10,499 results match your criteria detected adenomas


Identification of mutant K-RAS in pituitary macroadenoma.

Pituitary 2021 May 5. Epub 2021 May 5.

Laboratório de Biomedicina do Cérebro, Instituto Estadual do Cérebro Paulo Niemeyer, Rua do Rezende156-Centro, Rio de Janeiro, 20231-092, Brazil.

Purpose: RAS genes are among the most frequently mutated genes in cancer, where their mutation frequency varies according to the distinct RAS isoforms and tumour types. Despite occurring more prevalent in malignant tumours, RAS mutations were also observed in few benign tumours. Pituitary adenomas are examples of benign tumours which vary in size and aggressiveness. Read More

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Liver pseudolymphoma (reactive lymphoid hyperplasia): Difficulty in radiological and pathological diagnosis.

Curr Med Imaging 2021 May 4. Epub 2021 May 4.

NECMETTİN ERBAKAN ÜNİVERSİTESİ MERAM TIP FAKÜLTESİ, Turkey.

Pseudolymphoma of the liver (reactive lymphoid hyperplasia) (RLH) is a rare condition. It is usually asymptomatic and detected incidentally on radiological imaging. Imaging features are similar to hepatic adenoma, hepatocellular carcinoma, cholangiocarcinoma, and malignant lymphoma and are not specific for pseudolymphoma of the liver. Read More

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A novel 1-L PEG + ascorbate versus high-volume PEG regimen for colonoscopy cleansing: a multicenter, randomized, phase IV study.

Gastrointest Endosc 2021 Apr 30. Epub 2021 Apr 30.

Digestive Endoscopy Unit, Carpi-Mirandola Hospitals, Azienda USL Modena.

Background And Aims: An adequate bowel cleansing is critical to assure quality and safety of colonoscopy. A novel 1L-PEG plus ascorbate(PEG+ASC) regimen was previously validated against low-volume regimens, but it was never compared with high-volume regimens.

Methods: In a Phase IV study, patients undergoing colonoscopy were randomized 1:1 to receive split-dose 1L PEG+ASC or a split-dose 4L PEG-based regimen in 5 Italian centers. Read More

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Artificial intelligence (AI) real-time detection vs. routine colonoscopy for colorectal neoplasia: a meta-analysis and trial sequential analysis.

Int J Colorectal Dis 2021 May 1. Epub 2021 May 1.

Department of Internal Medicine - Division of Gastroenterology, Emory University, Atlanta, GA, USA.

Goals And Background: Studies analyzing artificial intelligence (AI) in colonoscopies have reported improvements in detecting colorectal cancer (CRC) lesions, however its utility in the realworld remains limited. In this systematic review and meta-analysis, we evaluate the efficacy of AI-assisted colonoscopies against routine colonoscopy (RC).

Study: We performed an extensive search of major databases (through January 2021) for randomized controlled trials (RCTs) reporting adenoma and polyp detection rates. Read More

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Expression and change of miR-199b-5p, s HLA-G in thyroid carcinoma.

Exp Mol Pathol 2021 Apr 28;120:104643. Epub 2021 Apr 28.

Department of Nuclear Medicine, the Affiliated Hospital of Southwest Medical University, Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou 646000, Sichuan Province, China. Electronic address:

Objective: This research aims to investigate the relationship between the expression of microRNA-199b-5p (miR-199b-5p) and soluble human leukocyte antigen G (sHLA-G) in thyroid cancer tissues and its clinicopathological characteristics, as well as its impact on prognosis.

Methods: Frozen tissues and serum from 85 patients with thyroid cancer, 27 with thyroid adenoma, 19 with Hashimoto's thyroiditis and 14 with nodular goiter from February 2014 to March 2016 were sampled. The miR-199b-5pmRNA expression in tissues was analyzed by real-time quantitative PCR. Read More

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Identification and characterization of primary cilia-positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation.

J Pathol 2021 Apr 30. Epub 2021 Apr 30.

Department of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Primary cilia (PC) are non-motile, antenna-like structures on the cell surface. Many types of neoplasms exhibit PC loss, whereas in some neoplasms PC are retained and involved in tumourigenesis. To elucidate the PC status and characteristics of major salivary gland tumours (SGTs), we examined 100 major SGTs encompassing eight histopathological types by immunohistochemical analysis. Read More

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Rare germline variants in the E-cadherin gene CDH1 are associated with the risk of brain tumors of neuroepithelial and epithelial origin.

Acta Neuropathol 2021 Apr 30. Epub 2021 Apr 30.

Department of Human Genetics OE 6300, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

The genetic basis of brain tumor development is poorly understood. Here, leukocyte DNA of 21 patients from 15 families with ≥ 2 glioma cases each was analyzed by whole-genome or targeted sequencing. As a result, we identified two families with rare germline variants, p. Read More

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IDH1 and IDH2 Mutations in Colorectal Cancers.

Am J Clin Pathol 2021 Apr 30. Epub 2021 Apr 30.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objectives: To elucidate clinicopathologic and molecular characteristics of IDH1 and IDH2 (IDH1/2) mutations in colorectal cancers (CRCs).

Methods: We evaluated IDH1/2 mutations in 1,623 CRCs using a next-generation sequencing assay.

Results: IDH1/2 mutations, predominantly IDH1 p. Read More

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Clinicopathological features and risk factors for developing colorectal neoplasia in Hodgkin lymphoma survivors.

Dig Endosc 2021 Apr 30. Epub 2021 Apr 30.

Department of Gastroenterology and Hepatology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Objectives: Hodgkin lymphoma (HL) survivors treated with abdominal radiotherapy and/or procarbazine have an increased risk of developing colorectal neoplasia. We evaluated clinicopathological characteristics and risk factors for developing (advanced) neoplasia (AN) in HL survivors.

Methods: 101 HL survivors (median age 51 years, median age of HL diagnosis 25 years) underwent colonoscopy and 350 neoplasia and 44 AN (classified as advanced adenomas/serrated lesions or colorectal cancer), mostly right-sided, were detected, as published previously. Read More

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Dietary inflammatory index and risk of colorectal adenoma: effect measure modification by race, nonsteroidal anti-inflammatory drugs, cigarette smoking and body mass index?

Cancer Causes Control 2021 Apr 29. Epub 2021 Apr 29.

Department of Family Medicine, University of Virginia School of Medicine, McKim Hall Rm 3156, Charlottesville, VA, 22908, USA.

Purpose: To investigate if the association between dietary inflammatory potential and colorectal adenoma (CRA) is modified by race and factors known to modulate inflammation.

Methods: We examined effect measure modification of race, nonsteroidal anti-inflammatory drugs (NSAIDs), cigarette smoking and body mass index (BMI) on the diet-CRA association by employing energy-adjusted dietary inflammatory index (E-DII™) to characterize dietary inflammatory potential among 587 cases and 1,313 controls participating in a colonoscopy screening-based cross-sectional study of CRA. Participants completed a food frequency questionnaire from which E-DII score was derived. Read More

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Evaluation of a risk score based on dietary and lifestyle factors to target a population at risk in colorectal cancer screening.

Dig Liver Dis 2021 Apr 26. Epub 2021 Apr 26.

Department of Hepato-Gastroenterology, University Hospital, 4 rue Larrey, 49933, Angers, France; HIFIH laboratory, UNIV Angers, Université Bretagne Loire, Angers, France; CAP-Santé 49, Angers, France. Electronic address:

Background: The aim of our study was to assess three risk scores to predict lesions, advanced neoplasia (high-risk adenomas and colorectal cancer (CRC)) and CRC in individuals who participate to colorectal cancer screening.

Methods: The data of dietary and lifestyle risk factors were carried out during 2 mass screening campaigns in France (2013-2016) and the FOBT result was collected until December 2018. The colonoscopy result in positive FOBT was recovered. Read More

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Role of the β-Catenin/REG Iα Axis in the Proliferation of Sessile Serrated Adenoma/Polyps Associated with .

Pathogens 2021 Apr 6;10(4). Epub 2021 Apr 6.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine 1-1, Mukogawa, Nishinomiya 663-8501, Japan.

Although sessile serrated adenoma/polyps (SSA/Ps) may arise through a pathway different from the traditional adenoma-carcinoma sequence, details of SSA/P tumorigenesis still remain unclear. () is frequently detected in colorectal cancer (CRC) tissues and may play a pivotal role in colorectal carcinogenesis. Here, we investigated the relationship between and the β-catenin/REG Iα axis in SSA/Ps and their involvement in the proliferation of these lesions. Read More

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[Clinicopathological features of bronchiolar adenoma versus mixed squamous cell and glandular papilloma: a comparative analysis].

Zhonghua Bing Li Xue Za Zhi 2021 May;50(5):458-464

Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China.

To observe the clinicopathological features of bronchiolar adenoma (BA) and mixed squamous cell and glandular papilloma (MSGP). The relationship between them was also analyzed. Clinical data of eight patients with BA and four patients with MSGP diagnosed in China-Japan Friendship Hospital were collected from January 2018 to January 2020. Read More

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Should Adrenal Venous Sampling Be Performed in PA Patients Without Apparent Adrenal Tumors?

Front Endocrinol (Lausanne) 2021 12;12:645395. Epub 2021 Apr 12.

Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Introduction: Some aldosterone-producing micro-adenomas cannot be detected through image inspection. Therefore, adrenal venous sampling (AVS) is often performed, even in primary aldosteronism (PA) patients who have no apparent adrenal tumors (ATs) on imaging. In most of these cases, however, the PA is bilateral. Read More

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Macroprolactin: From laboratory to clinical practice.

Endocrinol Diabetes Nutr 2021 Apr 23. Epub 2021 Apr 23.

Servicio de Análisis Clínicos, Hospital Universitario Severo Ochoa, Leganés, Madrid, España. Electronic address:

Prolactin measurement is very common in standard clinical practice. It is indicated not only in the study of pituitary adenomas, but also when there are problems with fertility, decreased libido, or menstrual disorders, among other problems. Inadequate interpretation of prolactin levels without contextualizing the laboratory results with the clinical, pharmacological, and gynecological/urological history of patients leads to erroneous diagnoses and, thus, to poorly based studies and treatments. Read More

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Impact of molecular testing on detecting mimics of oncocytic neoplasms in thyroid fine-needle aspirates diagnosed as follicular neoplasm of Hürthle cell (oncocytic) type.

Cancer Cytopathol 2021 Apr 26. Epub 2021 Apr 26.

Department of Pathology, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania.

Background: Some thyroid nodules cytologically presenting as follicular neoplasm, Hürthle cell (Oncocytic) type (FNHCT), are not oncocytic tumors and represent autonomously functioning thyroid nodules (AFTNs) with TSHR, GNAS, and EZH1 mutations or oncocytic metaplasia. A to be defined subset of FNHCT harbors genome haploidisation-type DNA copy number alterations (GH-CNA). Molecular profiling of FNHCT may distinguish oncocytic neoplasms from its mimics. Read More

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Genetics in Endocrinology: Impact of race and sex on genetic causes of aldosterone-producing adenomas.

Eur J Endocrinol 2021 Apr 1. Epub 2021 Apr 1.

W Rainey, Department of Molecular and Integrative Physiology , University of Michigan Medical school, Ann Arbor, United States.

Primary aldosteronism (PA) is a common cause of secondary hypertension. Recent technological advances in genetic analysis have provided a better understanding of the molecular pathogenesis of this disease. The application of next-generation sequencing has resulted in the identification of somatic mutations in aldosterone-producing adenoma (APA), a major subtype of PA. Read More

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Pan-TRK Immunohistochemistry Is Highly Correlated With NTRK3 Gene Rearrangements in Salivary Gland Tumors.

Am J Surg Pathol 2021 Apr 23. Epub 2021 Apr 23.

Department of Pathology, Centre Henri Becquerel INSERM 1245, Rouen Normandy Uniiversity Department of Pathology, Rouen University Hospital, Rouen Platform of Experimental Pathology, Department of Diagnostic and Theranostic Medicine, Curie Institute Department of Pathology, Lariboisière Hospital, Paris, France.

Aims: Secretory carcinoma (SC) is characterized by ETV6 rearrangements, most often ETV6-NTRK3 fusion. Given its histologic overlap with other salivary gland tumors (SGTs), SCs can be difficult to diagnose without genetic confirmation. A recently developed pan-TRK (tropomyosin receptor kinase) antibody shows promise for identifying tumors with NTRK (neurotrophic tyrosine kinase receptor 3) fusions. Read More

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Diffusion-weighted imaging with histogram analysis of the apparent diffusion coefficient maps in the diagnosis of parotid tumours.

Int J Oral Maxillofac Surg 2021 Apr 21. Epub 2021 Apr 21.

Department of Diagnosis and Oral Radiology, Mansoura Faculty of Dentistry, Mansoura, Egypt.

The aim of this study was to investigate the role of diffusion-weighted imaging (DWI) with histogram analysis of apparent diffusion coefficient (ADC) maps in the characterization of parotid tumours. This prospective study included 39 patients with parotid tumours. All patients underwent magnetic resonance imaging with DWI, and ADC maps were generated. Read More

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Clinical characteristics and genetic analyses in a Chinese family affected by primary aldosteronism: a case report.

Ann Palliat Med 2021 Apr 16. Epub 2021 Apr 16.

Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Branch of National Clinical Research Center for Metabolic Disease, Wuhan, China.

The clinical and aetiological characteristics of family-clustered primary aldosteronism (PA) are not fully understood and need further exploration. Our study reported a PA case with a family history accompanied by unusual concomitant disease and explored the genetic background of the affected family members, thus providing more evidence of the manifestation and pathogenesis of family-clustered PA. We studied a family with PA in which the proband and her maternal aunt were diagnosed with aldosteroneproducing adenoma (APA) and primary adrenal hyperplasia (PAH), respectively. Read More

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Distinct Prognostic Factors in Sporadic and Multiple Endocrine Neoplasia Type 1-Related Pancreatic Neuroendocrine Tumors.

Horm Metab Res 2021 May 20;53(5):319-325. Epub 2021 Apr 20.

Division of Endocrinology and Metabolism, Sheba Medical Center at Tel Hashomer, Tel Hashomer, Israel.

Pancreatic neuroendocrine tumors (PNET) may develop sporadically or in the context of hereditary syndromes. In patients with multiple endocrine neoplasia type 1 (MEN1), PNET is the leading cause of death. Our aim was to compare the mortality risk in sporadic and MEN1-related PNETs and identify high-risk populations. Read More

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Development and validation of a risk prediction model for high-risk adenomas at the time of first screening colonoscopy among screening aged Canadians.

Prev Med 2021 Apr 18;148:106563. Epub 2021 Apr 18.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Canada; Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Alberta, Canada; Department of Oncology, Cumming School of Medicine, University of Calgary, Canada. Electronic address:

The aim of this study was to develop a risk prediction model for high risk adenomas (HRAs) detected at screening colonoscopy based on readily available participant information. The cohort consisted of 3035 participants aged 50 to 74 years with no history of cancer who underwent a primary screening colonoscopy at a centralized colon cancer screening centre between 2008 and 2016. A multivariable logistic regression model was created using CRC risk factors identified from prior research. Read More

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Impact of simethicone on bowel cleansing during colonoscopy in Chinese patients.

World J Clin Cases 2021 Apr;9(10):2238-2246

Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei Province, China.

Background: Four-liter polyethylene glycol (PEG) solutions are effective for bowel cleansing, but their large volume might hinder patient compliance. Due to the unique features of Asians, 4 L PEG might be a suboptimal bowel preparation in predominantly ethnically Asian countries. In view of this, a balance should be achieved between the volume and effectiveness. Read More

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Participatory simulation modeling to inform colorectal cancer screening in a complex remote northern health system: Canada's Northwest Territories.

Int J Med Inform 2021 Apr 8;150:104455. Epub 2021 Apr 8.

Office of Research Services, MacEwan University, Edmonton, AB, Canada.

Background & Aims: Colorectal cancer (CRC) mortality in the Northwest Territories (NWT), a northern region of Canada, could be reduced by implementing a CRC screening program. However, this may require additional colonoscopy resources. We used participatory simulation modeling to predict colonoscopy demand and to develop strategies for implementing a feasible and effective CRC screening program in this complex remote northern health system. Read More

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Acromegaly presenting with myelopathy due to ossification of posterior longitudinal ligament: a case report.

BMC Musculoskelet Disord 2021 Apr 14;22(1):353. Epub 2021 Apr 14.

Department of Orthopedic Surgery, Toho University Omori Medical Center, 6-11-1, Omori-Nishi, Ota-Ku, Tokyo, 143-8541, Japan.

Background: Acromegaly is a rare disease caused by high serum levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), often originating from a pituitary adenoma. Spinal and peripheral joint abnormalities are caused by these hormonal hypersecretions. In particular, the response to GH is involved in the onset of ossification of the spinal ligament in vitro, especially ossification of the posterior longitudinal ligament (OPLL). Read More

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IMMUNOHISTOCHEMICAL FEATURES OF THE EXPRESSION OF HUMAN PAPILLOMA VIRUS TYPE 16 IN PLEOMORPHIC ADENOMAS OF SALIVARY GLAND.

Wiad Lek 2021 ;74(1):7-10

NATIONAL CANCER INSTITUTE, KYIV, UKRAINE.

Objective: The aim is to reveal the immunohistochemical features of human papilloma virus type 16 expression in various histological variants of pleomorphic adenomas of the salivary gland.

Patients And Methods: Materials and methods: The material of the study was surgical and biopsy material from 30 patients with pleomorphic adenomas of the salivary glands, among which in 15 cases mesenchymal was detected, in 10 - mixed, in 5 cases - epithelial histological variant, respectively. Immunohistochemical study was performed, using mouse monoclonal antibody to human papilloma virus type 16. Read More

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Deployment of a bioabsorbable plate as the rigid buttress for skull base repair after endoscopic pituitary surgery.

Gland Surg 2021 Mar;10(3):1010-1017

Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, China.

Background: Bioresorbable alloplastic implants have become desirable as a rigid buttress for reconstructing skull base defects. This study aimed to describe the use of a biodegradable plate (PolyMax RAPID) in skull base repair of endoscopic endonasal pituitary surgery and to investigate the clinical outcome and safety of this novel method.

Methods: Between January 2019 and January 2020, 22 patients with pituitary adenomas who underwent endoscopic skull base repair with a Polymax RAPID plate were included. Read More

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Metanephric Adenoma Mimicking Renal Cell Carcinoma on 99mTc-MIBI SPECT/CT.

Clin Nucl Med 2021 Apr 5. Epub 2021 Apr 5.

From the Departments of Radiology Nuclear Medicine, Changhai Hospital, Navy Military Medical University, Shanghai, China.

Abstract: Metanephric adenoma is a rare benign renal tumor. A 49-year-old woman presented with a left renal pelvic mass detected by ultrasound. Enhanced CT of the kidney showed slight enhancement of the mass. Read More

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Indel mutations of sheep gene and their associations with growth traits.

Anim Biotechnol 2021 Apr 7:1-7. Epub 2021 Apr 7.

Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China.

is mainly expressed in embryonic development, and it is reported to take an effect on the growth performance of mice, cattle, pigs, and sheep. To explore how conservative the is in different sheep breeds, the effects of the two indel variants on the growth traits of the Chinese Luxi blackhead (LXBH) sheep were firstly detected. The P2-del 30 bp and P4-del 45 bp indel loci of the sheep gene were significantly related to 15 growth traits ( < 0. Read More

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Mucinous Cystic Adenoma of the Liver: A Thought-Provoking Case of an Uncommon Hepatic Neoplasm.

Am J Case Rep 2021 Apr 3;22:e931368. Epub 2021 Apr 3.

Department of Surgery, Shiga General Hospital, Moriyama, Shiga, Japan.

BACKGROUND Mucinous cystic neoplasm (MCN) of the liver is a rare hepatic neoplasm: a cystic, mucus-producing tumor. Histopathologic examination reveals ovarian-like stroma. The origin of MCN of the liver is still unknown, although ectopic ovarian-like stroma in the liver has been suggested as a possibility. Read More

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