728 results match your criteria developed angioedema


Angioedema after rt-PA infusion led to airway emergency: a case report of rescue treatment with fresh frozen plasma.

Braz J Anesthesiol 2021 Apr 28. Epub 2021 Apr 28.

Ospedale Maggiore, Intensive Care and Prehospital Emergency Service, Department of Anesthesia, Bologna, Italy.

The authors report the case of a 71-year-old woman presented to the Emergency Department with AIS. She was treated with rt-PA and interventional endovascular revascularization and developed rapidly progressing angioedema that led to emergency intubation. The standard treatment was not very effective and the swelling improved after infusion of fresh frozen plasma. Read More

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Assessment and management of disease burden and quality of life in patients with hereditary angioedema: a consensus report.

Allergy Asthma Clin Immunol 2021 Apr 19;17(1):40. Epub 2021 Apr 19.

University of California San Diego, 8899 University Center Ln, San Diego, CA, 92122, USA.

Background: Hereditary angioedema (HAE) is a rare disease characterized by unpredictable, potentially life-threatening attacks, resulting in significant physical and emotional burdens for patients and families. To optimize care for patients with HAE, an individualized management plan should be considered in partnership with the physician, requiring comprehensive assessment of the patient's frequency and severity of attacks, disease burden, and therapeutic control. Although several guidelines and consensus papers have been published concerning the diagnosis and treatment of HAE, there has been limited specific clinical guidance on the assessment of disease burden and quality of life (QoL) in this patient population. Read More

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Therapeutic plasma exchange and dextran-sulfate plasma adsorption as extracorporeal treatments of extremely preterm preeclampsia with fetal growth restriction.

J Clin Apher 2021 Apr 13. Epub 2021 Apr 13.

Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Aim: To evaluate effectiveness and safety of therapeutic plasma exchange (TPE) and dextran-sulfate plasma adsorption (DSA) for extracorporeal removal of soluble Fms-like tyrosine kinase-1 (sFlt-1) as part of expectant management of preeclampsia at extremely preterm gestational age.

Methods: Retrospective case series of six patients with preeclampsia at <28 weeks of gestation, treated with DSA or TPE. Laboratory results, clinical characteristics and neonatal outcomes were collected from charts and National Perinatal Information System. Read More

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Case Report: Compromised Airway Following Anesthesia and Its Correlation With the Use of ACE Inhibitors-An Unexpected Clinical Event and Review of Literature.

Front Surg 2021 22;8:631456. Epub 2021 Mar 22.

MIOT International, Chennai, India.

Angiotensin-converting enzyme inhibitors associated angioedema involving the upper aerodigestive tract is indisputably a hazardous airway condition which is clinically poorly recognized and frequently underestimated. We describe and present case of a 70-year old man on ramipril who developed massive tongue swelling post-operatively after unremarkable laryngeal mask anaesthesia which was fortuitously managed conservatively. High index of suspicion, timely recognition and knowledge of pathophysiology and the clinical course should guide airway and further supportive management in these patients. Read More

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Iodine Contrast Complex Rash Responding to Topical Steroids: A Case Report.

Am J Case Rep 2021 Apr 7;22:e928930. Epub 2021 Apr 7.

Department of Emergency Medicine, Lebanese American University (LAU) Medical Center, Beirut, Lebanon.

BACKGROUND Iodine contrast allergy can cause acute and delayed allergic reactions. Just like any other sensitivity reaction, the severity can vary from mild to moderate skin manifestations such as erythematous rash to an even more severe presentation or life-threatening event, such as angioedema and anaphylaxis. CASE REPORT This case report discusses a patient who presented to our institution with a diffuse complex rash 2 days after undergoing CT scan imaging with intravenous iodine contrast injection. Read More

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Case Report: Post-operative Angioedema After a Laryngeal Mask Airway Application.

Front Med (Lausanne) 2021 15;8:566100. Epub 2021 Mar 15.

Department of Anesthesiology, Emory University Hospital, Atlanta, GA, United States.

Angioedema with macroglossia is a rare complication of anesthesia. We present a clinical case of post-operative development of angioedema presenting as macroglossia in a patient receiving chronic therapy with lisinopril, who developed symptoms in the early post-operative period following surgery in a lateral position, when a laryngeal mask airway was used. Possible mechanisms of angioedema and macroglossia development in our patient are discussed along with potential underlying predisposing mechanisms and available therapeutic approaches. Read More

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A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction.

Allergy Asthma Clin Immunol 2021 Mar 31;17(1):36. Epub 2021 Mar 31.

Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan.

Background: Although Japanese radish (Raphanus sativus L.) is a common Japanese ingredient, there are few reports of IgE-mediated immediate food allergy caused by Japanese radish.

Case Presentation: A 48-year-old woman developed urticarial lesions on her hands after grating Japanese radish and also developed lip edema and oral itching when she ate a salad composed of raw Japanese radishes. Read More

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How face masks influence the sinonasal quality of life during the COVID-19 pandemic.

Eur Arch Otorhinolaryngol 2021 Mar 27. Epub 2021 Mar 27.

Department of Otolaryngology and Head and Neck Surgery, The Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel.

Purpose: To study different mask types' impact on a sinonasal quality of life.

Methods: For this observational cross-sectional study, a web-based survey was distributed via social media forums. We used the validated Hebrew version of the Sinonasal Outcome Test-22 followed by a questionnaire developed specifically for the present study, focusing on the time of the COVID-19 pandemic (Mask Sinonasal Outcome Test), and questions regarding general health issues. Read More

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Targeted LC-MS/MS platform for the comprehensive determination of peptides in the kallikrein-kinin system.

Anal Bioanal Chem 2021 May 10;413(11):2971-2984. Epub 2021 Mar 10.

Institute of Clinical Pharmacy and Pharmacotherapy, Heinrich Heine University, 40225, Dusseldorf, Germany.

The kallikrein-kinin system (KKS) is involved in many physiological and pathophysiological processes and is assumed to be connected to the development of clinical symptoms of angioedema or COVID-19, among other diseases. However, despite its diverse role in the regulation of physiological and pathophysiological functions, knowledge about the KKS in vivo remains limited. The short half-lives of kinins, their low abundance and structural similarities and the artificial generation of the kinin bradykinin greatly hinder reliable and accurate determination of kinin levels in plasma. Read More

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Berotralstat: First Approval.

Authors:
Arnold Lee

Drugs 2021 Feb;81(3):405-409

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Berotralstat (ORLADEYO™) is an orally administered kallikrein inhibitor, which has been developed by BioCryst Pharmaceuticals for hereditary angioedema (HAE). The inhibition of kallikrein by berotralstat decreases the production of bradykinin, which prevents the localised tissue oedema that occurs during attacks of HAE. Berotralstat has been approved in the USA, and subsequently in Japan, for prophylaxis to prevent attacks of HAE in adults and paediatric patients aged 12 years or older. Read More

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February 2021

Survey of actual conditions of erythema marginatum as a prodromal symptom in Japanese patients with hereditary angioedema.

World Allergy Organ J 2021 Feb 6;14(2):100511. Epub 2021 Feb 6.

Department of Nephrology, Internal Medicine, Saiyu Soka Hospital, Soka City, Saitama, Japan.

Background: Hereditary angioedema (HAE) is a rare but life-threatening condition. HAE types I and II (HAE-1/2) result from C1-inhibitor (C1-INH) deficiency. However, recent genetic analysis has established a new type of HAE with normal C1-INH (HAEnC1-INH). Read More

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February 2021

Unusual presentation of linear wrist blisters associated with hereditary angioedema: The first case report in Taiwan.

J Formos Med Assoc 2021 Feb 24. Epub 2021 Feb 24.

Department of Allergy, Immunology and Rheumatology, Mackay Children's Hospital, Taipei, Taiwan. Electronic address:

Hereditary angioedema (HAE) is an autosomal dominant disease characterized clinically by recurrent episodes of swelling in the tissues of the extremities, face, abdomen, and respiratory tract. It is most often caused by C1 esterase inhibitor (C1 INH) gene mutation. This swelling may lead to bradykinin release, resulting in recurrent, paroxysmal, painful angioedema. Read More

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February 2021

Anti-IgE for the Treatment of Chronic Urticaria.

Immunotargets Ther 2021 17;10:27-45. Epub 2021 Feb 17.

Department of Dermatology and Allergy, Comprehensive Allergy Center, Hannover Medical School, Hannover, Germany.

Urticaria and angioedema are very common. Management of chronic urticaria subtypes, which usually persist for many years, is challenging. Recent years have demonstrated that targeting IgE with antibodies provides a safe and efficient treatment approach. Read More

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February 2021

A Case of Contact Allergic Dermatitis to Topical Minoxidil.

Cureus 2021 Jan 5;13(1):e12510. Epub 2021 Jan 5.

College of Medicine, King Saud University, Riyadh, SAU.

Coincidental findings of hypertrichosis in patients on minoxidil led to the development of a topical minoxidil formulation which has been approved by the Food and Drug Administration for the treatment of female pattern hair loss, the most common cause for hair loss in women. The most common side effect of topical minoxidil is irritant contact dermatitis with the typical symptoms of itching and scaling. Most commonly, these symptoms are a result of an allergic reaction to propylene glycol, or less commonly, to minoxidil itself. Read More

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January 2021

Fixed drug eruption and anaphylaxis induced concurrently by erdosteine: a case report.

Allergy Asthma Clin Immunol 2021 Feb 5;17(1):15. Epub 2021 Feb 5.

Division of Allergy, Asthma, and Clinical Immunology, Department of Internal Medicine, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju, 61469, Republic of Korea.

Background: Erdosteine is used as a mucolytic agent and has a low incidence of adverse drug reactions, most of which are gastrointestinal and mild. Moreover, drug antigens rarely induce multiple simultaneous immunologic reactions. Only one previous case report has demonstrated hypersensitivity reaction induced by erdosteine. Read More

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February 2021

The Enigma of Prodromes in Hereditary Angioedema (HAE).

Clin Rev Allergy Immunol 2021 Feb 3. Epub 2021 Feb 3.

Barzilai University Medical Center, Ashkelon, Israel.

A prodrome is a premonitory set of signs and symptoms indicating the onset of a disease. Prodromes are frequently reported by hereditary angioedema (HAE) patients, antedating attacks by a few hours or even longer. In some studies, high incidence of prodromes was reported by patients, with considerable number being able to predict oncoming attacks. Read More

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February 2021

The practice of active patient involvement in rare disease research using ICT: experiences and lessons from the RUDY JAPAN project.

Res Involv Engagem 2021 Feb 1;7(1). Epub 2021 Feb 1.

Department of Biomedical Ethics and Public Policy, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Background: The role of patients in medical research is changing, as more emphasis is being placed on patient involvement, and patient reported outcomes are increasingly contributing to clinical decision-making. Information and communication technology provides new opportunities for patients to actively become involved in research. These trends are particularly noticeable in Europe and the US, but less obvious in Japan. Read More

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February 2021

Characterization of interactions between local anesthetics and histamine H receptor by cell membrane chromatography model.

J Pharm Biomed Anal 2021 Mar 19;196:113911. Epub 2021 Jan 19.

School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address:

Local anesthetic has a wide application in clinical practice. However, angioedema, an adverse reaction caused by local anesthetics, has been reported to be related to histamine H receptor (HR). Hence, an effective and practical method for investigating the interaction characteristics between local anesthetics and HR is needed. Read More

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Critical angioedema induced by a renin angiotensin system blocker in the contemporary era of increasing heart failure: A case report and commentary.

J Clin Hypertens (Greenwich) 2021 Mar 25;23(3):692-695. Epub 2021 Jan 25.

The Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke-shi, Japan.

Bradykinin-mediated angioedema, a nonallergic reaction most commonly caused by renin angiotensin system (RAS) blockers, has the potential to lead to a critical condition. RAS blockers are important for treating heart failure and are widely used in clinical settings. We present the case of an 85-year-old man who was administered enalapril after percutaneous coronary intervention for an acute myocardial infarction and developed severe angioedema requiring a tracheostomy. Read More

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Graves' Disease Presenting as Urticaria.

Cureus 2020 Dec 17;12(12):e12134. Epub 2020 Dec 17.

Surgery, Alfaisal University College of Medicine, Riyadh, SAU.

Graves' disease (GD) is an autoimmune disease that is characterized by the presence of antibodies targeting the thyroid gland. Commonly, the disease presents with symptoms of thyrotoxicosis such as sweating, tremors, and weight loss; less frequently, patients with GD might also have urticaria. Urticaria is clinically defined as the presence of wheals, angioedema, or both. Read More

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December 2020

Tissue Plasminogen Activator-Induced Angioedema Involving a Posterior Cerebral Artery Infarct: A Case Presentation.

Am J Case Rep 2021 Jan 14;22:e927137. Epub 2021 Jan 14.

Department of Medicine, Arnot Ogden Medical Center, Elmira, NY, USA.

BACKGROUND Angioedema is characterized by localized swelling of subcutaneous or submucosal tissue resulting from fluid extravasation due to the loss of vascular integrity. It most commonly occurs with exposure to allergens and certain medications, namely nonsteroidal anti-inflammatory agents and angiotensin-converting enzyme inhibitors. There have been few incidences of angioedema following the administration of tissue plasminogen activator. Read More

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January 2021

Current and Prospective Targets of Pharmacologic Treatment of Hereditary Angioedema Types 1 and 2.

Clin Rev Allergy Immunol 2021 Jan 9. Epub 2021 Jan 9.

Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Hereditary angioedema (HAE) is a rare disease that causes episodic attacks of subcutaneous and submucosal edema, which can be painful, incapacitating, and potentially fatal. These attacks are mediated by excessive bradykinin production, as a result of uncontrolled activation of the plasma kallikrein/kinin system, which is caused by a C1 esterase inhibitor deficiency or dysfunction in HAE types 1 and 2, respectively. For many years, treatment options were limited to therapies with substantial adverse effects, insufficient efficacy, or difficult routes of administration. Read More

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January 2021

Neck angioedema after anterior cervical discectomy and fusion with coexistent epiglottic cyst.

Surg Neurol Int 2020 22;11:459. Epub 2020 Dec 22.

Department of Neurosurgery, University Hospital of Patras, Patras, Achaia, Greece.

Background: We present a case and reviewed the literature regarding airway obstruction and angioedema after an anterior cervical discectomy and fusion (ACDF).

Case Description: A 60-year-old female with degenerative cervical myelopathy and a previously undiagnosed epiglottic cyst underwent a C5-C6 ACDF; notably, the anesthesiologist found an epiglottic cyst when the patient was first intubated. Two hours postoperatively, the patient acutely developed severe neck swelling with airway obstruction due to angioedema. Read More

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December 2020

Life-threatening airway obstruction caused by angioedema in a morbidly obese postoperative patient: a case report.

JA Clin Rep 2021 Jan 4;7(1). Epub 2021 Jan 4.

Division of Intensive Care and Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Background: We report a case of a morbidly obese patient who developed life-threatening airway obstruction due to angioedema.

Case Presentation: A 50-year-old Japanese morbidly obese female was treated with enalapril for 10 years, with no history of angioedema. After 3 h of completion of breast cancer resection under general anesthesia with tracheal intubation, she developed airway obstruction and respiratory arrest. Read More

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January 2021

Paliperidone palmitate-induced facial angioedema: A case report.

World J Clin Cases 2020 Oct;8(20):4876-4882

Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Background: Paliperidone palmitate is a once-monthly injectable, atypical antipsychotic. To our knowledge, there has been only one report of paliperidone palmitate-induced angioedema presenting with acute laryngeal edema with subsequent respiratory arrest. Here, we present a case report of paliperidone palmitate-induced angioedema with a relatively mild clinical presentation compared with the previously reported case, and the patient's condition was not complicated by life-threatening anaphylaxis. Read More

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October 2020

Hereditary angioedema: On-demand treatment of angioedema attacks.

Allergy Asthma Proc 2020 11;41(Suppl 1):S26-S29

From the University of California San Diego, La Jolla, California; and.

The availability of effective acute treatment for angioedema has been fundamental in reducing the burden of illness for patients with hereditary angioedema (HAE). In building on the foundation of scientific advances that elucidate the pathomechanism(s) of attacks related to vascular permeability, novel targeted on-demand treatments have been developed and approved. These therapies have provided the means to arrest episodes of swelling, which, in the past, had the potential to inexorably lead to morbidity, and even mortality, for patients with HAE. Read More

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November 2020

Infusion-related angioedema associated with infliximab-abda: Case report.

Am J Health Syst Pharm 2021 01;78(2):108-112

Memphis Veterans Affairs Medical Center, Memphis, TN, and College of Medicine, University of Tennessee, Memphis, TN.

Purpose: A case of infusion-related angioedema associated with the use of an infliximab biosimilar (infliximab-abda) is reported in order to bring awareness that this adverse effect is still highly possible in biosimilars, similar to the reference infliximab biologic.

Summary: A 37-year-old white male with a past medical history significant for ileocolonic fistulizing Crohn's disease, depression, and gastroesophageal reflux disease (GERD) presented to an emergency department with shortness of breath, urticaria, and tongue swelling that had developed shortly after initiation of an infusion of infliximab-abda. The patient had no documented allergies at the time of presentation. Read More

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January 2021

Hereditary angioedema: Report of the dental treatment of 12 Brazilian patients.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Dec 9;130(6):651-658. Epub 2020 Sep 9.

Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; Clinical Dentistry Service, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Brazil. Electronic address:

Objective: The aim of this study was to report on clinical experience in Brazil in the dental treatment and the oral conditions of a group of patients with hereditary angioedema (HAE).

Study Design: The study analyzed demographic data, type of HAE, intensity of attacks, long-term and short-term prophylaxis, dental procedures, and occurrence of crises after the procedures were performed. Radiographic evaluation of the number of teeth and bone loss was also performed. Read More

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December 2020

Angioedema and Dual Nurse Flight Crew Cricothyrotomy After Envenomation by a Severed Rattlesnake Head.

Air Med J 2020 Sep - Oct;39(5):417-420. Epub 2020 Jul 10.

Department of Emergency Medicine, University of California Davis Medical Center, Sacramento, CA; Division of Toxicology, University of California Davis Medical Center, Sacramento, CA.

Crotalid envenomation may result in airway compromise from angioedema, anaphylaxis, or an anaphylactoid reaction. A 57-year-old man was transported by helicopter to the emergency department (ED) after a bite to his hand from a severed rattlesnake head. He rapidly developed facial and oropharyngeal edema that did not respond to standard treatment. Read More

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The Interaction of Innate and Adaptive Immunity and Stabilization of Mast Cell Activation in Management of Infusion Related Reactions in Patients with Fabry Disease.

Int J Mol Sci 2020 Sep 29;21(19). Epub 2020 Sep 29.

Translational Research Unit, Lysosomal and Rare Disorders Research and Treatment Center, Fairfax, VA 22030, USA.

Fabry disease (FD) is an X-linked lysosomal disorder caused by mutations in gene resulting in lack of or faulty α-galactosidase A (α-GalA) enzyme. Enzyme replacement therapy (ERT) with recombinant human α-GalA enzyme (agalsidase) is the standard treatment option for FD. Infusion-related reactions (IRRs), with symptoms ranging from rigors, to fever, pain, vomiting, angioedema and diarrhea, are often seen due to immune response against the exogenous enzyme. Read More

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September 2020