9,459 results match your criteria detected obese

Changes in the Macular Vascular Density After Bariatric Surgery Measured by Optical Coherence Tomography Angiography.

Clin Ophthalmol 2021 22;15:3131-3137. Epub 2021 Jul 22.

Ophthalmology Department, Cairo University, Cairo, Egypt.

Purpose: To evaluate the effect of the weight loss, 3 months after bariatric surgery, on the macular thickness and macular vascular density by optical coherence tomography angiography (OCTA).

Methods: Forty obese patients were included in this prospective study. Body mass index (BMI), macular thickness (whole, fovea, parafovea and perifovea), macular vascular density (VD) in superficial capillary plexus (whole, fovea, parafovea and perifovea), and macular vascular density in deep capillary plexus (whole, fovea, parafovea and perifovea) were measured before and 3 months after bariatric surgery. Read More

View Article and Full-Text PDF

recombinase driver mice reveal lineage-dependent and -independent expression of in the mouse brain.

eNeuro 2021 Jul 29. Epub 2021 Jul 29.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA

Bombesin receptor subtype-3 (BRS3) is an orphan receptor that regulates energy homeostasis. We compared driver mice with constitutive or inducible Cre recombinase activity. The constitutive BRS3-Cre mice show reporter signal (Cre-dependent tdTomato) in the adult brain due to lineage tracing in the dentate gyrus, striatal patches, and indusium griseum, in addition to sites previously identified in the inducible BRS3-Cre mice (including hypothalamic and amygdala subregions, and parabrachial nucleus). Read More

View Article and Full-Text PDF

Association Between Periconceptional Weight of Maternal Grandmothers and Attention-Deficit/Hyperactivity Disorder in Grandchildren.

JAMA Netw Open 2021 Jul 1;4(7):e2118824. Epub 2021 Jul 1.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Importance: Neurodevelopmental disorders have been proposed to involve alterations to epigenetic regulation, and epigenetic effects may extend to germline cells to affect later generations. Weight status may affect DNA methylation, and maternal weight before and during pregnancy has been associated with offspring DNA methylation as well as attention-deficit/hyperactivity disorder (ADHD).

Objective: To assess whether a woman's weight before and during pregnancy is associated with ADHD in her grandchild. Read More

View Article and Full-Text PDF

Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Are Associated With Diet, BMI, and Age.

Front Nutr 2021 12;8:691401. Epub 2021 Jul 12.

Else Kröner-Fresenius-Center of Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.

Fatty acid esters of hydroxy fatty acids (FAHFAs) are a group of fatty acids with potential anti-inflammatory and anti-diabetic effects. The blood levels of FAHFAs and their regulation in humans have hardly been studied. We aimed to investigate serum FAHFA levels in well-characterized human cohorts, to evaluate associations with age, sex, BMI, weight loss, diabetic status, and diet. Read More

View Article and Full-Text PDF

Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning.

PLoS Negl Trop Dis 2021 Jul 28;15(7):e0008824. Epub 2021 Jul 28.

Department of Health Policy Planning and Management, University of Health and Allied Sciences, Ho, Ghana.

Recent evidence suggests that, in some foci, elimination of onchocerciasis from Africa may be feasible with mass drug administration (MDA) of ivermectin. To achieve continental elimination of transmission, mapping surveys will need to be conducted across all implementation units (IUs) for which endemicity status is currently unknown. Using boosted regression tree models with optimised hyperparameter selection, we estimated environmental suitability for onchocerciasis at the 5 × 5-km resolution across Africa. Read More

View Article and Full-Text PDF

The glycosyltransferase ST3GAL2 modulates virus proliferation and the inflammation response in porcine reproductive and respiratory syndrome virus infection.

Arch Virol 2021 Jul 28. Epub 2021 Jul 28.

School of Life Sciences, Tianjin University, No. 92, Weijin Road, Nankai District, Tianjin, 300072, China.

β-galactoside α-2,3-sialyltransferase 2 (ST3GAL2) is a member of the sialyltransferase family that mediates terminal modification of glycoproteins and glycolipids. ST3GAL2 has been found to play a role in obesity, aging, and malignant diseases. In this study, we cloned porcine ST3GAL2 (pST3GAL2) from porcine alveolar macrophages (PAMs), and its role in porcine reproductive and respiratory syndrome virus (PRRSV) infection was investigated by transcriptome analysis. Read More

View Article and Full-Text PDF

Assessment and Establishment of Correlation between Reactive Oxidation Species, Citric Acid, and Fructose Level in Infertile Male Individuals: A Machine-Learning Approach.

J Hum Reprod Sci 2021 Apr-Jun;14(2):129-136. Epub 2021 Jun 28.

Department of Studies in Zoology, University of Mysore, Mysore, Karnataka, India.

Background: Biochemical complexity of seminal plasma and obesity has an important role in male infertility (MI); so far, it has not been possible to provide evidence of clinical significance for all of them.

Aims: Our goal here is to evaluate the correlation between biochemical markers with semen parameters, which might play a role in MI.

Study Setting And Design: We enlisted 100 infertile men as patients and 50 fertile men as controls to evaluate the sperm parameters and biochemical markers in ascertaining MI. Read More

View Article and Full-Text PDF

Evaluation of predictors of severe-moderate COVID-19 infections at children: a review of 292 children.

J Med Virol 2021 Jul 27. Epub 2021 Jul 27.

Department of Pediatric Infectious Diseases, Dr. Behçet Uz Children's Diseases and Surgery Training and Research Hospital, İzmir, Turkey.

Background: Although underlying disease is associated with a severe course in adults and laboratory abnormalities have been widely reported, there are not sufficient data on the clinical course of COVID-19 in children with pre-existing comorbid conditions and on laboratory findings. We aimed to describe the independent risk factors for estimating the severity of the COVID-19 in children METHODS: All children between one month to 18 years old who were hospitalized during the period of March 11 - December 31, 2020 resulting from COVID-19 were included in the study. Patients were categorized into mild (group 1) and moderate+severe/critically (group 2) of severity based on the criteria. Read More

View Article and Full-Text PDF

Higher levels of anti-phosphorylcholine autoantibodies in early rheumatoid arthritis indicate lower risk of incident cardiovascular events.

Arthritis Res Ther 2021 Jul 27;23(1):201. Epub 2021 Jul 27.

Division of Gastroenterology and Rheumatology, Department of Medicine Huddinge, Karolinska Institutet, 171 77, Stockholm, Sweden.

Background: The increased risk of cardiovascular events (CVE) in rheumatoid arthritis (RA) is not fully explained by traditional risk factors. Immuno-inflammatory mechanisms and autoantibodies could be involved in the pathogenesis of atherosclerotic disease. It has been suggested that anti-phosphorylcholine antibodies (anti-PC) of the IgM subclass may have atheroprotective effects. Read More

View Article and Full-Text PDF

Investigation of common risk factors between polycystic ovary syndrome and Alzheimer's disease: a narrative review.

Reprod Health 2021 Jul 26;18(1):156. Epub 2021 Jul 26.

Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: The most common endocrine and metabolic disorders in premenopausal women is polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, chronic anovulation, and/or ultrasound evidence of small ovarian cysts. Obesity and insulin resistance are also the main factors influencing the clinical manifestations of this syndrome. Alzheimer's disease (AD) is the most typical progressive neurodegenerative disorder of the brain, and recent studies suggest a relationship between endocrinal dysregulation and neuronal loss during AD pathology. Read More

View Article and Full-Text PDF

Relationship of Physical Activity at Older Age with Biomarkers of Oxidative Stress: A Large, Population-based Cohort Study.

Med Sci Sports Exerc 2021 Jun 19. Epub 2021 Jun 19.

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany Network Aging Research, Heidelberg University, Germany Centre for Health Protection, National Institute of Public Health and the Environment, Bilthoven, The Netherlands Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Background: No population-based cohort study on the associations of physical activity with biomarkers of oxidative stress has been performed so far.

Methods: The total thiol groups of serum proteins (TTP), which can be considered as a proxy biomarker for the antioxidant defense capacity of cells and the derivatives of reactive oxygen metabolites (D-ROM) serum concentration, which is mainly a biomarker of lipid peroxidation, were measured in 2,572 participants of a population-based cohort study of older adults (age range: 57-83 years) of whom 2,068 had repeated measurements 3 years later. Physical activity was assessed by a questionnaire specifically designed for the elderly. Read More

View Article and Full-Text PDF

Higher Socioeconomic Status is Associated with Improved Outcomes After Obesity Surgery Among Women in Germany.

World J Surg 2021 Jul 26. Epub 2021 Jul 26.

Department of General-, Visceral- and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

Background: Low socioeconomic status (SES) is associated with an increased prevalence of obesity. It is unknown whether SES influences the outcome after bariatric surgery in Germany. Therefore, the aim of our study was to investigate whether the SES is linked with an inferior outcome after bariatric surgery. Read More

View Article and Full-Text PDF

Prevalence of sleep-disordered breathing among adolescents and its association with the presence of obesity and hypertension.

Arch Argent Pediatr 2021 Aug;119(4):245-250

Fundación Centro de Salud e Investigaciones Médicas (CESIM), Santa Rosa, Argentina.

Introduction: The increased prevalence of sleepdisordered breathing (SDB) and its association with obesity and hypertension (HTN) have not been thoroughly explored in adolescents. The objective of this study was to investigate the prevalence of SDB and snoring in this population and analyze its association with obesity and HTN.

Population And Methods: This was a descriptive, cross-sectional study in a sample of adolescents. Read More

View Article and Full-Text PDF

PI3K/Akt pathway expression in children with different obesity degrees and its relationship with glucolipid metabolism and insulin resistance.

Am J Transl Res 2021 15;13(6):6592-6598. Epub 2021 Jun 15.

Department of Endocrinology, Zhuji People's Hospital of Zhejiang Province Zhuji 311800, Zhejiang, China.

Objective: This study investigated and analyzed the expression of PI3K/Akt pathway in children with different degree of obesity and its connection with glucolipid metabolism and insulin resistance (IR).

Methods: 157 children with simple obesity, who admitted to our hospital from March 2020 to September 2020, were enrolled as obesity group. These children were divided into mild-group (n=67), moderate-group (n=55) and severe-group (n=35) referring to their body mass index (BMI). Read More

View Article and Full-Text PDF

Metabolic Risk Factors Associated with Early Onset Colorectal Adenocarcinoma: A Case-Control Study at Kaiser Permanente Southern California.

Cancer Epidemiol Biomarkers Prev 2021 Jul 22. Epub 2021 Jul 22.

Department of Research and Evaluation, Kaiser Permanente Southern California

Background: The incidence of early onset colorectal cancer (eoCRC) diagnosed among individuals under age 50 has been rising. However, risk factors for eoCRC are unclear. We investigated whether metabolic abnormalities are risk factors for eoCRC adenocarcinoma. Read More

View Article and Full-Text PDF

Insulin Resistance Is Not Increased in Inflammatory Bowel Disease Patients but Is Related to Non-Alcoholic Fatty Liver Disease.

J Clin Med 2021 Jul 10;10(14). Epub 2021 Jul 10.

Division of Rheumatology, Hospital Universitario de Canarias, 38320 Tenerife, Spain.

Background: Insulin resistance (IR) has been linked to inflammatory states. The aim of this study was to determine whether IR is increased in a cohort of inflammatory bowel disease (IBD) patients with low disease activity. We additionally intended to establish which factors were the determinants of IR in this population, including the presence of nonalcoholic fatty liver disease (NAFLD). Read More

View Article and Full-Text PDF

Crown-like structures in breast adipose tissue of breast cancer patients: associations with CD68 expression, obesity, metabolic factors and prognosis.

NPJ Breast Cancer 2021 Jul 22;7(1):97. Epub 2021 Jul 22.

Department of Medicine, University of Toronto, Toronto, ON, Canada.

Crown-like structures of the breast (CLS-B), defined by the clustering of macrophages (identified using CD68 immunohistochemical staining) to surround a dying adipocyte, are a sign of adipose-tissue inflammation. In human cohorts, CLS-B positively correlates with older age, obesity, dyslipidemia and higher levels of glucose, insulin, C-reactive protein and IL-6. In an existing cohort of early-stage breast cancer patients, CLS-B were identified using H&E stained histologic sections (hCLS-B), and by CD68 immunohistochemistry (CD68 + CLS-B). Read More

View Article and Full-Text PDF

Evaluation of Acromegaly patients with sleep disturbance related symptoms.

Pak J Med Sci 2021 Jul-Aug;37(4):1161-1165

Prof. Dr. Bulent Ciftci, Yozgat Bozok University, Medical School, Department of Chest Diseases, Yozgat Turkey.

Background And Objectives: It is known that the prevalence of obstructive sleep apnea (OSA) is increased in acromegaly. Craniofacial anomalies, macroglossia, and thickening of the laryngeal wall caused by the increase in soft tissue in these patients lead to OSA. Also, the increase in growth hormone can trigger central apnea by causing a decrease in respiratory drive. Read More

View Article and Full-Text PDF
January 2021

Ultrasonography to detect cardiovascular damage in children with essential hypertension.

Cardiovasc Ultrasound 2021 Jul 21;19(1):26. Epub 2021 Jul 21.

Cardiology Department, Children's Hospital of Soochow University, Suzhou City, Jiangsu Province, 215025, China.

Background: Essential hypertension in adults may begin in childhood. The damages to the heart and blood vessels in children with essential hypertension are hidden and difficult to detect. We noninvasively examined changes in cardiovascular structure and function in children with hypertension at early stage using ultrasonography. Read More

View Article and Full-Text PDF

An Epigenetic Signature Is Associated With Serum 25-Hydroxyvitamin D in Colorectal Cancer Tumors.

Mol Nutr Food Res 2021 Jul 21:e2100125. Epub 2021 Jul 21.

Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Institute of Biomedical Research in Malaga (IBIMA), University of Malaga, Malaga, 29016, Spain.

Scope: Vitamin D has been widely associated with colorectal cancer (CRC) through different insights. Here, we aimed to explore the association between serum 25-hydroxyvitamin D (25(OH)D) and the global DNA methylation in tumor from CRC patients.

Methods And Results: A genome-wide DNA methylation analysis was conducted in 20 CRC patients under categorical (10 patients had 25(OH)D <30 ng/mL; 10 patients with 25(OH)D ≥30ng/mL) and continuous models of 25(OH)D. Read More

View Article and Full-Text PDF

Permanent Flank Bulge after Flank Incision: Patient- and Physician-Reported Outcome.

Urol Int 2021 Jul 20:1-10. Epub 2021 Jul 20.

Department of Urology, University Medical Center Rostock, Rostock, Germany.

Introduction: The aim of this study was to determine the incidence and risk factors for postoperative flank bulging and associated physiologic/psychologic consequences as well as to establish a clinical flank bulge classification system after open retroperitoneal surgery.

Methods: In this retrospective study, a postal patient survey was sent to 240 patients who underwent open retroperitoneal surgery between 2007 and 2017. Patients, who reported a flank bulge, were invited for further evaluation, which included a clinical examination and standardized photo documentation. Read More

View Article and Full-Text PDF

Electrocardiographic abnormalities, preclinical carotid atherosclerosis andcardiovascular risk, in an apparently healthy real-world population: data from the project "No Stroke, No Infarction" of the rotary international - District 2110 "Sicily & Malta".

Int Angiol 2021 Jul 20. Epub 2021 Jul 20.

G. D'Alessandro Department of Health Promotion and of Maternal and Child, Internal, and Specialist Medicine (PROMISE), University of Palermo, Palermo, Italy.

Background: Cardiovascular diseases (CVDs) represent important causes of morbidity and mortality. Our study aimed to evaluate cardiovascular risk using the EUROSCORE, ECG and carotid ultrasound for prevention purpose in a 50-70 years population and companions asymptomatic and without CVD.

Methods: History of CVD, risk factors (RFs), ECG and carotid ultrasound were evaluated. Read More

View Article and Full-Text PDF

Does intervention with GLP-1 receptor agonist semaglutide modulate perception of sweet taste in women with obesity: study protocol of a randomized, single-blinded, placebo-controlled clinical trial.

Trials 2021 Jul 19;22(1):464. Epub 2021 Jul 19.

Department of Endocrinology, Diabetes and Metabolic Diseases, Division of Internal Medicine, University Medical Centre Ljubljana, Zaloška cesta 7, SI-1000, Ljubljana, Slovenia.

Background: Preclinical studies demonstrated that glucagon-like peptide 1 (GLP-1) is locally synthesized in taste bud cells and that GLP-1 receptor exists on the gustatory nerves in close proximity to GLP-1-containing taste bud cells. This local paracrine GLP-1 signalling seems to be specifically involved in the perception of sweets. However, the role of GLP-1 in taste perception remains largely unaddressed in clinical studies. Read More

View Article and Full-Text PDF

[Influence of dietary carotenoids on biomarkers of cardiometabolic risk in peri- and post-menopausal women].

Nutr Hosp 2021 Jul 20. Epub 2021 Jul 20.

Departamento de Tecnología de los Alimentos, Nutrición y Bromatología. Facultad de Veterinaria. Campus de Excelencia Regional "Campus Mare Nostrum". Campus Universitario de Espinardo.

Background: peri- and post-menopausal women exhibit a high tendency towards obesity and visceral fat deposition, which increases cardiometabolic risk.

Objective: to evaluate through a prospective nutritional study the effect of carotenoid consumption on cardiometabolic risk biomarkers in peri- and post-menopausal women.

Material And Methods: twelve peri- and post-menopausal women without previous symptoms of cardiovascular disease, but with some cardiometabolic risk factor, were recruited. Read More

View Article and Full-Text PDF

Screening for monogenic subtypes of gestational diabetes in a high prevalence island population - A whole exome sequencing study.

Diabetes Metab Res Rev 2021 Jul 19:e3486. Epub 2021 Jul 19.

Centre for Molecular Medicine and Biobanking, Faculty of Medicine and Surgery, University of Malta, Msida, Malta.

Aims: The reported frequency of monogenic defects of beta cell function in gestational diabetes (GDM) varies extensively. This study aimed to evaluate the frequency and molecular spectrum of variants in genes associated with monogenic/atypical diabetes in non-obese females of Maltese ethnicity with GDM.

Methods: 50 non-obese females who met the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria for diagnosis of GDM and with a first-degree relative with non-autoimmune diabetes were included in this study. Read More

View Article and Full-Text PDF

STE20-Type Protein Kinase MST4 Controls NAFLD Progression by Regulating Lipid Droplet Dynamics and Metabolic Stress in Hepatocytes.

Hepatol Commun 2021 Jul 16;5(7):1183-1200. Epub 2021 Mar 16.

Department of Chemistry and Molecular Biology University of Gothenburg and Sahlgrenska University Hospital Gothenburg Sweden.

Nonalcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide, primarily because of the massive global increase in obesity. Despite intense research efforts in this field, the factors that govern the initiation and subsequent progression of NAFLD are poorly understood, which hampers the development of diagnostic tools and effective therapies in this area of high unmet medical need. Here we describe a regulator in molecular pathogenesis of NAFLD: STE20-type protein kinase MST4. Read More

View Article and Full-Text PDF

Whole genome metagenomic analysis of the gut microbiome of differently fed infants identifies differences in microbial composition and functional genes, including an absent CRISPR/Cas9 gene in the formula-fed cohort.

Hum Microb J 2019 Jun 25;12. Epub 2019 May 25.

Biomedical Research Department, Nemours Alfred I. duPont Hospital for Children, Wilmington, DE, United States.

Background: Advancements in sequencing capabilities have enhanced the study of the human microbiome. There are limited studies focused on the gastro-intestinal (gut) microbiome of infants, particularly the impact of diet between breast-fed (BF) versus formula-fed (FF). It is unclear what effect, if any, early feeding has on short-term or long-term composition and function of the gut microbiome. Read More

View Article and Full-Text PDF

Heparin impairs skeletal muscle glucose uptake by inhibiting insulin binding to insulin receptor.

Endocrinol Diabetes Metab 2021 Jul 5;4(3):e00253. Epub 2021 May 5.

Guangdong Laboratory of Lingnan Modern Agriculture Guangdong Province Key Laboratory of Animal Nutritional Regulation and National Engineering Research Center for Breeding Swine Industry College of Animal Science South China Agricultural University Guangzhou China.

Aim: Heparin, a widely used antithrombotic drug has many other anticoagulant-independent physiological functions. Here, we elucidate a novel role of heparin in glucose homeostasis, suggesting an approach for developing heparin-targeted therapies for diabetes.

Methods: For serum heparin levels and correlation analysis, 122 volunteer's plasma, DIO (4 weeks HFD) and db/db mice serums were collected and used for spectrophotometric determination. Read More

View Article and Full-Text PDF

Mouse Spexin: (I) NMR Solution Structure, Docking Models for Receptor Binding, and Histological Expression at Tissue Level.

Front Endocrinol (Lausanne) 2021 2;12:681646. Epub 2021 Jul 2.

School of Biological Sciences, The University of Hong Kong, Hong Kong, Hong Kong.

Spexin (SPX), a highly conserved neuropeptide, is known to have diverse functions and has been implicated/associated with pathological conditions, including obesity, diabetes, anorexia nervosa, and anxiety/mood disorders. Although most of the studies on SPX involved the mouse model, the solution structure of mouse SPX, structural aspects for SPX binding with its receptors GalR2/3, and its cellular expression/distribution in mouse tissues are largely unknown. Using CD and NMR spectroscopies, the solution structure of mouse SPX was shown to be in the form of a helical peptide with a random coil from Asn to Pro in the N-terminal followed by an α-helix from Gln to Gln in the C-terminus. Read More

View Article and Full-Text PDF

Intramuscular adipocyte and fatty acid differences between high-fat and control rabbit groups subject to a restricted diet.

Vet Med Sci 2021 Jul 17. Epub 2021 Jul 17.

College of Animal Science and Technology, Sichuan Agricultural University-Chengdu Campus, Chengdu, Sichuan, P. R. China.

Fatty acids of intramuscular fat (IMF) in rabbits can influence meat quality, but it is unclear which fatty acids benefit to human health. A rabbit model of weight gain and weight loss was constructed using two rabbit groups and two growth stages. Stage 1 included control group1 fed a commercial diet(CG1) and experimental group1 fed a high fat diet (EG1). Read More

View Article and Full-Text PDF