1,685,896 results match your criteria developed improve


Stress Fracture of the Femoral Shaft in Paget's Disease of Bone: A Case Report.

J Bone Metab 2021 May 31;28(2):171-178. Epub 2021 May 31.

Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Paget's disease of bone (PDB) is a progressive bone disorder characterized by increased osteoclast-mediated bone resorption and abnormal bone formation. Incomplete atypical femoral fracture, appearing radiographically as a stress fracture at the lateral aspect of the femur, is an uncommon low-trauma fracture frequently seen in association with long-term bisphosphonate therapy. We describe the case of a 61-year-old female patient with PDB who developed a stress fracture at the lateral femoral cortex after 5 doses of intravenous bisphosphonate. Read More

View Article and Full-Text PDF

Human Neutrophil Elastase Mediates MUC5AC Hypersecretion via the Tumour Necrosis Factor-α Converting Enzyme-Epidermal Growth Factor Receptor Signalling Pathway in vivo.

ORL J Otorhinolaryngol Relat Spec 2021 Jun 15:1-9. Epub 2021 Jun 15.

Department of Otolaryngology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Objectives: The objective of this study is to examine the role of the tumour necrosis factor-α converting enzyme-epidermal growth factor receptor (TACE-EGFR) pathway in human neutrophil elastase (HNE)-induced MUC5AC mucin expression in mice.

Method: Four groups of mice, treated with HNE alone (HNE group), HNE plus TACE inhibitor (HNE + TAPI-2 group), HNE plus EGFR inhibitor (HNE + AG1478 group), and untreated (control group), were used in the experiment. Histopathological changes were monitored by haematoxylin-eosin (HE) and periodic acid-Schiff (PAS) staining. Read More

View Article and Full-Text PDF

A bionic soft tongue driven by shape memory alloy and pneumatics.

Bioinspir Biomim 2021 Jun 15. Epub 2021 Jun 15.

Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, No.96, JinZhai Road Baohe District, Hefei, 230026, CHINA.

Soft grippers have exhibited considerable advantages owing to their flexible deformation, compliant operation, and safe interaction with the objects. The ability to grip solid and liquid objects can greatly expand the application range of the soft grippers. Dogs stick out their tongues and then curl backward to form a ladle shape for eating food and drinking water. Read More

View Article and Full-Text PDF

Detection of fixation points using a small visual landmark for brain-computer interfaces.

J Neural Eng 2021 Jun 15. Epub 2021 Jun 15.

Dept. of Biomedical Engineering, Tianjin University, School of Precision Instrument and Opto-Electronics Engineering, Tianjin 300072, Tianjin, 300072, CHINA.

Abstract- Objective: The speed of visual brain-computer interfaces (v-BCIs) has been greatly improved in recent years. However, the traditional v-BCI paradigms require users to directly gaze at the intensive flickering items, which would cause severe problems such as visual fatigue and excessive visual resource consumption in practical applications. Therefore, it is imperative to develop a user-friendly v-BCI. Read More

View Article and Full-Text PDF

Multimaterial bioprinting towards the fabrication of biomimetic tissues and organs.

Biofabrication 2021 Jun 15. Epub 2021 Jun 15.

UCLA, 570 Westwood Plaza, Los Angeles, California, 90095, UNITED STATES.

Tissue reconstruction requires the utilization of multiple biomaterials and cell types to replicate the delicate and complex structure of native tissues. Various three-dimensional (3D) bioprinting techniques have been developed to fabricate customized tissue structures; however, there are still significant challenges, such as vascularization, mechanical stability of printed constructs, and fabrication of gradient structures to be addressed for the creation of biomimetic and complex tissue constructs. One approach to address these challenges is to develop multimaterial 3D bioprinting techniques that can integrate various types of biomaterials and bioprinting capabilities towards the fabrication of more complex structures. Read More

View Article and Full-Text PDF

Incorporating oxygenation levels in analytical DNA-damage models - quantifying the oxygen fixation mechanism.

Phys Med Biol 2021 Jun 15. Epub 2021 Jun 15.

CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, Oxfordshire, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Purpose: To develop a framework to include oxygenation effects in radiation therapy treatment planning which is valid for all modalities, energy spectra and oxygen levels. The framework is based on predicting the difference in DNA--damage resulting from ionising radiation at variable oxygenation levels.

Methods: Oxygen fixation is treated as a statistical process in a simplified model of complex and simple damage. Read More

View Article and Full-Text PDF

Anisotropic compliance of robot legs improves recovery from swing-phase collisions.

Bioinspir Biomim 2021 Jun 15. Epub 2021 Jun 15.

Mechanical and Aerospace Engineering, University of California San Diego, 9500 Gilman Dr, La Jolla, California, 92093, UNITED STATES.

Uneven terrain in natural environments challenges legged locomotion by inducing instability and causing limb collisions. During the swing phase, the limb releases from the ground and arcs forward to target a secure next foothold. In natural environments leg-obstacle collisions may occur during the swing phase which can result in instability, and may require contact sensing and trajectory re-planning if a collision occurs. Read More

View Article and Full-Text PDF

Utility of multi-parametric quantitative magnetic resonance imaging of the lacrimal gland for diagnosing and staging Graves' ophthalmopathy.

Eur J Radiol 2021 Jun 8;141:109815. Epub 2021 Jun 8.

Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong Province, China. Electronic address:

Purpose: To explore radiological changes of the lacrimal gland (LG) in Graves' ophthalmopathy (GO) based on multi-parametric quantitative MRI and its clinical utility in LG diagnosis and activity in GO.

Methods: We enrolled 99 consecutive patients with GO (198 eyes) and 12 Graves' Disease (GD) patients (24 eyes) from July 2018 to June 2020. Clinical, laboratory, and MRI data were collected at the first visit. Read More

View Article and Full-Text PDF

Effect of the rapid increase of salinity on anoxic-oxic biofilm reactor for treatment of high-salt and high-ammonia-nitrogen wastewater.

Bioresour Technol 2021 Jun 4;337:125363. Epub 2021 Jun 4.

NingboTech University, Ningbo 315000, China; Ningbo Research Institute, Zhejiang University, Ningbo 315100, China.

The washing wastewater from the desulfuration and denitration of power plants has high salt (chloride and sulfate) and ammonia-nitrogen concentrations and is difficult to treat using microbiological methods. A novel anoxic/oxic biofilm process was developed to remove ammonia from wastewater. Three rapid strategies (sulfate concentration was increased from 0 to 60 g/L in 6, 13, and 22 days (R1, R2, and R3, respectively)) were applied and produced biofilm with the same nitrification capacity as slow strategies (100-203 days). Read More

View Article and Full-Text PDF

A simplified model for simulating anaerobic digesters: Application to valorisation of bagasse and distillery spent wash.

Bioresour Technol 2021 Jun 9;337:125395. Epub 2021 Jun 9.

Multiphase Flows, Reactors and Intensification Group, School of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast BT9 5AG, United Kingdom; Bernal Institute, University of Limerick, Limerick V94T9PX, Ireland. Electronic address:

Current anaerobic digestion (AD) design methods rely on crude empirical models or sophisticated anaerobic digestion models (like ADM1) requiring a large number of parameters which are difficult to obtain experimentally. A simplified model for simulating AD was developed in this work. The model requires knowledge of CH/CO ratio in biogas or indigestible fraction in substrate and batch biomethane potential (BMP) data for estimating three kinetic parameters (maximum specific growth rate, half velocity constant and cell death rate). Read More

View Article and Full-Text PDF

Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay.

Bioorg Med Chem 2021 Jun 6;42:116246. Epub 2021 Jun 6.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, United States. Electronic address:

We report the discovery of a fluorescent small molecule probe. This probe exhibits an emission increase in the presence of the oncoprotein MYC that can be attenuated by a competing inhibitor. Hydrogen-deuterium exchange mass spectrometry analysis, rationalized by induced-fit docking, suggests it binds to the "coiled-coil" region of the leucine zipper domain. Read More

View Article and Full-Text PDF

Ultrafiltration strategy combined with nanoLC-MS/MS based proteomics for monitoring potential residual proteins in TCMIs.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 May 30;1178:122818. Epub 2021 May 30.

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Traditional Chinese medicine injections (TCMIs) containing complex constituents frequently cause unpredictable adverse reactions. The residual heterologous proteins in TCMIs may be one kind of the sensitized constituents. However, few methods were developed to identify and monitor the residual proteins of TCMIs in industry. Read More

View Article and Full-Text PDF

COVID-19 in Argentine teriflunomide-treated multiple sclerosis patients: First national case series.

Mult Scler Relat Disord 2021 May 30;53:103049. Epub 2021 May 30.

Centro de Esclerosis Múltiple de Buenos Aires, CABA; Argentina; Servicio de Neurología, Hospital Universitario CEMIC, Buenos Aires, Argentina.

We report COVID-19 presentation, course and outcomes in teriflunomide-treated MS patients in Argentina.

Methods: descriptive, retrospective, multicentre, study that included MS patients receiving teriflunomide who developed COVID-19, with clinical follow-up at reference MS centres, also listed in a nationwide registry.

Results: Eighteen MS patients on teriflunomide treatment, from eight MS centres developed COVID-19. Read More

View Article and Full-Text PDF

Fatal necrotizing fasciitis in illegal abortion and the negligence tort.

Leg Med (Tokyo) 2021 Jun 7;53:101927. Epub 2021 Jun 7.

Department of Forensic Medicine & Toxicology, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry 605006, India; Department of Forensic Medicine & Toxicology, Jawaharlal Institute of Postgraduate Medical Education & Research, Karaikal, India.

The present paper is a case-based review on rare complications of illegal abortion, i.e., necrotizing fasciitis missed early by the treating gynecologists which landed up into a negligence tort against the physicians. Read More

View Article and Full-Text PDF

Evaluation of the sequential coupling of a bacterial treatment with a physicochemical process for the remediation of wastewater containing Cr and organic pollutants.

J Hazard Mater 2021 Jun 6;418:126307. Epub 2021 Jun 6.

Planta Piloto de Procesos Industriales Microbiológicos (PROIMI), CONICET, Av. Belgrano y Pasaje Caseros, 4000 Tucumán, Argentina; Facultad de Ciencias Naturales e Instituto Miguel Lillo, Universidad Nacional de Tucumán, Miguel Lillo 205, 4000 Tucumán, Argentina. Electronic address:

A restoration strategy was developed for the treatment of two artificial liquid systems (Minimal Medium, MM, and Water Carbon Nitrogen, WCN) contaminated with Cr(VI), lindane (γ-HCH), phenanthrene (Phe), and reactive black 5 (RB5), through the use of an actinobacteria consortium, coupled with a physicochemical treatment using a column filled with nano-scale zero valent iron particles immobilized on dried Macrocystis pyrifera algae biomass. The Sequential Treatment A (ST: physicochemical followed by biological method) removed the three organic compounds with different effectiveness; however, it was very ineffective for Cr(VI) removal. The Sequential Treatment B (ST: biological followed by the physicochemical method) removed the four compounds with variable efficiencies. Read More

View Article and Full-Text PDF

Delivery of a spheroids-incorporated human dermal fibroblast sheet increases angiogenesis and M2 polarization for wound healing.

Biomaterials 2021 Jun 7;275:120954. Epub 2021 Jun 7.

School of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi, 16419, Republic of Korea. Electronic address:

Low cell engraftment is a major problem in tissue engineering. Although various methods related with cell sheets have been attempted to resolve the issue, low cell viability due to oxygen and nutrient depletion remains an obstacle toward advanced therapeutic applications. Cell therapy using fibroblasts is thought of as a good alternative due to the short doubling times of fibroblasts together with their immunomodulatory properties. Read More

View Article and Full-Text PDF

Development of highly sensitive one step-PCR tests for improved detection of B. bigemina and B. bovis.

Vet Parasitol 2021 Jun 8;296:109493. Epub 2021 Jun 8.

Instituto de Agrobiotecnología y Biología Molecular (IABIMO) INTA - CONICET, de Los Reseros y Dr. Nicolás Repetto s/n, P.O. Box 25 (B1712WAA), Castelar, Buenos Aires, Argentina.

Bovine babesiosis caused by Babesia bigemina and B. bovis is an economically relevant tick-borne disease distributed over tropical and subtropical world regions. Animals that recover from the clinical disease can remain persistently infected, and those carriers are epidemiologically relevant since they can act as a source of infection to other animals through the tick bite. Read More

View Article and Full-Text PDF

Facile and rapid detection of SARS-CoV-2 antibody based on a noncompetitive fluorescence polarization immunoassay in human serum samples.

Biosens Bioelectron 2021 Jun 5;190:113414. Epub 2021 Jun 5.

Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo, 060-8628, Japan; Innovative Research Centre for Preventive Medical Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan; Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan. Electronic address:

Antibody detection methods for viral infections have received broad attention due to the COVID-19 pandemic. In addition, there remains an ever-increasing need to quantitatively evaluate the immune response to develop vaccines and treatments for COVID-19. Here, we report an analytical method for the rapid and quantitative detection of SARS-CoV-2 antibody in human serum by fluorescence polarization immunoassay (FPIA). Read More

View Article and Full-Text PDF

A continuum model and simulations for large deformation of anisotropic fiber-matrix composites for cardiac tissue engineering.

J Mech Behav Biomed Mater 2021 Jun 7;121:104627. Epub 2021 Jun 7.

School of Engineering, Brown University, Providence, RI, United States; Center for Biomedical Engineering, Brown University, Providence, RI, United States. Electronic address:

Cardiac patch therapies promise to restore heart function and lower the risk of heart failure after heart attack. Fiber-matrix engineered tissue scaffolds have gained significant attention due to their tunable micro-structures, providing nonlinear mechanical properties similar to native anisotropic heart tissues. Mechanical properties of engineered scaffolds directly affect the stress fields generated inside and around the tissue scaffolds and have significant impact on the tissue functionality. Read More

View Article and Full-Text PDF

Different nutritional screening tools and recommended screening algorithm for pediatric oncology patients.

Clin Nutr 2021 May 24;40(6):3836-3841. Epub 2021 May 24.

2nd Department of Pediatrics, Semmelweis University, Budapest, 1094, 7-9 Tuzolto Street, Hungary.

Background & Aims: Cancer is one of the leading causes of death for children; however, appropriate nutritional status can positively affect disease progression and outcome. The aim of this study was to present our self-developed nutritional risk screening method, relate it to another validated tool and to objective bio-impedance measures. We intended to recommend a screening algorithm which can be used in our pediatric oncology facilities. Read More

View Article and Full-Text PDF

Low dietary quercetin intake by food frequency questionnaire analysis is not associated with hypertension occurrence.

Clin Nutr 2021 May 12;40(6):3748-3753. Epub 2021 May 12.

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China. Electronic address:

Background & Aims: Quercetin is one of the most abundant flavonoids in plant kingdom. Because of its strong anti-inflammatory and antioxidant effect, it is of potential in anti-hypertension. The objective of the present study was to explore the relationship between dietary quercetin and hypertension incidence in a Chinese population. Read More

View Article and Full-Text PDF

Development and validation of a novel sepsis biomarker based on amino acid profiling.

Clin Nutr 2021 May 21;40(6):3668-3676. Epub 2021 May 21.

Department of Laboratory Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Republic of Korea. Electronic address:

Background & Aims: Sepsis is a potentially fatal condition influenced by pathogens and host factors. Current sepsis biomarkers such as white blood cell count and C-reactive protein and procalcitonin levels show unsatisfactory performance in terms of diagnostic sensitivity and specificity in clinical practice. Thus, we developed and validated a new sepsis biomarker based on amino acid profiling. Read More

View Article and Full-Text PDF

Evaluation of arsenic species in leukocytes and granulocytes of acute promyelocytic leukemia patients treated with arsenic trioxide.

J Pharm Biomed Anal 2021 Jun 8;203:114201. Epub 2021 Jun 8.

Department of Pharmacy, First Affiliated Hospital of Harbin Medical University, 23 YouZheng Str, Nangang District, Harbin, China. Electronic address:

Concentrations of arsenic metabolites were important to clarify the sensitivity and resistance of APL (acute promyelocytic leukemia) patients to arsenic trioxide (AsO). Our purpose was to evaluate levels and distributions of arsenic species in leukocytes and granulocytes of APL patients. Inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) were measured by high performance liquid chromatography coupled inductively coupled plasma mass spectrometry (HPLC-ICP-MS). Read More

View Article and Full-Text PDF

Metabolic and conformational stabilization of a VEGF-mimetic beta-hairpin peptide by click-chemistry.

Eur J Med Chem 2021 May 26;222:113575. Epub 2021 May 26.

Istituto di Scienze e Tecnologie Chimiche "Giulio Natta", CNR, Via M. Bianco 9, 20131, Milano, Italy. Electronic address:

HPLW is a Vascular Endothelial Growth Factor (VEGF)-mimicking beta-hairpin peptide endowed of proangiogenic effect and showing valuable biomedical application in the proangiogenic therapy. However, the translational potential of HPLW is limited by its low metabolic stability, which would shorten the in vivo efficacy of the molecule. Here, we developed a peptide analog of HPLW, named HPLW2, that retains the structural and biological properties of the original peptide but features an impressive resistance to degradation by human serum proteases. Read More

View Article and Full-Text PDF

Feature engineering and machine learning for causality assessment in pharmacovigilance: Lessons learned from application to the FDA Adverse Event Reporting System.

Comput Biol Med 2021 Jun 8;135:104517. Epub 2021 Jun 8.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine Baltimore, MD, USA. Electronic address:

Background: Our objective was to support the automated classification of Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) reports for their usefulness in assessing the possibility of a causal relationship between a drug product and an adverse event.

Method: We used a data set of 326 redacted FAERS reports that was previously annotated using a modified version of the World Health Organization-Uppsala Monitoring Centre criteria for drug causality assessment by a group of SEs at the FDA and supported a similar study on the classification of reports using supervised machine learning and text engineering methods. We explored many potential features, including the incorporation of natural language processing on report text and information from external data sources, for supervised learning and developed models for predicting the classification status of reports. Read More

View Article and Full-Text PDF

Effect of osteoporosis on adjacent segmental degeneration following posterior lumbar interbody fusion under whole body vibration.

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

School of Chinese medicine, Jinan university, Guangzhou, China. Electronic address:

Background: Adjacent segmental degeneration (ASD) is one of the common complications following posterior lumbar interbody fusion (PLIF). Both whole body vibration (WBV) and osteoporosis are important factors associated with the biomechanics of the lumbar spine. However, up to now, no literature has been published to investigate the effect of osteoporosis on ASD following PLIF under WBV. Read More

View Article and Full-Text PDF

Ototoxic hearing loss from antimalarials: A systematic narrative review.

Travel Med Infect Dis 2021 Jun 12:102117. Epub 2021 Jun 12.

Department of Linguistics, Macquarie University, Sydney, New South Wales, Australia.

Background: Drugs used in curative and prophylactic antimalarial treatment may be ototoxic and lead to permanent hearing loss, but there is no consensus regarding prevalence and permanence of ototoxic hearing loss caused by antimalarials. The purpose of this systematic narrative review was to synthesize current evidence on antimalarial ototoxicity in human populations.

Method: Studies published between 2005 and 2018 that reported prevalence of post-treatment hearing loss in individuals treated for malaria. Read More

View Article and Full-Text PDF

Quantitative Assessment of Age-dependent changes in Porphyrins from Fluorescence Images of Ultraviolet Photography by Image Processing.

Photodiagnosis Photodyn Ther 2021 Jun 12:102388. Epub 2021 Jun 12.

Graduate School of Science and Technology, Keio University, Yokohama, Japan. Electronic address:

Background: Skin is the first line of defense against harmful external environmental factors. Lots of skin flora living on the skin surface deal with skin health care and skin disease treatment and prevention, such as bacteria, which form the unique and complex skin micro-ecological system. Propionibacterium acnes (P. Read More

View Article and Full-Text PDF

Ultrasound-assisted CF-filled PLGA nanobubbles for enhanced FGF21 delivery and improved prophylactic treatment of diabetic cardiomyopathy.

Acta Biomater 2021 Jun 12. Epub 2021 Jun 12.

Department of Ultrasound in Medicine, Shanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, P.R. China.; Department of Ultrasound in Medicine, Shanghai Eighth People's Hospital, 8 Caobao Road, Shanghai 200235, P.R. China.

Diabetic cardiomyopathy (DCM) is a serious cardiac complication of diabetes that currently lacks specific treatment. Fibroblast growth factor 21 (FGF21) has been proved to have cardioprotective effect in DCM. However, the insufficient cardiac delivery effect of FGF21 limits its application in DCM. Read More

View Article and Full-Text PDF

Combining gene expression signature with clinical features for survival stratification of gastric cancer.

Genomics 2021 Jun 12;113(4):2683-2694. Epub 2021 Jun 12.

Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, P.R. China; Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, P.R. China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, Zhejiang 310003, P.R. China; Department of Molecular Genetics, University of Toronto, Toronto, ONM5S 1A8, Canada. Electronic address:

The AJCC staging system is considered as the golden standard in clinical practice. However, it remains some pitfalls in assessing the prognosis of gastric cancer (GC) patients with similar clinicopathological characteristics. We aim to develop a new clinic and genetic risk score (CGRS) to improve the prognosis prediction of GC patients. Read More

View Article and Full-Text PDF