64,458 results match your criteria developed exposure

Discontinued alcohol consumption elicits withdrawal symptoms in honeybees.

Biol Lett 2021 Jun 16;17(6):20210182. Epub 2021 Jun 16.

Institute of Systematics and Evolution of Animals, Polish Academy of Sciences, Sławkowska 17, 31-016 Kraków, Poland.

The honeybee continues to be developed as a model species in many research areas, including studies related to the effects of alcohol. Here, we investigate whether workers display one of the key features of alcoholism, namely withdrawal symptoms. We show that workers fed for a prolonged time on food spiked with ethanol, after discontinuation of access to such food, exhibited a marked increase in the consumption of ethanol and a slight increase in mortality. Read More

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Serial imaging of micro-agents and cancer cell spheroids in a microfluidic channel using multicolor fluorescence microscopy.

PLoS One 2021 15;16(6):e0253222. Epub 2021 Jun 15.

Surgical Robotics Laboratory, Department of Biomechanical Engineering, University of Twente, Enschede, The Netherlands.

Multicolor fluorescence microscopy is a powerful technique to fully visualize many biological phenomena by acquiring images from different spectrum channels. This study expands the scope of multicolor fluorescence microscopy by serial imaging of polystyrene micro-beads as surrogates for drug carriers, cancer spheroids formed using HeLa cells, and microfluidic channels. Three fluorophores with different spectral characteristics are utilized to perform multicolor microscopy. Read More

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Mapping the Clinical Experience of a New York City Residency Program During the COVID-19 Pandemic.

J Hosp Med 2021 Jun;16(6):353-356

Department of Medicine, NYU Grossman School of Medicine, New York, New York.

The COVID-19 pandemic has dramatically disrupted the educational experience of medical trainees. However, a detailed characterization of exactly how trainees' clinical experiences have been affected is lacking. Here, we profile residents' inpatient clinical experiences across the four training hospitals of NYU's Internal Medicine Residency Program during the pandemic's first wave. Read More

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Role of Toxicokinetic and Toxicodynamic Parameters in Explaining the Sensitivity of Zebrafish Larvae to Four Metals.

Environ Sci Technol 2021 Jun 15. Epub 2021 Jun 15.

Key Laboratory of Pollution Process and Environmental Criteria of Ministry of Education and Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, P. R. China.

Given the persistence and toxic potencies of metal contaminants in ecosystems, animals, and human beings, they are considered to be hazardous global pollutants. While the lethality of metal toxicities (e.g. Read More

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Reimagining spaces where children play: developing guidance for thermally comfortable playgrounds in Canada.

Can J Public Health 2021 Jun 15. Epub 2021 Jun 15.

Climate Change and Innovation Bureau, Health Canada, Ottawa, ON, Canada.

Setting: Planning and designing thermally comfortable outdoor spaces is increasingly important in the context of climate change, particularly as children are more vulnerable than adults to environmental extremes. However, existing playground standards focus on equipment and surfacing to reduce acute injuries, with no mention of potential negative health consequences related to heat illness, sun exposure, and other thermal extremes. The goal of this project was to develop proposed guidelines for designing thermally comfortable playgrounds in Canada for inclusion within the CAN/CSA-Z614 Children's playground equipment and surfacing standard. Read More

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Immunosuppression does not prevent severe gastrointestinal tract involvement in systemic sclerosis.

Clin Exp Rheumatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Medicine, McGill University, Montreal, Quebec; Division of Rheumatology, Jewish General Hospital, Montreal, Quebec, and Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.

Objectives: We aimed to test the hypothesis that exposure to immunosuppression in early systemic sclerosis (SSc) could modify the risk of developing new onset severe gastrointestinal (GIT) involvement.

Methods: A total of 762 subjects with <3 years of disease duration and without severe GIT disease at baseline study visit were identified from combined longitudinal cohort data from the Canadian Scleroderma Research Group (CSRG) and Australian Scleroderma Interest Group (ASIG). The primary exposure was ever use of methotrexate, cyclophosphamide, mycophenolate mofetil and/or azathioprine during the study period. Read More

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Analyzing musculoskeletal risk prevalence among workers in developing countries: an analysis of small-scale cast-iron foundries in India.

Arch Environ Occup Health 2021 Jun 15:1-18. Epub 2021 Jun 15.

Department of Mechanical Engineering, Ch. Ranbir Singh State Institute of Engineering & Technology, Jhajjar, Haryana, India.

Musculoskeletal disorders (MSDs) are the most common health issues around the globe and a major cause of disability among workers. In developing countries, most casting industries fall under Small and Medium Scale Enterprises (SMEs); SMEs lack modern equipment and often intensively rely on manual labor. As processes are mainly labor intensive, workers employed in the metal casting sector are often at risk of MSDs. Read More

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The World Trade Center Health Program: Petitions for adding qualifying health conditions.

Am J Ind Med 2021 Jun 15. Epub 2021 Jun 15.

National Institute for Occupational Safety and Health (NIOSH), Washington, DC, USA.

The federally mandated World Trade Center Health Program provides limited health benefits for qualifying health conditions related to the 9/11 terrorist attacks. A qualifying health condition is an illness or health condition for which the member's exposure to airborne toxins, any other hazard, or any other adverse condition resulting from the 9/11 terrorist attacks is considered substantially likely to be a significant factor in aggravating, contributing to, or causing the illness or health condition. These qualifying health conditions are listed in federal regulations. Read More

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Improved dynamic imaging of multiphase flow by constrained tomographic reconstruction.

Sci Rep 2021 Jun 14;11(1):12501. Epub 2021 Jun 14.

Department of Applied Mathematics and Computer Science, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.

Dynamic tomography has become an important technique to study fluid flow processes in porous media. The use of laboratory X-ray tomography instruments is, however, limited by their low X-ray brilliance. The prolonged exposure times, in turn, greatly limit temporal resolution. Read More

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Challenges in Treating Tardive Dyskinesia: Assessing the Impact of Virtual Medical Education.

CNS Spectr 2021 Apr;26(2):165

Global Medical Education, New York, NY, USA.

Introduction: Tardive Dyskinesia (TD) refers to abnormal, involuntary, choreoathetoid movements of the tongue, lips, face, trunk, and extremities and is associated with long-term exposure to dopamine-blocking agents, such as antipsychotic medications. Once established, these movements usually persist. The movements are disfiguring and can bring unwanted attention to affected individuals. Read More

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Knowledge of The Recognition and Management of Tardive Dyskinesia Markedly Improved Among Psychiatrists: Assessing the Impact of Online Medical Education.

CNS Spectr 2021 Apr;26(2):153-154

Neuroscience Education Institute, Chief Medical Officer, Carlsbad, CA, USA and SUNY Upstate Medical University, Clinical Associate Professor of Psychiatry, Syracuse, NY, USA.

Introduction: Tardive dyskinesia (TD) is a persistent and potentially disabling movement disorder associated with prolonged exposure to antipsychotic medications that jeopardizes adherence to treatment and reduces quality of life. The recognition and management of TD can be challenging in many instances. An online activity was developed to assess the ability of continuing medical education (CME) to improve awareness of the recognition and management of TD among psychiatrists. Read More

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Winning the fight against biofilms: the first six-month study showing no biofilm formation on zwitterionic polyurethanes.

Chem Sci 2020 Apr 25;11(18):4709-4721. Epub 2020 Apr 25.

Department of Chemical Engineering, The University of Illinois at Chicago Chicago IL 60607 USA https://gancheng.people.uic.edu.

Biofilms have been a long-standing challenge for healthcare, water transport, and many other industries. They lead to bacterial growth and infections in animals, food products, and humans, cause premature removal of the implanted materials or devices from patients, and facilitate fouling and corrosion of metals. Despite some published and patented methods on minimizing the effects of biofilms for a short period (less than two weeks), there exists no successful means to mitigate or prevent the long-term formation of biofilms. Read More

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Effects of coastal acidification on North Atlantic bivalves: interpreting laboratory responses in the context of populations.

Mar Ecol Prog Ser 2020 Jan;633:89-104

School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, NY 11794.

Experimental exposure of early life stage bivalves has documented negative effects of elevated CO on survival and growth, but the population consequences of these effects are unknown. Following standard practices from population viability analysis and wildlife risk assessment, we substituted laboratory-derived stress-response relationships into baseline population models of and . The models were constructed using inverse demographic analyses with time series of size-structured field data in NY, USA, whereas the stress-response relationships were developed using data from a series of previously published laboratory studies. Read More

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January 2020

Combined user-driven treadmill control and functional electrical stimulation increases walking speeds poststroke.

J Biomech 2021 Apr 24;124:110480. Epub 2021 Apr 24.

Mechanical Engineering, University of Delaware, Newark, DE, USA; Biomedical Engineering, University of Delaware, Newark, DE, USA.

The variety of poststroke impairments and compensatory mechanisms necessitate adaptive and subject-specific approaches to locomotor rehabilitation. To implement subject-specific, adaptive training to treadmill-based gait training, we developed a user-driven treadmill (UDTM) control algorithm that adjusts the user's speed in real-time. This study examines the response of individuals poststroke to the combination of UDTM control and electrical stimulation of the paretic ankle musculature to augment forward propulsion during walking. Read More

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Effects of bisphenol A exposure during cardiac cell differentiation.

Environ Pollut 2021 Jun 9;286:117567. Epub 2021 Jun 9.

Department of Animal Reproduction, INIA, Av. Puerta de Hierro, 18, Madrid, Spain. Electronic address:

Heart development requires a precise temporal regulation of gene expression in cardiomyoblasts. Therefore, the transcriptional changes in differentiating cells can lead to congenital heart diseases. Although the genetic mutations underlie most of these alterations, exposure to environmental contaminants, such as bisphenol A (BPA), has been recently considered as a risk factor as well. Read More

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Estimation of unattached and aerosol-attached activities of airborne short-lived radon progeny in indoor environments.

J Environ Radioact 2021 Jun 11;237:106665. Epub 2021 Jun 11.

Laboratory of Material Physics and Subatomic, Department of Physics, Faculty of Sciences, Ibn Toufail University, Kenitra, 14000, Morocco.

Inhalation of the airborne short-lived radon progeny is regarded as the most crucial way of internal exposure to the natural radiation dose delivered to the human lung. In this respect, this study aims to determine the unattached and aerosol-attached activities of radon progeny and to estimate some important physical parameters employed to assess the radiological impact of this radiation on humans. For this purpose, radioactive aerosol samples collected on polycarbonate membrane filters to measure total alpha activity by passive alpha dosimetric technique using CR-39 detectors in sixteen different locations including some houses and workplaces in El Jadida city, in Morocco. Read More

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Design, assembly and validation of a low-cost, high-fidelity simulator for heart exploration.

Gac Med Mex 2021 ;157(1):24-28

Department of Medical Sciences Integration, Faculty of Medicine, Universidad Nacional Autónoma de México. Mexico City, Mexico.

Introduction: Heart exploration is an essential clinical competence that requires continuous training and exposure. Low availability and accessibility to patients with heart disease constitutes a barrier to acquiring this competence. Inadequate cardiac auscultation skills in medical students, residents, and graduate physicians have been documented. Read More

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January 2021

A comprehensive review on gout: The epidemiological trends, pathophysiology, clinical presentation, diagnosis and treatment.

J Pak Med Assoc 2021 Apr;71(4):1234-1238

University of Lahore, Lahore, Pakistan.

The current review was planned to assess updated knowledge about gout and to highlight the various areas which need to be focussed upon for better healthcare. Relevant articles published in English language were reviewed by utilising various databases including Google Scholar, Springer Link, Science Direct and MEDLINE. Data revealed a precipitating number of gout cases from the developed countries, while the developing countries on the other hand were found to be faced with an even higher threat. Read More

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Seroprevalence of SARS-CoV-2 (COVID-19) exposure in pet cats and dogs in Minnesota, USA.

Virulence 2021 Dec;12(1):1597-1609

Department of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, USA.

The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 is continuing to spread globally. SARS-CoV-2 infections of feline and canine species have also been reported. However, it is not entirely clear to what extent natural SARS-CoV-2 infection of pet dogs and cats is in households. Read More

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December 2021

Fragmentation in the future of work: A horizon scan examining the impact of the changing nature of work on workers experiencing vulnerability.

Am J Ind Med 2021 Jun 14. Epub 2021 Jun 14.

Institute for Work and Health, Toronto, Ontario, Canada.

Introduction: The future of work is characterized by changes that could disrupt all aspects of the nature and availability of work. Our study aims to understand how the future of work could result in conditions, which contribute to vulnerability for different groups of workers.

Methods: A horizon scan was conducted to systematically identify and synthesize diverse sources of evidence, including academic and gray literature and resources shared over social media. Read More

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Treatment outcomes in the neovascular glaucoma tube versus trabeculectomy study.

Graefes Arch Clin Exp Ophthalmol 2021 Jun 14. Epub 2021 Jun 14.

Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Purpose: To compare surgical outcomes between patients who underwent Baerveldt glaucoma implantation versus trabeculectomy (TLE) for the treatment of neovascular glaucoma.

Methods: We performed a prospective, randomized, controlled clinical trial at Hiroshima University and Tsukazaki Hospital, Japan. Patients were randomized to Baerveldt glaucoma implantation (23 patients) or TLE (27 patients). Read More

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Increased Emergency Department Hallway Length of Stay is Associated with Development of Delirium.

West J Emerg Med 2021 Apr 9;22(3):726-735. Epub 2021 Apr 9.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Department of Emergency Medicine, Manhasset, New York.

Introduction: Our study aimed to determine 1) the association between time spent in the emergency department (ED) hallway and the development of delirium and 2) the hospital location of delirium development.

Methods: This single-center, retrospective chart review included patients 18+ years old admitted to the hospital after presenting, without baseline cognitive impairment, to the ED in 2018. We identified the Delirium group by the following: key words describing delirium; orders for psychotropics, special observation, and restraints; or documented positive Confusion Assessment Method (CAM) screen. Read More

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Investigation of the speeding behavior of motorcyclists through an innovative smartphone application.

Traffic Inj Prev 2021 Jun 14:1-7. Epub 2021 Jun 14.

Department of Transportation Planning and Engineering, National Technical University of Athens, Athens, Greece.

Objective: The objective of the present study is twofold: (i) to explore the riding behavior of motorcyclists while speeding, based on detailed riding analytics collected by smartphone sensors, and (ii) to investigate whether personalized feedback can improve motorcyclist behavior.

Methods: In order to achieve the objective, a naturalistic riding experiment with a sample of 13 motorcyclists based on a smartphone application developed within the framework of the BeSmart project was conducted. Using risk exposure and riding behavior indicators calculated from smartphone sensor data, Generalized Linear Mixed-Effects Models are calibrated to correlate the percentage of riding time over the speed limit with other riding behavior indicators. Read More

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immunogenicity prediction: bridging between innate and adaptive immunity.

Bioanalysis 2021 Jun 14. Epub 2021 Jun 14.

Department of BioAnalytical Sciences, Genentech, Inc., South San Francisco, CA 94080-4990, USA.

Development of antidrug antibodies (ADAs) is an undesirable potential outcome of administration of biotherapeutics and involves the innate and adaptive immune systems. ADAs can have detrimental clinical consequences: they can reduce biotherapeutic efficacy or produce adverse events. Because animal models are considered poor predictors of immunogenicity in humans, assays with human innate and adaptive immune cells are commonly used alternatives that can reveal cell-mediated unwanted immune responses. Read More

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Degrafting of Polymer Brushes by Exposure to Humid Air.

ACS Appl Polym Mater 2020 Aug 8;2(8):3039-3043. Epub 2020 Jul 8.

Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.

It is well-known that polymer brushes can degraft in aqueous liquids. Here we show that brushes can deteriorate in humid air too. We observe that the detachment rate of the brushes increases with increasing relative humidity and hydrophilicity of the brushes. Read More

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Sensitive Quantification of Nicotine in Bronchoalveolar Lavage Fluid by Acetone Precipitation Combined With Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry.

ACS Omega 2021 Jun 25;6(22):13962-13969. Epub 2021 May 25.

Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, U.S. Centers for Disease Control and Prevention (CDC), 4770 Buford Highway, Mail Stop S103-3, Atlanta, Georgia 30341, United States.

The United States experienced an outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI) that began in August 2019. Patient diagnosis and treatment sometimes involved bronchoscopy and collection of the bronchoalveolar lavage (BAL) fluid. Although this matrix has been useful for understanding some chemical exposures in the lungs, no methods existed for measuring the nicotine content. Read More

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Mental Health Status of Late-Middle-Aged Adults in China During the Coronavirus Disease 2019 Pandemic.

Front Public Health 2021 26;9:643988. Epub 2021 May 26.

Peking University Sixth Hospital, Peking University Institute of Mental Health, National Health Commission (NHC) Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit, Peking University, Beijing, China.

The novel coronavirus 2019 (COVID-19) pandemic and related compulsory measures have triggered a wide range of psychological issues. However, the effect of COVID-19 on mental health in late-middle-aged adults remains unclear. This cross-sectional, web-based survey recruited 3,730 participants (≥ 50 years old) between February 28 and March 11 of 2020. Read More

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Evaluation through outbreak simulation exercise points to the need for considerable improvement in the capacity of peripheral health workers for outbreak detection and response, South India, 2018.

J Family Med Prim Care 2021 Apr 29;10(4):1587-1591. Epub 2021 Apr 29.

SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.

Background: Outbreaks are emergencies, requiring skilled peripheral health workers in the health system. Given the lack of evaluation of the knowledge and practices of peripheral health workers regarding outbreak investigation and response, we surveyed to estimate the performance level of health workers in outbreak detection and response.

Methods: We developed a simulation exercise based on hepatitis and fever outbreak to ascertain knowledge and skills in outbreak detection and response. Read More

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Combination of Metformin, Sodium Oxamate and Doxorubicin Induces Apoptosis and Autophagy in Colorectal Cancer Cells Downregulation HIF-1α.

Front Oncol 2021 26;11:594200. Epub 2021 May 26.

Laboratorio de Genómica Funcional, Unidad de Biomedicina, FES-Iztacala, UNAM, Tlalnepantla, Mexico.

Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide in both sexes. Current therapies include surgery, chemotherapy, and targeted therapy; however, prolonged exposure to chemical agents induces toxicity in patients and drug resistance. So, we implemented a therapeutic strategy based on the combination of doxorubicin, metformin, and sodium oxamate called triple therapy (Tt). Read More

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Cryopreservation of mesenchymal stem cells derived from dental pulp: a systematic review.

Restor Dent Endod 2021 May 29;46(2):e26. Epub 2021 Apr 29.

Department of Restorative Dentistry, Universidade Federal do Paraná, Curitiba/PR, Brazil.

Objectives: The aim of the present systematic review was to investigate the cryopreservation process of dental pulp mesenchymal stromal cells and whether cryopreservation is effective in promoting cell viability and recovery.

Materials And Methods: This systematic review was developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and the research question was determined using the population, exposure, comparison, and outcomes strategy. Electronic searches were conducted in the PubMed, Cochrane Library, Science Direct, LILACS, and SciELO databases and in the gray literature (dissertations and thesis databases and Google Scholar) for relevant articles published up to March 2019. Read More

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