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Treatment of Short Stature with Aromatase Inhibitors: A Systematic Review and Meta-Analysis.

Horm Metab Res 2021 Jun 21;53(6):391-401. Epub 2021 Jun 21.

Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, China.

The objective of the study is to determine the risks and benefits of treating idiopathic short stature (ISS) with aromatase inhibitors (AIs). We comprehensively searched PubMed, Embase, and the China National Knowledge Infrastructure between establishment year and January 31, 2020. Mean difference (MD)/Standardized mean differences (SMD) with 95% confidence intervals (CI) of individual studies were pooled using fixed or random effects models. Read More

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Calcitonin Stimulation Tests: Rationale, Technical Issues and Side Effects: A Review.

Horm Metab Res 2021 Jun 21;53(6):355-363. Epub 2021 Jun 21.

"C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania.

Calcitonin (CT) stimulation tests have great value and could help to: differentiate thyroid causes of elevated CT apart from non-thyroid sources, determine whether the patients with slightly elevated basal CT could/could not be candidates for surgery, and indicate the right moment for prophylactic thyroidectomy in children with MEN syndromes when with normal basal CT. This triggered the requests for development of CT stimulation tests, taking into consideration their safety and aimed us to write a systematic review of literature regarding the rationale, technical issues, and side effects of CT stimulating tests used for diagnosis of MTC. After a thorough review of the literature, we classified the reported side effects by severity, as defined by United States Food and Drug Administration. Read More

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Disparities between Asian and Non-Asian Thrombolyzed Acute Ischemic Stroke Patients in the Enhanced Control of Hypertension and Thrombolysis Stroke Trial.

Cerebrovasc Dis 2021 Jun 21:1-7. Epub 2021 Jun 21.

The George Institute for Global Health, Faculty of Medicine, UNSW, Sydney, New South Wales, Australia.

Background And Purpose: As outcomes for acute ischemic stroke (AIS) vary according to clinical profile and management approaches, we aimed to determine disparities in clinical outcomes between Asian and non-Asian participants of the international, Enhanced Control of Hypertension and Thrombolysis Stroke study (ENCHANTED).

Methods: ENCHANTED was a multicenter, prospective, partial-factorial, randomized, open trial of low-dose (0.6 mg/kg) versus standard-dose (0. Read More

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The Effects of Firefighter Equipment and Gear on the Static and Dynamic Postural Stability of Fire Cadets.

Gait Posture 2021 Jun 10;88:292-296. Epub 2021 Jun 10.

Liberty University, 1971 University Blvd, Lynchburg, VA, 24515, USA. Electronic address:

Background: Slips, trips, falls, and jumps were the second leading cause of injuries at the fireground.

Research Question: The purpose of this study was to explore the effects of firefighter equipment and gear (EQG) on postural stability and determine if load per kg of body mass (L/BM) is associated with postural stability.

Methods: 26 male fire cadets (26. Read More

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Cortisol reactivity to stress predicts behavioral responsivity to reward moderation by sex, depression, and anhedonia.

J Affect Disord 2021 Jun 10;293:1-8. Epub 2021 Jun 10.

Department of Psychology, Queen's University, Canada. Electronic address:

Depression is associated with blunted reactivity to acute stress, as well as blunted responsivity to rewards. However, the extent to which responses to stress are associated with responses to reward in individuals meeting criteria for a depressive disorder is unknown. The goal of this study was to examine the relation of responses to stress and reward, and to determine if this relation is moderated by depression diagnosis, anhedonia, and sex. Read More

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Maximum intravenous alteplase dose for obese stroke patients is not associated with greater likelihood of worse outcomes.

Thromb Res 2021 Jun 7;204:76-80. Epub 2021 Jun 7.

Miami Neuroscience Institute, Baptist Health South Florida, 8900 North Kendall Drive, 2 Clarke Pavilion, Miami, FL 33176, USA. Electronic address:

Background: IV alteplase is a primary treatment for acute ischemic stroke (AIS) at a weight-based dose (WBD) of 0.9 mg/kg and maximum dose (MD) of 90 mg. There are conflicting data regarding outcomes for those weighing ≥100 kg. Read More

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Effects of sex differences on breath-hold diving performance.

Respir Physiol Neurobiol 2021 Jun 18:103721. Epub 2021 Jun 18.

Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa-city, Saitama, 359-1192, Japan.

Purpose: The present study aimed to measure diving response, CO sensitivity and forced vital capacity in male and female breath-hold divers (BHDs), and to determine their effect on breath-hold diving performance.

Methods: This study included 8 non-divers (NDs, 4 males and 4 females) and 15 BHDs (7 males and 8 females). For NDs, diving response was measured during breath-holding with facial immersion, whereas for BHDs CO sensitivity was also measured. Read More

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Perioperative Complications in Endoscopic Endonasal versus Transcranial Resections of Adult Craniopharyngiomas.

World Neurosurg 2021 Jun 18. Epub 2021 Jun 18.

University of Miami Miller School of Medicine, Department of Neurological Surgery, Miami, Florida, USA; Sylvester Comprehensive Cancer Center, University of Miami Health System, Miami, Florida, USA. Electronic address:

Introduction: Adult craniopharyngiomas are low-grade tumors of the pituitary infundibulum that can be locally aggressive and frequently present with profound visual deficits and endocrinopathies. Surgical resection remains the preferred initial treatment for these lesions and recently endoscopic endonasal approaches (EEAs) have become increasingly utilized. However, minimal data exists comparing these techniques to traditional transcranial (TC) methods. Read More

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Maxillofacial Trauma in the Ultimate Fighting Championship.

J Oral Maxillofac Surg 2021 May 18. Epub 2021 May 18.

Professor and Program Director, Oral and Maxillofacial Surgery Residency Program, School of Dental Medicine, University of Puerto Rico, San Juan, Puerto Rico.

Purpose: The Ultimate Fighting Championship (UFC) is an American mixed martial art (MMA) company. This study aims to characterize patterns and trends of maxillofacial injuries in MMA.

Materials And Methods: The study design is a retrospective cohort study. Read More

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[Prescription of phosphorus, calcium and magnesium: choice of the millimole unit to establish the equivalence of doses between oral and injectable forms].

Ann Pharm Fr 2021 Jun 18. Epub 2021 Jun 18.

Service pharmaceutique, hospices civils de Lyon, hôpital de la Croix-Rousse, groupement hospitalier Nord, 103 grande rue de la Croix Rousse, 69317 Lyon Cedex 04, France.

Objectives: Information available on the packaging of drugs indicated for patients electrolytes replenishment differs from one manufacturer to another. They relate, for example, the unit chosen to express elemental electrolyte concentration. These differences constitute a risk factor for medication errors. Read More

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Heat health risk assessment analysing heatstroke patients in Fukuoka City, Japan.

PLoS One 2021 21;16(6):e0253011. Epub 2021 Jun 21.

Kyushu Environmental Evaluation Association, Fukuoka, Japan.

Background: Climate change, as a defining issue of the current time, is causing severe heat-related illness in the context of extremely hot weather conditions. In Japan, the remarkable temperature increase in summer caused by an urban heat island and climate change has become a threat to public health in recent years.

Methods: This study aimed to determine the potential risk factors for heatstroke by analysing data extracted from the records of emergency transport to the hospital due to heatstroke in Fukuoka City, Japan. Read More

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Attitudes and practices of open data, preprinting, and peer-review-A cross sectional study on Croatian scientists.

PLoS One 2021 21;16(6):e0244529. Epub 2021 Jun 21.

Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, California, United States of America.

Attitudes towards open peer review, open data and use of preprints influence scientists' engagement with those practices. Yet there is a lack of validated questionnaires that measure these attitudes. The goal of our study was to construct and validate such a questionnaire and use it to assess attitudes of Croatian scientists. Read More

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Functional Outcomes of Nerve Allografts Seeded with Undifferentiated and Differentiated Mesenchymal Stem Cells in a Rat Sciatic Nerve Defect Model.

Plast Reconstr Surg 2021 Jun 21. Epub 2021 Jun 21.

From the Department of Orthopedic Surgery, Mayo Clinic; the Department of Plastic, Reconstructive, and Hand Surgery, Radboud University Medical Center; and the Department of Plastic, Reconstructive, and Hand Surgery, Erasmus Medical Center.

Background: Mesenchymal stem cells have the potential to produce neurotrophic growth factors and establish a supportive microenvironment for neural regeneration. The purpose of this study was to determine the effect of undifferentiated and differentiated mesenchymal stem cells dynamically seeded onto decellularized nerve allografts on functional outcomes when used in peripheral nerve repair.

Methods: In 80 Lewis rats, a 10-mm sciatic nerve defect was reconstructed with (1) autograft, (2) decellularized allograft, (3) decellularized allograft seeded with undifferentiated mesenchymal stem cells, or (4) decellularized allograft seeded with mesenchymal stem cells differentiated into Schwann cell-like cells. Read More

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No difference in clinical outcomes between portable navigation and conventional instrumentation in total knee arthroplasty: A randomised trial.

ANZ J Surg 2021 Jun 21. Epub 2021 Jun 21.

Sydney Knee Specialists, St George Private Hospital Specialist Consulting Suites, Sydney, New South Wales, Australia.

Background: Portable accelerometer-based navigation devices (PAD) in total knee arthroplasty (TKA) have been proposed to combine the alignment precision of computer navigation with the efficiency of conventional instrumentation (CON). The aim of this study was to determine if PAD was more effective than CON in TKA in improving clinical outcomes at medium term follow-up.

Methods: Participants undergoing primary TKA were randomly assigned to either PAD or CON. Read More

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Protective role of vitamin E in testicular development of mice exposed to valproic acid.

Andrologia 2021 Jun 21:e14140. Epub 2021 Jun 21.

Center of Biotechnology on Reproduction (CEBIOR-BIOREN), Faculty of Medicine, Universidad de La Frontera, Temuco, Chile.

Valproic acid (VPA) is a teratogenic antiepileptic, causing alterations in oxidative stress in prenatal development, being altered the development of the male reproductive system. The purpose of this study was to determine the protective effect of vitamin E (VE) on the testicular development in embryos, foetuses and pubertal mice exposed to VPA, VPA+VE and only VE. Sixty pregnant adult female mice were used, to which they were administered 600 mg/kg of VPA (VPA groups), 600 mg/kg of VPA and 200 IU of VE (VPA+VE groups), 200 IU VE (VE groups) and 0. Read More

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Patient satisfaction scores in adults with psoriasis.

Arch Dermatol Res 2021 Jun 21. Epub 2021 Jun 21.

Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Suite 2B-430, 2150 Pennsylvania Avenue NW, Washington, DC, 20037, USA.

Patient satisfaction is associated with improved patient retention and clinical outcomes. Previous studies investigated the impact of disease severity and mental health conditions on patient satisfaction among psoriasis patients. However, associations with healthcare utilization were not studied. Read More

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Screening and clinical significance of lymph node metastasis-related genes within esophagogastric junction adenocarcinoma.

Cancer Med 2021 Jun 21. Epub 2021 Jun 21.

Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Province, P. R. China.

Background: Despite recent improvements in treatment technologies, such as surgical resection and chemoradiotherapy, the prognosis of patients with esophagogastric junction adenocarcinoma (EJA) remains poor due to early lymph node metastasis. Since few studies have investigated genes associated with lymph node metastasis in EJA, we aimed to screen lymph node metastasis-associated genes and clarify their expression status and prognostic significance in EJA.

Methods: The differential frequency of mutations between carcinoma and para-carcinoma tissues from 199 cases with EJA was detected using targeted next-generation sequencing (tNGS). Read More

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Preclinical Metabolism and Disposition of an Orally Bioavailable Macrocyclic FXIa Inhibitor.

Xenobiotica 2021 Jun 21:1-50. Epub 2021 Jun 21.

Department of NCRD, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, New Jersey.

FXIa-6f is as a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species.The objectives of this study were to characterize the in vitro metabolism, determine circulating metabolites in pre-clinical species, and examine the disposition of the compound in a bile duct-cannulated rat study (BDC) study, to inform clinical development of the compound and the medicinal chemistry approach to identify molecules with improved properties.Across species, metabolic pathways included several oxidative metabolites, including hydroxylated metabolites on the macrocycle or P1 region, descarbamoylation of the methyl carbamate side chain, and a glutathione conjugate on the 2,6-difluoro-3-chlorophenyl ring. Read More

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Evaluation of 4-Hz log files and secondary Monte Carlo dose calculation as patient-specific quality assurance for VMAT prostate plans.

J Appl Clin Med Phys 2021 Jun 20. Epub 2021 Jun 20.

Department of Radio-Oncology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria.

Purpose: In this study, 4-Hz log files were evaluated with an independent secondary Monte Carlo dose calculation algorithm to reduce the workload for patient-specific quality assurance (QA) in clinical routine.

Materials And Methods: A total of 30 randomly selected clinical prostate VMAT plans were included. The used treatment planning system (TPS) was Monaco (Elekta, Crawley), and the secondary dose calculation software was SciMoCa (Scientific-RT, Munich). Read More

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Whole tissue homogenization preferable to mucosal scraping in determining the temporal profile of segmented filamentous bacteria in the ileum of weanling rats.

Access Microbiol 2021 Mar 23;3(3):000218. Epub 2021 Mar 23.

Riddet Institute, Massey University, Palmerston North, New Zealand.

Segmented filamentous bacteria (SFB) are thought to play a role in small intestine immunological maturation. Studies in weanling mice have shown a positive correlation between ileal SFB abundance and plasma and faecal interleukin 17 (IL-17) and immunoglobulin A (IgA) concentrations. Although the first observation of SFB presence was reported in rats, most studies use mice. Read More

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Chlamydial clinical isolates show subtle differences in persistence phenotypes and growth .

Access Microbiol 2021 Mar 19;3(3):000204. Epub 2021 Feb 19.

School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia.

Urogenital infection is the most common sexually transmitted bacterial infection throughout the world. While progress has been made to better understand how type strains develop and respond to environmental stress , very few studies have examined how clinical isolates behave under similar conditions. Here, we examined the development and persistence phenotypes of several clinical isolates, to determine how similar they are to each other, and the type strain D/UW-3/Cx. Read More

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Skin lesions in children during the first wave of the SARS-CoV-2 pandemic.

Med Clin (Engl Ed) 2021 Jun 12. Epub 2021 Jun 12.

Unidad de Reumatología Pediátrica, UGC Pediatría, Hospital Regional Universitario de Málaga, Málaga, Spain.

Background: Cutaneous manifestations have been included in COVID-19 patients' clinical spectrum. Our objective was to determine the association between skin lesions in children and SARS-CoV2 infection, analyzing others possible infectious/autoimmune etiologies.

Material And Methods: Observational, multicenter, cross-sectional study, about children with skin manifestations from April to May 2020. Read More

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Evaluation of the Relationship between Salivary Lipids, Proteins and Total Antioxidant Capacity with Gingival Health Status in Type-1 Diabetic Children.

J Dent (Shiraz) 2021 Jun;22(2):82-89

Biostatistics & Epidemiology, Medicine Faculty, Babol University of Medical Sciences, Babol, Iran.

Statement Of The Problem: Alteration in salivary composition and its effect on the oral cavity in diabetic child patients remains equivocal.

Purpose: This study was performed to assess the relationship between salivary factors and gingival status in children with type-1 diabetes mellitus (DM).

Material And Method: In this cross-sectional study, 120 subjects aged 6-16 years (60 well-controlled and poorly-controlled diabetics and 60 healthy individuals) were examined to determine the gingival index (GI) and plaque index (PI). Read More

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Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma.

Front Cell Dev Biol 2021 3;9:670185. Epub 2021 Jun 3.

Cancer CIBER (CIBERONC), Madrid, Spain.

The invasive tumor front (the tumor-host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. Herein we focus on the invasive tumor front, making an in-depth characterization of reticular fiber scaffolding, infiltrating immune cells, gene expression, and epigenetic profiles of classified aggressive primary uterine adenocarcinomas (24 patients) and leiomyosarcomas (11 patients). Read More

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Aggressiveness of Care at the End-of-Life in Cancer Patients and Its Association With Psychosocial Functioning in Bereaved Caregivers.

Front Oncol 2021 4;11:673147. Epub 2021 Jun 4.

Department of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg, Germany.

Study Registration: https://www.drks.de/drks_web/navigate. Read More

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Effect of Sequential Compression Device on Hemodynamic Changes After Spinal Anesthesia for Caesarean Section: A Randomized Controlled Trial.

Anesth Pain Med 2020 Oct 25;10(5):e104705. Epub 2020 Aug 25.

Menopause Andropause Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: The benefit of sequential compression device (SCD) for the prevention of hypotension after spinal anesthesia in cesarean sections has not been determined.

Objectives: In this study, an attempt was made to determine whether SCD can prevent hemodynamic changes following spinal anesthesia for cesarean sections.

Methods: In a prospective clinical trial, 76 parturient women undergoing elective cesarean sections under spinal anesthesia were randomly divided into SCD or control groups. Read More

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October 2020

Auscultation of Bowel Sounds and Ultrasound of Peristalsis Are Neither Compartmentalized Nor Correlated.

Cureus 2021 May 12;13(5):e14982. Epub 2021 May 12.

Emergency Medicine, MetroHealth Medical Center, Cleveland, USA.

Objective  Auscultation of bowel sounds has been taught as a component of the physical examination since the beginning of the 20th century. However, there has been little research or consensus on the significance of listening in different quadrants. Some textbooks indicate that bowel sounds are the result of peristalsis in that region, while others state that bowel sounds can be generalized over the entire abdominal wall. Read More

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Intimate partner violence among Arab women before and during the COVID-19 lockdown.

J Egypt Public Health Assoc 2021 Dec 16;96:15. Epub 2021 Jun 16.

Department of Family Health, High Institute of Public Health, Alexandria University, Alexandria, Egypt.

Introduction: Intimate partner violence (IPV) remains a serious human rights violation and an important health concern during the ongoing COVID-19 pandemic. The study aims to estimate the proportion of IPV among adult Arab women before and during the COVID-19 lockdown and to identify its possible predictors during the lockdown.

Methods: A cross-sectional study was conducted between April and June 2020 using an online questionnaire. Read More

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December 2021

Temporal subsidence patterns of cemented polished taper-slip stems: a systematic review.

EFORT Open Rev 2021 May 4;6(5):331-342. Epub 2021 May 4.

The Academic Surgical Unit, South West London Elective Orthopaedic Centre, UK.

The literature was reviewed to establish the levels of stem subsidence for both double and triple-tapered implants in order to determine whether there were any differences in subsidence levels with regard to the methods of measurement, the magnitude and rate of subsidence and clinical outcomes.All studies reporting subsidence of polished taper-slip stems were identified. Patient demographics, implant design, radiological findings, details of surgical technique, methods of measurement and levels of subsidence were collected to investigate which factors were related to increased subsidence. Read More

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