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GlcNAc is a mast-cell chromatin-remodeling oncometabolite that promotes systemic mastocytosis aggressiveness.

Blood 2021 May 11. Epub 2021 May 11.

Centre de Recherche en Cancérologie de Marseille - Inserm U1068, CNRS UMR7258, Aix-Marseille Université, Institut Paoli-Calmettes, Marseille, France.

Systemic mastocytosis (SM) is a KIT-driven hematopoietic neoplasm characterized by the excessive accumulation of neoplastic mast cells (MCs) in various organs and, mainly, the bone marrow (BM). Multiple genetic and epigenetic mechanisms contribute to the onset and severity of SM. However, little is known to date about the metabolic underpinnings underlying SM aggressiveness, which has thus far impeded the development of strategies to leverage metabolic dependencies when existing KIT-targeted treatments fail. Read More

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The Use of Head-Worn Displays for Vital Sign Monitoring in Critical and Acute Care: Systematic Review.

JMIR Mhealth Uhealth 2021 May 11;9(5):e27165. Epub 2021 May 11.

School of Psychology, The University of Queensland, St Lucia, QLD, Australia.

Background: Continuous monitoring of patient vital signs may improve patient outcomes. Head-worn displays (HWDs) can provide hands-free access to continuous vital sign information of patients in critical and acute care contexts and thus may reduce instances of unrecognized patient deterioration.

Objective: The purpose of the study is to conduct a systematic review of the literature to evaluate clinical, surrogate, and process outcomes when clinicians use HWDs for continuous patient vital sign monitoring. Read More

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A prospective evaluation of treatment recommendations compared to outcomes for a lung cancer multidisciplinary team and legal implications.

J Med Imaging Radiat Oncol 2021 May 10. Epub 2021 May 10.

Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Introduction: This cross-sectional study compared treatment recommendations made by a respiratory multi-disciplinary team with the treatment received by those patients in practice. The aim was to evaluate the rate at which patients were treated in keeping with MDT recommendations. It was hypothesised that most patients would be treated in accordance with these recommendations. Read More

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Compound heterozygous variants in progressive myoclonus epilepsy.

J Neurogenet 2021 May 10:1-10. Epub 2021 May 10.

NIH Undiagnosed Diseases Program, Common Fund, Office of the Director, NIH and National Human Genome Research Institute, NIH, Bethesda, MD, USA.

KCTD7 is a member of the potassium channel tetramerization domain-containing protein family and has been associated with progressive myoclonic epilepsy (PME), characterized by myoclonus, epilepsy, and neurological deterioration. Here we report four affected individuals from two unrelated families in which we identified compound heterozygous single nucleotide variants through exome sequencing. RNAseq was used to detect a non-annotated splicing junction created by a synonymous variant in the second family. Read More

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Clinical and ultrasound evaluation of patients with haemophilia on prophylaxis.

Haemophilia 2021 May 10. Epub 2021 May 10.

Haemophilia Foundation of Argentina, Buenos Aires, Argentina.

Introduction: Primary prophylaxis is the current gold standard in haemophilia care for the prevention of bleeding and ensuing joint damage. Early detection of joint bleeding, whether symptomatic or subclinical, preferably during childhood, helps prevent joint deterioration and subsequent disability. The aim of this study is to evaluate the level of agreement between the Haemophilia Joint Health Score and the Haemophilia Early Arthropathy Detection with Ultrasound tools in children with severe haemophilia on primary and secondary prophylaxis. Read More

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The use of Janus Kinase inhibitors in hospitalized patients with COVID-19: Systematic review and meta-analysis.

Clin Epidemiol Glob Health 2021 Jul-Sep;11:100755. Epub 2021 May 2.

Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia.

Background: The evidence of using JAK inhibitors among hospitalized patients with COVID-19 is conflicting. The systematic review and meta-analysis aimed to address the efficacy of Janus Kinase (JAK) Inhibitors in reducing risk of mortality among hospitalized patients with COVID-19.

Methods: Several electronic databases, including PubMed, EuropePMC, and the Cochrane Central Register of Controlled Trials, with relevant keywords "COVID-19″ AND ("JAK inhibitor" OR "Ruxolitinib" OR "Tofacitinib" OR "Fedratinib" OR "Baricitinib") AND ("Severe" OR "Mortality"), were used to perform a systematic literature search up to December 11, 2020. Read More

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Successful endoscopic surgery for emphysematous pyelonephritis in a non-diabetic patient with autosomal dominant polycystic kidney disease: A case report.

World J Clin Cases 2021 Apr;9(12):2862-2867

Department of Surgery, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, Guangdong Province, China.

Background: Emphysema pyelonephritis (EPN) is a very dangerous type of urinary tract infection. It is a lethal disease that develops rapidly and causes the patient to deteriorate rapidly, and it can easily lead to systemic infections and even sepsis. The incidence is extremely low, and it is prevalent in patients with diabetes. Read More

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Prevalence and Prognostic Value of Heart Failure Stages: An Elderly Inpatient Based Cohort Study.

Front Med (Lausanne) 2021 22;8:639453. Epub 2021 Apr 22.

Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

The prevalence and prognostic value of heart failure (HF) stages among elderly hospitalized patients is unclear. We conducted a prospective, observational, multi-center, cohort study, including hospitalized patients with the sample size of 1,068; patients were age 65 years or more, able to cooperate with the assessment and to complete the echocardiogram. Two cardiologists classified all participants in various HF stages according to 2013 ACC/AHA HF staging guidelines. Read More

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Clinical Factors and Quantitative CT Parameters Associated With ICU Admission in Patients of COVID-19 Pneumonia: A Multicenter Study.

Front Public Health 2021 22;9:648360. Epub 2021 Apr 22.

Xuanwu Hospital, Capital Medical University, Beijing, China.

The clinical spectrum of COVID-19 pneumonia is varied. Thus, it is important to identify risk factors at an early stage for predicting deterioration that require transferring the patients to ICU. A retrospective multicenter study was conducted on COVID-19 patients admitted to designated hospitals in China from Jan 17, 2020, to Feb 17, 2020. Read More

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Motor Control and Ergonomic Intervention Home-Based Program: A Pilot Trial Performed in the Framework of the Motor Control Home Ergonomics Elderlies' Prevention of Falls (McHeELP) Project.

Cureus 2021 Apr 7;13(4):e14336. Epub 2021 Apr 7.

Physiotherapy, Physiotherapy Department, Faculty of Health and Care Sciences, University of West Attica (UNIWA), Athens, GRC.

Objectives Falls are a serious problem that can reduce living autonomy and health-related quality of life of older adults. A decrease in the muscular strength of the lower limbs and the deterioration of balance or motor performance deficits may lead to falls. "Motor Control Home Ergonomics Elderlies' Prevention of Falls" (McHeELP) is a novel motor control exercise program combined with ergonomic arrangements of the home environment. Read More

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Comorbidity rates of Posttraumatic Stress Disorder in dementia: a systematic literature review.

Eur J Psychotraumatol 2021 Mar 12;12(1):1883923. Epub 2021 Mar 12.

School for Mental Health and Neuroscience (MHeNs), Department of Psychiatry and Neuropsychology, Maastricht University Medical Centre+, Maastricht, The Netherlands.

: Post Traumatic Stress Disorder (PTSD) has been described as an independent risk factor for cognitive decline and dementia. At the same time, cognitive deterioration and increased loss experiences in dementia may increase liability for the reactivation of traumatic memories and thereby PTSD symptoms. : In order to investigate co-occurrence of PTSD in dementia this systematic literature review summarizes all the available evidence on reported comorbidity rates of PTSD in patients with dementia. Read More

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Lessons learned from an audit of 1250 anal fistula patients operated at a single center: A retrospective review.

World J Gastrointest Surg 2021 Apr;13(4):340-354

Department of Statistics, Indian Council of Medical Research, New Delhi 110029, New Delhi, India.

Background: A complex anal fistula is a challenging disease to manage.

Aim: To review the experience and insights gained in treating a large cohort of patients at an exclusive fistula center.

Methods: Anal fistulas operated on by a single surgeon over 14 years were analyzed. Read More

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Influence of Cochlear Implantation on Vestibular Function in Children With an Enlarged Vestibular Aqueduct.

Front Neurol 2021 21;12:663123. Epub 2021 Apr 21.

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Cochlear implantation (CI) is becoming increasingly used in the rehabilitation of hearing-impaired patients. Children with an enlarged vestibular aqueduct (EVA) need CI for severe or profound hearing loss, with excellent outcomes in hearing rehabilitation. However, vestibular function influenced by CI in children with EVA has not been clarified. Read More

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Prevalence of Chemotherapy-Induced Peripheral Neuropathy in Multiple Myeloma Patients and its Impact on Quality of Life: A Single Center Cross-Sectional Study.

Front Pharmacol 2021 22;12:637593. Epub 2021 Apr 22.

INSERM U1107 NEURO-DOL, Université Clermont Auvergne, Clermont-Ferrand, France.

Bortezomib is a pivotal drug for the management of multiple myeloma. However, bortezomib is a neurotoxic anticancer drug responsible for chemotherapy-induced peripheral neuropathy (CIPN). CIPN is associated with psychological distress and a decrease of health-related quality of life (HRQoL), but little is known regarding bortezomib-related CIPN. Read More

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Temporary mechanical circulatory support: insights and evolving strategies.

Indian J Thorac Cardiovasc Surg 2021 May 9;37(3):265-273. Epub 2021 Jan 9.

Department of Anaesthesia, Fortis Hospital, Mumbai, India.

Purpose: The goal of this study is to evaluate the utilization and outcomes of temporary mechanical circulatory support (MCS) among patients listed for cardiac transplantation (CT). There is a constant threat of sudden clinical deterioration in these patients that could necessitate emergent MCS. All advanced heart failure and transplant centers in India are plagued by issues of late referrals, low organ donation rates, and financial constraints. Read More

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Clinical and obstetric characteristics of pregnant women with Covid-19: A case series study on 26 patients.

Taiwan J Obstet Gynecol 2021 May 23;60(3):458-462. Epub 2021 Mar 23.

Shahid Beheshti Hospital, Kashan, Iran. Electronic address:

Objective: To evaluate the clinical characteristics and outcomes of pregnant women with Covid-19.

Materials And Methods: This case series study was performed to investigate demographic, clinical and obstetric characteristics of 26 pregnant women with COVID-19 referring to a university hospital of Kashan during the epidemic of COVID-19 (March to May 2020).

Results: The mean gestational age of the patients at admission and delivery was 31. Read More

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Alpha-1 antitrypsin deficiency in the elderly: a case report.

J Med Case Rep 2021 May 10;15(1):231. Epub 2021 May 10.

UOC Pathophysiology and Respiratory Rehabilitation, Intensive Care Department, Monaldi Hospital, Naples, Italy.

Background: Generally, alpha-1 antitrypsin deficiency (AATD) is suspected in young patients with pulmonary emphysema or chronic obstructive pulmonary disease (COPD). Patients often suffer from diagnostic gaps and are misdiagnosed with chronic obstructive pulmonary disease (COPD), asthma, and airway hyperresponsiveness (AHR), as AATD may present with nonspecific respiratory symptoms. It is never too late to suspect AATD, especially in a patient with an unusual medical history. Read More

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Multimodal assessment of right ventricle overload-metabolic and clinical consequences in pulmonary arterial hypertension.

J Cardiovasc Magn Reson 2021 May 10;23(1):49. Epub 2021 May 10.

Department of Cardiology, Medical University of Bialystok, Białystok, Poland.

Background: In pulmonary arterial hypertension (PAH) increased afterload leads to adaptive processes of the right ventricle (RV) that help to maintain arterio-ventricular coupling of RV and preserve cardiac output, but with time the adaptive mechanisms fail. In this study, we propose a multimodal approach which allows to estimate prognostic value of RV coupling parameters in PAH patients.

Methods: Twenty-seven stable PAH patients (49. Read More

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Effects of a diuretic adjustment algorithm protocol on heart failure admissions: A randomized clinical trial.

J Telemed Telecare 2021 May 9:1357633X211009640. Epub 2021 May 9.

School of Nursing, Universidade Federal do Rio Grande do Sul, Brazil.

Introduction: The aim of this study was to evaluate the effectiveness of a diuretic adjustment algorithm (DAA) in maintaining clinical stability and reducing HF readmissions using telemonitoring Technologies.

Methods: Randomized clinical trial of patients with an indication for furosemide dose adjustment during routine outpatient visits. In the intervention group (IG), the diuretic dose was adjusted according to the DAA and the patients received telephone calls for 30 days. Read More

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CLINICAL, PHARMACOTHERAPEUTIC AND BIORHYTHMOLOGICAL PECULIARITIES OF DEPRESSIVE DISORDERS, COMORBID WITH CARDIOVASCULAR PATHOLOGY.

Georgian Med News 2021 Mar(312):57-61

2Communal Еnterprise «Regional Institution for Providing Psychiatric Care of Poltava Regional Council», Ukraine.

The spread of depressive disorders is extra high nowadays. Depressive disorders are widespread mental disorders in the structure of mental pathology, both causes of psychiatrists' visit, and causes of medical aid. The presence of depressive syndrome in patients with cardiovascular system leads to deterioration patient's condition and adaptive abilities and aggravates somatic abnormality. Read More

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Early warning of infection in patients undergoing hematopoietic stem cell transplantation using heart rate variability and serum biomarkers.

Transplant Cell Ther 2021 May 5. Epub 2021 May 5.

Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Ottawa, ON, Canada; Departments of Critical Care Medicine and Surgery, The Ottawa Hospital, Ottawa, ON, Canada.

Background: Early warning of infection is critical to reduce risk of deterioration and mortality, especially in neutropenic patients following hematopoietic stem cell transplantation (HCT). Given that heart rate variability (HRV) is a sensitive and early marker for infection and serum inflammatory biomarkers can have high specificity for infection, we hypothesized their combination may be useful for accurate early warning of infection.

Purpose: Develop and evaluate a composite predictive model utilizing continuous HRV with daily serum biomarker measurements to provide risk stratification of future deterioration in HCT patients. Read More

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Mechanical thrombectomy in distal residual occlusions of the middle cerebral artery after large vessel recanalization in acute stroke: 2b or not 2b? A pragmatic approach in real-life scenarios.

World Neurosurg 2021 May 5. Epub 2021 May 5.

Hopital Foch, Department of Diagnostic and Interventional Neuroradiology, Suresnes, Île-de-France, FR.

Background: AND PURPOSE: Recent studies have suggested that a recanalization grade of modified thrombolysis in cerebral infarction (mTICI) ≥2c is strongly related with good clinical outcome rather than the current therapeutic angiography target ≥2b. In order to achieve better recanalization, additional further maneuvers on distal residual vessel occlusion may be required. The aim of this paper was to evaluate the safety and efficacy of rescue treatment in residual vessel occlusions (RVOs) after recanalization of large vessel occlusions in the anterior circulation. Read More

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Neurotoxicity prevention with a multimodal program (ATENTO) prior to cancer treatment versus throughout cancer treatment in women newly diagnosed for breast cancer: Protocol for a randomized clinical trial.

Res Nurs Health 2021 May 7. Epub 2021 May 7.

Department of Physiotherapy, Faculty of Health Sciences, University of Granada, Granada, Spain.

A current challenge in breast cancer (BC) patients is how to reduce the side effects of cancer and cancer treatments and prevent a decrease in quality of life (QoL). Neurotoxic side effects, especially from chemotherapy, are present in up to 75% of women with BC, which implies a large impact on QoL. There is a special interest in the preventive possibilities of therapeutic exercise (TE) for these neurological sequelae, and the benefits of TE could be improved when it is combined with vagal activation techniques (VATs). Read More

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Mixed dementia and hyperactive delirium: a diagnostic challenge.

BMJ Case Rep 2021 May 7;14(5). Epub 2021 May 7.

Department of Acute Medicine, Royal Berkshire NHS Foundation Trust, Reading, UK.

It is well recognised that acute confusion or delirium complicates up to 10% of acute medical admissions. Disorientation in time and place with an impaired short-term memory and conscious level are the hallmarks of an acute confusion. In delirium, disorders of perception may produce restlessness and agitation. Read More

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The predictive value of intraoperative visual evoked potential for visual outcome after extended endoscopic endonasal surgery for adult craniopharyngioma.

J Neurosurg 2021 May 7:1-11. Epub 2021 May 7.

1Department of Neurosurgery, Beijing Tiantan Hospital, and.

Objective: Due to the proximity of craniopharyngioma to the optic apparatus, one of the most common complications after surgery is visual deterioration. Intraoperative visual evoked potential (VEP), as a means of real-time visual function monitoring, has been integrated into transsphenoidal surgery for pituitary adenoma to predict postoperative visual outcome. Compared with pituitary tumor, craniopharyngioma often adheres to optic nerves, with increased risk of postoperative visual impairment. Read More

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Impact of dialysis in patients undergoing bioprosthetic aortic valve replacement.

Interact Cardiovasc Thorac Surg 2021 May 7. Epub 2021 May 7.

Department of Cardiovascular Surgery, Kokura Memorial Hospital, Fukuoka, Japan.

Objectives: To determine the incidence of bioprosthetic structural valve deterioration in dialysis patients undergoing aortic valve replacement compared to that in patients without dialysis.

Methods: This single-centre retrospective observational study included 1159 patients who underwent aortic valve replacement using bioprosthetic valves for aortic stenosis and/or regurgitation at our institution between 2007 and 2017 [patients with dialysis (group D, n = 134, 12%) or without dialysis (group N, n = 1025, 88%)]. To adjust for potential differences between groups in terms of initial preoperative characteristics or selection bias, a propensity score analysis was conducted. Read More

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Cognitive deficit is correlated with sleep stability in insomnia: A cardiopulmonary coupling study.

Brain Behav 2021 May 7:e02068. Epub 2021 May 7.

Department of Neurology, Tianjin Medical University General Hospital Airport Site, Tianjin, China.

Objectives: To assess the correlation of cognitive function with sleep stability and depressive-anxious symptoms in insomnia patients.

Methods: Twenty-two insomnia patients with cognitive impairment (insomnia-CI), 21 insomnia patients with normal cognition (insomnia-CN), and 15 matched healthy control subjects (HCs) were enrolled and completed neuropsychological tests, the Hamilton Depression and Anxiety Scales (HAMD and HAMA), the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index (PSQI),the Insomnia Severity Index (ISI), and the cardiopulmonary coupling (CPC) examination. Ratios of high-frequency coupling (HFC), low-frequency coupling (LFC), and very low-frequency coupling (VLFC) measured by CPC analysis represent stable sleep, unstable sleep, and wake/rapid eye movement (REM) sleep, respectively. Read More

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Effectiveness of skin cleanser and protectant regimen on incontinence-associated dermatitis outcomes in acute care patients: A cluster randomised trial.

Int Wound J 2021 May 7. Epub 2021 May 7.

Nursing Research Unit, Tan Tock Seng Hospital, Singapore, Singapore.

Skin cleansers and protectants protect skin from incontinent matter to reduce the risk of incontinence-associated dermatitis (IAD), but their effectiveness treating established IAD in the tropics is unknown. We conducted an open-label cluster randomised trial to compare the effectiveness of a combined regimen of (1) specialised skin cleansers with disposable body wipes and (2) either an acrylic terpolymer (T1) or zinc oxide (T2) skin protectant against disposable body wipes and zinc oxide protectant (control) in promoting IAD healing and reducing the risk of deterioration. Eighty-four patients were recruited in a tertiary hospital in Singapore between April 2019 and January 2020 (T1: n = 23; T2: n = 37; Control: n = 24). Read More

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Effectiveness of maintenance Electroconvulsive Therapy - Evidence from modifications due to the COVID-19 Pandemic.

Acta Psychiatr Scand 2021 May 7. Epub 2021 May 7.

University Medical Center Göttingen, Department of Psychiatry and Psychotherapy, von-Siebold-Str. 5, D-37075, Göttingen, Germany.

Objective: Continuation and maintenance ECT (c-/m-ECT) are effective in the prevention of relapse and recurrence of both affective and psychotic disorders. However, data are scarce concerning the trajectories of severe mental disorders after the end of c-/m-ECT. This prospective study investigates the clinical outcome of patients with versus without modifications of their c-/m-ECT schedules. Read More

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The association between intracompartmental pressure and skeletal muscle recovery after tibial diaphyseal fractures: an ambispective cohort study.

J Orthop Traumatol 2021 May 6;22(1):18. Epub 2021 May 6.

Department of Radiology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China.

Background: Due to the special anatomy of the lower leg, tibial diaphyseal fracture causes increased intracompartmental pressure (ICP). Not only is this increased ICP the manifestation of skeletal muscle injury, but it induces further deterioration of the injury. The aim of this study was to assess the association between short-term ICP elevation and long-term skeletal muscle recovery after severe limb trauma. Read More

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