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Implementation of the MASK-Air® App for Rhinitis and Asthma in Older Adults: [email protected] Pilot Study.

Int Arch Allergy Immunol 2021 Sep 22:1-6. Epub 2021 Sep 22.

MACVIA-France, Montpellier, France.

Introduction: MASK-air® is an app whose aim is to reduce the global burden of allergic rhinitis and asthma. A transfer of innovative practices was performed to disseminate and implement MASK-air® in European regions. The aim of the study was to examine the implementation of the MASK-air® app in older adults of the Puglia TWINNING in order to investigate (i) the rate of acceptance in this population, (ii) the reasons for refusal and (iii) the evaluation of the app after its use. Read More

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September 2021

Case Report: Perioperative Kounis Syndrome in an Adolescent With Congenital Glaucoma.

Front Cardiovasc Med 2021 10;8:676188. Epub 2021 Sep 10.

Department of Pediatrics, Meyer Children's Hospital, Florence, Italy.

A 12-year-old male patient suffering from congenital glaucoma developed bradycardia, left ventricular failure, and hypotension after induction of anesthesia. Electrocardiography and echocardiography revealed a complete normalization of ECG and a complete spontaneous recovery in the cardiac function 72 hours from the beginning of the clinical manifestations, while cardiac Magnetic Resonance Imaging was performed, and coronary Computed Tomography scan revealed a myocardial bridge of a tract of the left anterior descendent coronary artery. Diagnosis of Kounis syndrome (KS) was made, a relatively novel, under-recognized clinical condition, defined as the manifestation of an acute coronary syndrome accompanied by mast cell activation and platelet aggregation involving interrelated and interacting inflammatory cells in the setting of allergic, hypersensitivity, anaphylactic or anaphylactoid insults. Read More

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September 2021

Anaphylaxis after jellyfish ingestion with no history of stings: a pediatric case report.

Allergy Asthma Clin Immunol 2021 Sep 26;17(1):99. Epub 2021 Sep 26.

Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, 700-8558, Okayama, Japan.

Background: Jellyfish stings are known to induce allergic skin reactions; however, case reports of anaphylaxis after jellyfish ingestion have been increasing, especially in Asian countries. Some cases of anaphylaxis after jellyfish ingestion have been reported in patients with a previous history of frequent jellyfish stings. Herein, we report a pediatric patient with anaphylaxis after jellyfish ingestion with no history of jellyfish stings. Read More

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September 2021

Perceptions of adolescents and young adults with allergy and/or asthma and their parents on EAACI guideline recommendations about transitional care: A European survey.

Allergy 2021 Sep 26. Epub 2021 Sep 26.

Faculty of Medicine, University of Southampton, Southampton, UK.

Background: The European Academy of Allergy and Clinical Immunology has developed a guideline to provide evidence-based recommendations for healthcare professionals to support the transitional care of adolescents and young adults (AYA) with allergy and/or asthma. The goal of this work was to ensure that the draft recommendations are also important for patients.

Methods: We surveyed patients aged 11-25 years with allergy and/or asthma and their parents across Europe between 17th February and 16th March 2020. Read More

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September 2021

Relationships between Long-Term Ozone Exposure and Allergic Rhinitis and Bronchitic Symptoms in Chinese Children.

Toxics 2021 Sep 14;9(9). Epub 2021 Sep 14.

Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.

Numerous studies have demonstrated that exposure to ambient ozone (O) could have adverse effects on children's respiratory health. However, previous studies mainly focused on asthma and wheezing. Evidence for allergic rhinitis and bronchitic symptoms (e. Read More

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September 2021

Formulation and assessment of hydroxyzine HCL solid lipid nanoparticles by dual emulsification technique for transdermal delivery.

Biomed Pharmacother 2021 Sep 21;143:112130. Epub 2021 Sep 21.

Department of Pharmaceutics, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt. Electronic address:

Hydroxyzine HCL (HHCL) is an antihistamine, used for the treatment of allergic skin conditions. The purpose of this study was to achieve a dual phase drug delivery rate across the intact skin, to enhance HHCL permeation through the stratum corneum, to assess the peripheral H-antihistaminic activity and the extent to which HHCL was systemically absorbed from transdermal gel loaded with solid lipid nanoparticles (SLNs), as well as to avoid its extreme bitterness. According to 2 factorial design, eight formulations of HHCL-SLNs were prepared by the double emulsification method. Read More

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September 2021

Immunoregulatory T cell epitope peptides for the treatment of allergic disease.

Immunotherapy 2021 Sep 24. Epub 2021 Sep 24.

Department of Medicine, Queen's University, Kingston, K7L 3N6 ON, Canada.

Allergic diseases are type 2 inflammatory reactions with an increasing worldwide prevalence, making the search for new therapeutic options pertinent. Allergen immunotherapy is the only disease-modifying approach for allergic rhinitis, though it can result in systemic reactions. Recently, peptide immunotherapy (PIT), involving T cell epitope peptides that bind to major histocompatibility complexes, have been developed. Read More

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September 2021

COVID vaccination and asthma exacerbation: might there be a link?

Int J Infect Dis 2021 Sep 18. Epub 2021 Sep 18.

Infectious Diseases I Unit, I.R.C.C.S. Policlinico San Matteo Foundation, Pavia; Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia.

Introduction: There is an ongoing debate as to the role of acute SARS-CoV-2 infection on asthma exacerbation, and its long-term impact on the lung function of individuals with asthma. In contrast, the potential impact of COVID -19 vaccination on asthma is entirely unexplored.

Case Study: We are shedding light on this critical topic by examining a challenging case of severe asthma exacerbation that a 28-year-old female patient developed after receiving two doses of mRNA-based vaccine BNT162b2 (Pfizer-BioNTech) at our Hospital, IRCCS Policlinico San Matteo of Pavia, in Northern Italy. Read More

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September 2021

Pediatric allergic fungal rhinosinusitis: optimizing outcomes.

Curr Opin Otolaryngol Head Neck Surg 2021 Sep 20. Epub 2021 Sep 20.

Department of Surgery-Otorhinolaryngology Head and Neck Surgery, Central Adelaide Local Health Network and the Department of Surgery, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Purpose Of Review: Allergic fungal rhinosinusitis (AFRS) is a debilitating condition for children. Despite there being several reviews on this topic in the adult population, there is a paucity of reviews of AFRS in the pediatric literature. This article reviews the recent evidence of pediatric AFRS with the aim to optimize outcomes of pediatric patients with this condition. Read More

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September 2021

Different Phenotypes in Asthma: Clinical Findings and Experimental Animal Models.

Clin Rev Allergy Immunol 2021 Sep 20. Epub 2021 Sep 20.

Department of Biosciences, Federal University of São Paulo, Campus Baixada Santista, Santos, SP, Brazil.

Asthma is a respiratory allergic disease presenting a high prevalence worldwide, and it is responsible for several complications throughout life, including death. Fortunately, asthma is no longer recognized as a unique manifestation but as a very heterogenic manifestation. Its phenotypes and endotypes are known, respectively, as pathologic and molecular features that might not be directly associated with each other. Read More

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September 2021

COVID-19 vaccines: Current evidence and considerations.

Metabol Open 2021 Dec 11;12:100124. Epub 2021 Sep 11.

School of Nursing and Allied Medical Sciences, Maragheh University of Medical Sciences, Maragheh, Iran.

The coronavirus disease 2019 (COVID-19) pandemic is a global crisis, with devastating health, business and social impacts. Vaccination is a safe, simple, and effective way of protecting a person against COVID-19. By the end of August 2021, only 24. Read More

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December 2021

Evaluation of the tolerability and effectiveness of Tenecteplase in patients with ST-Segment-Elevation Myocardial Infarction in a Secondary Hospital in Malaysia: A Retrospective Case Series.

Curr Ther Res Clin Exp 2021 21;95:100641. Epub 2021 Aug 21.

Clinical Research Centre, Hospital Taiping, Ministry of Health Malaysia, Perak, Malaysia.

Background: In Malaysia, knowledge regarding the clinical efficacy of tenecteplase (TNK), a fibrin-specific tissue-plasminogen activator, is limited.

Objectives: To evaluate the effectiveness and tolerability of TNK in patients with ST-segment-elevation myocardial infarction in a secondary referral Malaysian hospital.

Methods: This was a single-center retrospective case series based on the medical records of patients with ST-segment-elevation myocardial infarction admitted to the cardiac care unit between January 2016 and May 2019. Read More

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Targeting the human β receptor inhibits contact dermatitis in a transgenic mouse model.

J Invest Dermatol 2021 Sep 16. Epub 2021 Sep 16.

Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.

Allergic contact dermatitis (ACD) is a prevalent and poorly controlled inflammatory disease caused by skin infiltration of T cells and granulocytes. The β cytokines GM-CSF, IL-3 and IL-5 are powerful regulators of granulocyte function that signal through their common receptor subunit β, a property that has made β an attractive target to simultaneously inhibit these cytokines. However, the species specificity of β has precluded testing of inhibitors of human β in mouse models. Read More

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September 2021

The International EAACI/GA²LEN/EuroGuiDerm/APAAACI Guideline for the Definition, Classification, Diagnosis and Management of Urticaria.

Allergy 2021 Sep 18. Epub 2021 Sep 18.

Centre Hospitalier Université Laval/Centre Hospitalier Universitaire de Québec, Service d'allergie, Québec, QC, Canada.

This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA²LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), the European Dermatology Forum (EDF; EuroGuiDerm), and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology with the participation of 64 delegates of 50 national and international societies and from 31 countries. The consensus conference was held on 3 December 2020. Read More

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September 2021

A new method for investigating microbiota-produced small molecules in adenomatous polyps.

Anal Chim Acta 2021 Sep 7;1179:338841. Epub 2021 Jul 7.

Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy; Center for Translational Research on Autoimmune and Allergic Diseases, University of Piemonte Orientale, Novara, Italy. Electronic address:

The intestinal microbiota is composed of a large number of different bacteria that produce a variety of metabolites. Colorectal cancer, which typically develops from adenomatous polyps, is highly influenced by microbiota. Since a variety of molecular changes may occur as these polyps transform from benign tumor to malignant carcinoma, the ability to study the microbiota-produced metabolites can lead to new discoveries about the development and progression of this cancer. Read More

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September 2021

The effect of face mask usage on the allergic rhinitis symptoms in patients with pollen allergy during the covid-19 pandemic.

Am J Otolaryngol 2021 Sep 10;43(1):103206. Epub 2021 Sep 10.

Department of Otorhinolaryngology-Head and Neck Surgery, Pamukkale University School of Medicine, Denizli, Turkey.

Purpose: The study aims to evaluate the use of face masks on allergic rhinitis symptoms in pollen allergy patients who were compulsorily using face masks due to the covid-19 pandemic.

Materials And Methods: A 15-item questionnaire was developed following the study goals by a team experienced in allergic rhinitis. Then the records of patients who underwent allergy tests in our hospital between 2013 and 2019 were retrospectively analyzed. Read More

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September 2021

A meta-analysis on allergen-specific immunotherapy using MCT (MicroCrystalline Tyrosine)-adsorbed allergoids in pollen allergic patients suffering from allergic rhinoconjunctivitis.

Clin Transl Allergy 2021 Jun;11(4):e12037

ClinCompetence Cologne GmbH, Cologne, Germany.

Background: The World Allergy Organization and the European Academy of Allergy and Clinical Immunology recommend to perform product-specific meta-analyses for allergen-specific immunotherapies because of the high degree of heterogeneity between individual products. This meta-analysis evaluates the efficacy and safety of Glutaraldehyde-modified and MCT (MicroCrystalline Tyrosine)-adsorbed allergoids (MATA).

Methods: The databases MEDLINE, LILACS, embase, LIVIVO, Web of Science and Google (Scholar) were searched for publications on MATA up to June 2019. Read More

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Rapid response to leptin therapy in a FPLD patient with a novel PPARG missense variant.

Endocrinol Diabetes Metab Case Rep 2021 Sep 1;2021. Epub 2021 Sep 1.

Institute of Diabetes and Clinical Metabolic Research, Kiel, Germany.

Summary: Familial partial lipodystrophy (FPLD) syndromes are rare heterogeneous disorders especially in women characterized by selective loss of adipose tissue, reduced leptin levels and severe metabolic abnormalities. Here we report a 34-year-old female with a novel heterozygotic c.485 thymine>guanine (T>G) missense variant (p. Read More

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September 2021

Atopy: A Collection of Comorbid Conditions.

J Allergy Clin Immunol Pract 2021 Sep 9. Epub 2021 Sep 9.

Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Morsani College of Medicine and the James A. Haley Veterans' Hospital, Tampa, Fla.

The concept of atopy was initially developed in the first quarter of the 20th century on the basis of clinical observations without any knowledge of pathogenic mechanisms. Atopy involves a collection of comorbidities that share pathogenic features, and atopic comorbidities affect outcomes of concomitant conditions rather than existing synchronously. The clinical importance of understanding the relationship of these conditions is necessary because the treatment of one condition influences the others, and the development of one leads to or precedes the development of another. Read More

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September 2021

In chemico sequential testing strategy for assessing the photoallegic potential.

Toxicol In Vitro 2021 Sep 9;77:105245. Epub 2021 Sep 9.

Shiseido Global Innovation Center, 1-2-11, Takashima, Nishi-ku, Yokohama, Kanagawa 220-0011, Japan.

Several non-animal testing methods to assess photoallergic potential have been developed so far, while none of them have yet to be validated and regulatory accepted. Currently, some photoreactivity assays such as UV-VIS spectral analysis and ROS assay are generally used for initial photosafety assessments because of their high sensitivity. However, they have a low specificity, generating a high percentage of false positive results, and the development of a follow-up assessment method is desired. Read More

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September 2021

Evaluation of Risk Scores to Predict Pediatric Severe Asthma Exacerbations.

J Allergy Clin Immunol Pract 2021 Sep 8. Epub 2021 Sep 8.

Division of Pulmonary and Sleep Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:

Background: Asthma exacerbations commonly lead to unplanned health care utilization and are costly. Early identification of children at increased risk of asthma exacerbations would allow a proactive management approach.

Objective: We evaluated common asthma risk factors to predict the probability of exacerbation for individual children aged 0-21 years using data from the electronic medical record (EMR). Read More

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September 2021

Management of dupilumab-associated ocular surface diseases in atopic dermatitis patients.

Swiss Med Wkly 2021 Aug 20;151(33-34). Epub 2021 Aug 20.

Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Switzerland.

Atopic dermatitis is a chronic inflammatory skin disease characterised by eczematous skin lesions and intense pruritus. It is often associated with other atopic diseases such as allergic rhinitis and conjunctivitis, bronchial asthma and eosinophilic oesophagitis. Dupilumab is the first biologic approved for the treatment of moderate-to-severe atopic dermatitis in Switzerland. Read More

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Quality of life for children with allergic skin diseases.

Curr Pediatr Rev 2021 Sep 1. Epub 2021 Sep 1.

Department of Pediatrics, The University of Calgary, The Alberta Children's Hospital, Calgary, Alberta. Canada.

Allergic skin diseases are highly prevalent among children. Patients with allergic skin diseases experience sociopsychological and quality-of-life (QoL) burdens in excess of those in the general population. Children and their caregivers are especially vulnerable to the burden of many of the common allergic skin diseases. Read More

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September 2021

Achieving Precision Medicine in Allergic Disease: Progress and Challenges.

Front Immunol 2021 18;12:720746. Epub 2021 Aug 18.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Allergic diseases (atopic dermatitis, food allergy, eosinophilic esophagitis, asthma and allergic rhinitis), perhaps more than many other traditionally grouped disorders, share several overlapping inflammatory pathways and risk factors, though we are still beginning to understand how the relevant patient and environmental factors uniquely shape each disease. Precision medicine is the concept of applying multiple levels of patient-specific data to tailor diagnoses and available treatments to the individual; ideally, a patient receives the right intervention at the right time, in order to maximize effectiveness but minimize morbidity, mortality and cost. While precision medicine in allergy is in its infancy, the recent success of biologics, development of tools focused on large data set integration and improved sampling methods are encouraging and demonstrates the utility of refining our understanding of allergic endotypes to improve therapies. Read More

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Impact of mental health on disease activity in mastocytosis during COVID-19 pandemic.

Allergol Int 2021 Aug 9. Epub 2021 Aug 9.

Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address:

Background: Mast cell-related symptoms might be influenced by mental health status in mastocytosis. In this study, we aimed to investigate the influence of mental health problems developed during the COVID-19 pandemic on the course of mastocytosis.

Methods: Mental health status in 60 adult patients with mastocytosis was prospectively evaluated with the total Depression-Anxiety-Stress Scale (tDASS-21) and Fear of COVID-19 Scale (FCV-19S) in the lockdown period (LP) and the return to normal period (RTNP) during the pandemic. Read More

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The association between maternal urinary phthalate metabolites concentrations and pregnancy induced hypertension: Results from the EDEN Mother-Child Cohort.

J Gynecol Obstet Hum Reprod 2021 Sep 2;50(10):102216. Epub 2021 Sep 2.

L'Institut Desbrest d'Épidémiologie et de Santé Publique (IDESP), INSERM & University of Montpellier, IURC, 641, Avenue du Doyen Gaston Giraud, 34093, Montpellier, France.

Background: Studies have suggested that exposure to endocrine disruptors such as phthalates that are widely used in our daily life (food wrapping, cosmetics, toys, medical devices, polyvinyl chloride flooring, and building materials) might be related to raised blood pressure and increased risk of cardiovascular diseases. Phthalates might induce a pro-inflammatory response and increased oxidative stress and may be a cause of pregnancy induced hypertension.

Methods: We evaluated the association between maternal exposure to phthalates during pregnancy and pregnancy induced hypertension. Read More

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September 2021

Fabrication of pure-drug microneedles for delivery of montelukast sodium.

Drug Deliv Transl Res 2021 Sep 3. Epub 2021 Sep 3.

School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

Dissolving microneedle (MN) patches are usually formulated with a blend of drug and excipients added for mechanical strength and drug stabilization. In this study, we developed MNs made of pure drug to maximize drug loading capacity. MN patches were fabricated for transdermal delivery of montelukast sodium (MS) which is used to treat asthma and allergic rhinitis. Read More

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September 2021

Drug interactions in HIV-infected children undergoing treatment with antiretrovirals.

Andes Pediatr 2021 Jun;92(3):446-454

Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Introduction: Drug interactions are undesirable events observed in clinical practice. In patients with HIV infection on antiretroviral therapy (ART), it is particularly important to bear in mind that many drugs com monly used in pediatrics can cause such interactions.

Objective: to report a case of drug interaction between an antiretroviral drug (lopinavir/ritonavir) and inhaled corticosteroid in a child with HIV infection, and to review more frequent drug interactions in children on ART. Read More

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Laboratory screening test with inhalant and food allergens in atopic Brazilian children and adolescents: a performance.

Allergol Immunopathol (Madr) 2021 1;49(5):42-48. Epub 2021 Sep 1.

Pediatrics Department, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, São Paulo, Brazil.

The Phadiatop Infant (PhInf) is a panel developed to assess allergic sensitization (immunoglobulin E [IgE]) in children aged <5 years and combines inhalant and food allergens. The test has not been evaluated outside Europe. This is a cross-sectional study conducted at 11 pediatric allergy centers to evaluate PhInf as an allergic disease screening method in Brazilian children. Read More

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September 2021

Fish allergy tolerance 16 months after diagnosis.

Allergol Immunopathol (Madr) 2021 1;49(5):25-27. Epub 2021 Sep 1.

Department of Allergy, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.

Fish allergy is generally thought to be persistent, and approximately 80% of patients with fish allergies do not develop tolerance even 10 years after diagnosis. There have been no reports of rapid tolerance development in patients with severe fish allergies. We report the development of tolerance 16 months after the diagnosis of fish allergies. Read More

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September 2021