1,320 results match your criteria detrusor instability


Improvements in Bladder Function Following Activity-Based Recovery Training With Epidural Stimulation After Chronic Spinal Cord Injury.

Front Syst Neurosci 2020 5;14:614691. Epub 2021 Jan 5.

Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, United States.

Spinal cord injury (SCI) results in profound neurologic impairment with widespread deficits in sensorimotor and autonomic systems. Voluntary and autonomic control of bladder function is disrupted resulting in possible detrusor overactivity, low compliance, and uncoordinated bladder and external urethral sphincter contractions impairing storage and/or voiding. Conservative treatments managing neurogenic bladder post-injury, such as oral pharmacotherapy and catheterization, are important components of urological surveillance and clinical care. Read More

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January 2021

Overactive bladder syndrome - focus onto detrusor overactivity.

Scand J Urol 2021 Feb 29;55(1):56-60. Epub 2020 Oct 29.

Clinic of Urology/Neuro-Urology, University Clinic Rheinischen Friedrich-Wilhelms Universität Bonn and Neurologisches Rehabilitationszentrum Godeshoehe e.V. Bonn, Bonn, Germany.

Introduction And Hypothesis: To determine in patients with overactive bladder (OAB), urodynamic differences as well to compare the characteristics of patient's, with presence of detrusor overactivity on urodynamics with those with absence of detrusor overactivity.

Methods: Taking into account the urodynamic findings, the patients with OAB symptoms were categorized into one of two groups: group 1 (with detrusor overactivity) or group 2 (without detrusor overactivity), and comparative analyses for both groups were performed (epidemiological data, patient history, urodynamic criteria, bladder diaries, IC-OAB, IC-OABqol - questionnaires).

Results: There was a significant difference in age as well in the disease duration between group 1 and group 2. Read More

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February 2021

Deep brain stimulation effects on lower urinary tract function: Systematic review and meta-analysis.

Parkinsonism Relat Disord 2020 Aug 26;79:65-72. Epub 2020 Aug 26.

Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland. Electronic address:

Introduction: While efficacy of deep brain stimulation for motor symptoms of neurological disorders is well accepted, its effects on the autonomic system remain controversial. We aimed to systematically assess all available evidence of deep brain stimulation effects on lower urinary tract function.

Methods: This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Read More

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Construction and application of urinary system model with functional bladder module.

Authors:
Min Liu Yonghong Su

Saudi J Biol Sci 2019 Dec 16;26(8):2127-2131. Epub 2019 Oct 16.

Department of Urology, Cangzhou Central Hospital, CangZhou 061001, China.

In order to study the construction and application of urinary system model with functional bladder module, bladder model was designed, and appropriate materials was selected to make it, and its performance was studied. The results showed that in the analysis of pressure performance of bladder model, more detrusor instability was found in the model than in the urodynamic test, and there was significant statistical difference (P < 0.01). Read More

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December 2019

Effectiveness and tolerability of mirabegron in children with overactive bladder: A retrospective pilot study.

J Pediatr Surg 2020 Feb 5;55(2):316-318. Epub 2019 Nov 5.

Alder Hey Children's Hospital, Liverpool, United Kingdom. Electronic address:

Aims: Mirabegron has promising results for OAB symptoms in adults, although the potential for cardiovascular side effects has caused concern. Efficacy and tolerability in children have not been extensively studied. Effectiveness, tolerability, and side effects of Mirabegron are reported in children with refractory OAB. Read More

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February 2020

CoQ10 ameliorates monosodium glutamate-induced alteration in detrusor activity and responsiveness in rats via anti-inflammatory, anti-oxidant and channel inhibiting mechanisms.

BMC Urol 2019 Oct 28;19(1):103. Epub 2019 Oct 28.

Clinical Physiology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.

Background: Competent detrusor muscles with coordinated contraction and relaxation are crucial for normal urinary bladder storage and emptying functions. Hence, detrusor instability, and subsequently bladder overactivity, may lead to undesirable outcomes including incontinence. Multiple mechanisms may underlie the pathogenesis of detrusor overactivity including inflammation and oxidative stress. Read More

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October 2019

Impact of Overactive Bladder-Wet Syndrome on Female Sexual Function: A Systematic Review and Meta-Analysis.

Sex Med Rev 2019 10 17;7(4):565-574. Epub 2019 Jul 17.

Department of Obstetrics and Gynecology, University of Insubria, Varese, Italy.

Introduction: Overactive bladder (OAB) is subtyped into OAB-wet and OAB-dry, based on the presence or absence, respectively, of urgency incontinence. Although women with OAB frequently have a higher risk for sexual dysfunction, a systematic review on the impact of OAB-wet on female sexuality is lacking. This may be evaluated by measuring the effect of the bladder condition on sexuality per se, or by the effect of OAB treatment on female sexual dysfunction. Read More

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October 2019

Cure of Underactive and Overactive Bladder Symptoms in Women by 1,671 Apical Sling Operations Gives Fresh Insights into Pathogenesis and Need for Definition Change.

Urol Int 2019 11;103(2):228-234. Epub 2019 Jun 11.

Ozel Odak Hastanesi, Department of Gynecology and Obstetrics, Denizli, Turkey.

Introduction: To check evidence that symptoms identical with those constituting "underactive bladder" (UAB) and "overactive bladder" (OAB) are caused by apical prolapse and cured by repair thereof.

Material And Methods: After repair of apical prolapse by mesh tape reinforcement of lax uterosacral ligaments (USL) data form 1,671 women were retrospectively examined to determine the presence of OAB and UAB symptoms and to check, how many were cured surgically. Thereby 3 different techniques were performed: elevate (n = 277), "Posterior IVS" (n = 1,049), and TFS cardinal (CL)/USL (n = 345). Read More

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February 2020

Urodynamic characteristics of lower urinary tract of patients with idiopathic overactive bladder.

Urol Ann 2019 Jan-Mar;11(1):83-86

Department of Urology and Nephrology, Odessa National Medical University, Odessa, Ukraine.

Aims: The aims of this study were to determine the frequency and clinical significance of individual urodynamic signs, which revealed on the basis of the results of comprehensive urodynamic examination of patients with the idiopathic overactive bladder (IOAB), to produce definitions of these features, and to describe any necessary remedial action.

Materials And Methods: To identify the most common features and artifacts, we conducted a combined urodynamic examination of 137 patients with IOAB (105 women and 32 men). Age, comorbidities, and urodynamic parameters were analyzed to determine the association between bladder sensation and contractility. Read More

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February 2019

Canine Incontinence.

Vet Clin North Am Small Anim Pract 2019 Mar;49(2):125-140

Cummings School of Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, MA 01536, USA. Electronic address:

Incontinence is a frustrating condition for both pet owners and their veterinarians. Fortunately, most causes are easily diagnosed and most dogs respond to appropriate therapy. This article reviews normal urine storage and voiding, causes of incontinence, typical clinical presentation, diagnostics, and treatment. Read More

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Current perspectives on the correlation of nocturnal enuresis with obstructive sleep apnea in children.

World J Pediatr 2019 Apr 16;15(2):109-116. Epub 2018 Nov 16.

Department of Pediatric Respiratory Medicine and Sleep Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.

Background: Obstructive sleep apnea (OSA) and nocturnal enuresis (NE) are common clinical problems in children. OSA and NE are thought to be interrelated, but the exact pathophysiological mechanisms are not yet clear. This review aims to explain the possible pathogenesis of NE in children with OSA. Read More

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[Consequences of prostatic obstruction on bladder function, impact of removal, and management of recurrence after surgery].

Prog Urol 2018 Nov 24;28(15):813-820. Epub 2018 Sep 24.

Service d'urologie, CHU de Limoges, 87042 Limoges, France.

Objective: Our objective was to evaluate bladder outlet obstruction (BOO) consequences on the detrusor activity, to analyze the impact of medical and surgical treatments, and to study the reasons for recurrence of urinary symptoms after surgical treatment.

Method: A non-systematic review of the scientific literature was conducted from the PubMed database to retrieve the most relevant scientific publications between 2000 and July 2018 with the keywords: BPH, bladder obstruction, bladder instability, surgery, and reoperation. A first research was crossed with the results of the reviews of literature already published and was enriched by the contributions of the various authors. Read More

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November 2018

Urogenital symptoms in women with Tarlov cysts.

J Obstet Gynaecol Res 2018 Sep 5;44(9):1817-1823. Epub 2018 Jul 5.

Department of Obstetrics and Gynecology, University of California Davis, Sacramento, California, USA.

Aim: To describe the clinical findings and urogenital symptoms associated with sacral perineural cysts (Tarlov cysts).

Methods: A retrospective chart review including 65 female patients with Tarlov cysts was completed. Clinical findings were collected from a database of subjects seen in our institution's urogynecology and neurosurgery clinics between 2004 and 2015. Read More

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September 2018

[Coital incontinence].

Prog Urol 2018 Sep 1;28(11):515-522. Epub 2018 Jun 1.

Groupe de recherche clinique en neuro-urologie (GREEN), GRC 01, Sorbonne universités, 75006 Paris, France; Service de neuro-urologie et d'explorations périnéales, hôpital Tenon, AP-HP, 75020 Paris, France.

Introduction: Urinary incontinence may seriously impact quality of life, self-image and subsequently the sexual life. Beside this fact, urinary leakage can specifically occur during sexual intercourse, formally named coital incontinence, and thus lead to specific alteration of the sexual life.

Aim: To analyse the prevalence, pathophysiological mechanisms and possible therapeutic options for coital urinary incontinence. Read More

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September 2018

"Bladder Effect" - An Urodynamic Parameter to Distinguish Subtypes of Urinary Incontinence in Women.

Open Access Maced J Med Sci 2018 Apr 14;6(4):648-650. Epub 2018 Apr 14.

University Clinic of Nephrology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: Urinary incontinence (UI) is defined by the International Continence Society (ICS) as the involuntary loss of urine that represents a hygienic or social problem to the individual. The aetiology is multifactorial. The diagnosis of UI is important because it can result in the application of appropriate therapy. Read More

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The value of synchro-cystourethrometry for evaluating the relationship between urethral instability and overactive bladder.

Int Urol Nephrol 2018 Mar 3;50(3):441-449. Epub 2018 Jan 3.

Department of Urology, Pediatric Urodynamic Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Purpose: To investigate the correlation between urethral instability (URI) and overactive bladder (OAB) in children.

Methods: We retrospectively investigated 126 children with OAB and 36 children without OAB using synchro-cystourethrometry. The prevalence of detrusor overactivity (DO) and URI, and the diagnostic sensitivity of DO alone and DO combined with URI, was compared. Read More

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[Analysis of outcomes of tension-free mid-urethral sling procedure in women with mixed urinary incontinence].

Beijing Da Xue Xue Bao Yi Xue Ban 2017 08;49(4):638-642

Department of Urology, Peking University People's Hospital, Beijing 100044, China.

Objective: To evaluate the medium and long term outcomes of tension-free mid-urethral sling in the treatment of female patients with mixed urinary incontinence (MUI).

Methods: Twenty-six patients who underwent the tension-free mid-urethral sling procedure for MUI from April, 2010 to September, 2016, were followed up. Four of the 26 patients underwent retropubic tension free mid-urethral sling (TVT), and 22 of them underwent transurethral middle obturator sling (TOT). Read More

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Is urodynamic evaluation a must in all operated cases of open neural tube defects.

J Pediatr Urol 2017 Dec 20;13(6):614.e1-614.e4. Epub 2017 May 20.

Department of Pediatric Surgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background: Spina bifida is a common cause of pediatric neurogenic bladder. It causes renal failure in almost 100% of patients if the associated detrusor sphincter dyssynergia (DSD) is inadequately managed. Detrusor instability and high detrusor pressures (Figure) have been implicated as the major factors predictive of renal damage in these patients. Read More

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December 2017

The Dome Wall of Bladder Acts as a Pacemaker Site in Detrusor Instability in Rats.

Med Sci Monit 2017 05 21;23:2400-2407. Epub 2017 May 21.

Department of Urology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).

BACKGROUND The aim of this study was to confirm that the interstitial cells of Cajal (ICCs) in the dome wall of the bladder are pacemaker cells, and that the dome wall of the bladder acts as a pacemaker site in the detrusor instability (DI) rat model. MATERIAL AND METHODS The model of DI in Wistar rats was established and urodynamic studies measuring the bladder volume and pressure were performed. The detrusor excitability was investigated using the amplitude and frequency of phasic contraction of strips. Read More

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Associated factors to urinary incontinence in women undergoing urodynamic testing.

Rev Esc Enferm USP 2017 Apr 3;51:e03209. Epub 2017 Apr 3.

Universidade Federal de Mato Grosso do Sul, Três Lagoas, Mato Grosso do Sul, Brazil.

Objective: Analyzing factors associated with urinary incontinence (UI) among women submitted to urodynamic testing.

Method: A cross-sectional study of 150 women attended at a urological center. Data were analyzed using univariate and multivariate statistics. Read More

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Efficacy of Transcutaneous Electrical Nerve Stimulation in the Treatment of Overactive Bladder.

J Clin Diagn Res 2016 Oct 1;10(10):QC17-QC20. Epub 2016 Oct 1.

Head of the Department, Department of Obstetrics and Gynaecology, Saveetha Medical College , Chennai, Tamil Nadu, India .

Introduction: Overactive Bladder (OAB) accounts for 40-70% cases of incontinence. The etiology is unknown though detrusor instability is found in urodynamic evaluation of almost all cases. Detrusor instability or hyperreflexia can be inhibited by direct inhibition of impulses in the pre-ganglionic afferent neuron or by inhibition of bladder pre-ganglionic neurons of the efferent limb of micturition reflex. Read More

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October 2016

Urethral Pressure Variation: A neglected contributing factor in patients with overactive bladder syndrome?

Int Braz J Urol 2017 Mar-Apr;43(2):272-279

Departament of Neuro-urology, University Hospital Friederich Wilhelms, University Bonn, Germany.

Objective: To study urethral pressure variations during the whole filling phase among different groups of patients.

Material And Methods: We investigated 79 consecutive patients from January 2011 to June 2012. All patients were recruited within our routine practice in our continence clinic and were evaluated with urodynamic exam according to the standards of the International Continence Society (ICS) with an additional continuous measurement of the urethral pressure profile (cUPP) that was done in a supine position. Read More

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Ureteral Reflux into an Ectopic Upper Moeity of a Duplex Kidney from the Bladder Neck with Distal Ureteral Pseudodiverticulum Formation.

J Clin Diagn Res 2016 Sep 1;10(9):TD07-TD09. Epub 2016 Sep 1.

Professor, Department of Radiodiagnosis, St Johns Medical College , Bangalore, Karnataka, India .

Urinary incontinence is a condition causing significant psychological trauma and affects the quality of life of the affected individual. Though common causes of urinary incontinence of non-traumatic aetiology in young adults include detrusor instability and congenital conditions like meningomyelocoele, an ectopic ureter is an important surgically correctable cause of urinary incontinence. The cause of incontinence in an ectopic ureter is insertion of the ureter distal to the internal urethral sphincter. Read More

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September 2016

[Expression of Type 3 Acid Sensitive Ion Channels in Bladder of OAB Rat Model].

Sichuan Da Xue Xue Bao Yi Xue Ban 2016 Mar;47(2):174-9

Objective: To investigate the expression of type 3 acid-sensing ion channels (ASIC3) in bladder tissue of over active bladder (OAB) rat model.

Methods: Sixty adult female rats were randomly divided into control group (intraperitoneal injection of 0.9% sodium chloride), GAB group (intraperitoneal injection of cyclophosphamide) and the intervention group (OAB rats treated with ASIC3 inhibitor amiloride). Read More

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Spatiotemporal dynamics of synaptic drive in urinary bladder syncytium: A computational investigation.

Annu Int Conf IEEE Eng Med Biol Soc 2015 Aug;2015:8074-7

The urinary bladder wall is composed of the detrusor smooth muscle (DSM) in which adjacent cells are electrically coupled to form a three dimensional syncytium. The structural complexity of the tissue is further enhanced by a distributed innervation pattern. Experimental techniques employed in order to analyze detrusor excitability have been unable as yet to provide a satisfactory understanding of either the normal electrical functioning of the tissue, or of the changes that come about in pathological conditions. Read More

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Continuous urethral pressure measurements; measurement techniques; pressure variations; clinical interpretations; and clinical relevance. A Systematic Literature Analysis.

Neurourol Urodyn 2017 01 28;36(1):51-56. Epub 2015 Oct 28.

Department of Urology, Stichting MCH-Bronovo, The Hague, The Netherlands.

Aims: The clinical relevance of urethral pressure variations (UPV) in the pathophysiology of over active bladder syndrome (OAB) has remained controversial to date. Some studies report an association with OAB and/or detrusor over activity (DO). Recently the International Consultation on Incontinence-Research Society recommended new clinical research to be performed on this subject. Read More

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January 2017

Quantitative Proteomic Analysis of Differentially Expressed Proteins and Downstream Signaling Pathways in Chronic Bladder Ischemia.

J Urol 2016 Feb 28;195(2):515-23. Epub 2015 Sep 28.

Departments of Urology, Surgery, Pathology and Proteomics Laboratory, Veterans Affairs Boston Healthcare System and Boston University School of Medicine, Boston, Massachusetts. Electronic address:

Purpose: Growing evidence suggests that ischemia may contribute to aging associated bladder dysfunction and lower urinary tract symptoms. Our goal was to determine the effects of chronic ischemia on bladder proteomic profiles and characterize downstream signaling pathways.

Materials And Methods: Bilateral iliac artery atherosclerosis and chronic bladder ischemia were created in male Sprague Dawley® rats. Read More

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February 2016

ATP as a cotransmitter in the autonomic nervous system.

Authors:
Charles Kennedy

Auton Neurosci 2015 Sep 25;191:2-15. Epub 2015 Apr 25.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, United Kingdom. Electronic address:

The role of adenosine 5'-triphosphate (ATP) as a major intracellular energy source is well-established. In addition, ATP and related nucleotides have widespread extracellular actions via the ionotropic P2X (ligand-gated cation channels) and metabotropic P2Y (G protein-coupled) receptors. Numerous experimental techniques, including myography, electrophysiology and biochemical measurement of neurotransmitter release, have been used to show that ATP has several major roles as a neurotransmitter in peripheral nerves. Read More

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September 2015

The role of prostanoids in the urinary bladder function and a potential use of prostanoid-targeting pharmacological agents in bladder overactivity treatment.

Acta Pol Pharm 2015 Jan-Feb;72(1):13-9

Overactive bladder (OAB) is a syndrome involving urinary urgency with accompanying increased daytime urinary frequency and nocturia, with or without urgency urinary incontinence, in the absence of an urinary tract infection or other obvious pathology. The detailed OAB pathophysiology remains unclear. There is evidence that OAB pathogenesis also includes abnormal bladder paracrine activity, associated with release of local prostanoids. Read More

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