Carbohydr Polym 2021 Jun 26;262:117868. Epub 2021 Feb 26.
Department of Chemistry, University of Isfahan, 8174673441, Iran; California Institute for Quantitative Biosciences, University of California, Berkeley, California, USA. Electronic address:
In this study, we have investigated the host-guest inclusion complexes between β-cyclodextrin (βCD), 2-hydroxypropyl-β-cyclodextrin (2-HPβCD), and mono-6-tosyl-β-cyclodextrin (TS-βCD) excipients and two amino acids, such as L-arginine (L-Arg) and L-lysine (L-Lys). The formation of inclusion complexes was detected, and a comparative study was conducted at different pH, density, and viscosity. A physical mixture, comprising equal amount of amino acids was used to prepare the complex in a solid-state form. Read More