding with Permanent Magnets: Concept, Realization and Applications to Nanoparticles and Cells.

Authors:
Peter Blümler

Cells 2021 Oct 9;10(10). Epub 2021 Oct 9.

Institute of Physics, University of Mainz, Staudingerweg 7, 55099 Mainz, Germany.

The idea of remote magnetic guiding is developed from the underlying physics of a concept that allows for bijective force generation over the inner volume of magnet systems. This concept can equally be implemented by electro- or permanent magnets. Here, permanent magnets are in the focus because they offer many advantages. Read More

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October 2021

An Artificial Lens Capsule with a Lens Radial Stretching System Mimicking Dynamic Eye Focusing.

Polymers (Basel) 2021 Oct 15;13(20). Epub 2021 Oct 15.

College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK.

Presbyopia is a common eye disorder among aged people which is attributed to the loss of accommodation of the crystalline lens due to the increasing stiffness. One of the potential techniques to correct presbyopia involves removing the lens substance inside the capsule and replacing it with an artificial lens. The development of such devices, e. Read More

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October 2021

Development of Lactoferrin-Loaded Liposomes for the Management of Dry Eye Disease and Ocular Inflammation.

Pharmaceutics 2021 Oct 15;13(10). Epub 2021 Oct 15.

Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.

Dry eye disease (DED) is a high prevalent multifactorial disease characterized by a lack of homeostasis of the tear film which causes ocular surface inflammation, soreness, and visual disturbance. Conventional ophthalmic treatments present limitations such as low bioavailability and side effects. Lactoferrin (LF) constitutes a promising therapeutic tool, but its poor aqueous stability and high nasolacrimal duct drainage hinder its potential efficacy. Read More

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October 2021

Experimental and Theoretical Screening for Green Solvents Improving Sulfamethizole Solubility.

Materials (Basel) 2021 Oct 9;14(20). Epub 2021 Oct 9.

Department of Clinical Biochemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Karłowicza 24, 85-950 Bydgoszcz, Poland.

Solubility enhancement of poorly soluble active pharmaceutical ingredients is of crucial importance for drug development and processing. Extensive experimental screening is limited due to the vast number of potential solvent combinations. Hence, theoretical models can offer valuable hints for guiding experiments aimed at providing solubility data. Read More

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October 2021

Use of Digital Educational Technologies among Nursing Students and Teachers: An Exploratory Study.

J Pers Med 2021 Oct 8;11(10). Epub 2021 Oct 8.

Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Escola Superior de Saúde Egas Moniz, 2829-551 Almada, Portugal.

The emergence of digital educational technologies (DET) raises questions regarding the personalization of both teaching and care. DET use implies profound changes with consequences in nursing care and in nursing teaching-learning process. With the purpose of contributing to the improvement of the teaching-learning process through the use of DET, an exploratory-descriptive, cross-sectional, and observational study, with a quantitative approach (descriptive and inferential statistics), was developed. Read More

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October 2021

Patient Satisfaction and Hospital Quality of Care Evaluation in Malaysia Using SERVQUAL and Facebook.

Healthcare (Basel) 2021 Oct 14;9(10). Epub 2021 Oct 14.

Unit of Biostatistics and Research Methodology, Health Campus, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia.

Social media sites, dubbed patient online reviews (POR), have been proposed as new methods for assessing patient satisfaction and monitoring quality of care. However, the unstructured nature of POR data derived from social media creates a number of challenges. The objectives of this research were to identify service quality (SERVQUAL) dimensions automatically from hospital Facebook reviews using a machine learning classifier, and to examine their associations with patient dissatisfaction. Read More

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October 2021

Identifying Children at Readmission Risk: At-Admission versus Traditional At-Discharge Readmission Prediction Model.

Healthcare (Basel) 2021 Oct 7;9(10). Epub 2021 Oct 7.

Industrial and Management Systems Engineering, University of South Florida, Tampa, FL 33620, USA.

The timing of 30-day pediatric readmissions is skewed with approximately 40% of the incidents occurring within the first week of hospital discharges. The skewed readmission time distribution coupled with delay in health information exchange among healthcare providers might offer a limited time to devise a comprehensive intervention plan. However, pediatric readmission studies are thus far limited to the development of the prediction model after hospital discharges. Read More

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October 2021

Participatory Design of an Electronic Cross-Facility Health Record (ECHR) System for Pediatric Palliative Care: A Think-Aloud Study.

Children (Basel) 2021 Sep 24;8(10). Epub 2021 Sep 24.

Department of Didactics and Educational Research in Health Science, Faculty of Health, School of Medicine, Witten/Herdecke University, 58448 Witten, Germany.

Background: Pediatric palliative care (PPC) patients experience years of multisectoral and professional care. An electronic cross-facility health record (ECHR) system can support the immediate exchange of information among PPC professionals. Based on a needs assessment, a prototype ECHR system was developed. Read More

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September 2021

Seeking Alfalfa Resistance to a Rhizophagous Pest, the Clover Root Curculio ( F.).

Insects 2021 Oct 5;12(10). Epub 2021 Oct 5.

Department of Biology, Utah State University, Logan, UT 84322, USA.

Since the cancellation of broad-spectrum soil-active insecticides in alfalfa ( L.) production, clover root curculio ( F.) (CRC) larval root damage has increased. Read More

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October 2021

Artificial Intelligence-Based Segmentation of Residual Tumor in Histopathology of Pancreatic Cancer after Neoadjuvant Treatment.

Cancers (Basel) 2021 Oct 12;13(20). Epub 2021 Oct 12.

Department of Surgery, Amsterdam UMC, Cancer Center Amsterdam, University of Amsterdam, 1081 HV Amsterdam, The Netherlands.

Background: Histologic examination of resected pancreatic cancer after neoadjuvant therapy (NAT) is used to assess the effect of NAT and may guide the choice for adjuvant treatment. However, evaluating residual tumor burden in pancreatic cancer is challenging given tumor response heterogeneity and challenging histomorphology. Artificial intelligence techniques may offer a more reproducible approach. Read More

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October 2021

When Order Meets Disorder: Modeling and Function of the Protein Interface in Fuzzy Complexes.

Biomolecules 2021 Oct 16;11(10). Epub 2021 Oct 16.

CNRS, Laboratoire de Biochimie Théorique, UPR9080, Université de Paris, 13 Rue Pierre et Marie Curie, 75005 Paris, France.

The degree of proteins structural organization ranges from highly structured, compact folding to intrinsic disorder, where each degree of self-organization corresponds to specific functions: well-organized structural motifs in enzymes offer a proper environment for precisely positioned functional groups to participate in catalytic reactions; at the other end of the self-organization spectrum, intrinsically disordered proteins act as binding hubs via the formation of multiple, transient and often non-specific interactions. This review focusses on cases where structurally organized proteins or domains associate with highly disordered protein chains, leading to the formation of interfaces with varying degrees of fuzziness. We present a review of the computational methods developed to provide us with information on such fuzzy interfaces, and how they integrate experimental information. Read More

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October 2021

Redox Balance in Male Infertility: Excellence through Moderation-"Μέτρον ἄριστον".

Antioxidants (Basel) 2021 Sep 27;10(10). Epub 2021 Sep 27.

Department of Urology, "G. Gennimatas" General Hospital, Aristotle University of Thessaloniki, 54635 Thessaloniki, Greece.

Male infertility, a relatively common and multifactorial medical condition, affects approximately 15% of couples globally. Based on WHO estimates, a staggering 190 million people struggle with this health condition, and male factor is the sole or contributing factor in roughly 20-50% of these cases. Nowadays, urologists are confronted with a wide spectrum of conditions ranging from the typical infertile male to more complex cases of either unexplained or idiopathic male infertility, requiring a specific patient-tailored diagnostic approach and management. Read More

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September 2021

The Expected Demand for Elderly Care Services and Anticipated Living Arrangements Among the Oldest Old in China Based on the Andersen Model.

Front Public Health 2021 5;9:715586. Epub 2021 Oct 5.

Key Laboratory of Health Technology Assessment, School of Public Health, Xiamen University, Xiamen, China.

The first aim of this study was to explore expected demands of the oldest old and their determinants for different types of elderly care services. The second aim was to investigate preferred choices of living arrangements among the oldest old and the influencing factors. Data of 4,738 participants aged ≥80 years were extracted from the Chinese Longitudinal Health Longevity Survey carried out in 2014. Read More

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October 2021

Protoplast: A Valuable Toolbox to Investigate Plant Stress Perception and Response.

Front Plant Sci 2021 5;12:749581. Epub 2021 Oct 5.

Laboratoire de Biophysique Moléculaire aux Interfaces, SFR Condorcet FR CNRS 3417, Gembloux Agro-Bio Tech, Université de Liège, Gembloux, Belgium.

Plants are constantly facing abiotic and biotic stresses. To continue to thrive in their environment, they have developed many sophisticated mechanisms to perceive these stresses and provide an appropriate response. There are many ways to study these stress signals in plant, and among them, protoplasts appear to provide a unique experimental system. Read More

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October 2021

Advances in Implantable Optogenetic Technology for Cardiovascular Research and Medicine.

Front Physiol 2021 5;12:720190. Epub 2021 Oct 5.

Department of Biomedical Engineering, The George Washington University, Washington, DC, United States.

Optogenetic technology provides researchers with spatiotemporally precise tools for stimulation, sensing, and analysis of function in cells, tissues, and organs. These tools can offer low-energy and localized approaches due to the use of the transgenically expressed light gated cation channel Channelrhodopsin-2 (ChR2). While the field began with many neurobiological accomplishments it has also evolved exceptionally well in animal cardiac research, both and . Read More

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October 2021

Recent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin.

Int J Nanomedicine 2021 11;16:6861-6888. Epub 2021 Oct 11.

Department of Physical Therapy, College of Healthcare Medical Science & Engineering, Inje University, Gimhae, Gyeong-nam, 50834, Korea.

Tryptophan and melatonin are pleiotropic molecules, each capable of influencing several cellular, biochemical, and physiological responses. Therefore, sensitive detection of tryptophan and melatonin in pharmaceutical and human samples is crucial for human well-being. Mass spectrometry, high-performance liquid chromatography, and capillary electrophoresis are common methods for both tryptophan and melatonin analysis; however, these methods require copious amounts of time, money, and manpower. Read More

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October 2021

Developing Telemedicine Curriculum Competencies for Graduate Medical Education: Outcomes of a Modified Delphi Process.

Acad Med 2021 Oct 19. Epub 2021 Oct 19.

A. Hart is director of research, Disaster Medicine Fellowship, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; and emergency physician, Hartford Hospital, Hartford, Connecticut; ORCID: https://orcid.org/0000-0002-0910-2316. D. Romney is director of education, Disaster Medicine Fellowship, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and instructor of emergency medicine, Harvard Medical School, Boston, Massachusetts. R. Sarin is affiliated faculty, Disaster Medicine Fellowship, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts. O. Mechanic is director of telehealth, Harvard Medical Faculty Physicians, Beth Israel Deaconess Medical Center, Boston, Massachusetts. A.J. Hertelendy is assistant professor, Department of Information Systems and Business Analytics, College of Business, Florida International University, Miami, Florida; and director of innovation and technology, Disaster Medicine Fellowship, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; ORCID: https://orcid.org/0000-0001-6174-0289. D. Larson is senior vice president, Avera Health, and chief executive officer, Avera eCare, Sioux Falls, South Dakota. K. Rhone is medical director of outreach and innovation, Avera eCare, Sioux Falls, South Dakota; and assistant professor, University of South Dakota Sanford School of Medicine, Vermillion, South Dakota. K. Sidel is director of telemedicine education, American Board of Telehealth, Sioux Falls, South Dakota. A. Voskanyan is co-director, Disaster Medicine Fellowship, Department of Emergency Medicine, Harvard Medical Faculty Physicians, Boston, Massachusetts. G.R. Ciottone is director, Disaster Medicine Fellowship, Department of Emergency Medicine, Beth Israel Deaconess Medical Center; and associate professor of emergency medicine, Harvard Medical School, Boston, Massachusetts.

Purpose: Telemedical applications have only recently begun to coalesce into the field of telemedicine due to varying definitions of telemedicine and issues around reimbursement. This process has been accelerated by the COVID-19 pandemic and the ensuing expansion of telemedicine delivery. This article demonstrates the development of a set of proposed competencies for a telemedicine curriculum in graduate medical education. Read More

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October 2021

A new approach for leptomeningeal metastases: chemotherapy administered through lumbar intrathecal port.

Arq Neuropsiquiatr 2021 Sep;79(9):816-823

Demiroglu Bilim Üniversitesi, Department of Medical Oncology, Istanbul, Turkey.

Background: Intrathecal chemotherapy is a local therapeutic modality used for treatment of leptomeningeal metastases. However, the techniques currently used, i.e. Read More

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September 2021

Provision of services to persons experiencing homelessness during the COVID-19 pandemic: A qualitative study on the perspectives of homelessness service providers.

Health Soc Care Community 2021 Oct 19. Epub 2021 Oct 19.

School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.

This study aimed to explore the perspectives of homelessness service providers on the impact of the COVID-19 pandemic on service provision, barriers encountered and learning for the future. Semi-structured online interviews were conducted with homelessness service providers (n = 15) identified through the network of homelessness services operating within the United Kingdom. Data were transcribed verbatim and analysed thematically using framework technique. Read More

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October 2021

Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH.

Arch Toxicol 2021 Oct 20. Epub 2021 Oct 20.

School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK.

In an effort to replace, reduce and refine animal experimentation, there is an unmet need to advance current in vitro models that offer features with physiological relevance and enhanced predictivity of in vivo toxicological output. Hepatic toxicology is key following chemical, drug and nanomaterials (NMs) exposure, as the liver is vital in metabolic detoxification of chemicals as well as being a major site of xenobiotic accumulation (i.e. Read More

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October 2021

Visualizing DEPICT: A Multistep Model for Participatory Analysis in Photovoice Research for Social Change.

Health Promot Pract 2021 Oct 19:15248399211045017. Epub 2021 Oct 19.

York University, Toronto, Ontario, Canada.

As a critical narrative intervention, photovoice invites community members to use photography to identify, document, and discuss issues in their communities. The method is often employed with projects that have a social change mandate. Photovoice may help participants express issues that are difficult to articulate, create tangible and meaningful research products for communities, and increase feelings of ownership. Read More

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October 2021

Facilitating implementation of organs-on-chips by open platform technology.

Biomicrofluidics 2021 Sep 12;15(5):051301. Epub 2021 Oct 12.

BIOS Lab on a Chip Group, MESA+ Institute for Nanotechnology, Max Planck Institute for Complex Fluid Dynamics, University of Twente, Enschede, the Netherlands.

Organ-on-chip (OoC) and multi-organs-on-chip (MOoC) systems have the potential to play an important role in drug discovery, disease modeling, and personalized medicine. However, most devices developed in academic labs remain at a proof-of-concept level and do not yet offer the ease-of-use, manufacturability, and throughput that are needed for widespread application. Commercially available OoC are easier to use but often lack the level of complexity of the latest devices in academia. Read More

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September 2021

Capturing the Trajectory of Psychological Status and Analyzing Online Public Reactions During the Coronavirus Disease 2019 Pandemic Through Weibo Posts in China.

Front Psychol 2021 29;12:744691. Epub 2021 Sep 29.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, China.

When a major, sudden infectious disease occurs, people tend to react emotionally and display reactions such as tension, anxiety, fear, depression, and somatization symptoms. Social media played a substantial awareness role in developing countries during the outbreak of coronavirus disease 2019 (COVID-19). This study aimed to analyze public opinion regarding COVID-19 and to explore the trajectory of psychological status and online public reactions to the COVID-19 pandemic by examining online content from Weibo in China. Read More

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September 2021