150,919 results match your criteria detected cases

Multigene Combined Detection by RT-qPCR Using Cytological Specimens.

Acta Cytol 2021 Aug 3:1-10. Epub 2021 Aug 3.

Department of Cytology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Objective: The aim of the study was to investigate the mutation status of multiple driver genes by RT-qPCR and their significance in advanced lung adenocarcinoma using cytological specimens.

Materials And Methods: 155 cytological specimens that had been diagnosed with lung adenocarcinoma in the Fourth Hospital of Hebei Medical University were selected from April to November 2019. The cytological specimens included serous cavity effusion and fine-needle aspiration biopsies. Read More

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Femoral Nerve Neuromonitoring for Lateral Lumbar Interbody Fusion Surgery.

Spine J 2021 Jul 31. Epub 2021 Jul 31.

Long Island Spine Specialists, Long Island, NY; Northwell Health Huntington Hospital, Huntington, NY.

Background Context: The transpsoas lateral lumbar interbody fusion (LLIF) technique is an effective alternative to traditional anterior and posterior approaches to the lumbar spine; however, nerve injuries are the most reported post-operative complication. Commonly used strategies to avoid nerve injury (e.g. Read More

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Blood 2021 08 3. Epub 2021 Aug 3.

Munich Leukemia Laboratory, Munich, Germany.

Nucleophosmin (NPM1) mutations in acute myeloid leukemia (AML) affect exon 12, but sporadically also exon 9 and 11, all causing changes at protein C-terminal end (loss of tryptophans and creation of a nuclear export signal-NES motif) that lead to aberrant cytoplasmic NPM1 (NPM1c+), detectable by immunohistochemistry. Combining immunohistochemistry and molecular analyses in 929 AML patients, we found non-exon 12 NPM1 mutations in 5/387 (1.3%) NPM1c+ cases. Read More

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Maternal HIV and syphilis are not syndemic in Brazil: Hot spot analysis of the two epidemics.

PLoS One 2021 3;16(8):e0255590. Epub 2021 Aug 3.

Department of Pediatrics, Division of Pediatric Infectious Diseases, UCLA David Geffen School of Medicine, Los Angeles, California, United States of America.

While the annual incidence of HIV diagnosis in pregnancy in Brazil remains relatively stable, rates of maternal syphilis increased over six-fold in the past decade. We hypothesized that maternal HIV and syphilis are two distinct epidemics. Data on all cases of maternal HIV or syphilis detected in pregnancy between January 1, 2010 to December 31, 2018 were requested from the Brazilian Ministry of Health. Read More

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Preoperative Breast MRI for Newly Diagnosed Ductal Carcinoma in Situ: Imaging Features and Performance in a Multicenter Setting (ECOG-ACRIN E4112 Trial).

Radiology 2021 Aug 3:204743. Epub 2021 Aug 3.

From the Dept of Radiology, Massachusetts General Hosp, 55 Fruit Street, WAC-240, Boston, MA 02114 (S.H.S.C., C.D.L.); Ctr for Statistical Sciences, Brown Univ School of Public Health, Providence, RI (J.R., I.F.G., B.S.S., C.G.); Dept of Medicine, Northwestern Univ Feinberg School of Medicine, Chicago, Ill (S.A.K.); Dept of Radiology, Univ of Michigan Health System, Ann Arbor, Mich (R.C.); Depts of Pathology and Laboratory Medicine (S.S.B.) and Medicine (K.D.M.), Indiana Univ School of Medicine, Indianapolis, Ind; Dept of Radiology (J.X., H.R.) and Surgery (S.H.J.), Univ of Washington School of Medicine, Seattle, Wash; Dept of Surgery, Tulane Univ School of Medicine, New Orleans, La (R.L.C.); Community Oncology Research Program, Gulf-South National Cancer Inst, New Orleans, La (D.W.S.); Dept of Surgery, Parkview Cancer Inst, Fort Wayne, Ind (L.K.H.); Dept of Surgery, Lankenau Medical Ctr, Wynnewood, Pa (J.L.S.); Dept of Surgery, Mercy Hosp Springfield, Springfield, Mo (J.R.B.); Depts of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC (L.I.W.); Dept of Oncology, Johns Hopkins Univ School of Medicine, Baltimore, Md (A.C.W.); Dept of Medicine (Oncology), Montefiore Medical Center-Weiler Hosp, Bronx, NY (J.A.S.); and Dept of Radiology, Memorial Sloan-Kettering Cancer Ctr, New York, NY (C.E.C.).

Background There are limited data from clinical trials describing preoperative MRI features and performance in the evaluation of mammographically detected ductal carcinoma in situ (DCIS). Purpose To report qualitative MRI features of DCIS, MRI performance in the identification of additional disease, and associations of imaging features with pathologic, genomic, and surgical outcomes from the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network (ECOG-ACRIN) E4112 trial. Materials and Methods Secondary analyses of a multicenter prospective clinical trial from the ECOG-ACRIN Cancer Research Group included women with DCIS diagnosed with conventional imaging techniques (mammography and US), confirmed via core-needle biopsy (CNB), and enrolled between March 2015 and April 2016 who were candidates for wide local excision (WLE) based on conventional imaging and clinical examination results. Read More

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Outcomes of Osteosarcoma in Children Without High-Dose Methotrexate: Could It Be Less Toxic Without Effecting Survival Rates?

J Adolesc Young Adult Oncol 2021 Aug 2. Epub 2021 Aug 2.

Department of Pediatric Hematology Oncology, Marmara University, Marmara Faculty of Medicine, Istanbul, Turkey.

Osteosarcoma (OS) is the most common primary bone sarcoma in childhood. High-dose methotrexate, doxorubicine, cisplatin, and/or ifosfamide combinations are used as standard treatment in chemotherapy and could cause serious toxicity. Another alternative chemotherapy protocol is consisting of epirubicin, ifosfamide, and cisplatin (ECI), which we use in our center. Read More

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High-Precision Quantitative Analysis Reveals Carcinoembryonic Protein Expression Differs Among Colorectal Cancer Primary Foci and Metastases to Different Sites.

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211037175

Gastrointestinal Surgery Department, Guangxi Medical University Cancer Hospital, Nanning, People's Republic of China.

The expression of carcinoembryonic protein (CEA) is an important biological marker and therapeutic target in colorectal cancer (CRC). CEA expression heterogeneity confers resistance to CEA-targeting immunotherapy antibodies. Thus, quantification of the CEA-positive cell ratio among all tumor cells would be important in identifying patients that would benefit from CEA-targeted therapies. Read More

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Impact of ultrasonography detected quadriceps calcific tendinopathy on pain and function in patients with primary knee osteoarthritis.

Reumatismo 2021 Aug 3;73(2):111-116. Epub 2021 Aug 3.

Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University.

Calcific tendinopathy is most commonly seen around the shoulder joint. Only a few cases of quadriceps calcific tendinopathy (QCT) were reported. This study compares pain, function, clinical examination results, and ultrasonographic findings among primary knee osteoarthritis (KOA) patients with or without ultrasonography-detected QCT. Read More

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Equine infection with Leishmania spp. in Costa Rica: Study of five cases.

Vet Med Sci 2021 Aug 2. Epub 2021 Aug 2.

Histopatovet, Heredia, Costa Rica.

Background: Cutaneous forms of leishmaniosis due to Leishmania braziliensis have been reported in horses in the New World. Domestic animals play a role in the transmission of the disease. In Costa Rica, human cases of L. Read More

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Hemorrhagic shock caused by primary splenic pregnancy with spontaneous splenic rupture.

J Obstet Gynaecol Res 2021 Aug 2. Epub 2021 Aug 2.

China-Japan Union Hospital of Jilin University, Changchun, China.

The subject, splenic pregnancy, is very rare and interesting with about a few cases reported to date. This case report describes a healthy 17-year-old girl admitted to our hospital who complained of amenorrhea for 30 days, intermittent abdominal pain for 3 days and worsening for 1 h. The serum human chorionic gonadotropin (hCG) was greater than 10000. Read More

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Copy number variations characterization and possible candidate genes in miscarriage and stillbirth by next-generation sequencing analysis.

J Gene Med 2021 Aug 3:e3383. Epub 2021 Aug 3.

Center for Precision Medicine, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou, China.

Objective: To explore the etiological relationship between miscarriage and stillbirth and copy number variations (CNVs), and to provide useful genetic guidance for high-risk pregnancy.

Methods: 659 fetal samples were recruited and subjected to DNA extraction and CNV sequencing (CNV-Seq), relevant medical records were collected.

Results: There were 322 cases (48. Read More

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Lateral femoral notch sign and posterolateral tibial plateau fractures and their associated injuries in the setting of an anterior cruciate ligament rupture.

Arch Orthop Trauma Surg 2021 Aug 2. Epub 2021 Aug 2.

Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

Introduction: ACL injury is one of the most common injuries of the knee joint in sports. As accompanying osseous injuries of the ACL rupture a femoral impression the so-called lateral femoral notch sign and a posterolateral fracture of the tibial plateau are described. However, frequency, concomitant ligament injuries and when and how to treat these combined injuries are not clear. Read More

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Indications and outcomes for puppies undergoing mechanical ventilation: 59 cases (2006 to 2020).

Can Vet J 2021 Aug;62(8):839-842

Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA (Rozanski, Lemieux); University of Florida College of Veterinary Medicine - Small Animal Clinical Sciences, 2015 SW 16th Avenue, Gainesville, Florida 32608, USA (Buckley); University of Pennsylvania - Clinical Sciences and Advanced Medicine, 3900 Delancey Street, Ryan Veterinary Hospital, Philadelphia, Pennsylvania 19104, USA (Chalifoux, Silverstein); Canada West Veterinary Specialists Ringgold standard institution, Vancouver, British Columbia, Canada (Kennedy); North Carolina State University Ringgold standard institution - College of Veterinary Medicine, Raleigh, North Carolina, USA (Lynch, Tracy); College of Veterinary Medicine, Texas A&M University System Ringgold standard institution, College Station, Texas, USA (Rutter).

The medical records of 59 puppies from 6 hospitals undergoing mechanical ventilation (MV) between 2006 and 2020 were reviewed to describe the signalment, underlying disease, duration of ventilation, and outcome. The most common underlying diseases were pneumonia ( = 18), non-cardiogenic pulmonary edema ( = 16), and trauma ( = 8). Twenty-six (44%) puppies were weaned from the ventilator. Read More

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Serum miR371 in testicular germ cell cancer before and after orchiectomy, assessed by digital-droplet PCR in a prospective study.

Sci Rep 2021 Aug 2;11(1):15582. Epub 2021 Aug 2.

Mohn Cancer Research Laboratory, Department of Oncology and Medical Physics, Haukeland University Hospital, Jonas Lies vei 91B, 5021, Bergen, Norway.

MicroRNA-371a-3p (miR371) has been suggested as a sensitive biomarker in testicular germ cell cancer (TGCC). We aimed to compare miR371 with the classical biomarkers α-fetoprotein (AFP) and β-human chorionic gonadotropin (hCG). Overall, 180 patients were prospectively enrolled in the study, with serum samples collected before and after orchiectomy. Read More

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Fetus papyraceus-A surprise finding in a "normal" placenta.

Indian J Pathol Microbiol 2021 Jul-Sep;64(3):568-570

Department of Pathology, Bai Jerbai Wadia Hospital for Children and Nowrosjee Wadia Maternity Hospital, Parel, Mumbai, Maharashtra, India.

In the case of single fetal demise in a twin gestation, the fate of the dead twin, surviving twin, and mother depend on the exact time of fetal demise. The dead twin may "vanish" in a first trimester death; form a mummified "fetus papyraceus" due to mechanical compression in the second trimester or show changes of maceration in the third trimester. Hematological complications in the mother and neurological complications in the surviving twin may ensue in later trimester deaths. Read More

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A tale of tripartite: An experience from a tertiary care center of Eastern India.

Indian J Pathol Microbiol 2021 Jul-Sep;64(3):497-503

Department of Anatomy, IPGMER and SSKM Hospital, Kolkata, West Bengal, India.

Background: Crescentic glomerulonephritis (Cr GN) is pattern of glomerular injury resulting from wide range of diseases sharing a common pathogenesis.

Objectives: The objective of our study was to analyze the clinicopathological spectrum and outcome of Cr GN with special reference to its immunopathological subtypes using a panel of immunofluorescence stains.

Materials And Methods: Native renal biopsies with crescentic pattern of injury were included. Read More

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Rapid, early and accurate SARS-CoV-2 detection using RT-qPCR in primary care: a prospective cohort study (REAP-1).

BMJ Open 2021 08 2;11(8):e045225. Epub 2021 Aug 2.

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Objectives: We explore the importance of SARS-CoV-2 sentinel surveillance testing in primary care during a regional COVID-19 outbreak in Austria.

Design: Prospective cohort study.

Setting: A single sentinel practice serving 22 829 people in the ski-resort of Schladming-Dachstein. Read More

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Clinical application of whole transcriptome sequencing for the classification of patients with acute lymphoblastic leukemia.

BMC Cancer 2021 Aug 2;21(1):886. Epub 2021 Aug 2.

MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, 81377, Munich, Germany.

Background: Considering the clinical and genetic characteristics, acute lymphoblastic leukemia (ALL) is a rather heterogeneous hematological neoplasm for which current standard diagnostics require various analyses encompassing morphology, immunophenotyping, cytogenetics, and molecular analysis of gene fusions and mutations. Hence, it would be desirable to rely on a technique and an analytical workflow that allows the simultaneous analysis and identification of all the genetic alterations in a single approach. Moreover, based on the results with standard methods, a significant amount of patients have no established abnormalities and hence, cannot further be stratified. Read More

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First report of causing crown gall disease of roselle ( L.) in Taiwan.

Plant Dis 2021 Aug 2. Epub 2021 Aug 2.

National Taiwan University, 33561, Agricultural Chemistry, Taipei, Taiwan.

Roselle ( L.) plants, whose calyces are used for production of beverages or jams, are mainly cultivated in Taitung County of eastern Taiwan. Since 2016, large crown galls were observed on the roselle plants in the commercial plantations at Taimali and Jinfong Townships of Taitung County. Read More

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Transfer learning artificial intelligence for automated detection of atrial fibrillation in patients undergoing evaluation for suspected obstructive sleep apnoea: a feasibility study.

Sleep Med 2021 Jul 17;85:166-171. Epub 2021 Jul 17.

School of Medicine, The University of Notre Dame Australia, 21 Henry St., Fremantle, WA, 6160, Australia; Bendat Respiratory Research and Development Fund, SJOG Subiaco, WA, 6008, Australia.

Background: Individuals with obstructive sleep apnoea (OSA) experience a higher burden of atrial fibrillation (AF) than the general population, and many cases of AF remain undetected. We tested the feasibility of an artificial intelligence (AI) approach to opportunistic detection of AF from single-lead electrocardiograms (ECGs) which are routinely recorded during in-laboratory polysomnographic sleep studies.

Methods: Using transfer learning, an existing ECG AI model was applied to 1839 single-lead ECG traces recorded during in-laboratory sleep studies without any training of the algorithm. Read More

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Surgical candidates in children with epileptic spasms can be selected without invasive monitoring: A report of 70 cases.

Epilepsy Res 2021 Jul 27;176:106731. Epub 2021 Jul 27.

Epilepsy Center, Cleveland Clinic, Cleveland, OH, 44195, United States. Electronic address:

Objective: Prior surgical series in children with drug-resistant epileptic spasms have reported use of intracranial EEG monitoring in up to two-third of patients. We report outcome after epilepsy surgery for drug-resistant epileptic spasms in a cohort of children without the use of intracranial EEG monitoring in any of the patients.

Methods: Medical records of all consecutive children aged 5 years or under who had epilepsy surgery for epileptic spasms at Cleveland Clinic between 2000 and 2018 were reviewed. Read More

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The Medical Process in Pregnancy Terminations for Fetal Anomaly: An Analysis of Counselling and Bereavement.

J Obstet Gynaecol Can 2021 Jul 30. Epub 2021 Jul 30.

Obstetrics and Gynecology, CHU Sainte-Justine, Obstetrics and Gynecology, Université de Montréal, Center of Excellence in Ethics and Patient Partnership, Clinical Ethics Unit, CHU Ste-Justine, Montreal, Canada. Electronic address:

Pregnancy termination for fetal anomaly (TOPFA) is a possible outcome of a pregnancy complicated by a fetal anomaly detected during routine prenatal care. Limited research is available on the quality of the counselling offered to women, in terms of enabling them to make an informed decision. The goal of this descriptive cohort study was to examine the medical process offered to a cohort of 151 women who underwent TOPFA in 2018 in a single tertiary mother and child hospital to identify areas for potential quality improvement (QI). Read More

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Diarrhea treatment center (DTC) based diarrheal disease surveillance in settlements in the wake of the mass influx of forcibly displaced Myanmar national (FDMN) in Cox's Bazar, Bangladesh, 2018.

PLoS One 2021 2;16(8):e0254473. Epub 2021 Aug 2.

icddr,b, Dhaka, Bangladesh.

Background: In August 2017, after a large influx of forcibly displaced Myanmar nationals (FDMN) in Cox's Bazar, Bangladesh diarrhea treatment centers (DTCs) were deployed. This study aims to report the clinical, epidemiological, and laboratory characteristics of the hospitalized patients.

Methods: The study followed cross-sectional design. Read More

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Association between gene polymorphism and risk of rheumatoid arthritis: a meta-analysis.

Aging (Albany NY) 2021 Aug 2;13(undefined). Epub 2021 Aug 2.

Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital, Wuhan University, Wuhan 430000, Hubei, China.

Cytotoxic T lymphocyte-associated protein 4 () gene polymorphisms may be involved in the risk of Rheumatoid arthritis (RA). However, evidence for the association remains controversial. Therefore, we performed a meta-analysis to confirm the relationship between gene polymorphisms and RA. Read More

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Epidemiology of Plasmodium falciparum Infections in a Semi-Arid Rural African Setting: Evidence of Reactive Case Detection in Northwestern Kenya.

Am J Trop Med Hyg 2021 Aug 2. Epub 2021 Aug 2.

School of Medicine, Moi University College of Health Sciences, Eldoret, Kenya.

In northwestern Kenya, Turkana County has been historically considered unsuitable for stable malaria transmission because of its unfavorable climate and predominantly semi-nomadic population; consequently, it is overlooked during malaria control planning. However, the area is changing, with substantial development, an upsurge in travel associated with resource extraction, and more populated settlements forming. Recently, numerous malaria outbreaks have highlighted the need to characterize malaria transmission and its associated risk factors in the region to inform control strategies. Read More

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Impact of Recent SARS-CoV-2 Infection on the Course and Severity of Dengue in Children: A Prospective Observational Study from North India.

Am J Trop Med Hyg 2021 Aug 2. Epub 2021 Aug 2.

Pediatric Emergency and Intensive Care Units, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

In 2020, a considerable overlap occurred between the COVID-19 pandemic and seasonal dengue transmission in India. This study aimed to evaluate the effects of acute or recent infection with SARS-CoV-2 on the course and outcomes of dengue fever in children. We prospectively enrolled 44 children with a clinical and laboratory diagnosis of dengue fever. Read More

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Correlation of serotype-specific strain in patients with dengue virus infection with neurological manifestations and its outcome.

Neurol Sci 2021 Aug 2. Epub 2021 Aug 2.

Department of Neurology, King George's Medical University, Lucknow, India, PIN-226003.

Introduction: Neurological manifestation of dengue virus infection is a rare entity. Serotypes commonly associated with neurological manifestation are DENV-2 and DENV-3. We plan to detect the serotypes related to the neurological presentation in dengue infection and its correlation with different neurological complications and outcome. Read More

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Genetic etiology of hereditary hearing loss in the Gulf Cooperation Council countries.

Hum Genet 2021 Aug 2. Epub 2021 Aug 2.

Department of Applied Biology, College of Sciences, University of Sharjah, Building W8-Room 107, 27272, Sharjah, United Arab Emirates.

The past 30 years have seen an exponential growth concerning the identification of genes and variants responsible for hereditary hearing loss (HL) worldwide. This has led to a huge gain in our understanding of molecular mechanisms of hearing and deafness, which improved diagnosis for populations with hereditary HL. Many communities around the world, especially in the Middle East and North Africa, have a high prevalence of consanguineous marriages. Read More

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Instability and results after non-operative treatment of large anterior glenoid rim fractures: is there a correlation between fragment size or displacement and recurrence?

Arch Orthop Trauma Surg 2021 Aug 2. Epub 2021 Aug 2.

Department of General and Trauma Surgery, University Bergmannsheil Bochum, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.

Introduction: There is little data available on non-operative treatment of anterior glenoid rim fractures (GRF). Nothing is known about fracture size and displacement in comparison to clinical outcomes and instability in a mainly middle-aged patient population. The aim of this study was to demonstrate the results of non-operative treatment in anterior glenoid rim fractures with the special focus on potential instability/recurrence. Read More

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Involvement of the optic pathway and outcome of visual function in patients with neurohypophyseal germ cell tumor.

Acta Neurochir (Wien) 2021 Aug 2. Epub 2021 Aug 2.

Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Background: Patients with neurohypophyseal germ cell tumors (GCTs) typically present with visual problems. Hence, this study aimed to assess optic pathway involvement based on clinical and radiological findings and to validate the outcome of visual function.

Methods: A total of 16 patients with newly diagnosed neurohypophyseal GCTs who were treated at the University of Tsukuba Hospital between 2000 and 2020 were included in this study. Read More

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