264 results match your criteria determine mir-155

lncRNA NORAD promotes the progression of osteosarcoma via targeting of miR-155-5p.

Exp Ther Med 2021 Jun 18;21(6):645. Epub 2021 Apr 18.

Department of Orthopedics, Ezhou Central Hospital, Ezhou, Hubei 436000, P.R. China.

Osteosarcoma (OS) is the most common malignant bone tumor in teens. Non-coding RNA activated by DNA damage (NORAD), a long non-coding RNA (lncRNA), has been reported to be involved in cancer biology, although its role in OS remains largely unknown. In the present study reverse transcription-quantitative PCR (RT-qPCR) was used to determine the expression levels of NORAD and miR-155-5p in samples from patients with OS. Read More

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MicroRNAs Regulating Tumor and Immune Cell Interactions in the Prediction of Relapse in Early Stage Breast Cancer.

Biomedicines 2021 Apr 13;9(4). Epub 2021 Apr 13.

Laboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Vassilika Vouton, 71003 Crete, Greece.

MicroRNAs (miRNAs) are involved in the regulation of immune response and hold an important role in tumor immune escape. We investigated the differential expression of the immunomodulatory miR-10b, miR-19a, miR-20a, miR-126, and miR-155 in the plasma of healthy women and patients with early stage breast cancer and interrogated their role in the prediction of patients' relapse. Blood samples were obtained from healthy women ( = 20) and patients with early stage breast cancer ( = 140) before adjuvant chemotherapy. Read More

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Circulating miR-155 and JAK2/STAT3 Axis in Acute Ischemic Stroke Patients and Its Relation to Post-Ischemic Inflammation and Associated Ischemic Stroke Risk Factors.

Int J Gen Med 2021 21;14:1469-1484. Epub 2021 Apr 21.

Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Background: "Micro RNAs and their target genes recently have been identified to play a crucial role in the molecular pathogenesis of post-stroke ischemic cellular injury, which elucidates their new role in ischemic stroke diagnosis and therapy". Thus, we evaluated the relative serum expression of miR-155, an inflammatory micro RNA, and the mRNAs (JAK2/STAT3) in acute ischemic stroke patients and its associations with the inflammatory cytokine TNF-α and different stroke risk factors.

Subjects And Methods: The relative expression of serum miR-155 and mRNAs (JAK2/STAT3) was assessed using RT-PCR, serum TNF-α was measured using ELIZA in 46 acute ischemic stroke patients and 50 control subjects. Read More

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Pap Smear miR-92a-5p and miR-155-5p as potential diagnostic biomarkers of squamous intraepithelial cervical cancer.

Asian Pac J Cancer Prev 2021 Apr 1;22(4):1271-1277. Epub 2021 Apr 1.

Department of Obstetrics and Gynecology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

Background: one of the female-specific diseases with a high incidence and mortality is cervical cancer. The main cause of cervical cancer is infection with Human papilloma virus (HPV). Low-grade squamous intraepithelial lesions (LSIL) and High-grade squamous intraepithelial lesions (HSIL) usually is caused by an HPV infection. Read More

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Exosomal MicroRNAs as Biomarkers in Allergic Asthma.

Iran J Allergy Asthma Immunol 2021 Apr 17;20(2):160-168. Epub 2021 Apr 17.

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran AND Department of Allergy and Clinical Immunology, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Exosomes are extracellular vesicles that are involved in intracellular communication and different biological processes. Recently, the importance of microRNAs (miRNAs) in exosomes has been considered as biomarkers in asthma diagnosis. This study aimed to determine the expression of selective miRNAs from plasma-derived exosomes in moderate and severe asthmatic patients compared with healthy controls. Read More

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miR-155-5p upregulation ameliorates myocardial insulin resistance via mTOR signaling in chronic alcohol drinking rats.

PeerJ 2021 5;9:e10920. Epub 2021 Apr 5.

Department of Clinical Nutrition, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Background: Chronic alcohol intake is associated with an increased risk of alcoholic cardiomyopathy, which may present with pathological changes such as myocardial insulin resistance, leading to ventricular dilation and cardiac dysfunction. Although a correlation between microRNA-155 (miR-155) and insulin signaling has been identified, the underlying mechanism has not been elucidated to date. The purpose of the study was to determine whether overexpression of miR-155-5p in vivo could ameliorate chronic alcohol-induced myocardial insulin resistance and cardiac dysfunction. Read More

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Hsa-miR-155 regulates the cell cycle and barrier function of corneal endothelial cells through E2F2.

Am J Transl Res 2021 15;13(3):1505-1515. Epub 2021 Mar 15.

Department of Optometry Center, Tianjin Eye Hospital Tianjin 300022, China.

This study was aimed to determine the role of has-miR-155 and E2F2 on corneal endothelial cells. Real-time quantitative PCR and Western blot assays were carried out to determine the levels of has-miR-155 and E2F2, and Flow cytometry assay was conducted to detect cell cycle. In addition, Targetscan7. Read More

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Profiling Tissue and Biofluid miR-155-5p, miR-155, and miR-146a-5p Expression in Graft vs. Host Disease.

Front Immunol 2021 15;12:639171. Epub 2021 Mar 15.

Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.

Acute graft vs. host disease (aGvHD) is a frequent complication following allogeneic haematopoeitic transplantation (HSCT). Despite recent advances, there are no universally accepted biomarkers to determine development of aGvHD. Read More

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Circular RNA CHST15 Sponges miR-155-5p and miR-194-5p to Promote the Immune Escape of Lung Cancer Cells Mediated by PD-L1.

Front Oncol 2021 11;11:595609. Epub 2021 Mar 11.

Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: The effects of up-regulated CircCHST15 on lung cancer remained unclear. In this study, the role of CircCHST15 in lung cancer was investigated.

Methods: Dual-luciferase reporter verified the bioinformatics prediction that CircCHST15 targeted miR-155-5p and miR-194-5p. Read More

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Long non-coding RNA XIST promotes the proliferation of cardiac fibroblasts and the accumulation of extracellular matrix by sponging microRNA-155-5p.

Exp Ther Med 2021 May 12;21(5):477. Epub 2021 Mar 12.

Department of Cardiology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China.

Acute myocardial infarction (AMI) is characterized by cardiomyocyte death followed by myocardial fibrosis, eventually leading to heart failure. Long non-coding (lnc)RNA X-inactive specific transcript (XIST) serves a vital role in the regulation of fibrosis. The aim of the present study was to determine whether myocardial fibrosis may be regulated by XIST and to elucidate the underlying mechanism. Read More

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Inhibition of miRNA-155 Alleviates High Glucose-Induced Podocyte Inflammation by Targeting SIRT1 in Diabetic Mice.

J Diabetes Res 2021 8;2021:5597394. Epub 2021 Mar 8.

Department of Endocrinology, Dongfang Hospital, Beijing University of Chinese Medicine, 6 Fangxingyuan, Fengtai District, Beijing, China.

Objective: Microinflammation plays a crucial role in podocyte dysfunction in diabetic nephropathy, but its regulatory mechanism is still unclear. This study is aimed at discussing the mechanisms underlying the effect of miRNA-155 on podocyte injury to determine its potential as a therapeutic target.

Methods: Cultured immortalized mouse podocytes and diabetic KK-Ay mice models were treated with a miR-155 inhibitor. Read More

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LncRNA NEAT1 activates MyD88/NF-κB pathway in bronchopneumonia through targeting miR-155-5p.

Autoimmunity 2021 Mar 9;54(2):104-113. Epub 2021 Mar 9.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, Changsha, P. R. China.

Background: Bronchopneumonia is a disease of the respiratory tract. It leads to other complications and endangers life and health. Long non-coding RNA (lncRNA) participates in the occurrence and development of bronchopneumonia. Read More

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CircTP63 promotes hepatocellular carcinoma progression by sponging miR-155-5p and upregulating ZBTB18.

Cancer Cell Int 2021 Mar 8;21(1):156. Epub 2021 Mar 8.

Department of Gastroenterology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 264000, Shandong Province, China.

Background: Hepatocellular carcinoma (HCC) is the leading cause of tumor-related death worldwide due to high morbidity and mortality, yet lacking effective biomarkers and therapies. Circular RNAs (circRNAs) are a group of non-coding RNAs that regulate gene expression through interacting with miRNAs, implicating in the tumorigenesis and progression. A novel circRNA, circTP63, was reported to be an oncogene in HCC. Read More

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Weakly Acidic Bile Is a Risk Factor for Hypopharyngeal Carcinogenesis Evidenced by DNA Damage, Antiapoptotic Function, and Premalignant Dysplastic Lesions In Vivo.

Cancers (Basel) 2021 Feb 18;13(4). Epub 2021 Feb 18.

The Yale Larynx Laboratory, Department of Surgery (Otolaryngology), Yale School of Medicine, New Haven, CT 06510, USA.

Background: There is recent in vivo discovery documenting the carcinogenic effect of bile at strongly acidic pH 3.0 in hypopharynx, while in vitro data demonstrate that weakly acidic bile (pH 5.5) has a similar oncogenic effect. Read More

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February 2021

Inhibiting microRNA-155 attenuates atrial fibrillation by targeting CACNA1C.

J Mol Cell Cardiol 2021 Feb 24;155:58-65. Epub 2021 Feb 24.

Key Laboratory of Interdisciplinary Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; Medical School of University of Chinese Academy of Sciences, Beijing, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China. Electronic address:

Background: Reduction in L-type Ca current (I) density is a hallmark of the electrical remodeling in atrial fibrillation (AF). The expression of miR-155, whose predicted target gene is the α1c subunit of the calcium channel (CACNA1C), was upregulated in atrial cardiomyocytes (aCMs) from patients with paroxysmal AF.The study is to determine miR-155 could target the gene expression of I and contribute to electrical remodeling in AF. Read More

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February 2021

Exosomes Derived From Hypertrophic Cardiomyocytes Induce Inflammation in Macrophages miR-155 Mediated MAPK Pathway.

Front Immunol 2020 3;11:606045. Epub 2021 Feb 3.

Inner Mongolia Key Laboratory of Disease-Related Biomarkers, Baotou Medical College, Baotou, China.

The inflammatory immune microenvironment plays an important role in the development of cardiac hypertrophy. Exosomes have emerged as the potent modulators of inflammatory responses. This study aimed to determine how exosomes derived from angiotensin II (Ang II)-induced hypertrophic cardiomyocytes (HCs) interfere with the inflammatory signal pathways in macrophages. Read More

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February 2021

lncRNA MIR155HG Alleviates Depression-Like Behaviors in Mice by Regulating the miR-155/BDNF Axis.

Neurochem Res 2021 Apr 29;46(4):935-944. Epub 2021 Jan 29.

Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xian, 710069, China.

Depression is one of most common psychiatric disorders, and the detailed molecular mechanism remains to be fully elucidated. Brain-derived neurotrophic factor (BDNF) is a critical neurotrophic factor that is decreased and closely involved in the development of depression. Noncoding RNAs are central regulators of cellular activities that modulate target genes. Read More

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MicroRNA-155: Regulation of Immune Cells in Sepsis.

Mediators Inflamm 2021 8;2021:8874854. Epub 2021 Jan 8.

Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

MicroRNAs are small noncoding RNAs which regulate gene expression at the posttranscriptional level. miR-155 is encoded by the miR-155 host gene (miR155HG), also known as the noncoding B cell integration cluster (BIC). MicroRNAs are widely expressed in various hematopoietic cells and are involved in regulating the immune system. Read More

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January 2021

miR-155 promotes proliferation and epithelial-mesenchymal transition of MCF-7 cells.

Exp Ther Med 2021 Mar 15;21(3):218. Epub 2021 Jan 15.

Department of Surgery, Xinganmeng People's Hospital, Ulanhot, Inner Mongolia 137400, P.R. China.

Breast cancer (BC) is the second leading cause of cancer-associated deaths among women worldwide. Increasing evidence has indicated that microRNAs (miRNAs) have demonstrated great potential for improving the diagnosis and therapy for BC. In the present study, miRNA-155 was detected in human BC tissues using reverse transcription-quantitative (RT-q)PCR. Read More

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microRNA Sequencing of CD34+ Sorted Adipose Stem Cells Undergoing Endotheliogenesis.

Stem Cells Dev 2021 Mar 8;30(5):265-288. Epub 2021 Feb 8.

Bioengineering Laboratory, Department of Mechanical Engineering and Louisiana State University, Baton Rouge, Louisiana, USA.

While several microRNAs (miRNAs) that regulate the endotheliogenesis and further promote angiogenesis have been identified in various cancers, the identification of miRNAs that can drive the differentiation of adipose derived stromal/stem cells (ASCs) into the endothelial lineage has been largely unexplored. In this study, CD34+ ASCs sorted using magnetic bead separation were induced to differentiate along the endothelial pathway. miRNA sequencing of ASCs at day 3, 9, and 14 of endothelial differentiation was performed on Ion Proton sequencing system. Read More

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Tanshinone IIA Ameliorates Inflammation Response in Osteoarthritis via Inhibition of miR-155/FOXO3 Axis.

Pharmacology 2021 4;106(1-2):20-28. Epub 2021 Jan 4.

Department of Orthopedics, Wangjing Hospital of Chinese Academy of Chinese Medical Science, Beijing, China,

Background: Osteoarthritis (OA) is the most common joint disorder characterized by degeneration of the articular cartilage and joint destruction with an associated risk of mobility disability in elderly people. Although a lot of achievements have been made, OA is still regarded as an incurable disease. Therefore, the pathological mechanisms and novel therapeutic strategies of OA need more investigation. Read More

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Increased miR-142 Levels in Plasma and Atherosclerotic Plaques from Peripheral Artery Disease Patients with Post-Surgery Cardiovascular Events.

Int J Mol Sci 2020 Dec 16;21(24). Epub 2020 Dec 16.

Lipidomics Department, Institute of Cellular Biology and Pathology "Nicolae Simionescu" of the Romanian Academy, 8, B.P. Hasdeu Street, 050568 Bucharest, Romania.

There is an intensive effort to identify biomarkers to predict cardiovascular disease evolution. We aimed to determine the potential of microRNAs to predict the appearance of cardiovascular events (CVEs) in patients with peripheral artery disease (PAD) following femoral artery bypass surgery. Forty-seven PAD patients were enrolled and divided into two groups, without CVEs ( = 35) and with CVEs ( = 12), during 1 year follow-up. Read More

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December 2020

Immune effects of miRNA and Th17 cells on β-Lg allergy in dietary milk based on mouse model.

Saudi J Biol Sci 2020 Dec 21;27(12):3442-3448. Epub 2020 Aug 21.

Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester 01609, United States.

β-lactoglobulin (β-Lg) allergy in dietary milk seriously affects the use of high-quality milk protein in infants. In order to solve this problem, the expression of miRNA and Th17 cells in milk β-Lg allergic reaction of children's diet was studied.

Method: female BALB/c mice aged 5-6 weeks were selected as the subjects and randomly divided into blank group and β-Lg sensitized group, with 10 mice in each group. Read More

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December 2020

Identification of the miRNA-mRNA regulatory pathways and a miR-21-5p based nomogram model in clear cell renal cell carcinoma.

PeerJ 2020 4;8:e10292. Epub 2020 Nov 4.

Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Background: The purpose of this study was to determine the key microRNAs (miRNAs) and their regulatory networks in clear cell renal cell carcinoma (ccRCC).

Methods: Five mRNA and three microRNA microarray datasets were downloaded from the Gene Expression Omnibus database and used to screen the differentially expressed miRNAs (DEMs) and differentially expressed genes (DEGs). Gene ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis were performed with Metascape. Read More

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November 2020

TERF1 downregulation promotes the migration and invasion of the PC3 prostate cancer cell line as a target of miR‑155.

Mol Med Rep 2020 Dec 21;22(6):5209-5218. Epub 2020 Oct 21.

Department of Urology, Zigong Fourth People's Hospital, Zigong, Sichuan 643000, P.R. China.

Telomeric repeat binding factor 1 (TERF1) has been identified as a tumor suppressor gene in numerous types of human cancer. However, the expression of TERF1 and its mechanism in prostate cancer (PCa) remains unclear. The present study aimed to explore the expression and functions of TERF1 in PCa. Read More

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December 2020

lncRNA CASC2 Enhances I Sensitivity in Papillary Thyroid Cancer by Sponging miR-155.

Biomed Res Int 2020 19;2020:7183629. Epub 2020 Oct 19.

Department of Endocrinology, Xinyang Central Hospital, Xinyang 464000, China.

Long noncoding RNA cancer susceptibility candidate 2 (CASC2) has been reported to play an anticancer role in papillary thyroid cancer (PTC). Radioiodine (I) is a common option for the treatment of PTC. However, the role and mechanism of CASC2 in I sensitivity remain unclear. Read More

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miR-155 promotes T reg cell development by safeguarding medullary thymic epithelial cell maturation.

J Exp Med 2021 Feb;218(2)

Division of Biological Sciences, University of California, San Diego, La Jolla, CA.

During thymocyte development, medullary thymic epithelial cells (mTECs) provide appropriate instructive cues in the thymic microenvironment for not only negative selection but also the generation of regulatory T (T reg) cells. Here, we identify that miR-155, a microRNA whose expression in T reg cells has previously been shown to be crucial for their development and homeostasis, also contributes to thymic T reg (tT reg) cell differentiation by promoting mTEC maturation. Mechanistically, we show that RANKL stimulation induces expression of miR-155 to safeguard the thymic medulla through targeting multiple known and previously uncharacterized molecules within the TGFβ signaling pathway, which is recognized for its role in restricting the maturation and expansion of mTECs. Read More

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February 2021

MicroRNA-155-5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1.

Oncol Lett 2020 Dec 11;20(6):353. Epub 2020 Oct 11.

Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

The aim of the present study was to determine the effect of microRNA (miR)-155-5p on the expression of testican-1 (SPOCK1) and the invasion and migration of prostate cancer cells . Bioinformatics analysis and molecular biology assays revealed that SPOCK1 may be a direct target gene of miR-155-5p. In addition, a negative correlation was identified between SPCOK1 and miR-155-5p expression in prostate tumor tissues and cell lines. Read More

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December 2020

MicroRNAs in laser-induced choroidal neovascularization in mice and rats: their expression and potential therapeutic targets.

Neural Regen Res 2021 Apr;16(4):621-627

Department of Anatomy, University of Otago, Dunedin, New Zealand.

Choroidal neovascularization characterizes wet age-related macular degeneration. Choroidal neovascularization formation involves a primarily angiogenic process that is combined with both inflammation and proteolysis. A primary cause of choroidal neovascularization pathogenesis is alterations in pro- and anti-angiogenic factors derived from the retinal pigment epithelium, with vascular endothelium growth factor being mainly responsible for both clinical and experimental choroidal neovascularization. Read More

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MicroRNA-155-5p Diminishes in Vitro Ovarian Cancer Cell Viability by Targeting HIF1α Expression.

Adv Pharm Bull 2020 Sep 9;10(4):630-637. Epub 2020 Aug 9.

Medicine and Health Sciences of Doctoral Program, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Farmako Yogyakarta 55281, Indonesia.

Ovarian cancer is the most lethal of gynecological malignancies. Recently, the development of microRNA (miRNA) -based therapeutics that could impact broad cellular programs, leading to inhibition of cancer cell viability, is gaining attention in the therapeutic landscape. The therapy is based on the presence of aberrant expressions of miRNA in cancer cells. Read More

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September 2020