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The anti-inflammatory effects of an ethanolic extract of the rhizome of Atractylodes lancea, involves Akt/NF-κB signaling pathway inhibition.

J Ethnopharmacol 2021 May 12:114183. Epub 2021 May 12.

Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China; Research and Development Center for Natural Health Products, Shenzhen Institute of Research and Continuing Education, China. Electronic address:

Ethnopharmacological Relevance: The dried rhizome of Atractylodes lancea (Thumb.) DC. (Compositae) has been prescribed in folk medicine for the management of various inflammatory conditions such as rheumatic diseases, gastritis and hepatitis. Read More

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Altered hippocampal kynurenine pathway metabolism contribute to hyperexcitability in human mesial temporal lobe epilepsy-hippocampal sclerosis.

Br J Pharmacol 2021 May 14. Epub 2021 May 14.

Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.

Background And Purpose: Glutamate receptor mediated enhanced excitatory neurotransmission is typically associated with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). Kynurenic acid (KYNA) and quinolinic acid (QUIN) are two important tryptophan-kynurenine pathway (KP) metabolites that modulate glutamate receptor activity. This study was designed to test the hypothesis that alteration in metabolism of KP metabolites in the hippocampus of patients with MTLE-HS contributes to abnormal glutamatergic transmission. Read More

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Single-shot detection of 8 unique monochrome fringe patterns representing 4 distinct directions via multispectral fringe projection profilometry.

Sci Rep 2021 May 14;11(1):10367. Epub 2021 May 14.

Imaging Program, Lawson Health Research Institute, St. Joseph's Health Care, London, ON, N6A 4V2, Canada.

Spatial resolution in three-dimensional fringe projection profilometry is determined in large part by the number and spacing of fringes projected onto an object. Due to the intensity-based nature of fringe projection profilometry, fringe patterns must be generated in succession, which is time-consuming. As a result, the surface features of highly dynamic objects are difficult to measure. Read More

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Circ_CHFR promotes PDGF-BB-induced proliferation, invasion and migration in VSMCs via miR-149-5p/NRP2 axis.

J Cardiovasc Pharmacol 2021 May 10. Epub 2021 May 10.

Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Medical University, Xi'an, 710077, Shaanxi, China Department of General Practice, The First Affiliated Hospital of Xi'an Medical University, Xi'an, 710077, Shaanxi, China.

Abstract: Circular RNA Checkpoint With Forkhead And Ring Finger Domains (circ_CHFR) was reported to regulate vascular smooth muscle cell (VSMC) dysfunction during atherosclerosis (AS). However, the molecule mechanism of circ_CHFR in AS remains largely unclear. Human VSMCs (HVSMCs) were exposed to platelet-derived growth factor-bb (PDGF-BB) in vitro. Read More

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Thymoquinone sensitizes human hepatocarcinoma cells to TRAIL-induced apoptosis via oxidative DNA damage.

DNA Repair (Amst) 2021 Apr 15;103:103117. Epub 2021 Apr 15.

Department of General Surgery, the First Hospital Affiliated of Shandong First Medical University (Qianfoshan Hospital), Jinan, Shandong, 250014, China. Electronic address:

Introduction: Hepatocellular carcinoma (HCC) remains one of the most predominant types of digestive system malignancies worldwide. TNF-related apoptosis-inducing ligand (TRAIL) is a biological cytokine with the mentioned specificity, but some tumor cells' resistance limits its use as a therapeutic approach. The present study aimed to investigate thymoquinone (TQ) and TRAIL's combined effect and the potential mechanisms in human hepatic HepG2 carcinoma cells. Read More

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microRNA-210/ Long non-coding RNA MEG3 axis inhibits trophoblast cell migration and invasion by suppressing EMT process.

Placenta 2021 May 5;109:64-71. Epub 2021 May 5.

Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address:

Introduction: Pre-eclampsia is characterized by insufficient spiral artery remodeling, and trophoblast dysfunction plays an important role in this process. Noncoding RNAs (microRNAs (miRNAs) and long noncoding RNAs (LncRNAs) are included) can regulate trophoblasts. MicroRNA-210 (miR-210) can decrease trophoblast cell migration and invasion and may act as a biomarker for preeclampsia. Read More

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Inhibition of miR-1224 suppresses hypoxia/reoxygenation-induced oxidative stress and apoptosis in cardiomyocytes through targeting GPX4.

Exp Mol Pathol 2021 May 11:104645. Epub 2021 May 11.

Department of Cardiology, Zhuji People's Hospital of Zhejiang Province, Zhuji Affiliated Hospital of Shaoxing University, Zhuji, Zhejiang 311800, China. Electronic address:

We have focused on the underlying role of miR-1224 in cardiomyocyte injury stimulated by hypoxia/reoxygenation (H/R). In the current study, the rat cardiomyocyte cell line H9C2 was used to construct a H/R cell model to validate the cardioprotective effects of miR-1224. Data from the dual-luciferase assay revealed that the glutathione peroxidase 4 (GPX4) was a direct target of miR-1224. Read More

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Trunk muscle endurance, strength and flexibility in rural subsistence farmers and urban industrialized adults in western Kenya.

Am J Hum Biol 2021 May 14. Epub 2021 May 14.

Department of Human Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.

Objectives: High trunk muscle endurance, strength, and moderate flexibility reportedly help maintain musculoskeletal health, but there is evidence for tradeoffs among these variables as well as sex differences in trunk muscle endurance and strength. To test if these observations extend similarly to both men and women in nonindustrial and industrial environments, we investigated intra-individual associations and group and sex differences in trunk muscle endurance, strength, and flexibility among 74 (35 F, 39 M; age range: 18-61 years) adults from the same Kalenjin-speaking population in western Kenya. We specifically compared men and women from an urban community with professions that do not involve manual labor with rural subsistence farmers, including women who frequently carry heavy loads. Read More

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Analysis of the time evolution of COVID-19 lethality during the first epidemic wave in Italy.

Acta Biomed 2021 May 12;92(2):e2021171. Epub 2021 May 12.

Institute of Biostructures and Bioimaging, CNR, Naples.

Background And Aim: While the entire world is still experiencing the dramatic emergency due to SARS-CoV-2, Italy has a prominent position since it has been the locus of the first major outbreak among Western countries. The aim of this study is the evaluation of temporal connection between SARS-CoV-2 positive tests (cases) and deaths in Italy in the first wave of the epidemic.

Methods: A temporal link between cases and deaths was determined by comparing their daily/weekly trends using surveillance data of the period March 2-June 2020. Read More

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Korean red ginseng induces extrinsic and intrinsic apoptotic pathways in MCF-7 breast cancer cells and MCF-10A non-malignant breast cells.

J Obstet Gynaecol Res 2021 May 13. Epub 2021 May 13.

Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Among non-hormonal treatments, herbal products are frequently used by women. Korean red ginseng (KRG) is one of the popular herbal medicines. KRG could be one option for relieving menopausal symptoms. Read More

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Forkhead box O1 targeting replication factor C subunit 2 expression promotes glioma temozolomide resistance and survival.

Ann Transl Med 2021 Apr;9(8):692

Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Additional mechanisms of temozolomide (TMZ) resistance in gliomas remain uncertain. The aim of this study was to identify another DNA repair mechanism involving forkhead box O1 (FoxO1) and replicator C2 (RFC2) in gliomas.

Methods: We established glioma cells against TMZ, U87R, by exposure to TMZ. Read More

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CD2 T-helper 17-like cells differentiated from a CD133 subpopulation of non-small cell lung carcinoma cells promote the growth of lung carcinoma.

Ann Transl Med 2021 Apr;9(8):687

Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, China.

Background: Cancer stem cells (CSCs) give rise to a diverse variety of differentiated cells, which comprise the bulk of the tumor microenvironment (TME). However, the exact multi-directional differentiation potential of CSCs has not been fully clarified. This study was designed to explore whether CSCs differentiate into cellular components of the TME to promote the growth of lung carcinoma. Read More

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The effects of S-nitrosylation-induced PPARγ/SFRP5 pathway inhibition on the conversion of non-alcoholic fatty liver to non-alcoholic steatohepatitis.

Ann Transl Med 2021 Apr;9(8):684

Gastroenterology Department, Shanxi Provincial People's Hospital, Taiyuan, China.

Background: Peroxisome proliferators-activated receptors γ (PPARγ) and secreted frizzled related protein 5 (SFRP5) are abnormally expressed in liver cells. But their role in the transformation of non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH) remains to be studied. We aimed to explore the role of S-nitrosylation (SNO) in the conversion of NAFL to NASH via the peroxisome PPARγ/SFRP5 pathway. Read More

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CTNNB1 S37C mutation causing cells proliferation and migration coupled with molecular mechanisms in lung adenocarcinoma.

Ann Transl Med 2021 Apr;9(8):681

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Background: This study aimed to investigate the potential cytological effects and molecular mechanisms of β-catenin (CTNNB1) S37C mutation in lung adenocarcinoma (LUAD).

Methods: CTNNB1 with S37C mutation were transfected into LUAD cell lines. The expression of β-catenin were determined using Western blot. Read More

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Metastasis-associated gene 1 (MTA1) enhances cisplatin resistance of malignant pleural mesothelioma by ATR-Chk1-mediated DNA repair.

Ann Transl Med 2021 Apr;9(8):670

Department of Oncology of the First Affiliated Hospital of Soochow University, Suzhou, China.

Background: Malignant pleural mesothelioma (MPM) chemoresistance remains a challenge to oncologists. In our previous study, we demonstrated that the aberrant expression of metastasis-associated gene 1 () is associated with carcinogenesis and metastasis in MPM. The aim of the present study was to investigate the mechanism of and chemo-resistance in MPM. Read More

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Activation of the extracellular-signal-regulated kinase (ERK)/c-Jun N-terminal kinase (JNK) signal pathway and osteogenic factors in subchondral bone of patients with knee osteoarthritis.

Ann Transl Med 2021 Apr;9(8):663

Department of Orthopedics, the Second Affiliated Hospital of Soochow University, Suzhou, China.

Background: The objectives of this study was to explore the activation of the extracellular-signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling pathway and osteogenesis-related factors in the subchondral bone of patients with knee osteoarthritis (OA).

Methods: Ten patients with primary OA who underwent total knee arthroplasty in the Department of Arthritis Surgery of our hospital were enrolled, and subchondral bone tissue samples were obtained during the operation. He staining and saffron staining were used to observe the arrangement of chondrocytes in the patient tissues. Read More

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Apelin receptor upregulation in spontaneously hypertensive rat contributes to the enhanced vascular smooth muscle cell proliferation by activating autophagy.

Ann Transl Med 2021 Apr;9(8):627

Department of Geriatric Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.

Background: Proliferation of vascular smooth muscle cells (VSMCs) plays a vital role in the progression of vascular remodeling and hypertension. Apelin-13 promotes VSMC proliferation of normal rats. This study was designed to investigate the roles of apelin receptor (APJ) and apelin-13 in VSMC proliferation of hypertension rats and underlying mechanisms. Read More

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Identification and Validation of SNP-Containing Genes With Prognostic Value in Gastric Cancer Integrated Bioinformatics Analysis.

Front Oncol 2021 27;11:564296. Epub 2021 Apr 27.

Department of Oncology, Affiliated Hospital of Qingdao University, Qingdao, China.

Background: Gastric cancer is one of the most common malignancies worldwide. Although the diagnosis and treatment of this disease have substantially improved in recent years, the five-year survival rate of gastric cancer is still low due to local recurrence and distant metastasis. An in-depth study of the molecular pathogenesis of gastric cancer and related prognostic markers will help improve the quality of life and prognosis of patients with this disease. Read More

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Pre- and post-partum variation in wool cortisol and wool micron in Australian Merino ewe sheep ().

PeerJ 2021 27;9:e11288. Epub 2021 Apr 27.

School of Science, University of Western Sydney, Penrith, Australia.

An individual merino sheep's output of wool production is influenced by synergistic interactions of sheep genetics, climate, farm management, and nutrition available to the whole flock. The price paid to the producer for this wool commodity is determined via numerous tested parameters and /or subjective appraisal of the raw greasy wool. This research investigated the level of variation in wool cortisol (a physiological stress biomarker) and wool micron (MIC) in Merino ewes (), pre-partum and post-lambing (lactation/lambs at foot), using maiden ewe ( = 38) managed in an outdoor paddock in a commercial farm. Read More

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Chronic restraint stress impairs cognition via modulating HDAC2 expression.

Transl Neurosci 2021 Jan 29;12(1):154-163. Epub 2021 Apr 29.

Comparative Medical Center, Peking Union Medical College (PUMC) and Institute of Laboratory Animal Science, Chinese Academy of Medical Science (CAMS), Panjiayuan Nanli No. 5, Beijing, 100021, People's Republic of China.

Background: To investigate the effects of chronic restraint stress on cognition and the probable molecular mechanism in mice.

Methods: In the current work, a restraining tube was used as a way to induce chronic stress in mice. The protein levels were determined with ELISA and western blot. Read More

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January 2021

MicroRNA-891a-5p is a novel biomarker for non-small cell lung cancer and targets HOXA5 to regulate tumor cell biological function.

Oncol Lett 2021 Jul 2;22(1):507. Epub 2021 May 2.

Department of Integrated Traditional Chinese and Western Medicine, Yueqing People's Hospital, Yueqing, Zhejiang 325600, P.R. China.

Numerous studies have shown that the dysregulation of microRNA (miRNA/miR) is an important factor in the pathogenesis of lung cancer. However, the role of miR-891a-5p in non-small cell lung cancer (NSCLC) remains unclear. Therefore, the present study aimed to examine the clinical value and biological function of miR-891a-5p in NSCLC. Read More

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High expression of spermatogenesis associated serine rich 2 promotes tumorigenicity in esophageal squamous cell carcinoma cells and is associated with poor patient prognosis.

Exp Ther Med 2021 Jul 2;22(1):698. Epub 2021 May 2.

Department of Internal Medicine, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.

Spermatogenesis associated serine rich 2 (SPATS2), recognized as a cytoplasmic RNA-binding protein, is implicated in the tumorgenicity of several cancers. However, the potential role of SPATS2 in esophageal squamous cell carcinoma (ESCC) is yet to be elucidated. The present study aimed to explore the functional implication of SPATS2 in ESCC. Read More

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Proteomic analysis of Caenorhabditis elegans against Salmonella Typhi toxic proteins.

Genes Immun 2021 May 14. Epub 2021 May 14.

Department of Biotechnology, Alagappa University, Karaikudi, Tamil Nadu, India.

Bacterial effector molecules are crucial infectious agents that can cause pathogenesis. In the present study, the pathogenesis of toxic Salmonella enterica serovar Typhi (S. Typhi) proteins on the model host Caenorhabditis elegans was investigated by exploring the host's regulatory proteins during infection through the quantitative proteomics approach. Read More

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METTL13 inhibits progression of clear cell renal cell carcinoma with repression on PI3K/AKT/mTOR/HIF-1α pathway and c-Myc expression.

J Transl Med 2021 May 13;19(1):209. Epub 2021 May 13.

Department of Urology, First Hospital of China Medical University, School of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang City, 110004, Liaoning Province, People's Republic of China.

Background: Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive type of renal malignancy. Methyltransferase like 13 (METTL13) functions as an oncogene in most of human cancers, but its function and mechanism in ccRCC remains unreported.

Methods: qRT-PCR, western blotting and immunohistochemistry were used to detect METTL13's expression in tissues. Read More

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Soufeng sanjie formula alleviates collagen-induced arthritis in mice by inhibiting Th17 cell differentiation.

Chin Med 2021 May 13;16(1):39. Epub 2021 May 13.

Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, China.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease. Soufeng sanjie formula (SF), which is composed of scolopendra (dried body of Scolopendra subspinipes mutilans L. Koch), scorpion (dried body of Buthus martensii Karsch), astragali radix (dried root of Astragalus membranaceus (Fisch. Read More

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Chinese herbal medicine Feiyanning cooperates with cisplatin to enhance cytotoxicity to non-small-cell lung cancer by inhibiting protective autophagy.

J Ethnopharmacol 2021 May 10:114196. Epub 2021 May 10.

Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, PR China. Electronic address:

Ethnopharmacological Relevance: Feiyanning (FYN), the Chinese herbal medicine (CHM), has been used to manage non-small cell lung cancer (NSCLC) for the past 23 years. Chemotherapeutic drugs can induce autophagy in cancer cells to protect themselves from death. However, FYN can inhibit the protective autophagy in cancer cells. Read More

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Tanshinone IIA induces TRAIL sensitization of glioblastoma through death receptors induction and STAT3 pathway inhibition.

Brain Res 2021 May 10:147515. Epub 2021 May 10.

Department of Neurosurgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, PR China. Electronic address:

Objective: This work was designed to explore whether the combination of Tanshinone IIA (T-IIA) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has a direct anti-cancer effect in glioblastoma (GBM) and the possible mechanisms.

Methods: GBM cells (U-87 and U-251 MG) were treated with T-IIA or/and TRAIL, or the expression of death receptors (DRs), DR4 and DR5, was suppressed in GBM cells. The activity of GBM cells was determined by MTT, and the apoptosis was assessed by Hoechst33342 staining and flow cytometry. Read More

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Silencing Hoxa2 reverses dexamethasone-induced dysfunction of MC3T3-E1 osteoblasts and osteoporosis in rats.

Adv Clin Exp Med 2021 May 13. Epub 2021 May 13.

Department of Orthopedics, Liuzhou People's Hospital, Guangxi Medical University, China.

Background: Osteoporosis is damaging the health of women worldwide. Osteoporosis results from the imbalance between bone resorption and formation, which may be regulated by homeobox A2 (Hoxa2). However, the specific role and mechanism of Hoxa2 in osteogenesis and dexamethasone (Dex)-induced osteoporosis remain unknown. Read More

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Exogenous HS Protects Colon Cells in Ulcerative Colitis by Inhibiting and Activating Autophagy.

DNA Cell Biol 2021 May 13. Epub 2021 May 13.

Department of Gastroenterology, The Second Affiliated Hospital of Guilin Medical University, Guilin City, P.R. China.

Hydrogen sulfide (HS) has been reported to participate in intestinal mucosal defense and repair. However, the precise regulatory mechanisms of HS in ulcerative colitis (UC) remain unclear. We explored the effects of sodium hydrosulfide (NaHS), a donor of HS, in dextran sulfate sodium (DSS)-induced colitis in rats. Read More

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Hepatocyte steatosis inhibits hepatitis B virus secretion via induction of endoplasmic reticulum stress.

Mol Cell Biochem 2021 May 13. Epub 2021 May 13.

Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, 201 Dalian Street, Zunyi, 563003, Guizhou, China.

The effects of hepatocyte steatosis on hepatitis B virus (HBV) DNA replication and HBV-related antigen secretion are incompletely understood. The aims of this study are to explore the effects and mechanism of hepatocyte steatosis on HBV replication and secretion. Stearic acid (SA) and oleic acid (OA) were used to induce HepG2. Read More

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