2,771 results match your criteria developed hyperthyroidism


Prediction model for thyrotoxic atrial fibrillation: a retrospective study.

BMC Endocr Disord 2021 Jul 11;21(1):150. Epub 2021 Jul 11.

Almazov National Medical Research Centre, Institute of Endocrinology, 15 Parkhomenko street, St. Petersburg, 194156, Russia.

Background: Thyrotoxic atrial fibrillation (TAF) is a recognized significant complication of hyperthyroidism. Early identification of the individuals predisposed to TAF would improve thyrotoxic patients' management. However, to our knowledge, an instrument that establishes an individual risk of the condition is unavailable. Read More

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Thyrotoxicosis: a rare presentation of molar pregnancy.

BMJ Case Rep 2021 Jul 5;14(7). Epub 2021 Jul 5.

Department of Endocrinology and Metabolism, The George Washington University Hospital, Washington, District of Columbia, USA.

A 49-year-old woman, G8P7, presented with 1 week of worsening vaginal bleeding and abdominal cramps in the setting of a recently discovered unplanned pregnancy. Vaginal ultrasound findings and a significantly elevated human chorionic gonadotropin (hCG) level were concerning for molar pregnancy. She developed signs of hyperthyroidism on the night of admission, for which the endocrinology team was consulted. Read More

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Auto-destruction of the thyroid gland and coexisting glutamic acid decarboxylase mediated neurological disease in an adolescent: an unusual presentation of autoimmunity.

J Pediatr Endocrinol Metab 2021 Jun 24. Epub 2021 Jun 24.

Pediatric Endocrinology, NYU Langone Medical Center, New York, USA.

Objectives: Hashimoto's thyroiditis (HT) is characterized by lymphocytic thyroid infiltration. Gradual thyroid failure can occur due to thyroid cell apoptosis. Rarely neurological autoimmunity due to glutamic acid decarboxylase (GAD) antigen can co exist with HT. Read More

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[Normocalcemic with elevated post-operative parathormone in primary hyperpara-thyroidism: 9 case reports and literature review].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Jun;53(3):573-579

Department of Endocrinology, China-Japanese Friendship Hospital, Beijing 100029, China.

Objective: To summarize and analyze the clinical characteristics of primary hyperpara-thyroidism (PHPT) with normocalcemic parathormone elevation (NPE) after surgical treatment, so as to improve the therapeutic ability and standardized post-operative follow-up of PHPT patients.

Methods: Nine patients who were diagnosed with PHPT in the Department of Endocrinology of China-Japan Friendship Hospital from August 2017 to November 2019 were selected as the subjects. They all developed NPE within 6 months after surgical treatment. Read More

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Thyroid Hormone Therapy and Incident Stroke.

J Clin Endocrinol Metab 2021 Jun 17. Epub 2021 Jun 17.

Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.

Context: Stroke is a leading cause of death and disability and there is a need to identify modifiable risk factors.

Objective: Determine the relationship between thyroid hormone treatment intensity and incidence of atrial fibrillation and stroke.

Design: Retrospective cohort study using data from the Veterans Health Administration between 2004 and 2017, with a median follow-up of 59 months. Read More

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Utility of multi-parametric quantitative magnetic resonance imaging of the lacrimal gland for diagnosing and staging Graves' ophthalmopathy.

Eur J Radiol 2021 Aug 8;141:109815. Epub 2021 Jun 8.

Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong Province, China. Electronic address:

Purpose: To explore radiological changes of the lacrimal gland (LG) in Graves' ophthalmopathy (GO) based on multi-parametric quantitative MRI and its clinical utility in LG diagnosis and activity in GO.

Methods: We enrolled 99 consecutive patients with GO (198 eyes) and 12 Graves' Disease (GD) patients (24 eyes) from July 2018 to June 2020. Clinical, laboratory, and MRI data were collected at the first visit. Read More

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A randomised, controlled trial to determine the effect of levothyroxine on Standardbred racehorses.

Equine Vet J 2021 Jun 8. Epub 2021 Jun 8.

Department of Veterinary Clinical Sciences, Purdue University College of Veterinary Medicine, West Lafayette, Indiana, 47907, USA.

Background: The use of thyroid supplement is pervasive in athletic horses although its effects on measures of performance are not known.

Objectives: One purpose of this study was to determine whether supra-physiologic doses of levothyroxine affect the velocities at which blood lactate was greater than 4 mmol/L (V ) and heart rate was over 150 (V ) and 200 (V ) beats per minute respectively. Additionally, a survey of post-race blood samples was also conducted to determine whether high thyroxine concentrations were common in racehorses. Read More

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Unusual Endocrinopathies in 18q Deletion Syndrome: Pseudoparathyroidism and Hyper-/Hypo-Thyroidism.

AACE Clin Case Rep 2021 May-Jun;7(3):192-194. Epub 2020 Dec 24.

Department of Pediatric Endocrinology, University of South Alabama, Mobile, Alabama.

Objective: To describe new and unusual endocrinopathies in children with de novo 18q deletion (18q-) syndrome.

Methods: We describe 2 patients who have atypical thyroid conditions and 1 who also developed symptomatic hypocalcemia.

Results: The first patient developed hyperthyroidism at the age of 3 years, with a free thyroxine level of 3. Read More

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December 2020

Nonspecific orbital inflammation and thyroid eye disease, a rare comorbidity: report of two cases and review of literature.

BMC Ophthalmol 2021 Jun 5;21(1):251. Epub 2021 Jun 5.

Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: To present the very rare comorbidity of developing non-specific orbital inflammation (NSOI) in two patients with histories of definite thyroid eye disease (TED).

Case Presentation: Both patients complained of new-onset progressive proptosis although their thyroid disease was controlled and computed tomography scan revealed an intraorbital inflammatory mass. The pathological assessment indicated that both patients had developed fibrosing NSOI. Read More

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Incidence of Dysphonia and Dysphagia Exceeds Recurrent Laryngeal Nerve Injury During Thyroid Surgery.

J Voice 2021 May 27. Epub 2021 May 27.

Loma Linda University Health, Department of Otolaryngology, Loma Linda, California.

Objectives: To determine the prevalence of separate and combined voice and swallowing impairments before and after total thyroidectomy and to delineate risk factors for these symptoms.

Methods: Retrospective review of 592 consecutive patients who underwent total thyroidectomy from July 2003 to August 2015.

Results: Combined voice and swallowing problems occurred preoperatively in 4. Read More

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Outcome of Sars-COV-2-related thyrotoxicosis in survivors of Covid-19: a prospective study.

Endocrine 2021 08 28;73(2):255-260. Epub 2021 May 28.

Endocrinology, Diabetology and Medical Andrology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089, Milan, Italy.

Purpose: To evaluate the post- coronavirus disease-19 (COVID-19) outcome of thyroid function in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related thyrotoxicosis.

Methods: This was a single-center prospective study involving 29 patients (11 females, 18 males; median age 64 years, range: 43-85) with thyrotoxicosis diagnosed after hospitalization for COVID-19 and then followed-up for a median period of 90 days (range: 30-120) after hospital discharge. At follow-up, patients were evaluated for serum thyrotropin (TSH), free-thyroxine (FT4), free-triiodiothyronine (FT3), TSH receptor antibodies (TRAb), thyroglobulin antibodies (TgAb), thyroperoxidase antibodies (TPOAb) and ultrasonographic thyroid structure. Read More

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A case of thyroid storm caused by Graves' disease misdiagnosed as panic attack due to panic disorder.

Biopsychosoc Med 2021 May 27;15(1):11. Epub 2021 May 27.

Department of Psychiatry, Jichi Medical University, Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan.

Background: Graves' disease is characterized by hyperthyroidism and its symptoms often overlap with those of panic disorder, which may make it difficult to distinguish between the two conditions. In this report, we describe how proper diagnosis of thyroid disease in patients with mental illness can lead to appropriate treatment.

Case Presentation: We encountered a 34-year-old woman in whom thyroid crisis from Graves' disease was misdiagnosed as panic attack. Read More

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Thyroid dysfunction and breast cancer risk among women in the UK Biobank cohort.

Cancer Med 2021 Jul 26;10(13):4604-4614. Epub 2021 May 26.

Epidemiology of radiation Group, Center for Research in Epidemiology and Population Health, INSERM U1018, Paris Sud-Paris Saclay University, Villejuif, France.

This study aimed to evaluate the association between thyroid dysfunction and breast cancer risk. We included 239,436 females of the UK Biobank cohort. Information on thyroid dysfunction, personal and family medical history, medications, reproductive factors, lifestyle, and socioeconomic characteristics was retrieved from baseline self-reported data and hospital inpatient databases. Read More

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Management of Severe Graves' Hyperthyroidism in Pregnancy Following Immune Reconstitution Therapy in Multiple Sclerosis.

J Endocr Soc 2021 Jun 17;5(6):bvab044. Epub 2021 Mar 17.

Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Aker, Oslo, Norway.

Context: Alemtuzumab (ALZ), a CD52 monoclonal antibody, is highly efficacious in multiple sclerosis; however, side effects are common. Autoimmune thyroid disease (Graves' disease and Hashimoto thyroiditis) is a well-known complication of ALZ. Treatment of ALZ-induced Graves' disease can be challenging, and even more difficult during pregnancy. Read More

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Immobilization induced symptomatic hypercalcemia treated with zoledronate in a child with a left ventricular assist device.

Ann Pediatr Endocrinol Metab 2021 May 12. Epub 2021 May 12.

Department of Cardiovascular Surgery, Heart Center, Cebeci Hospitals, Ankara University School of Medicine, Ankara, Turkey.

Differential diagnosis of hypercalcemia in children includes hyperthyroidism, infection, inflammatory processes, malignant tumors. Immobilization-induced hypercalcemia is rare in healthy individuals; it can occur in adolescent males, especially after a fracture. Immobility caused increased skeletal calcium release and hypercalcemia, and this condition is also known as resorptive hypercalcemia. Read More

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Fetal Goitrous Hyperthyroidism in a Pregnant Woman with Triiodothyronine-Predominant Graves' Disease.

Kobe J Med Sci 2021 Feb 8;66(4):E153-E158. Epub 2021 Feb 8.

Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.

Triiodothyronine (T3)-predominant Graves' disease is characterized by increased serum free T3 (FT3) levels after free thyroxine (FT4) levels become normal or even low during antithyroid drug treatment. We encountered a 34-year-old pregnant woman, gravida 5 para 4, who was complicated by T3-predominant Graves' disease. She was diagnosed with Graves' disease at 20 years old, and had received methimazole. Read More

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February 2021

Symptomatic hypocalcemia after treatment for hyperthyroidism in a woman with chromosome 22q11.2 deletion syndrome complicated by Graves' disease: longitudinal changes in the number of subsets of CD4 and CD8 lymphocytes after thyroidectomy.

Endocr J 2021 May 11. Epub 2021 May 11.

Department of Endocrinology and Metabolism, Dokkyo Medical University, Tochigi 321-0293, Japan.

Chromosome 22q11.2 deletion syndrome is a multisystem genetic disorder that presents with hypocalcemia due to congenital hypoparathyroidism; cardiovascular, renal, and facial anomalies; and skeletal defects. This syndrome is also associated with an increased risk of autoimmune disease. Read More

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Refining age stratum of the CHEST score for predicting incident atrial fibrillation in a hospital-based Chinese population.

Eur J Intern Med 2021 May 8. Epub 2021 May 8.

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China;. Electronic address:

Background: The CHEST score (C: coronary artery disease [CAD] / chronic obstructive pulmonary disease [COPD] (1 point each); H: Hypertension; E: Elderly (Age≥75, doubled); S: Systolic heart failure (doubled); T: Thyroid disease (hyperthyroidism)) has been validated to predict incident atrial fibrillation (AF). Its performance in the hospital-based Chinese population has never been evaluated.

Methods: Risk factors for incident AF were investigated in a hospital-based population. Read More

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Rapidly progressive cognitive decline associated with teprotumumab in thyroid eye disease.

BMJ Case Rep 2021 May 10;14(5). Epub 2021 May 10.

Endocrinology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

Teprotumumab (Tepezza), an insulin-like growth factor type 1 receptor antagonist, was approved for treatment of thyroid eye disease in 2020. Teprotumumab is administered intravenously every 3 weeks for a total of eight doses. Common side effects include nausea, diarrhoea, muscle spasms, hearing impairment, dysgeusia, headaches, dry skin, infusion reactions and hyperglycaemia. Read More

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Risk factors for hypothyroidism and thyroid hormone replacement after hemithyroidectomy in papillary thyroid carcinoma.

Langenbecks Arch Surg 2021 Jun 10;406(4):1223-1231. Epub 2021 May 10.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea.

Purpose: Thyroid lobectomy is now preferred over total thyroidectomy to preserve thyroid function and reduce complications in patients with low-risk papillary thyroid carcinoma (PTC). One inevitable consequence of thyroidectomy includes hypothyroidism. This study aimed to evaluate the risk factors for hypothyroidism and thyroid hormone replacement after hemithyroidectomy in patients with PTC. Read More

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Alström syndrome with a novel mutation of and Graves' hyperthyroidism: A case report and review of the literature.

World J Clin Cases 2021 May;9(13):3200-3211

Department of Pediatrics, Ruijin Hospital, Shanghai Jiao-Tong University, School of Medicine, Shanghai 200025, China.

Background: Alström syndrome (AS, OMIM ID 203800) is a rare disease involving multiple organs in children and is mostly reported in non-Chinese patients. In the Chinese population, there are few reports on the clinical manifestations and pathogenesis of AS. This is the first report on the association between AS and Graves' hyperthyroidism. Read More

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Can we still consider thyroid hyperfunction a protective condition for the onset of thyroid cancer?

Gland Surg 2021 Apr;10(4):1359-1367

General Surgery Unit, Department of Medicine and Surgery, Parma University Hospital, Parma, Italy.

Background: Thyroid cancer is the ninth most commonly diagnosed cancer in the world, and the most common endocrine carcinoma. It was originally believed to be a rare event in patients with thyroid hyperfunction and it was reported that hyperthyroidism had a protective role against thyroid neoplasms. However, in recent years, several studies have hypothesized that differentiated thyroid carcinomas and hyperthyroidism may coexist. Read More

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Weathering the Storm: Thyroid Storm Precipitated by Radioiodine Contrast in Metastatic Thyroid Carcinoma.

Cureus 2021 Mar 31;13(3):e14219. Epub 2021 Mar 31.

Department of Pulmonary and Critical Care Medicine, Detroit Medical Center Sinai-Grace Hospital, Detroit, USA.

Thyroid storm is an extremely rare yet life-threatening medical emergency. It results from the decompensation of undiagnosed or undertreated hyperthyroidism in the presence of an acute stressor such as trauma to the thyroid, infections, acute iodine load, withdrawal from the antithyroid medication, or surgical procedures (including thyroid surgery). Clinical features of thyroid storm include hyperthermia, tachycardia, respiratory distress, gastrointestinal and hepatic symptoms, and central nervous system dysfunction. Read More

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Thyroid status regulates the tumor microenvironment delineating breast cancer fate.

Endocr Relat Cancer 2021 May 31;28(7):403-418. Epub 2021 May 31.

Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.

The patient's hormonal context plays a crucial role in the outcome of cancer. However, the association between thyroid disease and breast cancer risk remains unclear. We evaluated the effect of thyroid status on breast cancer growth and dissemination in an immunocompetent mouse model. Read More

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Thyroid immune-related adverse events following immune checkpoint inhibitor treatment.

J Clin Endocrinol Metab 2021 Apr 20. Epub 2021 Apr 20.

Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Background: Thyroid dysfunction occurs commonly following immune checkpoint inhibition. The etiology of thyroid immune-related adverse events (irAEs) remains unclear and clinical presentation can be variable. This study sought to define thyroid irAEs following immune checkpoint inhibitor (ICI) treatment and describe their clinical and biochemical associations. Read More

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Thyroid Disease-Induced Hepatic Dysfunction: A Clinical Puzzle.

ACG Case Rep J 2021 Apr 14;8(4):e00555. Epub 2021 Apr 14.

Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN.

The diagnostic evaluation of an individual with clinical and laboratory evidence of thyroid dysfunction in the setting of acute liver injury is crucial. There is a complex relationship between the thyroid and the liver, and so, it requires a careful elucidation of the inciting disease process before instituting a treatment plan. We discuss a patient who had presented with coagulopathy, encephalopathy, and laboratory evidence of acute liver injury, hence adjudged to have developed drug-induced acute liver failure and transferred for liver transplant evaluation. Read More

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[Purpura in a young woman with hyperthyroidism].

Rev Med Interne 2021 Jul 10;42(7):509-512. Epub 2021 Apr 10.

Service de dermatologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France; UPEC, université Paris Est Créteil EpidermE, Créteil, France. Electronic address:

Introduction: Propylthiouracil (PTU) is a synthetic antithyroid drug that can induce ANCA-associated vasculitis.

Observation: A 27-year-old woman diagnosed with Graves' disease was on PTU for the past 10 years. She developed purpuric lesions of the legs and on the tip of the nose diagnosed as vasculitis. Read More

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The effects of hypothyroidism and hyperthyroidism on placental Hofbauer cells of pregnant rats.

Biotech Histochem 2021 Apr 13:1-10. Epub 2021 Apr 13.

Department of Histology and Embryology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.

We investigated the effects of maternal thyroid disorders on Hofbauer cells of both the placenta and the fetus in pregnant rats. We divided 21 rats into three groups: control group, induced hypothyroidism (hypo) group and induced hyperthyroidism (hyper) group. Hypothyroidism was induced using propylthiouracil and hyperthyroidism was induced using L-thyroxine. Read More

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Familial Non-autoimmune Hyperthyroidism in Family Members Across Four Generations Due To a Novel Disease-causing Variant in The Thyrotropin Receptor Gene.

Balkan J Med Genet 2020 Nov 23;23(2):87-92. Epub 2021 Mar 23.

Deparment of Pediatric Endocrinology, Diabetes and Metabolism, University Medical Centre Ljubljana, University Children´s Hospital, Ljubljana, Slovenia.

Activating disease-causing variants in the thyrotropin-receptor () gene are associated with familial or sporadic congenital non-autoimmune hyperthyroidism. Familial non-autoimmune hyperthyroidism (FNAH) is a rare form of hyperthyroidism with 41 families reported so far in the gene mutation database. We present clinical and genetic features of 11 patients with FNAH across four generations of a Slovenian family. Read More

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November 2020

The Impact of Iodine Exposure in Excess on Hormonal Aspects and Hemato-Biochemical Profile in Rats.

Biol Trace Elem Res 2021 Mar 30. Epub 2021 Mar 30.

Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, 1 Alzeraa Street, Zagazig City, Sharkia Province, 44511, Egypt.

Excessive exposure of iodine over a time is well known to cause thyroid dysfunction, which may be followed by different effects on body organs. The present study aimed to illustrate the impacts of exposure of rats to excess iodine (above the tolerable range) and the reversibility of any negative impacts on hormonal profile related to thyroid besides cortisol and the hematological and biochemical parameters along with the histopathological alterations in the thyroid gland, liver, kidneys, and heart. Seventy-five rats were divided equally into three groups: Group 1 was control animals. Read More

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