9,591 results match your criteria determinants serum

Post-transplant Inotrope Score is Associated with Clinical Outcomes after Adult Heart Transplantation.

Clin Transplant 2021 May 9:e14347. Epub 2021 May 9.

University of Groningen, University Msedical Center Groningen, Department of Cardiology, The Netherlands.

Background: Inotrope score has been proposed as a marker of clinical outcome after adult heart transplantation (HTx) but is rarely used in practice.

Methods: Inotrope score during the first 48 hours after HTx was calculated in 81 patients as: dopamine + dobutamine + amrinone + milrinone (dose × 15) + epinephrine (dose × 100) + norepinephrine (dose × 100) + enoximone + isoprenaline (dose × 100), with each drug in µg/kg/min. Determinants of inotrope score were identified with linear regression. Read More

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Host-Specific Serum Factors Control the Development and Survival of .

Front Immunol 2021 23;12:635622. Epub 2021 Apr 23.

Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.

Introduction: Schistosomiasis is a neglected tropical disease (NTD) caused by blood-dwelling flatworms which develop from skin-penetrating cercariae, the freely swimming water-borne infective stage of , into adult worms. This natural course of infection can be mimicked in experimental mouse models of schistosomiasis. However, only a maximum of 20-30% of penetrated cercariae mature into fecund adults. Read More

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Increased Serum Levels of Soluble TNF-α Receptor Is Associated With ICU Mortality in COVID-19 Patients.

Front Immunol 2021 22;12:592727. Epub 2021 Apr 22.

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has infected over 112M patients and resulted in almost 2.5M deaths worldwide. The major clinical feature of severe COVID-19 patients requiring ventilation is acute respiratory distress syndrome (ARDS) possibly associated with a cytokine storm. Read More

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Fewer US adults had low or transitional vitamin B12 status based on the novel combined indicator of vitamin B12 status compared with individual, conventional markers, NHANES 1999-2004.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Centers for Disease Control and Prevention (CDC), National Center for Environmental Health, Atlanta, GA, USA.

Background: Elevated plasma methylmalonic acid (MMA) and/or total homocysteine (tHcy), as well as low serum vitamin B12 and/or holotranscobalamin (holoTC) are indicative of vitamin B12 deficiency. Combined indicators (cB12), which pool some or all 4 markers into an index, may be a more reliable diagnostic tool to overcome inconclusive diagnoses with individual markers.

Objectives: We aimed to describe different cB12 score combinations and estimate the prevalence of low or transitional vitamin B12 status compared with individual markers. Read More

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Detection and inhibition of IgE antibodies reactive with cross-reactive carbohydrate determinants in an ELISA for allergen-specific IgE in horses.

Vet Dermatol 2021 May 6. Epub 2021 May 6.

Montesano & Tallarico, LLP, PO Box 1396, Smithtown, NY, USA.

Background: It has been demonstrated that immunoglobulin (Ig)E specific for cross-reactive carbohydrate determinants (CCD) is present in the serum of sensitized humans, dogs and cats, and that these CCD-specific antibodies might confound serological testing.

Hypothesis/objective: The objective was to determine whether or not CCD-reactive antibodies occur in horses and to investigate the prevalence of CCD-reactive IgE antibodies in equine sera using a monoclonal cocktail-based enzyme-linked immunosorbent assay designed to detect allergen-specific IgE in horses, and to evaluate a means for successful inhibition of these CCD.

Methods And Materials: Sera from 28 horses suspected of clinical allergy were evaluated, with and without a proprietary inhibitor which contains carbohydrates derived from bromelain (BROM-CCD), using a panel of 72 allergens that include 15 grasses, 17 trees, nine weeds, five mites, 12 fungi, 12 insects and two environmental allergens. Read More

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CCD Inhibition Test Can Improve the Accuracy of the Detection of Pollen and Seed Food Allergen-Specific IgE in Southern China.

J Asthma Allergy 2021 28;14:439-447. Epub 2021 Apr 28.

Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, People's Republic of China.

Objective: The presence of cross-reactive carbohydrate determinants (CCDs) may cause false-positive results in vitro allergen sIgE tests. In this paper, we focused on pollen sensitisation and its relationship with CCD in patients with respiratory allergic diseases in South China. A CCD inhibition test was conducted to assess whether patients were truly allergic to pollen or whether their sIgE was caused by a CCD cross-reaction, thus providing an important basis for clinical diagnosis and treatment. Read More

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Molecular characterization and epidemiology of Streptococcus pneumoniae serotype 8 in Denmark.

BMC Infect Dis 2021 May 5;21(1):421. Epub 2021 May 5.

Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen S, Denmark.

Background: Streptococcus pneumoniae serotype 8 incidence has increased in Denmark after the introduction of pneumococcal conjugated vaccines (PCV). The mechanism behind the serotype 8 replacement is not well understood. In this study, we aimed to present epidemiological data on invasive pneumococcal disease (IPD) and molecular characterization of 96 serotype 8 clinical isolates. Read More

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Associations between rs9939609 polymorphism, serum vitamin D, mental health, and eating behaviors in overweight adults.

Nutr Neurosci 2021 May 3:1-9. Epub 2021 May 3.

Student Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Despite the significant role of the Fat Mass and Obesity-Associated (FTO) gene in obesity, the underlying mechanisms are not fully elucidated. Besides, vitamin D deficiency and obesity are mostly seen together, and it can be hypothesized that this nutrient may have an impact in the role of FTO genotype in adiposity. Thus, this study aimed to investigate the association of FTO rs9939609 gene polymorphism with eating behaviors, eating disorders, and general mental health in overweight adults, considering their vitamin D intake as a mediate confounding factor. Read More

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Organohalogens: A persisting burden in Slovenia?

Environ Res 2021 Apr 29;198:111224. Epub 2021 Apr 29.

Jožef Stefan Institute, Jamova Cesta 39, 1000, Ljubljana, Slovenia; Jožef Stefan International Postgraduate School, Jamova Cesta 39, 1000, Ljubljana, Slovenia. Electronic address:

Persistent organic pollutants (POPs) represent a concern for the environment and human health due to their persistence and toxicity. Exposure in Slovenia is geographically differentiated because the country, as part of former Yugoslavia, has a history of industry and regional contamination and is - at the same time - known for its clean nature. The PCB pollution of the Krupa River drew the public's attention to the chemical burden of Slovenians, and the demand for studies has been rising since. Read More

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Vitamin D Status and Its Determinants in Mexican Pregnant Women from a Rural and an Urban Area: A Comparative Study.

Int J Environ Res Public Health 2021 Apr 26;18(9). Epub 2021 Apr 26.

Nutrition and Bioprogramming Coordination, Instituto Nacional de Perinatología, Mexico City 11000, Mexico.

Background: During pregnancy, vitamin D requirements are higher due to fetal growth and development. Vitamin D production occurs mainly through sunlight exposure, which is affected by geographic location and lifestyle factors.

Methods: This was a case-control study nested within two cohorts of adult pregnant women ( = 298): urban (Mexico City) and rural (Cuetzalan). Read More

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Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4 T Cell Responsiveness.

Nutrients 2021 Apr 28;13(5). Epub 2021 Apr 28.

Laboratory of Mitochondrial Biology and Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Intermittent fasting and fasting mimetic diets ameliorate inflammation. Similarly, serum extracted from fasted healthy and asthmatic subjects' blunt inflammation in vitro, implicating serum components in this immunomodulation. To identify the proteins orchestrating these effects, SOMAScan technology was employed to evaluate serum protein levels in healthy subjects following an overnight, 24-h fast and 3 h after refeeding. Read More

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Neighborhood Environment Associates with Trimethylamine-N-Oxide (TMAO) as a Cardiovascular Risk Marker.

Int J Environ Res Public Health 2021 Apr 18;18(8). Epub 2021 Apr 18.

Social Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Background: Neighborhoods and the microbiome are linked to cardiovascular disease (CVD), yet investigations to identify microbiome-related factors at neighborhood levels have not been widely investigated. We sought to explore relationships between neighborhood deprivation index (NDI) and the microbial metabolite, trimethylamine-N-oxide. We hypothesized that inflammatory markers and dietary intake would be mediators of the relationship. Read More

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Determinants of In-Hospital Mortality in Elderly Patients Aged 80 Years or above with Acute Heart Failure: A Retrospective Cohort Study at a Single Rural Hospital.

J Clin Med 2021 Apr 2;10(7). Epub 2021 Apr 2.

Department of Surgery, Hitachiomiya Saiseikai Hospital, Hitachiomiya 319-2256, Japan.

Heart failure is one of the leading causes of mortality worldwide. Several predictive risk scores and factors associated with in-hospital mortality have been reported for acute heart failure. However, only a few studies have examined the predictors in elderly patients. Read More

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Performance and Determinants of Serum Creatinine and Cystatin C-Based GFR Estimating Equations in South Asians.

Kidney Int Rep 2021 Apr 16;6(4):962-975. Epub 2021 Jan 16.

Program in Health Services and Systems Research, Duke-NUS Medical School, Singapore.

Introduction: The creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimated glomerular filtration rate (eGFR) equation was calibrated for the general Pakistan population (eGFRcr-PK) to eliminate bias and improve accuracy. Cystatin C-based CKD-EPI equations (eGFRcys and eGFRcr-cys) have not been assessed in this population, and non-GFR determinants of cystatin C are unknown.

Methods: We assessed eGFRcys, eGFRcr-cys, and non-GFR determinants of cystatin C in a cross-sectional study of 557 participants (≥40 years of age) from Pakistan. Read More

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Enzyme kinetic and binding studies identify determinants of specificity for the immunomodulatory enzyme ScpA, a C5a inactivating bacterial protease.

Comput Struct Biotechnol J 2021 17;19:2356-2365. Epub 2021 Apr 17.

Department of Biological Sciences, University of Limerick, Limerick, Ireland.

The Streptococcal C5a peptidase (ScpA) specifically inactivates the human complement factor hC5a, a potent anaphylatoxin recently identified as a therapeutic target for treatment of COVID-19 infections. Biologics used to modulate hC5a are predominantly monoclonal antibodies. Here we present data to support an alternative therapeutic approach based on the specific inactivation of hC5a by ScpA in studies using recombinant hC5a (rhC5a). Read More

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Determinants of Serum Immunoglobulin Levels: A Systematic Review and Meta-Analysis.

Front Immunol 2021 7;12:664526. Epub 2021 Apr 7.

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.

Background: An up-to-date overview of determinants of serum immunoglobulins in adults is pivotal for clinical practice and research, but currently lacking. We therefore performed a systematic review and meta-analysis to identify determinants of serum immunoglobulin levels.

Methods: Embase, Web of Science, Medline, Cochrane, and Google Scholar were searched from inception to July 11, 2019 for articles reporting on determinants of serum immunoglobulin A, G or M (IgA, IgG or IgM) in adult humans. Read More

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[Uric acid in children and adolescents with primary hypertension].

Pol Merkur Lekarski 2021 Apr;49(290):119-124

Medical University of Warsaw, Poland: Department of Pediatrics and Nephrology.

Increased concentration of uric acid may play a role in the pathogenesis of primary hypertension (PH).

Aim: The aim of the study was to assess concentration of uric acid and to assess its correlation with selected clinical and biochemical parameters in children with PH.

Materials And Methods: In a group of 57 untreated pharmacologically children with PH (44 boys, 13 girls, mean age 14. Read More

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A pH-dependent protein stability switch coupled to the perturbed pKa of a single ionizable residue.

Biophys Chem 2021 Apr 20;274:106591. Epub 2021 Apr 20.

Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, Maharashtra, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:

The contribution of electrostatic interactions in protein stability has not been fully understood. Burial of an ionizable amino acid inside the hydrophobic protein core can affect its ionization equilibrium and shift its pKa differentially in the native (N) and unfolded (U) states of a protein and this coupling between the folding/unfolding cycle and the ionization equilibria of the ionizable residue can substantially influence the protein stability. Here, we studied the coupling of the folding/unfolding cycle with the ionization of a buried ionizable residue in a multi-domain protein, Human Serum Albumin (HSA) using fluorescence spectroscopy. Read More

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Dietary obesity in mice is associated with lipid deposition and metabolic shifts in the lungs sharing features with the liver.

Sci Rep 2021 Apr 22;11(1):8712. Epub 2021 Apr 22.

Univ Lyon, CarMeN Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, 69921, Oullins Cedex, France.

Obesity is associated with both chronic and acute respiratory illnesses, such as asthma, chronic obstructive pulmonary disease (COPD) or increased susceptibility to infectious diseases. Anatomical but also systemic and local metabolic alterations are proposed contributors to the pathophysiology of lung diseases in the context of obesity. To bring perspective to this discussion, we used NMR to compare the obesity-associated metabolomic profiles of the lung with those of the liver, heart, skeletal muscles, kidneys, brain and serum from male C57Bl/6J mice fed with a high-fat and high-sucrose (HFHSD) diet vs. Read More

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How mindful of their own health are healthcare professionals? perception and practice of personnel in a tertiary hospital in Nigeria.

Ghana Med J 2020 Dec;54(4):215-224

Department of Community Medicine, Delta State University Teaching Hospital, Oghara, Nigeria.

Objectives: To assess health professionals' perception and determinants of their health and practice of preventive self-care.

Methods: An analytic cross-sectional design was employed, and 232 professionals were selected by stratified sampling from all health professional departments of Delta State University Teaching Hospital. Healthcare professionals who had worked in the hospital for at least six months were included in the sampling frame. Read More

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December 2020

Triglyceride/High-Density Lipoprotein Cholesterol Ratio: A Clue to Metabolic Syndrome, Insulin Resistance, and Severe Atherosclerosis.

Lipids 2021 Apr 21. Epub 2021 Apr 21.

Stroke Prevention & Atherosclerosis Research Centre (SPARC), Robarts Research Institute, Western University, 1400 Western Road, London, ON, N6aG 2V4, Canada.

High serum levels of triglycerides (Tg) and low levels of high-density lipoprotein cholesterol (HDL-C) are characteristic of the Metabolic Syndrome (MetS). We assessed the ratio of Tg to HDL-C as a way to identify MetS and insulin resistance. We also evaluated its association with severity of carotid atherosclerosis. Read More

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Neuromuscular junction instability and altered intracellular calcium handling as early determinants of force loss during unloading in humans.

J Physiol 2021 Apr 21. Epub 2021 Apr 21.

Department of Biomedical Sciences, University of Padova, Padova, 35131, Italy.

Key Points: Few days of unloading are sufficient to induce a decline of skeletal muscle mass and function; notably, contractile force is lost at a faster rate than mass. The reasons behind this disproportionate loss of muscle force are still poorly understood. We provide strong evidence of two mechanisms only hypothesized until now for the rapid muscle force loss in only 10 days of bed rest. Read More

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Oleic acid to stearic acid ratio might be a potential marker for insulin resistance in non-obese Japanese.

J Clin Biochem Nutr 2021 Mar 13;68(2):164-168. Epub 2020 Oct 13.

Department of Clinical Health Science, Tokai University School of Medicine, 1-2-5 Yoyogi, Shibuya-ku, Tokyo 151-0053, Japan.

Results from a recent study indicate that a higher level of oleic acid/stearic acid ratio was associated with metabolically unhealthy obesity. This was further validated in cross-sectional and interventional studies; however, this was not extensively studied in a non-obese population. We recruited 260 Japanese subjects with serum free fatty acid profiles undergoing anti-aging health examinations. Read More

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The Detection of Hypermucoviscous Carbapenem-Resistant from a Tertiary Teaching Hospital in Malaysia and Assessment of Hypermucoviscous as Marker of Hypervirulence.

Microb Drug Resist 2021 Apr 20. Epub 2021 Apr 20.

Department of Medical Microbiology and Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Hypermucoviscous carbapenem-resistant (hmCRKp) is emerging globally and approaching the worst-case scenario in health care system. The main objective in this study was to determine the hypermucoviscous characteristics among the carbapenem-resistant (CRKp) isolated from a teaching hospital in Malaysia. The association of hypermucoviscous phenotype with the virulence traits and clinical presentations were also investigated. Read More

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Evaluation of iron, ferritin, copper, and ceruloplasmin along with proviral load in human T lymphotropic virus type 1-associated myelopathy.

J Neurovirol 2021 Apr 20. Epub 2021 Apr 20.

Department of Neurology, Faculty of Medicine, Qaem Hospital, Mashhad University of Medical Sciences, Ahmadabad Avenue, 91766-99199, Mashhad, Iran.

Human T-cell lymphotropic virus type 1 (HTLV-1) infection can cause HTLV-I-associated myelopathy (HAM). In this study, we evaluated the levels of serum iron, ferritin, copper, and ceruloplasmin, and their correlations with HTLV-1 proviral load (PVL) and standard indices of HAM severity. In total, 114 subjects were recruited in this cross sectional study in Qaem Hospital, Mashhad, Iran between 2017 and 2018, including 36 HAM and 32 asymptomatic cases (ACs) and 46 healthy people (HSs). Read More

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Antibody Affinity Governs the Inhibition of SARS-CoV-2 Spike/ACE2 Binding in Patient Serum.

ACS Infect Dis 2021 Apr 20. Epub 2021 Apr 20.

Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

The humoral immune response plays a key role in suppressing the pathogenesis of SARS-CoV-2. The molecular determinants underlying the neutralization of the virus remain, however, incompletely understood. Here, we show that the ability of antibodies to disrupt the binding of the viral spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor on the cell, the key molecular event initiating SARS-CoV-2 entry into host cells, is controlled by the affinity of these antibodies to the viral antigen. Read More

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Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort.

Gut Microbes 2021 Jan-Dec;13(1):1-14

Department of Medical Biosciences, Pathology, Umeå University, Ireland.

Experimental evidence has implicated genotoxic () and enterotoxigenic (ETBF) in the development of colorectal cancer (CRC). However, evidence from epidemiological studies is sparse. We therefore assessed the association of serological markers of and ETBF exposure with odds of developing CRC in the European Prospective Investigation into Nutrition and Cancer (EPIC) study. Read More

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A contemporary insight into the sero-epidemiology of infection in the foot-hills of Himalayas: A cross-sectional study from a tertiary care center in Northern India.

Nepal J Epidemiol 2021 Mar 31;11(1):937-948. Epub 2021 Mar 31.

Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Background: infects 30-50% of the world's population with high diversity in the geo-epidemiology and seroprevalence. The burden of toxoplasmosis and its determinants from remote and vulnerable regions of India is unknown. Therefore, this study aim to evaluate the prevalence of toxoplasma antibodies and factors associated with seropositivity among individuals from Uttarakhand and adjoining areas. Read More

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Testicular Growth and Pubertal Onset in GH-Deficient Children Treated With Growth Hormone: A Retrospective Study.

Front Endocrinol (Lausanne) 2021 2;12:619895. Epub 2021 Apr 2.

Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

The prevalence of idiopathic oligozoospermia has been esteemed as high as 75%. An Italian survey has reported bilateral testicular hypotrophy in 14% of final-year high school students. The search for determinants of testicular growth in childhood is important for the primary prevention of spermatogenic failure. Read More

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Effect of glutamine supplementation on cardiometabolic risk factors and inflammatory markers: a systematic review and meta-analysis.

BMC Cardiovasc Disord 2021 Apr 17;21(1):190. Epub 2021 Apr 17.

Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.

Background: Evidence exists that glutamine plays multiple roles in glucose metabolism, insulin sensitivity, and anti-inflammatory effects. This systematic review and meta-analysis of controlled trials aimed to assess the effect of glutamine supplementation on cardio-metabolic risk factors and inflammatory markers.

Methods: The processes of systematic reviews and meta-analyses were performed according to the PRISMA checklist. Read More

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