1,073 results match your criteria develop hospital-based

Hepatitis B vaccination in Indian children: Seroprotection and age-related change in antibody titres.

Med J Armed Forces India 2021 Apr 6;77(2):200-204. Epub 2020 Nov 6.

Professor, Dept of Community Medicine, Armed Forces Medical College, Pune, India.

Background: Childhood immunization against hepatitis B is one of the most effective strategies for reducing the global burden of chronic hepatitis B infection and its sequelae. There are limited data from India on both the anti-Hep B antibody titres in children after vaccination and the age-related decline in the titres. This study was planned to estimate the proportion of children in the age group of 1-10 years who develop protective levels of anti-hepatitis B antibodies after childhood vaccination and to examine the change in antibody titres with age in these children. Read More

View Article and Full-Text PDF

The Neurological Study Unit: "A Combined Attack on a Single Problem from Many Angles".

Elan D Louis

Can Bull Med Hist 2021 Apr 5:e463082020. Epub 2021 Apr 5.

Elan Louis - Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, United States.

In the 1920s, neurology was a fledgling discipline. Various attempts were made to establish programs relating to neurological care and research. One such initiative was the Neurological Study Unit (NSU) at the Yale School of Medicine. Read More

View Article and Full-Text PDF

[Risk scoring systems for assessment of patients with upper gastrointestinal bleeding].

Ugeskr Laeger 2021 Mar;183(12)

Many scoring systems have been developed to predict various outcomes in patients with upper gastrointestinal bleeding (UGIB) including need-for-intervention, endoscopy, transfusion and/or death. This review summarises the present knowledge of the various scoring systems. It has been impossible to develop one score to predict all outcomes of interest. Read More

View Article and Full-Text PDF

A novel osimertinib-resistant human lung adenocarcinoma cell line harbouring mutant EGFR and activated IGF1R.

Jpn J Clin Oncol 2021 Apr 7. Epub 2021 Apr 7.

Allergy and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.

Objective: A third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), osimertinib, is the standard treatment for patients with non-small cell lung cancer harbouring mutant EGFR. Unfortunately, these patients inevitably acquire resistance to EGFR-TKI therapies, including osimertinib. However, the mechanism associated with this resistance remains unclear. Read More

View Article and Full-Text PDF

The Limitless Future of RNA Therapeutics.

Front Bioeng Biotechnol 2021 18;9:628137. Epub 2021 Mar 18.

RNA Therapeutics Program, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, United States.

Recent advances in the generation, purification and cellular delivery of RNA have enabled development of RNA-based therapeutics for a broad array of applications. RNA therapeutics comprise a rapidly expanding category of drugs that will change the standard of care for many diseases and actualize personalized medicine. These drugs are cost effective, relatively simple to manufacture, and can target previously undruggable pathways. Read More

View Article and Full-Text PDF

Individualized Prediction of Breast Cancer Survival Using Flexible Parametric Survival Modeling: Analysis of a Hospital-Based National Clinical Cancer Registry.

Cancers (Basel) 2021 Mar 29;13(7). Epub 2021 Mar 29.

Division of Vascular and Endovascular Surgery, Department of Surgery, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand.

Prognostic models for breast cancer developed from Western countries performed less accurately in the Asian population. We aimed to develop a survival prediction model for overall survival (OS) and disease-free survival (DFS) for Thai patients with breast cancer. We conducted a prognostic model research using a multicenter hospital-based cancer clinical registry from the Network of National Cancer Institutes of Thailand. Read More

View Article and Full-Text PDF

Coronavirus disease 2019 (COVID-19) and QTc prolongation.

BMC Cardiovasc Disord 2021 03 30;21(1):158. Epub 2021 Mar 30.

Department of Cardiovascular Medicine and Interventional Cardiology, Promedica Toledo Hospital, 2109 Hughes Dr, Jobst Tower 3rd, Floor, Toledo, OH, 43606, USA.

Introduction: The cause-and-effect relationship of QTc prolongation in Coronavirus disease 2019 (COVID-19) patients has not been studied well.

Objective: We attempt to better understand the relationship of QTc prolongation in COVID-19 patients in this study.

Methods: This is a retrospective, hospital-based, observational study. Read More

View Article and Full-Text PDF

Digital readiness in 3D bioprinting: software, governance and hospitals' proto-clinical interfaces.

Regen Med 2021 Mar 24;16(3):237-252. Epub 2021 Mar 24.

School of Law, Politics & Sociology, University of Sussex, Falmer, Brighton BN1 9SJ, UK.

To understand the process through which some hospitals have become ready to assimilate the digital technologies required for 3D bioprinting. By enhancing their digital readiness, hospitals will be able to develop the current proto-clinical potentialities of bioprinting. We conducted interviews with bioprinting researchers, entrepreneurs and regulators in three countries (United Kingdom, Italy and Brazil). Read More

View Article and Full-Text PDF

A multi-dimensional EBP educational program to improve evidence-based practice and critical thinking of hospital-based nurses: Development, implementation, and preliminary outcomes.

Nurse Educ Pract 2020 Dec 31;52:102964. Epub 2020 Dec 31.

Guangzhou Women and Children's Medical Center, China.

Improving outcomes and quality of care through evidence-based practice (EBP) is a priority globally. But most nurses have insufficient competence in EBP. How to conduct Educational interventions to enhance clinical nurses' EBP competencies and critical thinking disposition (CTD) requires more evidence. Read More

View Article and Full-Text PDF
December 2020

Anti-tumor necrosis factor-induced lupus in patients with inflammatory bowel disease: a hospital-based cohort study from Korea.

Therap Adv Gastroenterol 2021 3;14:1756284821997794. Epub 2021 Mar 3.

Department of Rheumatology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.

Background: Anti-tumor necrosis factor (TNF) agents are increasingly used for rheumatic diseases and inflammatory bowel disease (IBD), but are associated with the development of anti-TNF-induced lupus (ATIL). Nonetheless, few ATIL studies on non-Caucasian IBD patients exist. Here, we investigated the incidence, clinical features, and risk factors of ATIL in Korea. Read More

View Article and Full-Text PDF

Antimicrobial Resistance among Pregnant Women with Urinary Tract Infections Attending Antenatal Clinic at Levy Mwanawasa University Teaching Hospital (LMUTH), Lusaka, Zambia.

Int J Microbiol 2021 4;2021:8884297. Epub 2021 Mar 4.

School of Public Health, Department of Epidemiology and Biostatistics, University of Zambia, Lusaka, Zambia.

Introduction: Globally, there is a growing concern over antimicrobial resistance (AMR) which is currently estimated to account for more than 700,000 deaths per year worldwide. AMR undermines the management of infectious diseases in general especially in pregnancy where significant bacteriuria continues to be a serious cause of maternal and perinatal morbidity and mortality. We therefore aimed to determine the prevalence of AMR and the associated factors among pregnant women with urinary tract infections (UTIs) attending antenatal clinic at a selected hospital in Lusaka, Zambia. Read More

View Article and Full-Text PDF

Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.

Jonathan G Best Gareth Ambler Duncan Wilson Keon-Joo Lee Jae-Sung Lim Masayuki Shiozawa Masatoshi Koga Linxin Li Caroline Lovelock Hugues Chabriat Michael Hennerici Yuen Kwun Wong Henry Ka Fung Mak Luis Prats-Sanchez Alejandro Martínez-Domeño Shigeru Inamura Kazuhisa Yoshifuji Ethem Murat Arsava Solveig Horstmann Jan Purrucker Bonnie Yin Ka Lam Adrian Wong Young Dae Kim Tae-Jin Song Robin Lemmens Sebastian Eppinger Thomas Gattringer Ender Uysal Zeynep Tanriverdi Natan M Bornstein Einor Ben Assayag Hen Hallevi Jeremy Molad Masashi Nishihara Jun Tanaka Shelagh B Coutts Alexandros Polymeris Benjamin Wagner David J Seiffge Philippe Lyrer Ale Algra L Jaap Kappelle Rustam Al-Shahi Salman Hans R Jäger Gregory Y H Lip Urs Fischer Marwan El-Koussy Jean-Louis Mas Laurence Legrand Christopher Karayiannis Thanh Phan Sarah Gunkel Nicolas Christ Jill Abrigo Thomas Leung Winnie Chu Francesca Chappell Stephen Makin Derek Hayden David J Williams Werner H Mess Paul J Nederkoorn Carmen Barbato Simone Browning Kim Wiegertjes Anil M Tuladhar Noortje Maaijwee Anne Cristine Guevarra Chathuri Yatawara Anne-Marie Mendyk Christine Delmaire Sebastian Köhler Robert van Oostenbrugge Ying Zhou Chao Xu Saima Hilal Bibek Gyanwali Christopher Chen Min Lou Julie Staals Régis Bordet Nagaendran Kandiah Frank-Erik de Leeuw Robert Simister Jeroen Hendrikse Peter J Kelly Joanna Wardlaw Yannie Soo Felix Fluri Velandai Srikanth David Calvet Simon Jung Vincent I H Kwa Stefan T Engelter Nils Peters Eric E Smith Hideo Hara Yusuke Yakushiji Dilek Necioglu Orken Franz Fazekas Vincent Thijs Ji Hoe Heo Vincent Mok Roland Veltkamp Hakan Ay Toshio Imaizumi Beatriz Gomez-Anson Kui Kai Lau Eric Jouvent Peter M Rothwell Kazunori Toyoda Hee-Joon Bae Joan Marti-Fabregas David J Werring

Lancet Neurol 2021 04 17;20(4):294-303. Epub 2021 Mar 17.

UCL Stroke Research Centre, Department of Brain Repair and Rehabilitation, University College London Queen Square Institute of Neurology, London, UK. Electronic address:

Background: Balancing the risks of recurrent ischaemic stroke and intracranial haemorrhage is important for patients treated with antithrombotic therapy after ischaemic stroke or transient ischaemic attack. However, existing predictive models offer insufficient performance, particularly for assessing the risk of intracranial haemorrhage. We aimed to develop new risk scores incorporating clinical variables and cerebral microbleeds, an MRI biomarker of intracranial haemorrhage and ischaemic stroke risk. Read More

View Article and Full-Text PDF

Prevalence and characteristics of ventricular septal defects in a non-racehorse equine population (2008-2019).

J Vet Intern Med 2021 Mar 20. Epub 2021 Mar 20.

Equine Cardioteam, Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Background: Ventricular septal defects (VSDs) are the most common congenital cardiac defect in horses.

Objectives: To identify prevalence, age, breed, and sex distribution of VSD and to describe associated clinical and ultrasonographic findings.

Animals: Hospital-based population of 21 136 horses presented to the equine internal medicine department. Read More

View Article and Full-Text PDF

Risk Factors of the First-Time Stroke in the Southwest of Saudi Arabia: A Case-Control Study.

Brain Sci 2021 Feb 11;11(2). Epub 2021 Feb 11.

Departments of Family and Community Medicine, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia.

Worldwide, stroke is the second leading cause of death and a frequent cause of permanent disability. The objective was to identify the first-time stroke modifiable risk factors in the Aseer region, southwest Saudi Arabia. In a multicenter hospital-based case-control study design, all first stroke patients admitted to hospitals in the Aseer region were included consecutively over one year. Read More

View Article and Full-Text PDF
February 2021

Methods and Effectiveness of Communication Between Hospital Allied Health and Primary Care Practitioners: A Systematic Narrative Review.

J Multidiscip Healthc 2021 22;14:493-511. Epub 2021 Feb 22.

Department of Occupational Therapy, Social Work and Social Policy, School of Allied Health, La Trobe University, Melbourne, Australia.

Background: There is a compelling rationale that effective communication between hospital allied health and primary care practitioners may improve the quality and continuity of patient care. It is not known which methods of communication to use, nor how effectively they facilitate the transition of care when a patient is discharged home from hospital. Our systematic review aims to investigate the methods and effectiveness of communication between hospital allied health and primary care practitioners. Read More

View Article and Full-Text PDF
February 2021

Rapid Design and Delivery of an Experience-Based Co-designed Mobile App to Support the Mental Health Needs of Health Care Workers Affected by the COVID-19 Pandemic: Impact Evaluation Protocol.

JMIR Res Protoc 2021 Mar 9;10(3):e26168. Epub 2021 Mar 9.

Department of Medicine, The University of Melbourne, Parkville, Australia.

Background: The COVID-19 pandemic has highlighted the importance of health care workers' mental health and well-being for the successful function of the health care system. Few targeted digital tools exist to support the mental health of hospital-based health care workers, and none of them appear to have been led and co-designed by health care workers.

Objective: RMHive is being led and developed by health care workers using experience-based co-design (EBCD) processes as a mobile app to support the mental health challenges posed by the COVID-19 pandemic to health care workers. Read More

View Article and Full-Text PDF

Austerity, resilience and the management of actors in public hospitals: a qualitative study from South Africa.

BMJ Glob Health 2021 Feb;6(2)

Centre for Health Policy, University of the Witwatersrand School of Public Health, Johannesburg, Gauteng, South Africa.

Background: Global economic recession coupled with internal inefficiencies and corruption has led to a period of austerity in the South African healthcare system.This paper examines the strategies used by management in response to austerity in the three public hospitals and their effect on organisational functioning.

Methods: We used a comparative qualitative case study approach, collecting data using a combination of in-depth interviews with managers, and focus group discussion and interviews with shop stewards and staff. Read More

View Article and Full-Text PDF
February 2021

Atopy and Lifestyle Survey of Allergic Patients From Urban Environment in Romania: Preliminary Data From an Interactive Qualifying Project.

Cureus 2021 Jan 15;13(1):e12714. Epub 2021 Jan 15.

Computer Science, Worcester Polytechnic Institute, Worcester, USA.

Introduction Respiratory allergies represent an important public health problem, with increasing prevalence and severity in Europe during the last decades. The rise of pollen allergies is an issue that continues to negatively impact people's daily lives across the globe and has become more important in the light of global warming and increasing air pollution. The aim of our paper is to evaluate the prevalence of declared atopy and the influence of lifestyle on allergic diseases, particularly on pollen allergies, in the urban environment from Romania. Read More

View Article and Full-Text PDF
January 2021

Necessity is the mother of invention: how the COVID-19 pandemic could change medical student placements for the better.

Postgrad Med J 2021 Feb 16. Epub 2021 Feb 16.

Infectious and tropical diseases, Hospital for Tropical Diseases, University College London Hospitals, London, UK.

COVID-19 led to the widespread withdrawal of face-to-face hospital-based clinical placements, with many medical schools switching to online learning. This precipitated concern about potential negative impact on clinical and interprofessional skill acquisition. To overcome this problem, we piloted a 12-week COVID-19 safe face-to-face clinical placement for 16 medical students at the Hospital for Tropical Diseases, London, during the first wave of the COVID-19 pandemic. Read More

View Article and Full-Text PDF
February 2021

COVID-19 Personal Protective Equipment in the Home: Navigating the Complexity of Donning and Doffing.

Ann Fam Med 2021 Feb 15. Epub 2021 Feb 15.

Division of Palliative Care, Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada

Purpose: The safety of care professionals and patients is paramount while caring for people with infectious diseases, including those with confirmed or suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19). Existing policies and protocols for donning and doffing personal protective equipment (PPE) are primarily for institutional settings such as hospitals, not for home visits for patient care. We describe a protocol for donning and doffing PPE in home settings. Read More

View Article and Full-Text PDF
February 2021

Transcriptomic analysis of endometrial receptivity for a genomic diagnostics model of Chinese women.

Fertil Steril 2021 Feb 12. Epub 2021 Feb 12.

Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People's Republic of China; Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People's Republic of China. Electronic address:

Objective: To define the transcriptomic signature with respect to human endometrial receptivity in Chinese women by next-generation sequencing and to develop a more refined and customized bioinformatic predictive method for endometrial dating in Chinese women.

Design: Randomized.

Setting: A tertiary hospital-based reproductive medicine center. Read More

View Article and Full-Text PDF
February 2021

Comparative study of emphysematous pyelonephritis and pyelonephritis in type 2 diabetes: a single-centre experience.

J Diabetes Metab Disord 2020 Dec 28;19(2):1273-1282. Epub 2020 Sep 28.

Department of Microbiology, Govt. Medical College, Srinagar, J&K India.

Purpose: Emphysematous pyelonephritis (EPN) patients with type 2 diabetes (T2D) have severe complications and high morbidity with poor prognosis as compared to Pyelonephritis. The aim was to study clinical features, microbiological profile, complications of EPN and pyelonephritis in T2D patients.

Methods: This was a hospital-based prospective study done on 200 T2D patients with upper UTI. Read More

View Article and Full-Text PDF
December 2020

Knowledge, Attitude and Practice on Hospital-Acquired Infection Prevention and Associated Factors Among Healthcare Workers at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

Infect Drug Resist 2021 27;14:259-266. Epub 2021 Jan 27.

Department of Immunology and Molecular Biology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Hospital-acquired infections can be acquired by a patient or develop among hospital staff, as a more serious problem in low- and middle-income hospital settings. Assessing the level of knowledge, attitude and practice towards hospital-acquired infection prevention among healthcare workers and identifying the associated factors has an unquestionable importance of handling and management of these infections. Thus, in this study, we evaluated the knowledge, attitude and practice towards HAIs prevention and associated factors in healthcare workers at the University of Gondar Comprehensive Specialized Hospital, North West Ethiopia. Read More

View Article and Full-Text PDF
January 2021

Increasing Parent Satisfaction With Discharge Planning: An Improvement Project Using Technology in a Level 3 NICU.

Adv Neonatal Care 2021 Feb 4. Epub 2021 Feb 4.

Division of Neonatal & Developmental Medicine, Stanford University, Palo Alto, California (Drs Balasundaram, Miller, Sivakumar, and McCallie); and Neonatal Intensive Care Unit, El Camino Hospital, Mountain View, California (Drs Balasundaram, Miller, Sivakumar, and McCallie and Mss Porter and Fleming).

Background: Neonatal intensive care unit (NICU) families are often overwhelmed by the discharge process. Their anxiety can inhibit learning and contribute to poor infant outcomes and increased healthcare utilization after discharge. Quality of the discharge teaching is the strongest predictor of discharge readiness, so NICUs must develop excellent discharge preparation programs. Read More

View Article and Full-Text PDF
February 2021

Practice patterns in the management of congestive heart failure and post-discharge quality of life: A hospital-based cross-sectional study.

J Family Med Prim Care 2020 Nov 30;9(11):5592-5596. Epub 2020 Nov 30.

Department of Internal Medicine, All India Institute of Medical Sciences (AIIMS), Bhopal, Madhya Pradesh, India.

Objective: The objective of the study is to identify the etiology, risk factors, frequency of major and minor components of the Framingham criteria for heart failure, discharge medications, mortality, and quality of life after discharge from the hospital, for patients who were admitted to the in-patient unit of a tertiary care hospital in central India, with a diagnosis of congestive heart failure (CHF).

Methods: This hospital-based cross-sectional study involved retrospective chart review of patients who were admitted to the in-patient unit with a diagnosis of CHF. These patients were then attempted to reach via their telephone numbers listed in the medical records and their current quality of life was assessed using Euro-QoL 5D questionnaire. Read More

View Article and Full-Text PDF
November 2020

Maternal and perinatal Health Research Collaboration, India (MaatHRI): methodology for establishing a hospital-based research platform in a low and middle income country setting.

F1000Res 2020 7;9:683. Epub 2020 Jul 7.

National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Headington, Oxford, Oxfordshire, OX3 7LF, UK.

Maternal and perinatal Health Research collaboration, India (MaatHRI) is a research platform that aims to improve evidence-based pregnancy care and outcomes for mothers and babies in India, a country with the second highest burden of maternal and perinatal deaths. The objective of this paper is to describe the methods used to establish and standardise the platform and the results of the process. MaatHRI is a hospital-based collaborative research platform. Read More

View Article and Full-Text PDF

Risk factors and prognosis of adult-onset post-pump chorea.

J Neurol Sci 2021 Mar 23;422:117328. Epub 2021 Jan 23.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea; Neuroscience Center, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea. Electronic address:

Objectives: Post-pump chorea (PPC), defined as the development of chorea after major cardiac surgery utilizing cardiopulmonary bypass (CPB), has been rarely reported in adults.

Methods: We compared 17 patients with adult-onset PPC to controls who did not develop chorea after cardiac surgery with CPB. Two patients were enrolled using hospital based data and 15 were collected by a systematic literature review. Read More

View Article and Full-Text PDF

Occupational pesticide exposure increases risk of acute myeloid leukemia: a meta-analysis of case-control studies including 3,955 cases and 9,948 controls.

Sci Rep 2021 Jan 21;11(1):2007. Epub 2021 Jan 21.

Department of Biological Hematology, Tours University Hospital, Tours, France.

The impact of pesticides on health is a major public health concern. A higher risk to develop chronic lymphoid malignancies has been demonstrated to be associated with occupational pesticide exposure (OPE). By contrast, little is known of the impact of OPE on the occurrence of myeloid malignancies especially acute myeloid leukemia (AML). Read More

View Article and Full-Text PDF
January 2021