Med Sci Sports Exerc 2021 Jun 19. Epub 2021 Jun 19.
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany Network Aging Research, Heidelberg University, Germany Centre for Health Protection, National Institute of Public Health and the Environment, Bilthoven, The Netherlands Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Background: No population-based cohort study on the associations of physical activity with biomarkers of oxidative stress has been performed so far.
Methods: The total thiol groups of serum proteins (TTP), which can be considered as a proxy biomarker for the antioxidant defense capacity of cells and the derivatives of reactive oxygen metabolites (D-ROM) serum concentration, which is mainly a biomarker of lipid peroxidation, were measured in 2,572 participants of a population-based cohort study of older adults (age range: 57-83 years) of whom 2,068 had repeated measurements 3 years later. Physical activity was assessed by a questionnaire specifically designed for the elderly. Read More