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Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study.

BMJ Open 2022 Jun 27;12(6):e055082. Epub 2022 Jun 27.

Department of Ophthalmology, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.

Objectives: Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) is a novel OCT technology that was specifically designed for home monitoring of neovascular age-related macular degeneration (AMD). First clinical findings have been reported before. This trial investigates an improved prototype for patients with AMD and focusses on device operability and diagnostic accuracy compared with established spectral-domain OCT (SD-OCT). Read More

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Non-ischaemic cardiomyopathy associated with elevated serum cobalt and accelerated wear of a metal-on-metal hip resurfacing.

BMJ Case Rep 2022 Jun 27;15(6). Epub 2022 Jun 27.

Orthopaedic Surgery, Henry Ford Health System, Detroit, Michigan, USA.

A man in his late 30s developed non-ischaemic cardiomyopathy due to systemic cobalt toxicity associated with accelerated bearing surface wear from metal-on-metal hip resurfacing implanted in the previous 6 years. Following revision arthroplasty, the patient regained baseline cardiac function. Cobalt-induced cardiomyopathy is a grave condition that deserves early consideration due to potentially irreversible morbidity. Read More

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Virtual respiratory therapy delivered through a smartphone app: a mixed-methods randomised usability study.

BMJ Open Respir Res 2022 Jun;9(1)

Physical Activity Research Group, Central Queensland University Appleton Institute, Rockhampton, Queensland, Australia.

Introduction: A new smartphone app (QUT Inspire) has been developed to detect inspiratory sound and deliver virtual incentive spirometry (ISy), a respiratory therapy technique used in postoperative recuperation, management of some chronic conditions and with potential applications in SARS-CoV-2 rehabilitation. The aim of this study was to compare the usability of this new app with a clinical ISy device as measured by effectiveness, efficiency and satisfaction.

Methods: In this mixed-methods randomised usability study, healthy volunteers (aged 39. Read More

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Review on public private mix TB control strategy in India.

Indian J Tuberc 2022 Jul 15;69(3):277-281. Epub 2021 Jul 15.

KSPH, KIIT University, Bhubaneswar, Odisha, India.

In India, around 70% of health care services are offered by the private sector. National strategic plan (NSP) has emphasized private sector engagement to TB program. Public private mix strategy along with web based mandatory notification of TB cases were established in 2002. Read More

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Polio's detection in London is a wake-up call.

BMJ 2022 Jun 27;377:o1589. Epub 2022 Jun 27.

Imperial College London.

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Transcriptome analysis of walnut quality formation and color change mechanism of pellicle during walnut development.

Gene Expr Patterns 2022 Jun 24:119260. Epub 2022 Jun 24.

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, China. Electronic address:

Walnuts (including those covered with a pellicle) are loved for their rich nutritional value. And the popular varieties of walnut cultivation are Juglans sigillata L. The pellicle (seed coat) of these walnut cultivars has different colors and has an indispensable influence on the walnut quality formation. Read More

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Scientific evidence of the duration of antibiotic treatment in intra-abdominal infections with surgical focus control.

Cir Esp (Engl Ed) 2022 Jun 24. Epub 2022 Jun 24.

Servicio de Cirugía General y Aparato Digestivo, Hospital del Mar de Barcelona, Spain.

A non-systematic review of the published scientific evidence has been carried out on the duration of empirical antibiotic treatment in surgical intra-abdominal infections (IIA) with effective focus control. Given the progressive increase in antibiotic resistance, it is urgent to have strategies to reduce the pressure on the microbiota. The American guidelines made by Mazuski et al. Read More

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Illicit drug consumption estimated using wastewater analysis and compared by settlement size in New Zealand.

Sci Total Environ 2022 Jun 24:156956. Epub 2022 Jun 24.

Institute of Environmental Science and Research Ltd., New Zealand.

Estimation of consumption of illicit drugs by wastewater-based epidemiology provides estimates of community drug-use patterns. This study describes monitoring data of three illicit drugs in New Zealand using wastewater-based epidemiology. Wastewater samples were collected at monthly intervals for larger (population ~ 50,000+) cities or in smaller towns where more data was required by authorities. Read More

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Detection of M. tuberculosis in the environment as a tool for identifying high-risk locations for tuberculosis transmission.

Sci Total Environ 2022 Jun 24:156970. Epub 2022 Jun 24.

Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Tuberculosis (TB) remains a leading cause of infectious mortality globally, yet most cases cannot be epidemiologically linked even with extensive contact investigations and whole genome sequencing. Consequently, there remain major gaps in our understanding of where and when M. tuberculosis (Mtb) exposures occur. Read More

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Optimized flow cytometry protocol for dihydrorhodamine 123-based detection of reactive oxygen species in leukocyte subpopulations in whole blood.

J Immunol Methods 2022 Jun 24:113308. Epub 2022 Jun 24.

Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Sweden. Electronic address:

Reactive oxygen species (ROS) and the ability of immune cells to mount an oxidative burst represent an important defense during microbial invasion, but is also recognized for playing a significant role in the progression of inflammatory disorders and disease. Although neutrophils produce the strongest ROS-response, other leukocytes and their cell subsets could play a significant role. Isolation of specific cells for determining their ROS-response can affect their functionality and is laborious or hard to replicate in different settings. Read More

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Evidence of decoupling of surface and bulk states in Dirac semimetal CdAs.

Nanotechnology 2022 Jun 27. Epub 2022 Jun 27.

Sandia National Laboratories, Sandia National Laboratories, 7011 East Avenue, Livermore, California, 94551, UNITED STATES.

Dirac semimetals have attracted a great deal of current interest due to their potential applications in topological quantum computing, low-energy electronic applications, and single photon detection in the microwave frequency range. Herein are results from analyzing the low magnetic (B) field weak-antilocalization behaviors in a Dirac semimetal CdAsthin flake device. At high temperatures, the phase coherence lengthfirst increases with decreasing temperature (T) and follows a power law dependence of∝ T. Read More

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High Prevalence of Cervical High-Grade Lesions and High-Risk Human Papillomavirus Infections in Women Living with HIV: A Case for Prioritizing Cervical Screening in This Vulnerable Group.

Acta Cytol 2022 Jun 27:1-11. Epub 2022 Jun 27.

Division of Cytopathology, ICMR-National Institute of Cancer Prevention and Research, Noida, India.

Introduction: Women living with HIV (WLHIV) are at an increased risk of developing cervical precancerous lesions and cervical human papillomavirus (HPV) infection. This study aimed at evaluating the prevalence of cervical lesions and high-risk HPV (HR-HPV) infection in WLHIV in comparison to the HIV-negative women undergoing opportunistic screening. In addition, these findings among WLHIV were correlated with the clinic-demographic factors. Read More

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Diagnosing Tuberculosis: What Do New Technologies Allow Us to (Not) Do?

Respiration 2022 Jun 27:1-17. Epub 2022 Jun 27.

DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

New tuberculosis (TB) diagnostics are at a crossroads: their development, evaluation, and implementation is severely damaged by resource diversion due to COVID-19. Yet several technologies, especially those with potential for non-invasive non-sputum-based testing, hold promise for efficiently triaging and rapidly confirming TB near point-of-care. Such tests are, however, progressing through the pipeline slowly and will take years to reach patients and health workers. Read More

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Sensitivity improvement of hybrid active layer containing 2D nanoplatelets for indirect x-ray detector.

Nanotechnology 2022 Jun 27. Epub 2022 Jun 27.

Department of Electronic and Electrical Engineering and Convergence Semiconductor Research Center, Dankook University, 152, Jukjeon-ro, Suji-gu, Yongin-si, Gyeonggi-do, 16890, Yongin, 16890, Korea (the Republic of).

In this paper, we attempted to improve the detection sensitivity of an indirect X-ray detector through using a hybrid active layer composed of a poly [N-90-heptadecanyl-2,7-carbazole-alt-5,5-(40,70-di-2-thienyl-20,10,30-benzothiadiazole)] (PCDTBT) organic semiconductor and cadmium selenide nanoplatelets (CdSe NPLs) colloidal inorganic semiconductors. First, different blending ratio in the active layer (i.e. Read More

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Excitation-independent deep-blue emitting dual-doped carbon dots ‎with 62% emission quantum efficiency and monoexponential decay profile for high-resolution fingerprint identification.

Nanotechnology 2022 Jun 27. Epub 2022 Jun 27.

Zhengzhou University, Zhengzhou, Zhengzhou, Henan, 450001, CHINA.

Reaching emissive nanomaterials at short wavelengths with a high quantum efficiency (QE) is ‎an attractive task for researchers. This is more demanding in carbon dots (CDs) with diverse ‎applications that usually emit photons at wavelengths around 450-620 nm. In this study, deep ‎blue-emissive doped-CDs (d-CDs) with high photoluminescence (PL) QE up to 62% and ‎excitation-independent properties were prepared via a short-time microwave irradiation ‎method. Read More

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Hemoglobin-catalyzed atom transfer radical polymerization for ultrasensitive electrochemical DNA detection.

Biosens Bioelectron 2022 Jun 15;213:114485. Epub 2022 Jun 15.

School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen Guangdong, 518060, PR China.

The use of hemoglobin (Hb) to drive atom transfer radical polymerization (ATRP) process (Hb-ATRP) for detection of lung cancer related nucleic acid is firstly reported. Hb does not need to be treated prior to using indicating the potential for synthetic engineering in complex biological microenvironments without the need for in vitro techniques. Here, we report a new signal amplification strategy using Hb-mediated graft of nitronyl niroxide monoradical polymers as a signal-on electrochemical biosensor for ultralow level DNA highly selective detection. Read More

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Cost-effective and disposable label-free voltammetric immunosensor for sensitive detection of interleukin-6.

Biosens Bioelectron 2022 Jun 8;213:114467. Epub 2022 Jun 8.

Istituto di Farmacologia Traslazionale-CNR (IFT-CNR), Via Fosso del Cavaliere 100, 00133, Roma, Italy. Electronic address:

IL-6 detection is highly desirable since can monitor many diseases in humans and assess the response to treatments. Herein, two novel label-free voltammetric immunosensors for rapid and accurate interleukin-6 (IL-6) detection in human serum are presented. The immunosensors are fabricated by immobilising two different IL-6 antibodies, identified as mAb-IL-6 clone-5 and clone-7, on in-house produced screen-printed electrodes modified with inexpensive recycling biochar (Bio-SPEs). Read More

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Detection of social-ecological drivers and impact thresholds of ecological degradation and ecological restoration in the last three decades.

Authors:
Juan He Xueyi Shi

J Environ Manage 2022 Jun 24;318:115513. Epub 2022 Jun 24.

School of Land Science and Technology, China University of Geosciences, Beijing 100083, China; Key Laboratory of Land Consolidation and Rehabilitation, Ministry of Natural Resources, Beijing 100035, China; Technology Innovation Center for Ecological Restoration in Mining Areas, Ministry of Natural Resources, Beijing 100083, China. Electronic address:

Special consideration should be given to the differential coupling relationships between natural and anthropogenic factors on ecological degradation and ecological restoration. However, few studies have focused on how to quantify the contribution rate of social-ecological interactions to vegetation growth and determine the impact thresholds of vegetation coverage at the county scale. Notably, it is more conducive to evaluating the impact of anthropogenic factors on vegetation coverage by integrating ecological land use policy into the research framework. Read More

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Surface modification of acid-functionalized mesoporous gamma-alumina for non-fission Mo/Tc generator.

Appl Radiat Isot 2022 Jun 21;187:110342. Epub 2022 Jun 21.

Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, 16424, Indonesia.

Mesoporous gamma-alumina (MGA) was synthesized for neutron-activated Mo adsorbent. Acid functionalization of the MGA was carried out to enhance the Mo adsorption capacity and the Mo breakthrough profile. The acid-treated MGA has a more positive particle charge, rougher surface, smaller particle and pore size, larger surface area, and wider pore distance. Read More

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L-histidine functionalized ZiF-8 with aggregation-induced emission for detection of tetracycline.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 22;280:121546. Epub 2022 Jun 22.

Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China; YuZhang Normal University, Nanchang 330013, PR China. Electronic address:

In this study, we constructed zinc based metal-organic framework functionalized by L-histidine ([email protected]). The [email protected] had high porosity, large surface area, abundant carboxyl and amino group, which has been found to greatly enhance the aggregation-induced emission (AIE) of tetracycline (TC). After the [email protected] enrichment with TC, the TC exhibited strong fluorescence emission peak at 565 nm based on AIE. Read More

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A simple lysosome-targeted fluorescent probe based on flavonoid for detection of cysteine in living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 23;280:121552. Epub 2022 Jun 23.

Key Laboratory of Occupational Environment and Health, Guangzhou Twelfth People's Hospital, No. 1 Tianqiang Road, Tianhe District, Guangzhou 510620, Guangdong, PR China. Electronic address:

Cysteine (Cys) is one of the most important biothiols that plays a crucial role in many physiological and pathological processes, and therefore it is of great importance to detect and analyze Cys in subcellular environments, such as in lysosomes. However, only a few fluorescent probes were reported to be capable of detecting Cys in lysosomes selectively. In this wok, we designed and developed a simple, accessible flavone-based fluorescent probe LFA for detecting Cys in lysosomes. Read More

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IL-1 family cytokines serve as 'activity recognition receptors' for aberrant protease activity indicative of danger.

Cytokine 2022 Jun 24;157:155935. Epub 2022 Jun 24.

Molecular Cell Biology Laboratory, Dept. of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland.

Members of the extended IL-1 cytokine family play key roles as instigators of inflammation in numerous infectious and sterile injury contexts and are highly enriched at barrier surfaces such as the skin, lungs and intestinal mucosa. Because IL-1 family cytokines do not possess conventional ER-golgi trafficking and secretory signals, these cytokines are typically released into the extracellular space due to tissue damage resulting in necrosis, or pathogen detection resulting in pyroptosis. The latter feature, in combination with other factors, suggests that IL-1 family cytokines serve as canonical damage-associated molecular patterns (DAMPs), which instigate inflammation in response to tissue damage. Read More

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Comparing and contrasting In-Vial and full-scale systems for sparging volatile analytes.

J Chromatogr A 2022 Jun 17;1676:463256. Epub 2022 Jun 17.

Savannah River National Laboratory, Savannah River Site, SC, USA 29808.

In-vial sparging was demonstrated as an effective, practical alternative to a full-scale sparging system for supporting the analysis of volatile constituents. Using elemental mercury (Hg) and toluene as representative purgeable analytes, the mass removal for various sparge configurations was measured and a reduced order model was developed and validated. In the primary experiments, Hg in the sparge gas was trapped on activated carbon or gold, thermally desorbed, and quantified using atomic absorption or atomic fluorescence spectroscopy. Read More

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Bigram frequency analysis for detection of radiology report errors.

Authors:
Phillip M Cheng

Clin Imaging 2022 Jun 23;89:84-88. Epub 2022 Jun 23.

Department of Radiology, Keck School of Medicine of USC, 1441 Eastlake Ave., Suite 2315B, Los Angeles, CA 90033, United States of America. Electronic address:

Purpose: This pilot study evaluates the utility of analyzing bigram frequencies for detecting radiology report errors.

Methods: A corpus of 48,050 CT reports was used to enumerate the frequency of each bigram (F), and the expected frequency of each bigram in the corpus based on the constituent unigram frequencies (P). A test set consisted of a separate random sample of 200 radiology reports dictated by attendings for CT scans of the abdomen in 2019, as well as a random sample of 200 radiology reports for CT scans of the abdomen dictated in 2019 by 52 different residents or fellows prior to editing by the signing attendings. Read More

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Microbial contamination in surface water and potential health risks for peri-urban farmers of the Bengal delta.

Int J Hyg Environ Health 2022 Jun 24;244:114002. Epub 2022 Jun 24.

Environmental Technology, Wageningen University and Research, P.O. Box 17, 6700AA, Wageningen, the Netherlands.

Ensuring safe irrigation practices is vital to sustaining food production in water-scarce delta areas. Bangladesh and many other developing countries discharge untreated wastewater into their surrounding surface water bodies, serving as the primary irrigation source. This indirect irrigation of wastewater is believed to pose threats to the farmers, consumers and market vendors and may also affect crop and soil quality. Read More

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A comprehensive insight on modern green analyses for quality control determination and processing monitoring in coffee and cocoa seeds.

Food Chem 2022 Jun 18;394:133529. Epub 2022 Jun 18.

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. Electronic address:

Green analysis is defined as the analysis of chemicals in a manner where sample extraction and analysis are performed with least amounts of steps, low hazardous materials, while maintaining efficiency in terms of analytes detection. Coffee and cocoa represent two of the most popular and valued beverages worldwide in addition to their several products i.e. Read More

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Optimizing accelerated solvent extraction combined with liquid chromatography-Orbitrap mass spectrometry for efficient lipid profile characterization of mozzarella cheese.

Food Chem 2022 Jun 21;394:133542. Epub 2022 Jun 21.

Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata, Via Manfredonia, 20 - 71121 Foggia, Italy. Electronic address:

In this study, a novel Accelerated Solvent Extraction (ASE) procedure combined with UHPLC-Q-Orbitrap-MS was developed for detailed untargeted lipid profile of mozzarella cheese. Response Surface Methodology and Pareto front, using a Central Composite Design (CCD), were employed to define the optimised combination of extraction temperature, number of extraction cycles and mix of solvents. LipidSearch™ software was used for a reliable and accurate lipid identification. Read More

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Uncovering aroma boundary compositions of barley malts by untargeted and targeted flavoromics with HS-SPME-GC-MS/olfactometry.

Food Chem 2022 Jun 21;394:133541. Epub 2022 Jun 21.

Department of Plant Sciences, North Dakota State University, Fargo, ND 58108, USA. Electronic address:

In this study, HS-SPME/GC-MS based untargeted and targeted flavoromics combing with olfactometry were employed to uncover aroma boundary compositions of five types of commercial barley malts with a wide range of Lovibond (L), including kilned base malts (1.8 L and 3.5 L) and roasted caramel malts (10 L, 60 L, and 120 L). Read More

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An automatic on-line sol-gel pyridylethylthiopropyl functionalized silica-based sorbent extraction system coupled to flame atomic absorption spectrometry for lead and copper determination in beer samples.

Food Chem 2022 Jun 21;394:133548. Epub 2022 Jun 21.

Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. Electronic address:

A novel sol-gel pyridylethylthiopropyl functionalized silica-based sorbent was synthesized and utilized in an on-line column preconcentration system coupled with flame atomic absorption spectrometry for metal determination. The developed platform was used for the determination of Pb(II) and Cu(II) in beer samples, since there are limited automatic methods for routine analysis of alcoholic beverage. For a preconcentration time of 60 s, the calculated enhancement factors were 96 for Cu(II) and 130 for Pb(II). Read More

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Multi-electrode platform for selective electrochemical sensing: 3D-printed insulating plastic is turned into a five-electrodes chip.

Talanta 2022 Jun 22;250:123705. Epub 2022 Jun 22.

Institute of Physics, Universidade Federal de Mato Grosso do Sul, CP 549, 79070-900, Campo Grande, MS, Brazil. Electronic address:

We report a method to turn a 3D-printed plastic piece into a five-electrodes chip for multiple analytes detection. A chip containing Pd, Ni, and Ru working electrodes is used to sense hydroquinone, acetaminophen, salicylic acid, and hydroxychloroquine at once. The analysis is sequentially achieved simply by changing the proper electrode connection, without changing mobile parts, neither adding reactants, nor electrolytes. Read More

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